{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:47:24Z","timestamp":1777416444020,"version":"3.51.4"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["journalofliquidbiopsy.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Liquid Biopsy"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jlb.2025.100328","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:13:58Z","timestamp":1758791638000},"page":"100328","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Liquid biopsy biomarkers in cervical cancer: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"10","author":[{"given":"Isaac Kinyua","family":"Njangiru","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5197-564X","authenticated-orcid":false,"given":"Bizhar Ahmed","family":"Tayeb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hazhmat","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafl M.","family":"Kamil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jlb.2025.100328_bib2","series-title":"StatPearls","article-title":"Cervical cancer","author":"Fowler","year":"2024"},{"key":"10.1016\/j.jlb.2025.100328_bib3","doi-asserted-by":"crossref","first-page":"112","DOI":"10.4132\/jptm.2019.11.29","article-title":"Comparison of papanicolaou smear and human papillomavirus (HPV) test as cervical screening tools: can we rely on HPV test alone as a screening method? An 11-Year retrospective experience at a single institution","volume":"54","author":"Kang","year":"2020","journal-title":"J Pathol Transl Med"},{"key":"10.1016\/j.jlb.2025.100328_bib4","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1056\/NEJMoa071430","article-title":"Canadian cervical cancer screening trial study group human papillomavirus DNA versus papanicolaou screening tests for cervical cancer","volume":"357","author":"Mayrand","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jlb.2025.100328_bib5","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s40944-018-0221-x","article-title":"Evaluation of sensitivity and specificity of pap smear, LBC and HPV in screening of cervical cancer","volume":"16","author":"Pankaj","year":"2018","journal-title":"Indian J Gynecol Oncol"},{"key":"10.1016\/j.jlb.2025.100328_bib6","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1177\/0049475518798532","article-title":"Pap smear accuracy for the diagnosis of cervical precancerous lesions","volume":"49","author":"Nkwabong","year":"2019","journal-title":"Trop Doct"},{"key":"10.1016\/j.jlb.2025.100328_bib7","doi-asserted-by":"crossref","DOI":"10.1177\/1533033820970667","article-title":"A novel circulating MiRNA-Based signature for the diagnosis and prognosis prediction of early-stage cervical cancer","volume":"19","author":"Qiu","year":"2020","journal-title":"Technol Cancer Res Treat"},{"key":"10.1016\/j.jlb.2025.100328_bib8","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.gore.2018.02.004","article-title":"The value of visual inspection with acetic acid and pap smear in cervical cancer screening program in low resource settings \u2013 a population-based study","volume":"24","author":"Huy","year":"2018","journal-title":"Gynecol Oncol Rep"},{"key":"10.1016\/j.jlb.2025.100328_bib9","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.anndiagpath.2018.11.007","article-title":"Clinicopathological study of role of CD34 expressions in the stroma of premalignant and malignant lesions of uterine cervix","volume":"38","author":"Aijaz","year":"2019","journal-title":"Ann Diagn Pathol"},{"key":"10.1016\/j.jlb.2025.100328_bib10","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s13193-020-01118-2","article-title":"Diagnostic accuracy of cervical pap smear and colposcopy in detecting premalignant and malignant lesions of cervix","volume":"11","author":"Najib","year":"2020","journal-title":"Indian J Surg Oncol"},{"key":"10.1016\/j.jlb.2025.100328_bib11","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/s41416-022-01868-6","article-title":"Clinical applications and utility of cell-free DNA-based liquid biopsy analyses in cervical cancer and its precursor lesions","volume":"127","author":"Herbst","year":"2022","journal-title":"Br J Cancer"},{"key":"10.1016\/j.jlb.2025.100328_bib12","doi-asserted-by":"crossref","DOI":"10.21037\/tcr.2018.01.31","article-title":"Clinical relevance of liquid biopsy for cancer screening","volume":"7","author":"Tanos","year":"2018","journal-title":"Transl Cancer Res"},{"key":"10.1016\/j.jlb.2025.100328_bib13","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-006013","article-title":"Cell-free DNA approaches for cancer early detection and interception","volume":"11","author":"Medina","year":"2023","journal-title":"J