{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T19:02:47Z","timestamp":1785178967020,"version":"3.55.0"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019180","name":"HORIZON EUROPE European Research Council","doi-asserted-by":"publisher","award":["4H-2024-PJ-03-4"],"award-info":[{"award-number":["4H-2024-PJ-03-4"]}],"id":[{"id":"10.13039\/100019180","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024370","name":"Ministry of Education and Merit","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024370","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"Horizon Europe","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofliquidbiopsy.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Liquid Biopsy"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jlb.2026.100466","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T07:50:10Z","timestamp":1775634610000},"page":"100466","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Breaking news from ESMO 2025: liquid biopsy novelties in gastrointestinal cancer"],"prefix":"10.1016","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8861-8718","authenticated-orcid":false,"given":"Serena","family":"Pillozzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Petroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Lavacchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Rossini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Antonuzzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 9","key":"10.1016\/j.jlb.2026.100466_bib1","article-title":"Real-world outcomes of trastuzumab-based therapy in HER2-positive metastatic gastroesophageal adenocarcinoma: predictive value of ERBB2 copy number gain","volume":"36","author":"Mascar\u00f3 Baselga","year":"2025","journal-title":"Ann Oncol"},{"issue":"Suppl 9","key":"10.1016\/j.jlb.2026.100466_bib2","article-title":"Neoadjuvant adebrelimab plus chemotherapy for locally advanced resectable gastric or gastroesophageal junction adenocarcinoma: a single-arm, open-label, phase II trial","volume":"36","author":"He","year":"2025","journal-title":"Ann Oncol"},{"issue":"Suppl 9","key":"10.1016\/j.jlb.2026.100466_bib3","first-page":"S1209","article-title":"Prognostic value of cfDNA methylation in predicting the efficacy of neoadjuvant chemoradiotherapy combined with anti\u2013PD-1 in locally advanced esophageal squamous cell cancer","volume":"36","author":"Chen","year":"2025","journal-title":"Ann Oncol"},{"issue":"1","key":"10.1016\/j.jlb.2026.100466_bib4","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1186\/s12885-025-14063-6","volume":"25","author":"Nasca","year":"2025","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jlb.2026.100466_bib5","article-title":"Evaluating trastuzumab deruxtecan in patients with gastroesophageal adenocarcinoma who are ctDNA and HER2 positive: DECIPHER","volume":"6","author":"Smyth","year":"2024","journal-title":"ESMO Gastrointest Oncol"},{"issue":"Suppl 9","key":"10.1016\/j.jlb.2026.100466_bib6","article-title":"Serum levels of galectin-9 predict survival in patients with gastric and gastroesophageal junction adenocarcinoma","volume":"36","author":"Digomann","year":"2025","journal-title":"Ann Oncol"},{"issue":"24","key":"10.1016\/j.jlb.2026.100466_bib7","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1056\/NEJMoa2200075","article-title":"Circulating tumor DNA analysis guiding adjuvant therapy in stage II Colon cancer","volume":"386","author":"Tie","year":"2022","journal-title":"N Engl J Med"},{"issue":"Suppl 9","key":"10.1016\/j.jlb.2026.100466_bib8","article-title":"ctDNA-guided adjuvant chemotherapy de-escalation in stage III colon cancer: primary analysis of the ctDNA-negative cohort from the randomized AGITG DYNAMIC-III trial","volume":"36","author":"Tie","year":"2025","journal-title":"Ann Oncol"},{"issue":"Suppl 9","key":"10.1016\/j.jlb.2026.100466_bib9","article-title":"Post-surgical liquid biopsy\u2013guided treatment of stage III and high-risk stage II colon cancer: final results of the PEGASUS trial","volume":"36","author":"Marsoni","year":"2025","journal-title":"Ann Oncol"},{"issue":"Suppl 9","key":"10.1016\/j.jlb.2026.100466_bib10","article-title":"Circulating