{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T19:29:10Z","timestamp":1770060550131,"version":"3.49.0"},"reference-count":33,"publisher":"Scientific Scholar","issue":"2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T00:00:00Z","timestamp":1638230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014108","name":"University of Texas Rio Grande Valley","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA204552"],"award-info":[{"award-number":["R01 CA204552"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA206069"],"award-info":[{"award-number":["R01 CA206069"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA210192"],"award-info":[{"award-number":["R01 CA210192"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of King Saud University - Science"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.jksus.2021.101751","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T06:52:07Z","timestamp":1638773527000},"page":"101751","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["In silico CD4\u00a0+\u00a0T-cell multiepitope prediction and HLA distribution analysis for Marburg Virus\u2014A strategy for vaccine designing"],"prefix":"10.25259","volume":"34","author":[{"given":"Anupam","family":"Dhasmana","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swati","family":"Dhasmana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Alsulimani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudhir","family":"Kotnala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivek Kumar","family":"Kashyap","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shafiul","family":"Haque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meena","family":"Jaggi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murali M.","family":"Yallapu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subhash C.","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","reference":[{"issue":"5","key":"10.1016\/j.jksus.2021.101751_b0005","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1177\/0300985810378597","article-title":"Aerosol exposure to the angola strain of marburg virus causes lethal viral hemorrhagic Fever in cynomolgus macaques","volume":"47","author":"Alves","year":"2010","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.jksus.2021.101751_b0010","doi-asserted-by":"crossref","first-page":"684","DOI":"10.3389\/fimmu.2017.00684","volume":"8","author":"Athanasiou","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jksus.2021.101751_b0015","unstructured":"Bano, T., Mohammed Janahi, E., Dhasmana, A., Lohani, M., Haque, S., R, K.M., S, A.D., Jawed, A., Wahid, M., Akhter, N., and M, Y.A. (2018). In silico CD4+, CD8+ & humoral immunity associated antigenic epitope prediction and HLA distribution analysis of HTLV-I. J. Buon 23, 1514-1527."},{"key":"10.1016\/j.jksus.2021.101751_b0020","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1242\/dmm.000471","article-title":"Disease modeling for Ebola and Marburg viruses","volume":"2","author":"Bente","year":"2009","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.jksus.2021.101751_b0025","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/1471-2105-7-153","article-title":"Predicting population coverage of T-cell epitope-based diagnostics and vaccines","volume":"7","author":"Bui","year":"2006","journal-title":"BMC Bioinf."},{"issue":"15-16","key":"10.1016\/j.jksus.2021.101751_b0030","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1016\/j.vaccine.2003.10.027","article-title":"The societal value of universal childhood vaccination","volume":"22","author":"Chabot","year":"2004","journal-title":"Vaccine"},{"issue":"10","key":"10.1016\/j.jksus.2021.101751_b0035","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.vaccine.2004.08.046","article-title":"Defining putative T cell epitopes from PE and PPE families of proteins of Mycobacterium tuberculosis with vaccine potential","volume":"23","author":"Chaitra","year":"2005","journal-title":"Vaccine"},{"issue":"11","key":"10.1016\/j.jksus.2021.101751_b0040","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/s41573-021-00283-5","article-title":"mRNA vaccines for infectious diseases: principles, delivery and clinical translation","volume":"20","author":"Chaudhary","year":"2021","journal-title":"Nat. Rev. Drug Discovery"},{"issue":"1","key":"10.1016\/j.jksus.2021.101751_b0045","doi-asserted-by":"crossref","first-page":"73","DOI":"10.4103\/0974-777X.77299","article-title":"Fundamentals of vaccine immunology","volume":"3","author":"Clem","year":"2011","journal-title":"J. Glob. Infect. Dis."