{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T13:53:12Z","timestamp":1781877192393,"version":"3.54.5"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofliquidbiopsy.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Liquid Biopsy"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jlb.2026.100468","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T23:26:00Z","timestamp":1776295560000},"page":"100468","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Clinician perspectives on the clinical utility of Belay Summit\u2122 2.0 cerebrospinal fluid test \u2013 A mixed methods study"],"prefix":"10.1016","volume":"12","author":[{"given":"Matthias","family":"Holdhoff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vindhya","family":"Udhane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DeElegant","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Larson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kala F.","family":"Schilter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chetan","family":"Bettegowda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1280-9993","authenticated-orcid":false,"given":"Honey V.","family":"Reddi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jlb.2026.100468_bib1","first-page":"381","article-title":"Brain and other central nervous system tumor statistics, 2021","volume":"71","author":"Miller","year":"2021","journal-title":"CA Cancer J Clin"},{"issue":"Supplement_6","key":"10.1016\/j.jlb.2026.100468_bib2","doi-asserted-by":"crossref","first-page":"vi1","DOI":"10.1093\/neuonc\/noae145","article-title":"CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2017-2021","volume":"26","author":"Price","year":"2024","journal-title":"Neuro Oncol"},{"issue":"1","key":"10.1016\/j.jlb.2026.100468_bib3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41572-018-0055-y","article-title":"Brain metastases","volume":"5","author":"Achrol","year":"2019","journal-title":"Nat Rev Dis Primers"},{"issue":"3","key":"10.1016\/j.jlb.2026.100468_bib4","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1001\/jamaoncol.2024.5506","article-title":"Molecular testing for the world health organization classification of central nervous system tumors: a review","volume":"11","author":"Horbinski","year":"2025","journal-title":"JAMA Oncol"},{"issue":"1","key":"10.1016\/j.jlb.2026.100468_bib5","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/s41698-024-00674-y","article-title":"Comprehensive genetic profiling and molecularly guided treatment for patients with primary CNS tumors","volume":"8","author":"Kuehn","year":"2024","journal-title":"npj Precis Oncol"},{"issue":"8","key":"10.1016\/j.jlb.2026.100468_bib6","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/s41576-021-00338-8","article-title":"Clinical cancer genomic profiling","volume":"22","author":"Chakravarty","year":"2021","journal-title":"Nat Rev Genet"},{"issue":"25","key":"10.1016\/j.jlb.2026.100468_bib7","doi-asserted-by":"crossref","first-page":"12524","DOI":"10.1073\/pnas.1902672116","article-title":"Specific factors in blood from young but not old mice directly promote synapse formation and NMDA-receptor recruitment","volume":"116","author":"Gan","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"10.1016\/j.jlb.2026.100468_bib8","doi-asserted-by":"crossref","first-page":"13906","DOI":"10.1038\/s41598-021-93293-7","article-title":"Association of peripheral anterior synechiae with anterior segment parameters in eyes with primary angle closure glaucoma","volume":"11","author":"Loo","year":"2021","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.jlb.2026.100468_bib9","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/jalm\/jfad091","article-title":"Clinical utility and benefits of comprehensive genomic profiling in cancer","volume":"9","author":"Tjota","year":"2024","journal-title":"J Appl Lab Med"},{"issue":"4","key":"10.1016\/j.jlb.2026.100468_bib10","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.wneu.2015.05.025","article-title":"Complications following stereotactic needle biopsy of intracranial tumors","volume":"84","author":"Malone","year":"2015","journal-title":"World Neurosurg"},{"issue":"5","key":"10.1016\/j.jlb.2026.100468_bib11","doi-asserted-by":"crossref","first-page":"897","DOI":"10.3171\/jns.2005.102.5.0897","article-title":"Independent predictors of morbidity after image-guided stereotactic brain biopsy: a risk assessment of 270 cases","volume":"102","author":"McGirt","year":"2005","journal-title":"J Neurosurg"},{"issue":"2","key":"10.1016\/j.jlb.2026.100468_bib12","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s11060-016-2166-1","article-title":"Stereotactic biopsy of brainstem lesions: 21 years experiences of a single center","volume":"129","author":"Quick-Weller","year":"2016","journal-title":"J Neuro Oncol"},{"issue":"3","key":"10.1016\/j.jlb.2026.100468_bib13","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s41571-020-00447-z","article-title":"EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood","volume":"18","author":"Weller","year":"2021","journal-title":"Nat Rev Clin