tumor DNA analysis of BRAF V600E dynamics in patients with first-line BRAF V600E\u2013mutant metastatic colorectal cancer treated in BREAKWATER","volume":"36","author":"Kopetz","year":"2025","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jlb.2026.100466_bib11","article-title":"Clinical, genomic, and transcriptomic data profiling of biliary tract cancer reveals subtype-specific immune signatures","volume":"6","author":"Mody","year":"2022","journal-title":"JCO Precis Oncol"},{"issue":"Suppl 2","key":"10.1016\/j.jlb.2026.100466_bib12","article-title":"Dynamic circulating tumor DNA\u2013guided adjuvant therapy for biliary tract carcinoma: a prospective study","volume":"36","author":"Wang","year":"2025","journal-title":"Ann Oncol"},{"issue":"1","key":"10.1016\/j.jlb.2026.100466_bib13","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.1038\/s41467-024-47195-7","article-title":"A cfDNA methylation-based tissue-of-origin classifier for cancers of unknown primary","volume":"15","author":"Conway","year":"2024","journal-title":"Nat Commun"},{"issue":"Suppl 2","key":"10.1016\/j.jlb.2026.100466_bib14","article-title":"Utilising cell-free DNA for the detection of biliary tract cancers","volume":"36","author":"Conway","year":"2025","journal-title":"Ann Oncol"},{"issue":"Suppl","key":"10.1016\/j.jlb.2026.100466_bib15","article-title":"Early detection of pancreatic cancer with a multi-omic liquid biopsy","volume":"36","author":"Cameron","year":"2025","journal-title":"Ann Oncol"},{"issue":"Suppl","key":"10.1016\/j.jlb.2026.100466_bib16","article-title":"Evaluation of a cfDNA-based blood test for early detection of pancreatic cancer in high-risk individuals","volume":"36","author":"Brand","year":"2025","journal-title":"Ann Oncol"},{"issue":"Suppl","key":"10.1016\/j.jlb.2026.100466_bib17","doi-asserted-by":"crossref","first-page":"S1158","DOI":"10.1016\/j.annonc.2025.08.2863","article-title":"Multicenter identification and validation of a low-abundance serum miRNA panel for pancreatic cancer detection","volume":"36","author":"Kahlert","year":"2025","journal-title":"Ann Oncol"},{"issue":"Suppl","key":"10.1016\/j.jlb.2026.100466_bib18","article-title":"Novel metabolomic signatures for early detection of multiple solid tumors","volume":"36","author":"Kim","year":"2025","journal-title":"Ann Oncol"},{"issue":"Suppl","key":"10.1016\/j.jlb.2026.100466_bib19","article-title":"Clinical significance of ctDNA conversion during systemic therapy in metastatic pancreatic cancer: insights from ctDNA-RECIST","volume":"36","author":"Steiniche","year":"2025","journal-title":"Ann Oncol"},{"issue":"Suppl","key":"10.1016\/j.jlb.2026.100466_bib20","article-title":"Longitudinal cfDNA dynamics predict recurrence and survival after curative surgery for pancreatic cancer","volume":"36","author":"Huang","year":"2025","journal-title":"Ann Oncol"},{"issue":"Suppl","key":"10.1016\/j.jlb.2026.100466_bib21","article-title":"Growth differentiation factor 15 in localized pancreatic cancer treated with induction chemotherapy: biomarker analysis from the NEOLAP-1 trial","volume":"36","author":"Kimmel","year":"2025","journal-title":"Ann Oncol"}],"container-title":["The Journal of Liquid Biopsy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950195426000123?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950195426000123?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T13:10:31Z","timestamp":1781874631000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2950195426000123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":21,"alternative-id":["S2950195426000123"],"URL":"https:\/\/doi.org\/10.1016\/j.jlb.2026.100466","relation":{},"ISSN":["2950-1954"],"issn-type":[{"value":"2950-1954","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Breaking news from ESMO 2025: liquid biopsy novelties in gastrointestinal cancer","name":"articletitle","label":"Article Title"},{"value":"The Journal of Liquid Biopsy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jlb.2026.100466","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of The International Society of Liquid Biopsy.","name":"copyright","label":"Copyright"}],"article-number":"100466"}}