{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:59:50Z","timestamp":1790819990718,"version":"4.1.0"},"reference-count":69,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007834","name":"Ningbo Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["2022J249"],"award-info":[{"award-number":["2022J249"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004387","name":"Ningbo University","doi-asserted-by":"publisher","award":["2022-F21"],"award-info":[{"award-number":["2022-F21"]}],"id":[{"id":"10.13039\/501100004387","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-cardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.jjcc.2025.04.015","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T02:47:35Z","timestamp":1746499655000},"page":"328-338","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Causal relationship between circulating inflammatory proteins and atherosclerosis: a bidirectional Mendelian randomization study and meta-analysis"],"prefix":"10.1016","volume":"86","author":[{"given":"Bin","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dehai","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuodong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jjcc.2025.04.015_bb0005","first-page":"67","article-title":"Atherosclerosis: TREM1 in atherosclerosis development","volume":"14","author":"Huynh","year":"2017","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0010","author":"World Health Organization"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0015","first-page":"507","article-title":"Atherosclerosis: treating atherosclerosis with antitumour antibodies","volume":"13","author":"Fern\u00e1ndez-Ruiz","year":"2016","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0020","first-page":"437","article-title":"Atherosclerosis","volume":"2","author":"Skillings","year":"1998","journal-title":"Lippincotts Prim Care Pract"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0025","doi-asserted-by":"crossref","first-page":"794","DOI":"10.2174\/138920110793262060","article-title":"Natural products in regression and slowing of progression of atherosclerosis","volume":"11","author":"Prasad","year":"2010","journal-title":"Curr Pharm Biotechnol"},{"issue":"Suppl. 1","key":"10.1016\/j.jjcc.2025.04.015_bb0030","first-page":"38","article-title":"Soluble vascular cell adhesion molecule-1 (VCAM-1) as potential marker of atherosclerosis","volume":"82","author":"Peter","year":"1999","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0035","first-page":"11922","article-title":"Roles of antibody against oxygenized low density lipoprotein in atherosclerosis: recent advances. Int","volume":"8","author":"Zhang","year":"2015","journal-title":"J Clin Exp Med"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0040","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.atherosclerosis.2011.09.013","article-title":"The association between cerebral atherosclerosis and arterial stiffness in acute ischemic stroke","volume":"219","author":"Kim","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0045","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.jjcc.2022.09.013","article-title":"Emerging roles of protease-activated receptors in cardiometabolic disorders","volume":"81","author":"Hara","year":"2023","journal-title":"J Cardiol"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0050","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3390\/diagnostics11020318","article-title":"Circulating miRNAs are associated with the systemic extent of atherosclerosis: novel observations for miR-27b and miR-146","volume":"11","author":"Pereira-da-Silva","year":"2021","journal-title":"Diagnostics (Basel)"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0055","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.07.043","article-title":"Distribution of cervicocephalic atherosclerotic lesions and their correlation with cardiovascular risk factors in a population of Amerindians. The Atahualpa Project","volume":"27","author":"Del Brutto","year":"2018","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0060","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1001\/jama.2017.17219","article-title":"Mendelian randomization","volume":"318","author":"Emdin","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0065","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1001\/jama.2021.18236","article-title":"Strengthening the reporting of observational studies in epidemiology using Mendelian randomization: the STROBE-MR Statement","volume":"326","author":"Skrivankova","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0070","doi-asserted-by":"crossref","first-page":"186","DOI":"10.12688\/wellcomeopenres.15555.3","article-title":"Guidelines for performing Mendelian randomization investigations: update for summer 2023","volume":"4","author":"Burgess","year":"2023","journal-title":"Wellcome Open Res"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0075","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1038\/s41590-023-01588-w","article-title":"Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets","volume":"24","author":"Zhao","year":"2023","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0080","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/s41586-022-05473-8","article-title":"FinnGen provides genetic insights from a well-phenotyped isolated