{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T04:01:05Z","timestamp":1785556865724,"version":"3.56.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21\\u202FK08087"],"award-info":[{"award-number":["21\\u202FK08087"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-cardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.jjcc.2025.01.021","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T01:38:58Z","timestamp":1738805938000},"page":"164-171","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prediction of left ventricular reverse remodeling in patients with heart failure with reduced ejection fraction using cardiopulmonary exercise testing"],"prefix":"10.1016","volume":"86","author":[{"given":"Yoshihiro","family":"Hosoda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumi","family":"Goda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Yanagisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Miura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Nakamaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayaka","family":"Funabashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Tashiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Nishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinsuke","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Soejima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kohno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jjcc.2025.01.021_bb0005","first-page":"e895","article-title":"2022 AHA\/ACC\/HFSA guideline for the management of heart failure: a report of the American College of Cardiology\/American Heart Association joint committee on clinical practice guidelines","volume":"145","author":"Heidenreich","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0010","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0015","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1093\/eurheartj\/ehac210","article-title":"Accelerated and personalized therapy for heart failure with reduced ejection fraction","volume":"43","author":"Shen","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0020","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1002\/ejhf.2149","article-title":"Rapid evidence-based sequencing of foundational drugs for heart failure and a reduced ejection fraction","volume":"23","author":"Packer","year":"2021","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0025","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jacc.2020.05.075","article-title":"Heart failure with recovered left ventricular ejection fraction: JACC scientific expert panel","volume":"76","author":"Wilcox","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0030","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.jchf.2019.06.004","article-title":"Imaging, biomarker, and clinical predictors of cardiac remodeling in heart failure with reduced ejection fraction","volume":"7","author":"Aimo","year":"2019","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0035","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1002\/ejhf.2522","article-title":"Cardiac remodelling - part 2: clinical, imaging and laboratory findings. A review from the study group on biomarkers of the heart failure Association of the European Society of cardiology","volume":"24","author":"Aimo","year":"2022","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0040","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1161\/01.CIR.83.3.778","article-title":"Value of peak exercise oxygen consumption for optimal timing of cardiac transplantation in ambulatory patients with heart failure","volume":"83","author":"Mancini","year":"1991","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0045","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.jchf.2016.03.022","article-title":"Cardiopulmonary exercise testing in heart failure","volume":"4","author":"Malhotra","year":"2016","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0050","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/ejhf.979","article-title":"Role of cardiopulmonary exercise testing in clinical stratification in heart failure. A position paper from the committee on exercise physiology and training of the heart failure Association of the European Society of cardiology","volume":"20","author":"Corra","year":"2018","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0055","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.healun.2010.09.007","article-title":"The heart failure survival score outperforms the peak oxygen consumption for heart transplantation selection in the era of device therapy","volume":"30","author":"Goda","year":"2011","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0060","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/S0735-1097(97)00078-8","article-title":"Clinical correlates and prognostic significance of the ventilatory response to exercise in chronic heart failure","volume":"29","author":"Chua","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0065","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1053\/euhj.1999.1863","article-title":"Cardiopulmonary exercise testing for prognosis in chronic heart failure: continuous and independent prognostic value from VE\/VCO(2)slope and peak VO(2)","volume":"21","author":"Francis","year":"2000","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0070","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.ahj.2003.07.014","article-title":"Peak VO2 and VE\/VCO2 slope in patients with heart failure: a prognostic comparison","volume":"147","author":"Arena","year":"2004","journal-title":"Am Heart J"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0075","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.jcmg.2008.04.012","article-title":"Dobutamine stress testing as a diagnostic tool for evaluation of myocardial contractile reserve in asymptomatic or mildly symptomatic patients with dilated cardiomyopathy","volume":"1","author":"Kobayashi","year":"2008","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0080","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1016\/j.jacc.2004.08.051","article-title":"Regional coronary flow and contractile reserve in patients with idiopathic dilated cardiomyopathy","volume":"44","author":"Skalidis","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0085","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1093\/ejechocard\/jep033","article-title":"Myocardial contractile reserve during exercise predicts left ventricular reverse remodelling after cardiac resynchronization therapy","volume":"10","author":"Lancellotti","year":"2009","journal-title":"Eur J Echocardiogr"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0090","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/eurheartj\/ehn483","article-title":"Exercise stress echocardiography is superior to rest echocardiography in predicting left ventricular reverse remodelling and functional improvement after cardiac resynchronization therapy","volume":"30","author":"Rocchi","year":"2009","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0095","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.jjcc.2012.03.004","article-title":"Peak oxygen uptake during cardiopulmonary exercise testing determines response to cardiac resynchronization therapy","volume":"60","author":"Arora","year":"2012","journal-title":"J