{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:07:37Z","timestamp":1777874857688,"version":"3.51.4"},"reference-count":40,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,4,1]],"date-time":"2027-04-01T00:00:00Z","timestamp":1806537600000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL159945"],"award-info":[{"award-number":["R01 HL159945"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-cardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiology"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jjcc.2025.11.015","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:36:58Z","timestamp":1764808618000},"page":"314-322","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trajectories in renal perfusion pressure during hemodynamically guided therapy are associated with worsening renal function and patient outcomes"],"prefix":"10.1016","volume":"87","author":[{"given":"Emily","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Bilchick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nishaki","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Younghoon","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onyedika","family":"Ilonze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khadijah","family":"Breathett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Phiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Ernest","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrija","family":"Vidic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Kabwe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olayiwola","family":"Bolaji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyothsna","family":"Bandaru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mwenya","family":"Mubanga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chayakrit","family":"Krittanawong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Ashur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sula","family":"Mazimba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jjcc.2025.11.015_bb0005","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/ejhf.2384","article-title":"Worsening renal function in acute heart failure in the context of diuretic response","volume":"24","author":"Emmens","year":"2022","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.jjcc.2025.11.015_bb0010","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1093\/eurheartj\/ehx035","article-title":"Renal sodium avidity in heart failure: from pathophysiology to treatment strategies","volume":"38","author":"Mullens","year":"2017","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.jjcc.2025.11.015_bb0015","doi-asserted-by":"crossref","first-page":"3672","DOI":"10.1093\/eurheartj\/ehad557","article-title":"Renal function and decongestion with acetazolamide in acute decompensated heart failure: the ADVOR trial","volume":"44","author":"Meekers","year":"2023","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.jjcc.2025.11.015_bb0020","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.amjcard.2015.01.019","article-title":"Interaction between worsening renal function and persistent congestion in acute decompensated heart failure","volume":"115","author":"Wattad","year":"2015","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.jjcc.2025.11.015_bb0025","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1093\/eurjhf\/hfp108","article-title":"Both in- and out-hospital worsening of renal function predict outcome in patients with heart failure: results from the coordinating study evaluating outcome of advising and counseling in heart failure (COACH)","volume":"11","author":"Damman","year":"2009","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.jjcc.2025.11.015_bb0030","doi-asserted-by":"crossref","first-page":"e840","DOI":"10.1161\/CIR.0000000000000664","article-title":"Cardiorenal syndrome: classification, pathophysiology, diagnosis, and treatment strategies: a scientific statement from the American Heart Association","volume":"139","author":"Rangaswami","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2025.11.015_bb0035","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1002\/clc.24080","article-title":"Patients hospitalized with acute heart failure, worsening renal function, and persistent congestion are at high risk for adverse outcomes despite current medical therapy","volume":"46","author":"Cooper","year":"2023","journal-title":"Clin. Cardiol."},{"key":"10.1016\/j.jjcc.2025.11.015_bb0040","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1002\/ejhf.1697","article-title":"Evaluation of kidney function throughout the heart failure trajectory \u2013 a position statement from the heart failure Association of the European Society of cardiology","volume":"22","author":"Mullens","year":"2020","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.jjcc.2025.11.015_bb0045","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.cardfail.2007.04.008","article-title":"Worsening renal function and prognosis in heart failure: systematic review and meta-analysis","volume":"13","author":"Damman","year":"2007","journal-title":"J Cardiac Fail"},{"key":"10.1016\/j.jjcc.2025.11.015_bb0050","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ahj.2018.07.019","article-title":"Worsening renal function during decongestion among patients hospitalized for heart failure: findings from the evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness (ESCAPE) trial","volume":"204","author":"Fudim","year":"2018","journal-title":"Am. Heart J."