Immunother Cancer"},{"key":"10.1016\/j.jlb.2025.100328_bib14","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1039\/D2SD00010E","article-title":"Recent advances in liquid biopsy technologies for cancer biomarker detection","volume":"1","author":"Soda","year":"2022","journal-title":"Sens Diagn"},{"key":"10.1016\/j.jlb.2025.100328_bib15","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1186\/s13643-017-0590-8","article-title":"Recommendations for reporting of systematic reviews and meta-analyses of diagnostic test accuracy: a systematic review","volume":"6","author":"McGrath","year":"2017","journal-title":"Syst Rev"},{"key":"10.1016\/j.jlb.2025.100328_bib16","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1001\/jama.2017.19163","article-title":"Preferred reporting items for a systematic review and meta-analysis of diagnostic test accuracy studies: the PRISMA-DTA statement","volume":"319","author":"McInnes","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.jlb.2025.100328_bib17","doi-asserted-by":"crossref","first-page":"529","DOI":"10.7326\/0003-4819-155-8-201110180-00009","article-title":"The QUADAS-2 group QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies","volume":"155","author":"Whiting","year":"2011","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jlb.2025.100328_bib18","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1471-2288-6-31","article-title":"Meta-DiSc: a software for meta-analysis of test accuracy data","volume":"6","author":"Zamora","year":"2006","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.jlb.2025.100328_bib19","series-title":"Version 5.4.1 the cochrane collaboration","year":"2020"},{"key":"10.1016\/j.jlb.2025.100328_bib20","series-title":"RStudio: integrated development environment for R","year":"2020"},{"key":"10.1016\/j.jlb.2025.100328_bib21","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/s12874-019-0817-6","article-title":"Statistical approaches to identify subgroups in meta-analysis of individual participant data: a simulation study","volume":"19","author":"Belias","year":"2019","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.jlb.2025.100328_bib22","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1651-2227.2006.00179.x","article-title":"Understanding diagnostic tests 2: likelihood ratios, pre\u2010 and post\u2010test probabilities and their use in clinical practice","volume":"96","author":"Akobeng","year":"2007","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.jlb.2025.100328_bib23","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.jclinepi.2005.01.016","article-title":"The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed","volume":"58","author":"Deeks","year":"2005","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.jlb.2025.100328_bib24","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1089\/fpd.2023.0004","article-title":"Antimicrobial susceptibility profile of Listeria Monocytogenes isolated from meat products: a systematic review and meta-analysis","volume":"20","author":"Tayeb","year":"2023","journal-title":"Foodb Pathog Dis"},{"key":"10.1016\/j.jlb.2025.100328_bib25","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3892\/br.2017.970","article-title":"A pooled analysis of the diagnostic efficacy of plasmic methylated Septin-9 as a novel biomarker for colorectal cancer","volume":"7","author":"Zhang","year":"2017","journal-title":"Biomed Rep"},{"key":"10.1016\/j.jlb.2025.100328_bib26","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","article-title":"Rayyan\u2014A web and Mobile app for systematic reviews","volume":"5","author":"Ouzzani","year":"2016","journal-title":"Syst Rev"},{"key":"10.1016\/j.jlb.2025.100328_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-89388-w","article-title":"Urine miRNA signature as a potential non-invasive diagnostic and prognostic biomarker in cervical cancer","volume":"11","author":"Aftab","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jlb.2025.100328_bib28","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.3390\/cancers15092590","article-title":"Circulating HPV DNA as a biomarker for pre-invasive and early invasive cervical cancer: a feasibility study","volume":"15","author":"Bryan","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.jlb.2025.100328_bib29","doi-asserted-by":"crossref","DOI":"10.1080\/01443615.2022.2151356","article-title":"Septin9 DNA methylation as a promising biomarker for cervical cancer","volume":"43","author":"Bu","year":"2023","journal-title":"J Obstet Gynaecol"},{"key":"10.1016\/j.jlb.2025.100328_bib30","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.3390\/cells11142170","article-title":"The