Oncol"},{"issue":"11","key":"10.1016\/j.jlb.2026.100468_bib14","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1038\/s41416-023-02446-0","article-title":"Liquid biopsy: creating opportunities in brain space","volume":"129","author":"Trivedi","year":"2023","journal-title":"Br J Cancer"},{"issue":"6","key":"10.1016\/j.jlb.2026.100468_bib15","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1097\/CCO.0000000000001079","article-title":"Liquid biopsy in brain tumors: moving on, slowly","volume":"36","author":"Berzero","year":"2024","journal-title":"Curr Opin Oncol"},{"key":"10.1016\/j.jlb.2026.100468_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2024.101881","article-title":"Clinical applications of cerebrospinal fluid liquid biopsies in central nervous system tumors","volume":"41","author":"Diaz","year":"2024","journal-title":"Transl Oncol"},{"key":"10.1016\/j.jlb.2026.100468_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlb.2025.100317","article-title":"Demonstrating the clinical utility of genomic profiling using cerebrospinal fluid to inform management of central nervous system tumors - a meta analysis of the literature","volume":"9","author":"Khurana","year":"2025","journal-title":"J Liq Biopsy"},{"issue":"7","key":"10.1016\/j.jlb.2026.100468_bib18","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.jmoldx.2025.03.010","article-title":"Analytical validation and clinical sensitivity of the belay summit assay for the detection of DNA variants in cerebrospinal fluid of primary and metastatic central nervous system cancer","volume":"27","author":"Nie","year":"2025","journal-title":"J Mol Diagn"},{"key":"10.1016\/j.jlb.2026.100468_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlb.2025.100318","article-title":"Analysis of cerebrospinal fluid tumor-derived DNA to obviate biopsy of IDH-mutant brainstem glioma in an adult","volume":"9","author":"Youssef","year":"2025","journal-title":"J Liq Biopsy"},{"issue":"31","key":"10.1016\/j.jlb.2026.100468_bib20","doi-asserted-by":"crossref","first-page":"9704","DOI":"10.1073\/pnas.1511694112","article-title":"Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord","volume":"112","author":"Wang","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.jlb.2026.100468_bib21","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3390\/cancers18020256","article-title":"Analytical validation and clinical sensitivity of the belay summit\u2122 2.0 cerebrospinal fluid liquid biopsy test \u2014an expanded comprehensive genomic profiling platform for central nervous system malignancies. Research article","volume":"18","author":"Khurana","year":"2026","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.jlb.2026.100468_bib22","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jmoldx.2016.10.002","article-title":"Standards and guidelines for the interpretation and reporting of sequence variants in cancer: a joint consensus recommendation of the association for molecular pathology, American society of clinical oncology, and college of American pathologists","volume":"19","author":"Li","year":"2017","journal-title":"J Mol Diagn"},{"issue":"2","key":"10.1016\/j.jlb.2026.100468_bib23","first-page":"168","article-title":"Understanding and evaluating survey research","volume":"6","author":"Ponto","year":"2015","journal-title":"J Adv Pract Oncol"},{"issue":"48","key":"10.1016\/j.jlb.2026.100468_bib24","doi-asserted-by":"crossref","DOI":"10.3346\/jkms.2023.38.e403","article-title":"Designing, conducting, and reporting survey studies: a primer for researchers","volume":"38","author":"Zimba","year":"2023","journal-title":"J Kor Med Sci"},{"issue":"6","key":"10.1016\/j.jlb.2026.100468_bib25","doi-asserted-by":"crossref","DOI":"10.1002\/aet2.10835","article-title":"Educator's blueprint: a how-to guide for collecting validity evidence in survey- based research","volume":"6","author":"Hill","year":"2022","journal-title":"AEM Educ Train"},{"issue":"4","key":"10.1016\/j.jlb.2026.100468_bib26","doi-asserted-by":"crossref","first-page":"640","DOI":"10.3126\/nje.v6i4.17258","article-title":"Guide to the design and application of online questionnaire surveys","volume":"6","author":"Regmi","year":"2016","journal-title":"Nepal J Epidemiol"},{"issue":"3","key":"10.1016\/j.jlb.2026.100468_bib27","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4103\/picr.picr_157_24","article-title":"Crafting an effective questionnaire: an essential prerequisite of engaging surveys","volume":"16","author":"Sharma","year":"2025","journal-title":"Perspect Clin Res"},{"key":"10.1016\/j.jlb.2026.100468_bib28","article-title":"Physician practice patterns associated with diagnostic evaluation of patients with suspected mild cognitive impairment and Alzheimer's disease","volume":"2019","author":"Judge","year":"2019","journal-title":"Int J Alzheimers Dis"},{"key":"10.1016\/j.jlb.2026.100468_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.944963","article-title":"Case report: cerebrospinal fluid-derived circulating tumor DNA diagnoses and guides the treatment of a lung adenocarcinoma case with leptomeningeal metastasis","volume":"12","author":"Bai","year":"2022","journal-title":"Front Oncol"},{"issue":"1","key":"10.1016\/j.jlb.2026.100468_bib30","article-title":"Cerebrospinal