{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T22:10:10Z","timestamp":1751062210017,"version":"3.41.0"},"reference-count":42,"publisher":"Scientific Scholar","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["RSP-2021\/398"],"award-info":[{"award-number":["RSP-2021\/398"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of King Saud University - Science"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.jksus.2021.101693","type":"journal-article","created":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T03:42:07Z","timestamp":1636688527000},"page":"101693","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Antiviral and cytotoxic effects of a traditional drug KanthaRasaVillai with a cocktail of metallic nanoparticles"],"prefix":"10.25259","volume":"34","author":[{"given":"Amirtham J.A.","family":"Ranjitsingh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandhanasamy","family":"Devanesan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad S.","family":"AlSalhi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parameswari","family":"Paul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Padmalatha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","reference":[{"issue":"1","key":"10.1016\/j.jksus.2021.101693_b0005","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1080\/17458080.2020.1799981","article-title":"Anti-bacterial\/fungal and anticancer performance of green synthesized Ag nanoparticles using summer savory extract","volume":"15","author":"Ahmadi","year":"2020","journal-title":"J. Exp. Nanosci"},{"key":"10.1016\/j.jksus.2021.101693_b0010","doi-asserted-by":"crossref","first-page":"111389","DOI":"10.1016\/j.colsurfb.2020.111389","article-title":"Phytochemical delivery through nanocarriers: a review","volume":"197","author":"Ahmad","year":"2021","journal-title":"Colloids Surf B Biointerface"},{"key":"10.1016\/j.jksus.2021.101693_b0015","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.578970","article-title":"Indian medicinal plants and formulations and their potential against COVID-19-preclinical and clinical research","volume":"11","author":"Ahmad","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.jksus.2021.101693_b0020","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/j.sjbs.2020.12.005","article-title":"Nano-formulation of herbo-mineral alternative medicine from linga chenduram and evaluation of antiviral efficacy","volume":"28","author":"Al-Ansari","year":"2021","journal-title":"Saudi J. Biol. Sci."},{"key":"10.1016\/j.jksus.2021.101693_b0025","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jphotobiol.2019.01.011","article-title":"Eco-friendly green synthesis of silver nanoparticles from the sesame oil cake and its potential anticancer and antimicrobial activities","volume":"192","author":"Alfuraydi","year":"2019","journal-title":"J Photochem. Photobiol."},{"issue":"1","key":"10.1016\/j.jksus.2021.101693_b0030","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1080\/19336950.2020.1837439","article-title":"Similarities between the effect of SARS-CoV-2 and HCV on the cellular level, and the possible role of ion channels in COVID19 progression: a review of potential targets for diagnosis and treatment","volume":"14","author":"Alothaid","year":"2020","journal-title":"Channels (Austin)"},{"issue":"5","key":"10.1016\/j.jksus.2021.101693_b0035","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.sjbs.2019.04.001","article-title":"Synthesis of silver nanoparticles using plant derived 4-N-methyl benzoic acid and evaluation of antimicrobial, antioxidant and antitumor activity","volume":"26","author":"AlSalhi","year":"2019","journal-title":"Saudi J. Biol. Sci."},{"key":"10.1016\/j.jksus.2021.101693_b0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/9390784","article-title":"Anticancer potential of green synthesized silver nanoparticles using extract of nepeta deflersiana against human cervical cancer cells (HeLA)","volume":"2018","author":"Al-Sheddi","year":"2018","journal-title":"Bioinorg. Chem. Appl."