{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:08:44Z","timestamp":1789016924868,"version":"build-2803163510"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Jiangxi Provincial Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofliquidbiopsy.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Liquid Biopsy"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jlb.2026.100483","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:33:18Z","timestamp":1784302398000},"page":"100483","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A serum-clinical composite model for prostate cancer diagnosis: multicenter validation and CRISPR\/Cas13a-based detection"],"prefix":"10.1016","volume":"13","author":[{"given":"Cong","family":"Lai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yelisudan","family":"Mulati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuohang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Usman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiliang","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiasi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huasheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kewei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jlb.2026.100483_bib1","first-page":"10","article-title":"Cancer statistics, 2025","volume":"75","author":"Siegel","year":"2025","journal-title":"CA Cancer J Clin"},{"issue":"2","key":"10.1016\/j.jlb.2026.100483_bib2","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.eururo.2024.03.027","article-title":"EAU-EANM-ESTRO-ESUR-ISUP-SIOG guidelines on prostate Cancer-2024 update. Part I: screening, diagnosis, and local treatment with curative intent","volume":"86","author":"Cornford","year":"2024","journal-title":"Eur Urol"},{"issue":"5","key":"10.1016\/j.jlb.2026.100483_bib3","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.eururo.2023.05.036","article-title":"Differing recommendations on prostate biopsy approach to minimize infections: an examination of the european association of urology and American urological association guidelines","volume":"84","author":"Kaplan-Marans","year":"2023","journal-title":"Eur Urol"},{"issue":"6","key":"10.1016\/j.jlb.2026.100483_bib4","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1097\/JU.0000000000002910","article-title":"Effectiveness of intrarectal povidone-iodine cleansing plus formalin disinfection of the needle tip in decreasing infectious complications after transrectal prostate biopsy: a randomized controlled trial","volume":"208","author":"Pontes-Junior","year":"2022","journal-title":"J Urol"},{"issue":"1","key":"10.1016\/j.jlb.2026.100483_bib5","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/JU.0000000000002497","article-title":"The effect of different types of prostate biopsy techniques on post-biopsy infectious complications","volume":"208","author":"Tops","year":"2022","journal-title":"J Urol"},{"issue":"15","key":"10.1016\/j.jlb.2026.100483_bib6","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1200\/JCO.2009.24.1968","article-title":"Reducing unnecessary biopsy during prostate cancer screening using a four-kallikrein panel: an independent replication","volume":"28","author":"Vickers","year":"2010","journal-title":"J Clin Oncol"},{"issue":"8","key":"10.1016\/j.jlb.2026.100483_bib7","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/d41573-023-00111-y","article-title":"Trends in the use of liquid biopsy in oncology","volume":"22","author":"Xie","year":"2023","journal-title":"Nat Rev Drug Discov"},{"issue":"11","key":"10.1016\/j.jlb.2026.100483_bib8","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1038\/s41591-023-02605-z","article-title":"Liquid biopsy epigenomic profiling for cancer subtyping","volume":"29","author":"Baca","year":"2023","journal-title":"Nat Med"},{"issue":"7","key":"10.1016\/j.jlb.2026.100483_bib9","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.3390\/cancers16071377","article-title":"The role of circulating tumor cells as a liquid biopsy for cancer: advances, biology, technical challenges, and clinical relevance","volume":"16","author":"Allen","year":"2024","journal-title":"Cancers (Basel)"},{"issue":"7","key":"10.1016\/j.jlb.2026.100483_bib10","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.3390\/cancers16071363","article-title":"Biomarkers