diagnostic value of circulating cell-free HPV DNA in plasma from cervical cancer patients","volume":"11","author":"B\u00f8nl\u00f8kke","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.jlb.2025.100328_bib31","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.01480-21","article-title":"Detection of circulating HPV16 DNA as a biomarker for cervical cancer by a bead-based HPV genotyping assay","volume":"10","author":"Galati","year":"2022","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.jlb.2025.100328_bib32","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/dc.23838","article-title":"Aberrant single\u2010minded homolog 1 methylation as a potential biomarker for cervical cancer","volume":"46","author":"Kim","year":"2018","journal-title":"Diagn Cytopathol"},{"key":"10.1016\/j.jlb.2025.100328_bib33","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3233\/CBM-190256","article-title":"Circulating plasma microRNA signature for the diagnosis of cervical cancer","volume":"26","author":"Ma","year":"2019","journal-title":"Cancer Biomarkers"},{"key":"10.1016\/j.jlb.2025.100328_bib34","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1177\/1535370220978899","article-title":"Rapid and ultrasensitive detection of circulating human papillomavirus E7 cell-free DNA as a cervical cancer biomarker","volume":"246","author":"Rungkamoltip","year":"2021","journal-title":"Exp Biol Med"},{"key":"10.1016\/j.jlb.2025.100328_bib35","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/ijc.26360","article-title":"Detection of circulating Bmi\u20101 mRNA in plasma and its potential diagnostic and prognostic value for uterine cervical cancer","volume":"131","author":"Zhang","year":"2012","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jlb.2025.100328_bib36","article-title":"Diagnostic value of vaginal microecology, serum miR-18a, and PD-L1 for identifying HPV-positive cervical cancer","volume":"20","author":"Zhang","year":"2021","journal-title":"Technol Cancer Res Treat"},{"key":"10.1016\/j.jlb.2025.100328_bib37","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12943-019-0999-x","article-title":"Exosomal Let-7d-3p and miR-30d-5p as diagnostic biomarkers for non-invasive screening of cervical cancer and its precursors","volume":"18","author":"Zheng","year":"2019","journal-title":"Mol Cancer"},{"key":"10.1016\/j.jlb.2025.100328_bib38","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0895-4356(03)00177-X","article-title":"The diagnostic odds ratio: a single indicator of test performance","volume":"56","author":"Glas","year":"2003","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.jlb.2025.100328_bib39","article-title":"Preferred reporting items for systematic review and meta-analysis of diagnostic test accuracy studies (PRISMA-DTA): explanation, elaboration, and checklist","volume":"370","author":"Salameh","year":"2020","journal-title":"BMJ"},{"key":"10.1016\/j.jlb.2025.100328_bib40","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat Med"},{"key":"10.1016\/j.jlb.2025.100328_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/vco.12865","article-title":"Evaluating the relevance of surgical margins. Part one: the problems with current methodology","volume":"21","author":"Bray","year":"2023","journal-title":"Vet Comp Oncol"},{"key":"10.1016\/j.jlb.2025.100328_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0224001","article-title":"Circulating HPV cDNA in the blood as a reliable biomarker for cervical cancer: a meta-analysis","volume":"15","author":"Gu","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.jlb.2025.100328_bib43","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.ygyno.2017.05.038","article-title":"Liquid biopsy of PIK3CA mutations in cervical cancer in Hong Kong Chinese women","volume":"146","author":"Chung","year":"2017","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.jlb.2025.100328_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2024.120063","article-title":"Liquid biopsy biomarkers in breast cancer: an overview of systematic reviews","volume":"566","author":"Tayeb","year":"2025","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jlb.2025.100328_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41392-024-01823-2","article-title":"Tumor biomarkers for diagnosis, prognosis and targeted therapy","volume":"9","author":"Zhou","year":"2024","journal-title":"Signal Transduct Targeted Ther"},{"key":"10.1016\/j.jlb.2025.100328_bib46","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.jlb.2025.100328_bib47","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1080\/01443615.2019.1634030","article-title":"Human