population","volume":"613","author":"Kurki","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0085","doi-asserted-by":"crossref","first-page":"1334361","DOI":"10.3389\/fimmu.2023.1334361","article-title":"The causal effect of cytokine cycling levels on osteoarthritis: a bidirectional Mendelian randomized study","volume":"14","author":"Jiang","year":"2024","journal-title":"Front Immunol"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0090","doi-asserted-by":"crossref","first-page":"113","DOI":"10.12688\/wellcomeopenres.15334.1","article-title":"Using the MR-Base platform to investigate risk factors and drug targets for thousands of phenotypes","volume":"4","author":"Walker","year":"2019","journal-title":"Wellcome Open Res"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0095","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1093\/bioinformatics\/btw373","article-title":"PhenoScanner: a database of human genotype-phenotype associations","volume":"32","author":"Staley","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0100","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/ije\/dyr036","article-title":"Avoiding bias from weak instruments in Mendelian randomization studies","volume":"40","author":"Burgess","year":"2011","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0105","doi-asserted-by":"crossref","first-page":"R89","DOI":"10.1093\/hmg\/ddu328","article-title":"Mendelian randomization: genetic anchors for causal inference in epidemiological studies","volume":"23","author":"Davey Smith","year":"2014","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0110","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/gepi.21758","article-title":"Mendelian randomization analysis with multiple genetic variants using summarized data","volume":"37","author":"Burgess","year":"2013","journal-title":"Genet Epidemiol"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0115","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression","volume":"44","author":"Bowden","year":"2015","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0120","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/gepi.21965","article-title":"Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator","volume":"40","author":"Bowden","year":"2016","journal-title":"Genet Epidemiol"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0125","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1093\/ije\/dyx102","article-title":"Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption","volume":"46","author":"Hartwig","year":"2017","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0130","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1002\/sim.5453","article-title":"Quantifying the impact of between-study heterogeneity in multivariate meta-analyses","volume":"31","author":"Jackson","year":"2012","journal-title":"Stat Med"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0135","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/jrsm.1346","article-title":"Meta-analysis and Mendelian randomization: a review","volume":"10","author":"Bowden","year":"2019","journal-title":"Res Synth Methods"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0140","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10654-017-0255-x","article-title":"Interpreting findings from Mendelian randomization using the MR-Egger method","volume":"32","author":"Burgess","year":"2017","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0145","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat Genet"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0150","article-title":"Orienting the causal relationship between imprecisely measured traits using GWAS summary data","volume":"13","author":"Hemani","year":"2017","journal-title":"PLoS Genet"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0155","series-title":"Meta-analysis with R (use-R!)","author":"Schwarzer","year":"2015"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0160","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jjcc.2022.08.010","article-title":"Role of DNA damage in the pathogenesis of atherosclerosis","volume":"81","author":"Ishida","year":"2023","journal-title":"J Cardiol"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0165","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jjcc.2024.03.003","article-title":"The role of the NLRP3 inflammasome in atherosclerotic disease: systematic review and meta-analysis","volume":"84","author":"Khair","year":"2024","journal-title":"J Cardiol"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0170","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.jtcvs.2020.05.002","article-title":"Cerebral atherosclerosis and early ischemic stroke after left-sided valve replacement surgery","volume":"163","author":"Kim","year":"2022","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0175","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1242\/dev.087601","article-title":"Coronary veins determine the pattern of sympathetic innervation in the developing heart","volume":"140","author":"Nam","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0180","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.healun.2012.09.030","article-title":"VEGF-C, VEGF-A and related angiogenesis factors as biomarkers of allograft vasculopathy in cardiac transplant recipients","volume":"32","author":"Daly","year":"2013","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0185","first-page":"10","article-title":"The role of