},{"key":"10.1016\/j.jksus.2021.101751_b0050","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.4269\/ajtmh.1978.27.1210","article-title":"Epidemiologic investigation of Marburg virus disease, Southern Africa, 1975","volume":"27","author":"Conrad","year":"1978","journal-title":"Am. J. Trop. Med. Hyg."},{"issue":"6","key":"10.1016\/j.jksus.2021.101751_b0055","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nrd.2017.251","article-title":"Post-exposure treatments for Ebola and Marburg virus infections","volume":"17","author":"Cross","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"issue":"1","key":"10.1016\/j.jksus.2021.101751_b0065","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1146\/annurev.micro.51.1.151","article-title":"RNA virus mutations and fitness for survival","volume":"51","author":"Domingo","year":"1997","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.jksus.2021.101751_b0070","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2105-8-4","article-title":"VaxiJen: a server for prediction of protective antigens, tumour antigens and subunit vaccines","volume":"8","author":"Doytchinova","year":"2007","journal-title":"BMC Bioinf."},{"issue":"4","key":"10.1016\/j.jksus.2021.101751_b0075","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s40005-019-00439-x","article-title":"Biocompatibility, biodegradation and biomedical applications of poly(lactic acid)\/poly(lactic-co-glycolic acid) micro and nanoparticles","volume":"49","author":"Elmowafy","year":"2019","journal-title":"J. Pharmaceut. Investigat."},{"issue":"Web Server","key":"10.1016\/j.jksus.2021.101751_b0080","doi-asserted-by":"crossref","first-page":"W35","DOI":"10.1093\/nar\/gkn211","article-title":"PVS: a web server for protein sequence variability analysis tuned to facilitate conserved epitope discovery","volume":"36","author":"Garcia-Boronat","year":"2008","journal-title":"Nucleic Acids Res."},{"issue":"9","key":"10.1016\/j.jksus.2021.101751_b0085","doi-asserted-by":"crossref","first-page":"e73957","DOI":"10.1371\/journal.pone.0073957","article-title":"In silico approach for predicting toxicity of peptides and proteins","volume":"8","author":"Gupta","year":"2013","journal-title":"PLoS ONE"},{"issue":"43","key":"10.1016\/j.jksus.2021.101751_b0090","doi-asserted-by":"crossref","first-page":"7092","DOI":"10.1016\/j.vaccine.2010.08.005","article-title":"In silico CD4+ T-cell epitope prediction and HLA distribution analysis for the potential proteins of Neisseria meningitidis Serogroup B\u2013a clue for vaccine development","volume":"28","author":"Gupta","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.jksus.2021.101751_b0095","first-page":"63","article-title":"In silico CD4+, CD8+ T-cell and B-cell immunity associated immunogenic epitope prediction and HLA distribution analysis of Zika virus","volume":"16","author":"Janahi","year":"2017","journal-title":"EXCLI J"},{"key":"10.1016\/j.jksus.2021.101751_b0100","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3389\/fonc.2018.00404","article-title":"Interactions Between Nanoparticles and Dendritic Cells: From the Perspective of Cancer Immunotherapy","volume":"8","author":"Jia","year":"2018","journal-title":"Front. Oncol."},{"issue":"1851","key":"10.1016\/j.jksus.2021.101751_b0105","doi-asserted-by":"crossref","first-page":"20162562","DOI":"10.1098\/rspb.2016.2562","article-title":"Why does drug resistance readily evolve but vaccine resistance does not?","volume":"284","author":"Kennedy","year":"2017","journal-title":"Proc. R. Soc. B."},{"issue":"8","key":"10.1016\/j.jksus.2021.101751_b0110","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.2217\/fvl.15.53","article-title":"Addressing viral resistance through vaccines","volume":"10","author":"Laughlin","year":"2015","journal-title":"Future Virol."},{"issue":"7","key":"10.1016\/j.jksus.2021.101751_b0115","doi-asserted-by":"crossref","first-page":"e1001005","DOI":"10.1371\/journal.ppat.1001005","article-title":"Quasispecies theory and the behavior of RNA viruses","volume":"6","author":"Lauring","year":"2010","journal-title":"PLoS Pathog."