for pre-treatment risk stratification of prostate cancer patients: a systematic review","volume":"16","author":"Sequeira","year":"2024","journal-title":"Cancers (Basel)"},{"issue":"10","key":"10.1016\/j.jlb.2026.100483_bib11","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.urolonc.2025.07.034","article-title":"Liquid biopsy testing in urological cancers: focus on urine","volume":"43","author":"Pisapia","year":"2025","journal-title":"Urol Oncol"},{"key":"10.1016\/j.jlb.2026.100483_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlb.2025.100305","article-title":"Blood and urine-based biomarkers in prostate cancer: current advances, clinical applications, and future directions","volume":"9","author":"Crocetto","year":"2025","journal-title":"J Liq Biopsy"},{"issue":"7","key":"10.1016\/j.jlb.2026.100483_bib13","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1038\/s12276-023-01050-9","article-title":"MicroRNA: trends in clinical trials of cancer diagnosis and therapy strategies","volume":"55","author":"Kim","year":"2023","journal-title":"Exp Mol Med"},{"issue":"1","key":"10.1016\/j.jlb.2026.100483_bib14","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2217\/fon-2022-0891","article-title":"The role of miRNA in prostate cancer diagnosis, prognosis and treatment response: a narrative review","volume":"19","author":"Vazquez-Urrutia","year":"2023","journal-title":"Future Oncol"},{"issue":"9","key":"10.1016\/j.jlb.2026.100483_bib15","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/nm.4377","article-title":"Implications of human genetic variation in CRISPR-based therapeutic genome editing","volume":"23","author":"Scott","year":"2017","journal-title":"Nat Med"},{"issue":"7","key":"10.1016\/j.jlb.2026.100483_bib16","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/s41551-021-00760-7","article-title":"CRISPR-based diagnostics","volume":"5","author":"Kaminski","year":"2021","journal-title":"Nat Biomed Eng"},{"issue":"2","key":"10.1016\/j.jlb.2026.100483_bib17","first-page":"966","article-title":"PddCas: a polydisperse droplet digital CRISPR\/Cas-Based assay for the rapid and ultrasensitive amplification-free detection of viral DNA\/RNA","volume":"95","author":"Xue","year":"2023","journal-title":"Anal Chem"},{"issue":"1","key":"10.1016\/j.jlb.2026.100483_bib18","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.eururo.2023.12.015","article-title":"Transperineal versus transrectal magnetic resonance imaging-targeted and systematic prostate biopsy to prevent infectious complications: the PREVENT randomized trial","volume":"86","author":"Hu","year":"2024","journal-title":"Eur Urol"},{"key":"10.1016\/j.jlb.2026.100483_bib19","article-title":"Stard 2015: an updated list of essential items for reporting diagnostic accuracy studies","volume":"351","author":"Bossuyt","year":"2015","journal-title":"Br Med J"},{"issue":"11","key":"10.1016\/j.jlb.2026.100483_bib20","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.crad.2019.03.016","article-title":"Prostate biopsy: when and how to perform","volume":"74","author":"Das","year":"2019","journal-title":"Clin Radiol"},{"issue":"10","key":"10.1016\/j.jlb.2026.100483_bib21","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1158\/1078-0432.CCR-18-2849","article-title":"Large-scale circulating microRNA profiling for the liquid biopsy of prostate cancer","volume":"25","author":"Urabe","year":"2019","journal-title":"Clin Cancer Res"},{"issue":"19","key":"10.1016\/j.jlb.2026.100483_bib22","doi-asserted-by":"crossref","first-page":"7676","DOI":"10.1021\/acs.analchem.3c00701","article-title":"Nanoarchitectonics-assisted simultaneous fluorescence detection of urinary dual miRNAs for noninvasive diagnosis of prostate cancer","volume":"95","author":"Jiang","year":"2023","journal-title":"Anal Chem"},{"issue":"13","key":"10.1016\/j.jlb.2026.100483_bib23","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3390\/cancers14133157","article-title":"Urinary microRNAs and their significance in prostate cancer diagnosis: a 5-Year update","volume":"14","author":"Juracek","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jlb.2026.100483_bib24","article-title":"MicroRNA panel in serum reveals novel diagnostic