interleukins in the pathogenesis of atherosclerosis","volume":"84","author":"Gitel\u2019","year":"2006","journal-title":"Klin Med (Mosk)"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0190","doi-asserted-by":"crossref","first-page":"891","DOI":"10.3892\/etm.2017.4600","article-title":"The role of tumor necrosis factor-like weak inducer of apoptosis in atherosclerosis via its two different receptors","volume":"14","author":"Liu","year":"2017","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0195","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.826630","article-title":"The role of tumor necrosis factor associated factors (TRAFs) in vascular inflammation and atherosclerosis","volume":"9","author":"Gissler","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0200","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1158\/0008-5472.CAN-20-2978","article-title":"The CDCP1 signaling hub: a target for cancer detection and therapeutic intervention","volume":"81","author":"Khan","year":"2021","journal-title":"Cancer Res"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0205","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.1038\/s41418-020-0578-0","article-title":"An oncogenic viral interferon regulatory factor upregulates CUB domain-containing protein 1 to promote angiogenesis by hijacking transcription factor lymphoid enhancer-binding factor 1 and metastasis suppressor CD82","volume":"27","author":"Li","year":"2020","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0210","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1161\/CIRCRESAHA.123.323200","article-title":"Myocardial recovery in recent onset dilated cardiomyopathy: role of CDCP1 and cardiac fibrosis","volume":"133","author":"Liu","year":"2023","journal-title":"Circ Res"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0215","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1161\/ATVBAHA.111.229302","article-title":"Arginase I attenuates inflammatory cytokine secretion induced by lipopolysaccharide in vascular smooth muscle cells","volume":"31","author":"Wang","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0220","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/cvr\/cvp241","article-title":"Interleukin 8 and cardiovascular disease","volume":"84","author":"Apostolakis","year":"2009","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0225","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1007\/s10787-024-01437-8","article-title":"Sinomenine protects against atherosclerosis in apolipoprotein E-knockout mice by inhibiting of inflammatory pathway","volume":"32","author":"Gao","year":"2024","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0230","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.atherosclerosis.2018.03.007","article-title":"CD137: a checkpoint regulator involved in atherosclerosis","volume":"272","author":"S\u00f6derstr\u00f6m","year":"2018","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0235","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1189\/jlb.0311160","article-title":"Nuocytes: expanding the innate cell repertoire in type-2 immunity","volume":"90","author":"Barlow","year":"2011","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0240","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1365-2567.2011.03499.x","article-title":"Insights into the initiation of type 2 immune responses","volume":"134","author":"Oliphant","year":"2011","journal-title":"Immunology"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0245","first-page":"cm8","article-title":"Interleukin-13 (IL-13) pathway","volume":"2005","author":"Kelly-Welch","year":"2005","journal-title":"Sci STKE"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0250","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1002\/emmm.201201374","article-title":"Interleukin-13 protects from atherosclerosis and modulates plaque composition by skewing the macrophage phenotype","volume":"4","author":"Cardilo-Reis","year":"2012","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0255","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1744-313X.2005.00504.x","article-title":"Genetic contribution of the tumour necrosis factor (TNF) B + 252*2\/2 genotype, but not the TNFa,b microsatellite alleles, to systemic lupus erythematosus in Japanese patients","volume":"32","author":"Takeuchi","year":"2005","journal-title":"Int J Immunogenet"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0260","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41584-021-00639-6","article-title":"Insights into the biology and therapeutic implications of TNF and regulatory T cells","volume":"17","author":"Salomon","year":"2021","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0265","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.3390\/biom13111640","article-title":"A systematic review of interleukins as diagnostic and prognostic biomarkers for peripheral artery disease","volume":"13","author":"Djahanpour","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0270","doi-asserted-by":"crossref","first-page":"186","DOI":"10.31083\/j.rcm2505186","article-title":"Association between IL-2 receptor and severe coronary artery calcification in patients with coronary artery disease","volume":"25","author":"Wang","year":"2024","journal-title":"Rev Cardiovasc Med"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0275","doi-asserted-by":"crossref","DOI":"10.1056\/EVIDoa2100009","article-title":"Regulatory