},{"issue":"3","key":"10.1016\/j.jksus.2021.101751_b0120","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3390\/vaccines2030515","article-title":"Peptide Vaccine: Progress and Challenges. Peptide Vaccine: Progress and Challenges","volume":"2","author":"Li","year":"2014","journal-title":"Vaccines (Basel)"},{"issue":"9","key":"10.1016\/j.jksus.2021.101751_b0125","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.2217\/fvl.11.79","article-title":"Clinical aspects of Marburg hemorrhagic fever","volume":"6","author":"Mehedi","year":"2011","journal-title":"Future Virol"},{"key":"10.1016\/j.jksus.2021.101751_b0130","doi-asserted-by":"crossref","unstructured":"Nielsen, M., Lundegaard, C., Blicher, T., Peters, B., Sette, A., Justesen, S., Buus, S., and Lund, O. (2008). Quantitative predictions of peptide binding to any HLA-DR molecule of known sequence: NetMHCIIpan. PLoS Comput Biol 4, e1000107.","DOI":"10.1371\/journal.pcbi.1000107"},{"issue":"43","key":"10.1016\/j.jksus.2021.101751_b0135","doi-asserted-by":"crossref","first-page":"7530","DOI":"10.1016\/j.vaccine.2007.08.044","article-title":"Computational analysis of proteome of H5N1 avian influenza virus to define T cell epitopes with vaccine potential","volume":"25","author":"Parida","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.jksus.2021.101751_b0140","doi-asserted-by":"crossref","first-page":"4409","DOI":"10.1038\/s41598-019-40833-x","article-title":"In-silico design of a multi-epitope vaccine candidate against onchocerciasis and related filarial diseases","volume":"9","author":"Shey","year":"2019","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.jksus.2021.101751_b0145","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1039\/C5SC03892H","article-title":"Peptide-based synthetic vaccines","volume":"7","author":"Skwarczynski","year":"2016","journal-title":"Chem. Sci."},{"issue":"26","key":"10.1016\/j.jksus.2021.101751_b0150","doi-asserted-by":"crossref","first-page":"14764","DOI":"10.1073\/pnas.94.26.14764","article-title":"A system for functional analysis of Ebola virus glycoprotein","volume":"94","author":"Takada","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"13","key":"10.1016\/j.jksus.2021.101751_b0155","doi-asserted-by":"crossref","first-page":"6497","DOI":"10.1128\/JVI.00069-06","article-title":"Marburgvirus genomics and association with a large hemorrhagic fever outbreak in Angola","volume":"80","author":"Towner","year":"2006","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.jksus.2021.101751_b0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/viro.1999.0110","article-title":"Proteolytic processing of Marburg virus glycoprotein","volume":"268","author":"Volchkov","year":"2000","journal-title":"Virology"},{"issue":"15","key":"10.1016\/j.jksus.2021.101751_b0165","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1016\/j.vaccine.2006.12.023","article-title":"Predicted epitopes of Lig A of Leptospira interrogans by bioinformatics method: a clue for further vaccine development","volume":"25","author":"Wiwanitkit","year":"2007","journal-title":"Vaccine"},{"issue":"4","key":"10.1016\/j.jksus.2021.101751_b0170","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.1128\/JVI.72.4.3155-3160.1998","article-title":"Characterization of Ebola virus entry by using pseudotyped viruses: identification of receptor-deficient cell lines","volume":"72","author":"Wool-Lewis","year":"1998","journal-title":"J. Virol."}],"container-title":["Journal of King Saud University - Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1018364721004134?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1018364721004134?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T21:32:10Z","timestamp":1751059930000},"score":1,"resource":{"primary":{"URL":"https:\/\/jksus.org\/in-silico-cd4t-cell-multiepitope-prediction-and-hla-distribution-analysis-for-marburg-virusa-strategy-for-vaccine-designing\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["S1018364721004134"],"URL":"https:\/\/doi.org\/10.1016\/j.jksus.2021.101751","relation":{},"ISSN":["1018-3647"],"issn-type":[{"value":"1018-3647","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In silico CD4\u00a0+\u00a0T-cell multiepitope prediction and HLA distribution analysis for Marburg Virus\u2014A strategy for vaccine designing","name":"articletitle","label":"Article Title"},{"value":"Journal of King Saud University - Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jksus.2021.101751","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V. on behalf of King Saud University.","name":"copyright","label":"Copyright"}],"article-number":"101751"}}