},{"issue":"10","key":"10.1016\/j.jksus.2021.101693_b0045","doi-asserted-by":"crossref","first-page":"e1000182","DOI":"10.1371\/journal.ppat.1000182","article-title":"High-resolution functional profiling of hepatitis C virus genome","volume":"4","author":"Arumugaswami","year":"2008","journal-title":"PLoS Pathog."},{"issue":"2","key":"10.1016\/j.jksus.2021.101693_b0050","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4103\/0974-8520.175541","article-title":"Researches on mercurial preparations: The prime requirement for their acceptance in medical world","volume":"36","author":"Arunachalam","year":"2015","journal-title":"Ayu."},{"key":"10.1016\/j.jksus.2021.101693_b0055","first-page":"145","article-title":"Phytochemistry, pharmacological activities, nanoparticle fabrication, commercial products and waste utilization of Carica papaya L.: A comprehensive review","volume":"2","author":"Sharma","year":"2020","journal-title":"CRBIOT"},{"key":"10.1016\/j.jksus.2021.101693_b0060","doi-asserted-by":"crossref","unstructured":"Behzadi, S., Serpooshan, V., Tao, W., Hamaly, M. A., Alkawareek, M. Y., Dreaden, E. C., Brown, D., Alkilany, A. M., Farokhzad, O. C., Mahmoudi, M., 2017. Cellular uptake of nanoparticles: journey inside the cell. Behzadi S, Serpooshan V, Tao W, et al. Cellular uptake of nanoparticles: journey inside the cell. Chem. Soc. Rev. 46(14), 4218\u20134244.","DOI":"10.1039\/C6CS00636A"},{"key":"10.1016\/j.jksus.2021.101693_b0065","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.ejmech.2017.05.031","article-title":"Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells","volume":"136","author":"Bommagani","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jksus.2021.101693_b0070","doi-asserted-by":"crossref","first-page":"112299","DOI":"10.1016\/j.jep.2019.112299","article-title":"Protective role of cinnabar and realgar in Hua-Feng-Dan against LPS plus rotenone-induced neurotoxicity and disturbance of gut microbiota in rats","volume":"247","author":"Chen","year":"2020","journal-title":"J Ethnopharmacol."},{"key":"10.1016\/j.jksus.2021.101693_b0075","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.2147\/IJN.S307676","article-title":"Green synthesis of silver nanoparticles using the flower extract of Abelmoschus esculentus for cytotoxicity and antimicrobial studies","volume":"16","author":"Devanesan","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.jksus.2021.101693_b0080","doi-asserted-by":"crossref","first-page":"4351","DOI":"10.2147\/IJN.S258319","article-title":"Cytotoxic and antimicrobial efficacy of silver nanoparticles synthesized using a traditional phytoproduct, Asafoetida Gum","volume":"15","author":"Devanesan","year":"2020","journal-title":"Int. J. Nanomed."},{"issue":"6","key":"10.1016\/j.jksus.2021.101693_b0085","doi-asserted-by":"crossref","first-page":"535","DOI":"10.4103\/0250-474X.110598","article-title":"Comparative physicochemical evaluation of a marketed herbomineral formulation: Nagabhasma","volume":"74","author":"Garg","year":"2012","journal-title":"Indian J. Pharm. Sci."},{"issue":"2","key":"10.1016\/j.jksus.2021.101693_b0090","doi-asserted-by":"crossref","first-page":"314","DOI":"10.7150\/ijms.51935","article-title":"Perspective adjunctive therapies for COVID-19: beyond antiviral therapy","volume":"18","author":"Ho","year":"2021","journal-title":"Int. J. Med. Sci."},{"issue":"254","key":"10.1016\/j.jksus.2021.101693_b0095","first-page":"12674","article-title":"Mercury sulfide-containing Hua-Feng-Dan and 70W (Rannasangpei) protect against LPS plus MPTP-induced neurotoxicity and disturbance of gut microbiota in mice","volume":"23","author":"Hu","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jksus.2021.101693_b0100","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s42269-021-00487-0","article-title":"A proposed insight into the antiviral potential of metallic nanoparticles against novel coronavirus disease-19 (COVID-19)","volume":"2945","author":"Ibrahim Fouad","year":"2021","journal-title":"Bull. Natl. Res. Cent."