Cardiol"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0100","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/ejhf.2115","volume":"23","author":"Bozkurt","year":"2021","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0286057","article-title":"Characteristics of cardiopulmonary exercise testing in patients with combined post- and pre-capillary pulmonary hypertension due to left heart disease","volume":"18","author":"Goda","year":"2023","journal-title":"PLoS One"},{"issue":"60","key":"10.1016\/j.jjcc.2025.01.021_bb0110","first-page":"2020","article-title":"A new method for detecting anaerobic threshold by gas exchange","volume":"1986","author":"Beaver","year":"1985","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0120","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.031179","article-title":"Temporal trends in heart failure management and outcomes: insights from a Japanese multicenter registry of tertiary care centers","volume":"12","author":"Nakamaru","year":"2023","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0125","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.echo.2020.08.015","article-title":"Cardiac reserve and exercise capacity: insights from combined cardiopulmonary and exercise echocardiography stress testing","volume":"34","author":"Pugliese","year":"2021","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0130","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jjcc.2017.02.005","article-title":"Myocardial contractile reserve predicts left ventricular reverse remodeling and cardiac events in dilated cardiomyopathy","volume":"70","author":"Morimoto","year":"2017","journal-title":"J Cardiol"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0135","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1161\/01.RES.59.3.297","article-title":"Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure","volume":"59","author":"Bristow","year":"1986","journal-title":"Circ Res"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0140","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1253\/circj.CJ-14-1058","article-title":"Novel scoring system using postoperative cardiopulmonary exercise testing predicts future explantation of left ventricular assist device","volume":"79","author":"Imamura","year":"2015","journal-title":"Circ J"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0145","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.116.003694","article-title":"Predicting success: left ventricular assist device explantation evaluation protocol using comprehensive cardiopulmonary exercise testing","volume":"10","author":"Steiner","year":"2017","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0150","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1136\/heartjnl-2016-309746","article-title":"Longitudinal strain combined with delayed-enhancement magnetic resonance improves risk stratification in patients with dilated cardiomyopathy","volume":"103","author":"Chimura","year":"2017","journal-title":"Heart"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0155","doi-asserted-by":"crossref","first-page":"1301509","DOI":"10.3389\/fcvm.2023.1301509","article-title":"The predictive value of coronary microvascular dysfunction for left ventricular reverse remodelling in dilated cardiomyopathy","volume":"10","author":"Kan","year":"2023","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0160","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.89169","article-title":"Myocardial microRNAs associated with reverse remodeling in human heart failure","volume":"2","author":"Sucharov","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0165","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1136\/heartjnl-2016-311017","article-title":"Association between mutation status and left ventricular reverse remodelling in dilated cardiomyopathy","volume":"103","author":"Dal Ferro","year":"2017","journal-title":"Heart"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0170","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jchf.2022.09.008","article-title":"Prediction of left ventricular reverse remodeling and outcomes by circulating collagen-derived peptides","volume":"11","author":"Ravassa","year":"2023","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0175","first-page":"2745","article-title":"Diagnostic yield and predictive value on left ventricular remodelling of genetic testing in dilated cardiomyopathy. ESC","volume":"10","author":"Bertero","year":"2023","journal-title":"Heart Fail"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0180","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1002\/ehf2.14619","article-title":"Incidence and predictors of heart failure with improved ejection fraction category in a HFrEF patient population","volume":"11","author":"Solymossi","year":"2024","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0185","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s00380-015-0648-2","article-title":"Time course of left ventricular reverse remodeling in response to pharmacotherapy: clinical implication for heart failure prognosis in patients with idiopathic dilated cardiomyopathy","volume":"31","author":"Ikeda","year":"2016","journal-title":"Heart Vessel"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0190","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.jacc.2018.05.042","article-title":"Dynamic trajectories of left ventricular ejection fraction in heart failure","volume":"72","author":"Lupon","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0195","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1093\/eurheartj\/ehz233","article-title":"Frequency, predictors, and prognosis of ejection fraction improvement in heart failure: an echocardiogram-based registry study","volume":"40","author":"Ghimire","year":"2019","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0200","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ijcard.2015.02.019","article-title":"Biomarker-assist score for reverse remodeling prediction in heart failure: the ST2-R2 score","volume":"184","author":"Lupon","year":"2015","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jjcc.2025.01.021_bb0205","doi-asserted-by":"crossref","first-page":"8768","DOI":"10.1038\/s41598-022-12823-z","article-title":"Prognosis and diastolic dysfunction predictors in patients with heart failure and recovered ejection fraction","volume":"12","author":"Takada","year":"2022","journal-title":"Sci Rep"}],"container-title":["Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0914508725000218?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0914508725000218?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T03:16:11Z","timestamp":1785554171000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0914508725000218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S0914508725000218"],"URL":"https:\/\/doi.org\/10.1016\/j.jjcc.2025.01.021","relation":{},"ISSN":["0914-5087"],"issn-type":[{"value":"0914-5087","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prediction of left ventricular reverse remodeling in patients with heart failure with reduced ejection fraction using cardiopulmonary exercise testing","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jjcc.2025.01.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Japanese College of Cardiology. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}