biomarkers for prostate cancer","volume":"9","author":"Zhang","year":"2021","journal-title":"PeerJ"},{"issue":"1","key":"10.1016\/j.jlb.2026.100483_bib25","doi-asserted-by":"crossref","first-page":"6653","DOI":"10.1038\/s41598-018-24424-w","article-title":"A plasma biomarker panel of four MicroRNAs for the diagnosis of prostate cancer","volume":"8","author":"Matin","year":"2018","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.jlb.2026.100483_bib26","doi-asserted-by":"crossref","first-page":"8","DOI":"10.5534\/wjmh.230386","article-title":"Liquid biomarkers in prostate cancer diagnosis: current status and emerging prospects","volume":"43","author":"Liu","year":"2025","journal-title":"World J Mens Health"},{"key":"10.1016\/j.jlb.2026.100483_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2024.102196","article-title":"Prostate cancer risk biomarkers from large cohort and prospective metabolomics studies: a systematic review","volume":"51","author":"L\u00f3pez-Hern\u00e1ndez","year":"2025","journal-title":"Transl Oncol"},{"issue":"3","key":"10.1016\/j.jlb.2026.100483_bib28","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.eururo.2024.04.037","article-title":"Performance of 4Kscore as a reflex test to prostate-specific antigen in the G\u00d6TEBORG-2 prostate cancer screening trial","volume":"86","author":"Josefsson","year":"2024","journal-title":"Eur Urol"},{"issue":"7","key":"10.1016\/j.jlb.2026.100483_bib29","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djv095","article-title":"Predicting high-grade cancer at ten-core prostate biopsy using four kallikrein markers measured in blood in the ProtecT study","volume":"107","author":"Bryant","year":"2015","journal-title":"J Natl Cancer Inst"},{"issue":"4","key":"10.1016\/j.jlb.2026.100483_bib30","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.eururo.2018.10.047","article-title":"A multicentre evaluation of the role of the prostate health index (PHI) in regions with differing prevalence of prostate cancer: adjustment of PHI reference ranges is needed for European and Asian settings","volume":"75","author":"Chiu","year":"2019","journal-title":"Eur Urol"},{"issue":"6","key":"10.1016\/j.jlb.2026.100483_bib31","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1016\/j.juro.2013.12.005","article-title":"Urinary PCA3 as a predictor of prostate cancer in a cohort of 3,073 men undergoing initial prostate biopsy","volume":"191","author":"Chevli","year":"2014","journal-title":"J Urol"},{"issue":"10","key":"10.1016\/j.jlb.2026.100483_bib32","doi-asserted-by":"crossref","first-page":"343","DOI":"10.31083\/j.fbl2910343","article-title":"Mechanistic insights and molecular diagnostics of TMPRSS2-ERG: overview of the journey from regulation of signaling landscape in fusion positive prostate cancer to appraisal as a diagnostic marker","volume":"29","author":"Farooqi","year":"2024","journal-title":"Front Biosci (Landmark Ed)"},{"issue":"3","key":"10.1016\/j.jlb.2026.100483_bib33","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/bib\/bbr049","article-title":"Gene set enrichment analysis: performance evaluation and usage guidelines","volume":"13","author":"Hung","year":"2012","journal-title":"Briefings Bioinf"}],"container-title":["The Journal of Liquid Biopsy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950195426000299?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950195426000299?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:30:48Z","timestamp":1789014648000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2950195426000299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":33,"alternative-id":["S2950195426000299"],"URL":"https:\/\/doi.org\/10.1016\/j.jlb.2026.100483","relation":{},"ISSN":["2950-1954"],"issn-type":[{"value":"2950-1954","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A serum-clinical composite model for prostate cancer diagnosis: multicenter validation and CRISPR\/Cas13a-based detection","name":"articletitle","label":"Article Title"},{"value":"The Journal of Liquid Biopsy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jlb.2026.100483","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of The International Society of Liquid Biopsy.","name":"copyright","label":"Copyright"}],"article-number":"100483"}}