},{"issue":"4","key":"10.1016\/j.jksus.2021.101693_b0105","doi-asserted-by":"crossref","first-page":"268","DOI":"10.4103\/0975-9476.172383","article-title":"Preparation and characterization of mercury-based traditional herbomineral formulation: Shwas kuthar rasa","volume":"6","author":"Janadri","year":"2015","journal-title":"J. Ayurveda Integr. Med."},{"issue":"3","key":"10.1016\/j.jksus.2021.101693_b0110","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.jaim.2018.05.006","article-title":"Antiviral activity of ethanolic extract of Nilavembu Kudineer against dengue and chikungunya virus through in vitro evaluation","volume":"11","author":"Jain","year":"2020","journal-title":"J. Ayurveda Integr. Med."},{"key":"10.1016\/j.jksus.2021.101693_b0115","doi-asserted-by":"crossref","first-page":"691","DOI":"10.26452\/ijrps.v11iSPL1.3067","article-title":"Alternative medicine suggestions for treatment of Covid - 19 \u2013 a review","volume":"11","author":"Jayashree","year":"2020","journal-title":"Int. J. Pharm. Sci. Res."},{"issue":"3","key":"10.1016\/j.jksus.2021.101693_b0120","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jaim.2016.11.005","article-title":"Structural and elemental characterization of traditional Indian Siddha formulation: Thalagak karuppu","volume":"8","author":"Kannan","year":"2017","journal-title":"J. Ayurveda Integr. Med."},{"issue":"6","key":"10.1016\/j.jksus.2021.101693_b0125","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.3390\/molecules26061764","article-title":"Nanoformulations for delivery of pentacyclic triterpenoids in anticancer therapies","volume":"26","author":"Kaps","year":"2021","journal-title":"Molecules"},{"issue":"12","key":"10.1016\/j.jksus.2021.101693_b0130","doi-asserted-by":"crossref","first-page":"e0226855","DOI":"10.1371\/journal.pone.0226855","article-title":"Chemical analysis of Hg0-containing Hindu religious objects","volume":"14","author":"Kiefer","year":"2019","journal-title":"PLoS ONE"},{"issue":"3","key":"10.1016\/j.jksus.2021.101693_b0135","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1385\/BTER:109:3:231","article-title":"Bhasmas: Unique ayurvedic metallic-herbal preparations, chemical characterization","volume":"109","author":"Kumar","year":"2006","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.jksus.2021.101693_b0140","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s11671-019-2967-1","article-title":"Shape-dependent cytotoxicity and cellular uptake of gold nanoparticles synthesized using green tea extract","volume":"14","author":"Lee","year":"2019","journal-title":"Nanoscale Res. Lett."},{"issue":"2","key":"10.1016\/j.jksus.2021.101693_b0145","doi-asserted-by":"crossref","first-page":"206","DOI":"10.2174\/1871520614666141114201749","article-title":"Synthesis of nitroaromatic compounds as potential anticancer agents","volume":"15","author":"Lopes","year":"2015","journal-title":"Anticancer Agents Med. Chem."},{"issue":"15","key":"10.1016\/j.jksus.2021.101693_b0150","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.2147\/IJN.S241702","article-title":"Antiviral activity of chitosan nanoparticles encapsulating curcumin against hepatitis C virus genotype 4a in human hepatoma cell lines","volume":"22","author":"Loutfy","year":"2020","journal-title":"Int. J. Nanomed."},{"issue":"2","key":"10.1016\/j.jksus.2021.101693_b0155","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jaim.2017.01.009","article-title":"Mercury based drug in ancient India: the red sulfide of mercury in nanoscale","volume":"8","author":"Mukhi","year":"2017","journal-title":"J. Ayurveda Integr. Med."},{"issue":"6","key":"10.1016\/j.jksus.2021.101693_b0160","doi-asserted-by":"crossref","first-page":"2000112","DOI":"10.1002\/gch2.202000112","article-title":"Could nanotheranostics be the answer to the coronavirus crisis?","volume":"5","author":"Mosselhy","year":"2021","journal-title":"Glob Chall."},{"key":"10.1016\/j.jksus.2021.101693_b0165","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s43094-020-00174-3","article-title":"Ethnobotanical, phytochemistry, and pharmacological property of Waltheria Indica Linn","volume":"7","author":"Nirmala","year":"2021","journal-title":"Futur. J. Pharm. Sci."