T-cell response to low-dose interleukin-2 in ischemic heart disease","volume":"1","author":"Zhao","year":"2022","journal-title":"NEJM Evid"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0280","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1161\/CIRCRESAHA.119.316461","article-title":"Regulatory T cells license macrophage pro-resolving functions during atherosclerosis regression","volume":"127","author":"Sharma","year":"2020","journal-title":"Circ Res"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0285","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1159\/000485818","article-title":"The IL-2\/anti-IL-2 complex attenuates cardiac ischaemia-reperfusion injury through expansion of regulatory T cells","volume":"44","author":"Xiao","year":"2017","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0290","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1161\/hq1201.100220","article-title":"Immune mechanisms in atherosclerosis","volume":"21","author":"Hansson","year":"2001","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0295","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.chom.2014.08.017","article-title":"Epithelial IL-22RA1-mediated fucosylation promotes intestinal colonization resistance to an opportunistic pathogen","volume":"16","author":"Pham","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0300","doi-asserted-by":"crossref","first-page":"19108","DOI":"10.1038\/s41598-020-73600-4","article-title":"Expression of CARD8 in human atherosclerosis and its regulation of inflammatory proteins in human endothelial cells","volume":"10","author":"Paramel","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0305","doi-asserted-by":"crossref","first-page":"586","DOI":"10.3346\/jkms.2015.30.5.586","article-title":"Association between serum fibroblast growth factor 21 and coronary artery disease in patients with type 2 diabetes","volume":"30","author":"Kim","year":"2015","journal-title":"J Korean Med Sci"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0310","first-page":"1453","article-title":"Therapeutic effects of fibroblast growth factor-21 against atherosclerosis via the NF-\u03baB pathway","volume":"17","author":"Zhang","year":"2018","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0315","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s10020-021-00353-9","article-title":"Interleukin-22: a potential therapeutic target in atherosclerosis","volume":"27","author":"Luo","year":"2021","journal-title":"Mol Med"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0320","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3390\/biom14010038","article-title":"GDF-15 inhibits ADP-induced human platelet aggregation through the GFRAL\/RET signaling complex","volume":"14","author":"Xie","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0325","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1182\/blood.2019004571","article-title":"Protein expression profiling suggests relevance of noncanonical pathways in isolated pulmonary embolism","volume":"137","author":"Ten Cate","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0330","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cytogfr.2018.04.004","article-title":"IL-6 family cytokines: key inflammatory mediators as biomarkers and potential therapeutic targets","volume":"41","author":"Unver","year":"2018","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0335","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/CRD.0000000000000021","article-title":"Inflammation and atherosclerosis: a review of the role of interleukin-6 in the development of atherosclerosis and the potential for targeted drug therapy","volume":"22","author":"Hartman","year":"2014","journal-title":"Cardiol Rev"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0340","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.1161\/01.CIR.0000148135.08582.97","article-title":"Impact of interleukin-6 on plaque development and morphology in experimental atherosclerosis","volume":"110","author":"Schieffer","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2025.04.015_bb0345","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.3390\/jpm13121669","article-title":"Pro-inflammatory biomarkers and progression of atherosclerosis in patients with myocardial infarction with non-obstructive coronary artery disease: 1-year follow-up","volume":"13","author":"Ryabov","year":"2023","journal-title":"J Pers Med"}],"container-title":["Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0914508725001145?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0914508725001145?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:22:03Z","timestamp":1790817723000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0914508725001145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":69,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S0914508725001145"],"URL":"https:\/\/doi.org\/10.1016\/j.jjcc.2025.04.015","relation":{},"ISSN":["0914-5087"],"issn-type":[{"value":"0914-5087","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Causal relationship between circulating inflammatory proteins and atherosclerosis: a bidirectional Mendelian randomization study and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jjcc.2025.04.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Japanese College of Cardiology. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}