papillomavirus and cervical cancer","volume":"40","author":"Okunade","year":"2020","journal-title":"J Obstet Gynaecol J Inst Obstet Gynaecol"},{"key":"10.1016\/j.jlb.2025.100328_bib48","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1136\/bmj.329.7458.168","article-title":"Diagnostic tests 4: likelihood ratios","volume":"329","author":"Deeks","year":"2004","journal-title":"BMJ"},{"key":"10.1016\/j.jlb.2025.100328_bib49","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1515\/cclm-2021-0193","article-title":"The assessment of circulating cell-free DNA as a diagnostic tool for breast cancer: an updated systematic review and meta-analysis of quantitative and qualitative ssays","volume":"59","author":"Guo","year":"2021","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.jlb.2025.100328_bib50","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14737159.2023.2195552","article-title":"Diagnostic and predictive value of liquid biopsy-derived exosome miR-21 for breast cancer: a systematic review and meta-analysis","volume":"23","author":"Wang","year":"2023","journal-title":"Expert Rev Mol Diagn"},{"key":"10.1016\/j.jlb.2025.100328_bib51","doi-asserted-by":"crossref","DOI":"10.1177\/1758835918794630","article-title":"Liquid biopsy of cancer: a multimodal diagnostic tool in clinical oncology","volume":"10","author":"Palmirotta","year":"2018","journal-title":"Ther Adv Med Oncol"},{"key":"10.1016\/j.jlb.2025.100328_bib52","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.csbj.2018.05.002","article-title":"ctDNA and CTCs in liquid biopsy \u2013 current status and where we need to progress","volume":"16","author":"Neumann","year":"2018","journal-title":"Comput Struct Biotechnol J"},{"key":"10.1016\/j.jlb.2025.100328_bib53","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1093\/jnci\/djy105","article-title":"Circulating tumor DNA assays in clinical cancer research","volume":"110","author":"Ossandon","year":"2018","journal-title":"JNCI J Natl Cancer Inst"},{"key":"10.1016\/j.jlb.2025.100328_bib54","doi-asserted-by":"crossref","first-page":"6625","DOI":"10.3390\/ijms24076625","article-title":"Investigation of the antineoplastic effects of 2-(4-Chlorophenyl)-13\u03b1-Estrone sulfamate against the HPV16-Positive human invasive cervical carcinoma cell line SiHa","volume":"24","author":"Ali","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jlb.2025.100328_bib55","article-title":"Prevalence and genotype distribution of human papillomavirus in invasive cervical cancer, cervical intraepithelial neoplasia, and asymptomatic women in Southeast China","volume":"2018","author":"Wang","year":"2018","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.jlb.2025.100328_bib56","doi-asserted-by":"crossref","first-page":"6856","DOI":"10.1158\/1078-0432.CCR-17-1553","article-title":"Circulating cell-free DNA for metastatic cervical cancer detection, genotyping, and monitoring","volume":"23","author":"Kang","year":"2017","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jlb.2025.100328_bib57","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0189165","article-title":"Comparison of miRNA quantitation by nanostring in serum and plasma samples","volume":"12","author":"Foye","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jlb.2025.100328_bib58","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.trsl.2015.10.010","article-title":"Vesicle-associated microRNAs are released from blood cells on incubation of blood samples","volume":"169","author":"K\u00f6berle","year":"2016","journal-title":"Transl Res"}],"container-title":["The Journal of Liquid Biopsy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S295019542500044X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S295019542500044X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T01:44:40Z","timestamp":1771897480000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S295019542500044X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":57,"alternative-id":["S295019542500044X"],"URL":"https:\/\/doi.org\/10.1016\/j.jlb.2025.100328","relation":{},"ISSN":["2950-1954"],"issn-type":[{"value":"2950-1954","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Liquid biopsy biomarkers in cervical cancer: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"The Journal of Liquid Biopsy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jlb.2025.100328","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of The International Society of Liquid Biopsy.","name":"copyright","label":"Copyright"}],"article-number":"100328"}}