},{"key":"10.1016\/j.jjcc.2025.11.015_bb0055","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.cardfail.2010.02.001","article-title":"The relationship between transient and persistent worsening renal function and mortality in patients with acute decompensated heart failure","volume":"16","author":"Aronson","year":"2010","journal-title":"J. Card. Fail."},{"key":"10.1016\/j.jjcc.2025.11.015_bb0060","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1161\/CIRCHEARTFAILURE.111.963413","article-title":"Is worsening renal function an ominous prognostic sign in patients with acute heart failure?: the role of congestion and its interaction with renal function","volume":"5","author":"Metra","year":"2012","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.jjcc.2025.11.015_bb0065","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.117.004644","article-title":"Prognostic significance of creatinine increases during an acute heart failure admission in patients with and without residual congestion: a post hoc analysis of the PROTECT data","volume":"11","author":"Metra","year":"2018","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.jjcc.2025.11.015_bb0070","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1093\/eurheartj\/ehi859","article-title":"Prevalence and impact of worsening renal function in patients hospitalized with decompensated heart failure: results of the prospective outcomes study in heart failure (POSH)","volume":"27","author":"Cowie","year":"2006","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.jjcc.2025.11.015_bb0075","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/eurheartj\/eht386","article-title":"Renal impairment, worsening renal function, and outcome in patients with heart failure: an updated meta-analysis","volume":"35","author":"Damman","year":"2014","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.jjcc.2025.11.015_bb0080","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jjcc.2022.12.008","article-title":"Prevalence and predictive factors for clinical outcomes of isolated functional tricuspid regurgitation","volume":"82","author":"Nakagawa","year":"2023","journal-title":"J. Cardiol."},{"key":"10.1016\/j.jjcc.2025.11.015_bb0085","doi-asserted-by":"crossref","first-page":"128","DOI":"10.36628\/ijhf.2020.0050","article-title":"Clinical impact of worsening renal function in elderly patients with acute decompensated heart failure","volume":"3","author":"Sawamura","year":"2021","journal-title":"Int J Heart Fail"},{"key":"10.1016\/j.jjcc.2025.11.015_bb0090","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jacc.2008.05.068","article-title":"Importance of venous congestion for worsening of renal function in advanced decompensated heart failure","volume":"53","author":"Mullens","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jjcc.2025.11.015_bb0095","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1113\/jphysiol.1931.sp002761","article-title":"The influence of venous pressure on the isolated mammalian kidney","volume":"72","author":"Winton","year":"1931","journal-title":"J. Physiol."},{"key":"10.1016\/j.jjcc.2025.11.015_bb0100","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1007\/s00380-020-01578-0","article-title":"Decreased mean perfusion pressure as an independent predictor of acute kidney injury after cardiac surgery","volume":"35","author":"Hu","year":"2020","journal-title":"Heart Vessel."},{"key":"10.1016\/j.jjcc.2025.11.015_bb0105","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1161\/CIRCULATIONAHA.119.045409","article-title":"Altered hemodynamics and end-organ damage in heart failure: impact on the lung and kidney","volume":"142","author":"Verbrugge","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2025.11.015_bb0110","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/eurjhf\/hfq195","article-title":"Central venous pressure and impaired renal function in patients with acute heart failure","volume":"13","author":"Uthoff","year":"2011","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.jjcc.2025.11.015_bb0115","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.779828","article-title":"Different renal function patterns in patients with acute heart failure: relationship with outcome and congestion","volume":"9","author":"Palazzuoli","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.jjcc.2025.11.015_bb0120","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1001\/jama.294.13.1625","article-title":"Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness: the ESCAPE trial","volume":"294","author":"Binanay","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.jjcc.2025.11.015_bb0125","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1177\/0049124106292364","article-title":"Advances in group-based trajectory modeling and an SAS procedure for estimating them","volume":"35","author":"Jones","year":"2007","journal-title":"Sociol. Methods Res."},{"key":"10.1016\/j.jjcc.2025.11.015_bb0130","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1177\/0962280216673085","article-title":"Group-based multi-trajectory modeling","volume":"27","author":"Nagin","year":"2018","journal-title":"Stat. Methods Med. Res."