fluid liquid biopsy guides differential diagnosis of relapsed medulloblastoma versus secondary glioma: a case report of a pediatric patient enrolled on a PDGFRA inhibitor trial","volume":"7","author":"Fischer","year":"2025","journal-title":"Neurooncol Adv"},{"issue":"10","key":"10.1016\/j.jlb.2026.100468_bib31","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1182\/blood.2024023832","article-title":"Rapid tumor DNA analysis of cerebrospinal fluid accelerates treatment of central nervous system lymphoma","volume":"144","author":"Gupta","year":"2024","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.jlb.2026.100468_bib32","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.20040","article-title":"Detection of leptomeningeal disease using cell-free DNA from cerebrospinal fluid","volume":"4","author":"White","year":"2021","journal-title":"JAMA Netw Open"},{"issue":"1","key":"10.1016\/j.jlb.2026.100468_bib33","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12883-019-1317-3","article-title":"Diagnosis of central nervous system lymphoma via cerebrospinal fluid cytology: a case report","volume":"19","author":"Zhao","year":"2019","journal-title":"BMC Neurol"},{"issue":"7","key":"10.1016\/j.jlb.2026.100468_bib34","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1093\/neuonc\/noae049","article-title":"Challenges, limitations, and pitfalls of PET and advanced MRI in patients with brain tumors: a report of the PET\/RANO group","volume":"26","author":"Galldiks","year":"2024","journal-title":"Neuro Oncol"},{"issue":"10","key":"10.1016\/j.jlb.2026.100468_bib35","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1177\/0883073808320753","article-title":"Imaging of central nervous system tumors in children: advances and limitations","volume":"23","author":"Vezina","year":"2008","journal-title":"J Child Neurol"},{"key":"10.1016\/j.jlb.2026.100468_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlb.2024.100281","article-title":"Liquid biopsy for evaluating mutations and chromosomal aberrations in cerebrospinal fluid from patients with primary or metastatic CNS tumors","volume":"6","author":"Charifa","year":"2024","journal-title":"J Liq Biopsy"},{"issue":"1","key":"10.1016\/j.jlb.2026.100468_bib37","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s40478-024-01846-4","article-title":"Real-world experience with circulating tumor DNA in cerebrospinal fluid from patients with central nervous system tumors","volume":"12","author":"Hickman","year":"2024","journal-title":"Acta Neuropathol Commun"},{"issue":"6","key":"10.1016\/j.jlb.2026.100468_bib38","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.jmoldx.2021.03.001","article-title":"Clinical experience of cerebrospinal fluid-based liquid biopsy demonstrates superiority of cell-free DNA over cell pellet genomic DNA for molecular profiling","volume":"23","author":"Bale","year":"2021","journal-title":"J Mol Diagn"},{"issue":"8","key":"10.1016\/j.jlb.2026.100468_bib39","article-title":"Seq-ing the SINEs of central nervous system tumors in cerebrospinal fluid","volume":"4","author":"Douville","year":"2023","journal-title":"Cell Rep Med"},{"issue":"11","key":"10.1016\/j.jlb.2026.100468_bib40","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1016\/j.ccell.2021.09.012","article-title":"Serial assessment of measurable residual disease in medulloblastoma liquid biopsies","volume":"39","author":"Liu","year":"2021","journal-title":"Cancer Cell"},{"issue":"12","key":"10.1016\/j.jlb.2026.100468_bib41","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1093\/neuonc\/noz156","article-title":"The potential of cerebrospinal fluid-based liquid biopsy approaches in CNS tumors","volume":"21","author":"Mattox","year":"2019","journal-title":"Neuro Oncol"},{"issue":"15","key":"10.1016\/j.jlb.2026.100468_bib42","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2220704120","article-title":"Detection of rare mutations, copy number alterations, and methylation in the same template DNA molecules","volume":"120","author":"Wang","year":"2023","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["The Journal of Liquid Biopsy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950195426000147?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950195426000147?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T13:10:08Z","timestamp":1781874608000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2950195426000147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":42,"alternative-id":["S2950195426000147"],"URL":"https:\/\/doi.org\/10.1016\/j.jlb.2026.100468","relation":{},"ISSN":["2950-1954"],"issn-type":[{"value":"2950-1954","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinician perspectives on the clinical utility of Belay Summit\u2122 2.0 cerebrospinal fluid test \u2013 A mixed methods study","name":"articletitle","label":"Article Title"},{"value":"The Journal of Liquid Biopsy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jlb.2026.100468","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of The International Society of Liquid Biopsy.","name":"copyright","label":"Copyright"}],"article-number":"100468"}}