{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T18:37:38Z","timestamp":1775932658924,"version":"3.50.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-cardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jjcc.2025.09.006","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T22:12:58Z","timestamp":1758060778000},"page":"576-585","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prodromal symptoms and the care-seeking behavior in patients with acute ST-segment elevation myocardial infarction"],"prefix":"10.1016","volume":"86","author":[{"given":"Akinori","family":"Tamura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Shiomi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Morimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Imada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihisa","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazushige","family":"Kadota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natsuhiko","family":"Ehara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoji","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiro","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Miyake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Tamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Ogita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Suwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Ando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koh","family":"Ono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jjcc.2025.09.006_bb0005","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0735-1097(95)80002-X","article-title":"Preinfarction angina as a major predictor of left ventricular function and long-term prognosis after a first Q wave myocardial infarction","volume":"26","author":"Anzai","year":"1995","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2025.09.006_bb0010","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1161\/01.CIR.91.2.291","article-title":"Prodromal angina limits infarct size. A role for ischemic preconditioning","volume":"91","author":"Ottani","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2025.09.006_bb0015","doi-asserted-by":"crossref","first-page":"S103","DOI":"10.1016\/S0167-5273(98)00298-8","article-title":"Clinical relevance of prodromal angina before acute myocardial infarction","volume":"68","author":"Ottani","year":"1999","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jjcc.2025.09.006_bb0020","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/S0002-9149(03)00896-8","article-title":"Effects of preinfarction angina pectoris on infarct size and in-hospital mortality after coronary intervention for acute myocardial infarction","volume":"92","author":"Kosuge","year":"2003","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jjcc.2025.09.006_bb0025","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/j.jacc.2003.09.069","article-title":"Angina pectoris prior to myocardial infarction protects against subsequent left ventricular remodeling","volume":"43","author":"Solomon","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2025.09.006_bb0030","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/S0735-1097(97)00256-8","article-title":"Angina-induced protection against myocardial infarction in adult and elderly patients: a loss of preconditioning mechanism in the aging heart?","volume":"30","author":"Abete","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2025.09.006_bb0035","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/S0735-1097(97)00238-6","article-title":"Implications of prodromal angina pectoris in anterior wall acute myocardial infarction: acute angiographic findings and long-term prognosis","volume":"30","author":"Ishihara","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jjcc.2025.09.006_bb0040","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1161\/01.CIR.91.1.37","article-title":"Previous angina alters in-hospital outcome in TIMI 4. A clinical correlate to preconditioning?","volume":"91","author":"Kloner","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2025.09.006_bb0045","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1161\/01.CIR.97.11.1042","article-title":"Prospective temporal analysis of the onset of preinfarction angina versus outcome: an ancillary study in TIMI-9B","volume":"97","author":"Kloner","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2025.09.006_bb0050","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.amjcard.2014.07.038","article-title":"Effect of preinfarction angina pectoris on long-term survival in patients with ST-segment elevation myocardial infarction who underwent primary percutaneous coronary intervention","volume":"114","author":"Taniguchi","year":"2014","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jjcc.2025.09.006_bb0055","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0147-9563(05)80089-5","article-title":"Prodromal symptoms in subsets of patients hospitalized for suspected acute myocardial infarction","volume":"24","author":"Hofgren","year":"1995","journal-title":"Heart Lung"},{"key":"10.1016\/j.jjcc.2025.09.006_bb0060","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1161\/CIRCULATIONAHA.117.031650","article-title":"Sex differences in the presentation and perception of symptoms among young patients with myocardial infarction: evidence from the VIRGO Study (Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients)","volume":"137","author":"Lichtman","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2025.09.006_bb0065","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.021417","article-title":"Newly diagnosed atrial fibrillation in acute myocardial infarction","volume":"10","author":"Obayashi","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jjcc.2025.09.006_bb0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0259268","article-title":"Differences in mortality and causes of death between STEMI and NSTEMI in the early and late phases after acute myocardial infarction","volume":"16","author":"Takeji","year":"2021","journal-title":"PloS One"},{"key":"10.1016\/j.jjcc.2025.09.006_bb0075","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.amjcard.2023.07.038","article-title":"The impact of mitral regurgitation on long-term outcomes in acute myocardial infarction undergoing percutaneous coronary intervention","volume":"203","author":"Obayashi","year":"2023","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jjcc.2025.09.006_bb0080","series-title":"Braunwald\u2019s heart disease: a textbook of cardiovascular medicine","year":"2022"},{"key":"10.1016\/j.jjcc.2025.09.006_bb0085","article-title":"Changes in demographics, clinical practices and long-term outcomes of patients with ST segment-elevation myocardial infarction who underwent coronary revascularisation in the past two decades: cohort study","volume":"11","author":"Takeji","year":"2021","journal-title":"BMJ Open"},{"key":"10.1016\/j.jjcc.2025.09.006_bb0090","first-page":"1355","article-title":"Association between acute myocardial infarction symptoms and short- and long-term mortality after the event","volume":"40","author":"Schmitz","year":"2024","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.jjcc.2025.09.006_bb0095","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1002\/clc.22819","article-title":"Clinical outcomes according to symptom presentation in patients with acute myocardial infarction: results from the FAST-MI 2010 registry","volume":"40","author":"Puymirat","year":"2017","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.jjcc.2025.09.006_bb0100","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jjcc.2010.11.008","article-title":"Atypical presentation of acute coronary syndrome: a significant independent predictor of in-hospital mortality","volume":"57","author":"El-Menyar","year":"2011","journal-title":"J Cardiol"},{"key":"10.1016\/j.jjcc.2025.09.006_bb0105","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/j.ahj.2008.07.016","article-title":"Sex differences in patients seeking medical attention for prodromal symptoms before an acute coronary event","volume":"156","author":"Graham","year":"2008","journal-title":"Am Heart J"},{"key":"10.1016\/j.jjcc.2025.09.006_bb0110","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.e3257","article-title":"Association of onset to balloon and door to balloon time with long term clinical outcome in patients with ST elevation acute myocardial infarction having primary percutaneous coronary intervention: observational study","volume":"344","author":"Shiomi","year":"2012","journal-title":"BMJ"},{"key":"10.1016\/j.jjcc.2025.09.006_bb0115","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.jjcc.2023.01.008","article-title":"Shorter door-to-balloon time, better long-term clinical outcomes in ST-segment elevation myocardial infarction patients: J-MINUET substudy","volume":"81","author":"Nishio","year":"2023","journal-title":"J Cardiol"},{"key":"10.1016\/j.jjcc.2025.09.006_bb0120","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.jcmg.2015.06.016","article-title":"hs-Troponin I followed by CT angiography improves acute coronary syndrome risk stratification accuracy and work-up in acute chest pain patients: results from ROMICAT II trial","volume":"8","author":"Ferencik","year":"2015","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jjcc.2025.09.006_bb0125","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s10140-019-01668-1","article-title":"CCTA in patients with positive troponin and low clinical suspicion for ACS: a useful diagnostic option to exclude obstructive CAD","volume":"26","author":"Nugent","year":"2019","journal-title":"Emerg Radiol"},{"key":"10.1016\/j.jjcc.2025.09.006_bb0130","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s00330-024-10930-1","article-title":"Coronary computed tomography angiography improves assessment of patients with acute chest pain and inconclusively elevated high-sensitivity troponins","volume":"35","author":"Arslan","year":"2025","journal-title":"Eur Radiol"}],"container-title":["Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0914508725002369?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0914508725002369?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T06:12:35Z","timestamp":1764828755000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0914508725002369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S0914508725002369"],"URL":"https:\/\/doi.org\/10.1016\/j.jjcc.2025.09.006","relation":{},"ISSN":["0914-5087"],"issn-type":[{"value":"0914-5087","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prodromal symptoms and the care-seeking behavior in patients with acute ST-segment elevation myocardial infarction","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jjcc.2025.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Japanese College of Cardiology. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}