},{"key":"10.1016\/j.jksus.2021.101693_b0170","doi-asserted-by":"crossref","unstructured":"Qi, L., Xiao, L., Lin, R., 2020. Convenient synthesis and biological evaluation of bis(indolyl)methane alkaloid and bis(aryl)alkanes derivatives with anti-cancer properties beilstein Arch. 2020, 202060. doi:10.3762\/bxiv.2020.60.v1.","DOI":"10.3762\/bxiv.2020.60.v1"},{"key":"10.1016\/j.jksus.2021.101693_b0175","doi-asserted-by":"crossref","unstructured":"Rajput, S.K., 2021. Scientific review of Tribhuvan Keerti Ras a potent ayurvedic herbomineral combination against viral infection. Nat. J. Res. Ayurvedic Sci., 9 (2), 1\u201310.","DOI":"10.52482\/ayurlog.v9i02.835"},{"key":"10.1016\/j.jksus.2021.101693_b0180","doi-asserted-by":"crossref","unstructured":"Rajput, S. K., Irole, S., Dandekar, S., 2021. Scientific review of Tribhuvan Keerti Ras a potent Ayurvedic Herbomineral Combination against viral infection. Nat. J. Res. Ayurvedic Sci., 2021, 9 (02). https:\/\/doi.org\/10.52482\/ayurlog.v9i02.835.","DOI":"10.52482\/ayurlog.v9i02.835"},{"issue":"8","key":"10.1016\/j.jksus.2021.101693_b0185","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1001\/jama.300.8.915","article-title":"Lead, mercury, and arsenic in U.S.- and Indian-manufactured Ayurvedic medicines sold via the Internet","volume":"300","author":"Saper","year":"2008","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.jksus.2021.101693_b0190","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s13530-020-00018-w","article-title":"Acute and sub-chronic toxicity study of traditional Indian medicine Manahshila (realgar)","volume":"12","author":"Sharma","year":"2020","journal-title":"Toxicol. Environ. Health Sci."},{"key":"10.1016\/j.jksus.2021.101693_b0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/948375","article-title":"Toxicity of a novel herbomineral preparation Las01 on human cancer cell lines and its safety profile in humans and animals","volume":"2012","author":"Sheikh","year":"2012","journal-title":"Evid. Based Complement Alternat. Med."},{"key":"10.1016\/j.jksus.2021.101693_b0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2021\/6634553","article-title":"Purification, detoxification, and incineration methods of minerals and metals in traditional medicine formulations of Sri Lanka","volume":"2021","author":"Sujatha Pushpakanthi Hewageegana","year":"2021","journal-title":"Evid. Based Complement Alternat. Med."},{"issue":"3","key":"10.1016\/j.jksus.2021.101693_b0205","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"C.A. Cancer J Clin."},{"issue":"3","key":"10.1016\/j.jksus.2021.101693_b0210","doi-asserted-by":"crossref","first-page":"164","DOI":"10.4103\/wjtcm.wjtcm_1_19","article-title":"Advances in the safety evaluation of mineral medicines \u2013 Cinnabar and Realgar","volume":"5","author":"Tian","year":"2019","journal-title":"World J. Tradit. Chin. Med."}],"container-title":["Journal of King Saud University - Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1018364721003554?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1018364721003554?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T21:31:52Z","timestamp":1751059912000},"score":1,"resource":{"primary":{"URL":"https:\/\/jksus.org\/antiviral-and-cytotoxic-effects-of-a-traditional-drug-kantharasavillai-with-a-cocktail-of-metallic-nanoparticles\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S1018364721003554"],"URL":"https:\/\/doi.org\/10.1016\/j.jksus.2021.101693","relation":{},"ISSN":["1018-3647"],"issn-type":[{"type":"print","value":"1018-3647"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antiviral and cytotoxic effects of a traditional drug KanthaRasaVillai with a cocktail of metallic nanoparticles","name":"articletitle","label":"Article Title"},{"value":"Journal of King Saud University - Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jksus.2021.101693","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.","name":"copyright","label":"Copyright"}],"article-number":"101693"}}