},{"key":"10.1016\/j.jjcc.2025.11.015_bb0135","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1146\/annurev.clinpsy.121208.131413","article-title":"Group-based trajectory modeling in clinical research","volume":"6","author":"Nagin","year":"2010","journal-title":"Annu. Rev. Clin. Psychol."},{"key":"10.1016\/j.jjcc.2025.11.015_bb0140","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.resuscitation.2019.02.030","article-title":"A novel methodological framework for multimodality, trajectory model-based prognostication","volume":"137","author":"Elmer","year":"2019","journal-title":"Resuscitation"},{"key":"10.1016\/j.jjcc.2025.11.015_bb0145","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.jclinepi.2004.02.012","article-title":"Statistical measures were proposed for identifying longitudinal patterns of change in quantitative health indicators","volume":"57","author":"Leffondr\u00e9","year":"2004","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.jjcc.2025.11.015_bb0150","first-page":"215","article-title":"Organ perfusion pressure at admission and clinical outcomes in patients hospitalized for acute heart failure","volume":"13","author":"Bocchino","year":"2024","journal-title":"Eur. Heart J. Acute Cardiovasc. Care"},{"key":"10.1016\/j.jjcc.2025.11.015_bb0155","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s12882-017-0568-8","article-title":"Low mean perfusion pressure is a risk factor for progression of acute kidney injury in critically ill patients - a retrospective analysis","volume":"18","author":"Ostermann","year":"2017","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.jjcc.2025.11.015_bb0160","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1002\/ehf2.13990","article-title":"Association between central haemodynamics and renal function in advanced heart failure: a nationwide study from Sweden","volume":"9","author":"Bobbio","year":"2022","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.jjcc.2025.11.015_bb0165","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.jacc.2007.08.072","article-title":"Cardiorenal interactions","volume":"51","author":"Nohria","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jjcc.2025.11.015_bb0170","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1016\/j.jacc.2016.02.058","article-title":"Reduced cardiac index is not the dominant driver of renal dysfunction in heart failure","volume":"67","author":"Hanberg","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jjcc.2025.11.015_bb0175","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1161\/CIRCHEARTFAILURE.107.746933","article-title":"Admission or changes in renal function during hospitalization for worsening heart failure predict postdischarge survival: results from the outcomes of a prospective trial of intravenous Milrinone for exacerbations of chronic heart failure (OPTIME-CHF)","volume":"1","author":"Klein","year":"2008","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.jjcc.2025.11.015_bb0180","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0002-8703(99)70113-4","article-title":"Aggravated renal dysfunction during intensive therapy for advanced chronic heart failure","volume":"138","author":"Weinfeld","year":"1999","journal-title":"Am. Heart J."},{"key":"10.1016\/j.jjcc.2025.11.015_bb0185","first-page":"S57","article-title":"Sodium and water retention in heart failure: pathogenesis and treatment","volume":"59","author":"Martin","year":"1997","journal-title":"Kidney Int. Suppl."},{"key":"10.1016\/j.jjcc.2025.11.015_bb0190","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1161\/01.CIR.102.2.203","article-title":"Renal function, neurohormonal activation, and survival in patients with chronic heart failure","volume":"102","author":"Hillege","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jjcc.2025.11.015_bb0195","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S0735-1097(99)00608-7","article-title":"The prognostic implications of renal insufficiency in asymptomatic and symptomatic patients with left ventricular systolic dysfunction","volume":"35","author":"Dries","year":"2000","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jjcc.2025.11.015_bb0200","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ahj.2004.02.007","article-title":"Impaired renal function in patients with ischemic and nonischemic chronic heart failure: association with neurohormonal activation and survival","volume":"148","author":"Smilde","year":"2004","journal-title":"Am. Heart J."}],"container-title":["Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0914508725002977?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0914508725002977?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:28:29Z","timestamp":1777580909000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0914508725002977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S0914508725002977"],"URL":"https:\/\/doi.org\/10.1016\/j.jjcc.2025.11.015","relation":{},"ISSN":["0914-5087"],"issn-type":[{"value":"0914-5087","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trajectories in renal perfusion pressure during hemodynamically guided therapy are associated with worsening renal function and patient outcomes","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jjcc.2025.11.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Japanese College of Cardiology. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}