{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T04:33:10Z","timestamp":1793075590689,"version":"4.5.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020581","name":"AIRC Foundation for Cancer Research","doi-asserted-by":"publisher","award":["26237"],"award-info":[{"award-number":["26237"]}],"id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofliquidbiopsy.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Liquid Biopsy"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.jlb.2026.100506","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:39:33Z","timestamp":1791387573000},"page":"100506","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["NK cell immune fitness stratifies small cell lung cancer into four functional states associated with clinical response"],"prefix":"10.1016","volume":"14","author":[{"given":"Caterina","family":"De Rosa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Somma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Amato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Capaldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faiz","family":"Ul Haq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"De Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Iommelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"De Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concetta","family":"Tuccillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"di Guida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Sepe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Di Liello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilia","family":"Rea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Grande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Sapio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Ragone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio","family":"Naviglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Capuano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Tirino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Marcenaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Sivori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giusi","family":"Barra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Gambardella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Viscardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Gilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Vitiello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola Maria","family":"Medusa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Servetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Sodano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinando","family":"De Vita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fortunato","family":"Ciardiello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floriana","family":"Morgillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Papaccio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Ercolano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carminia Maria","family":"Della Corte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jlb.2026.100506_bib1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/s41590-022-01127-z","article-title":"Innate lymphoid cells and cancer","volume":"23","author":"Jacquelot","year":"2022","journal-title":"Nat Immunol"},{"issue":"2","key":"10.1016\/j.jlb.2026.100506_bib2","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/cyto.b.21508","article-title":"Markers and function of human NK cells in normal and pathological conditions","volume":"92","author":"Del Zotto","year":"2017","journal-title":"Cytometry B Clin Cytom"},{"issue":"7","key":"10.1016\/j.jlb.2026.100506_bib3","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.annonc.2021.03.207","article-title":"Small-cell lung cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up","volume":"32","author":"Dingemans","year":"2021","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jlb.2026.100506_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.lungcan.2024.107924","article-title":"Five-year survival in patients with extensive-stage small cell lung cancer treated with atezolizumab in the phase III IMpower133 study and the phase III IMbrella A extension study","volume":"196","author":"Reck","year":"2024","journal-title":"Lung Cancer"},{"issue":"3","key":"10.1016\/j.jlb.2026.100506_bib5","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.ccell.2020.12.014","article-title":"Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities","volume":"39","author":"Gay","year":"2021","journal-title":"Cancer Cell"},{"issue":"7","key":"10.1016\/j.jlb.2026.100506_bib6","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1158\/0008-5472.CAN-20-2808","article-title":"Evasion of innate immunity contributes to small cell lung cancer progression and metastasis","volume":"81","author":"Zhu","year":"2021","journal-title":"Cancer Res"},{"issue":"3","key":"10.1016\/j.jlb.2026.100506_bib7","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.jtho.2022.11.008","article-title":"An Interleukin-15 superagonist enables antitumor efficacy of natural killer cells against all molecular variants of SCLC","volume":"18","author":"Fousek","year":"2023","journal-title":"J Thorac Oncol"},{"issue":"4","key":"10.1016\/j.jlb.2026.100506_bib8","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1002\/JLB.5MA0122-467R","article-title":"CAR NK-92 cells targeting DLL3 kill effectively small cell lung cancer cells in vitro and in vivo","volume":"112","author":"Liu","year":"2022","journal-title":"J Leukoc Biol"},{"issue":"10","key":"10.1016\/j.jlb.2026.100506_bib9","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1007\/s12094-024-03479-4","article-title":"Peripheral NK cells identified as the predictor of response in extensive-stage small cell lung cancer patients treated with first-line immunotherapy plus chemotherapy","volume":"26","author":"Cui","year":"2024","journal-title":"Clin Transl Oncol"},{"key":"10.1016\/j.jlb.2026.100506_bib10","article-title":"Consolidative thoracic radiation therapy for extensive-stage small cell lung cancer in the era of first-line chemoimmunotherapy: preclinical data and a retrospective study in southern Italy","volume":"14","author":"Longo","year":"2023","journal-title":"Front Immunol"},{"issue":"4","key":"10.1016\/j.jlb.2026.100506_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12040809","article-title":"PBMCs as tool for identification of novel immunotherapy biomarkers in lung cancer","volume":"12","author":"De Rosa","year":"2024","journal-title":"Biomedicines"},{"issue":"18","key":"10.1016\/j.jlb.2026.100506_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16183151","article-title":"Immune-cell-derived exosomes as a potential novel tool to investigate immune responsiveness in SCLC patients: a proof-of-concept study","volume":"16","author":"Amato","year":"2024","journal-title":"Cancers (Basel)"},{"issue":"3","key":"10.1016\/j.jlb.2026.100506_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2025.111943","article-title":"DNA-PK inhibition sustains the antitumor innate immune response in small cell lung cancer","volume":"28","author":"De Rosa","year":"2025","journal-title":"iScience"},{"issue":"39","key":"10.1016\/j.jlb.2026.100506_bib14","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ado4618","article-title":"ATR inhibition activates cancer cell cGAS\/STING-interferon signaling and promotes antitumor immunity in small-cell lung cancer","volume":"10","author":"Taniguchi","year":"2024","journal-title":"Sci Adv"},{"issue":"12","key":"10.1016\/j.jlb.2026.100506_bib15","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1016\/j.jtho.2019.08.009","article-title":"Combination treatment of the oral CHK1 inhibitor, SRA737, and low-dose gemcitabine enhances the effect of programmed death ligand 1 blockade by modulating the immune microenvironment in SCLC","volume":"14","author":"Sen","year":"2019","journal-title":"J Thorac Oncol"},{"issue":"12","key":"10.1016\/j.jlb.2026.100506_bib16","article-title":"Lurbinectedin sensitizes PD-L1 blockade therapy by activating STING-IFN signaling in small-cell lung cancer","volume":"5","author":"Chakraborty","year":"2024","journal-title":"Cell Rep Med"},{"issue":"8","key":"10.1016\/j.jlb.2026.100506_bib17","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1038\/s41590-024-01883-0","article-title":"High-dimensional single-cell analysis of human natural killer cell heterogeneity","volume":"25","author":"Rebuffet","year":"2024","journal-title":"Nat Immunol"},{"issue":"1","key":"10.1016\/j.jlb.2026.100506_bib18","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.cell.2023.12.004","article-title":"Proteogenomic characterization of small cell lung cancer identifies biological insights and subtype-specific therapeutic strategies","volume":"187","author":"Liu","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.jlb.2026.100506_bib19","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.3389\/fimmu.2019.02836","article-title":"Harnessing NK cells for cancer treatment","volume":"10","author":"Minetto","year":"2019","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.jlb.2026.100506_bib20","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s13046-022-02332-2","article-title":"Anti-tumor activity of cetuximab plus avelumab in non-small cell lung cancer patients involves innate immunity activation: findings from the CAVE-lung trial","volume":"41","author":"Della Corte","year":"2022","journal-title":"J Exp Clin Cancer Res"},{"issue":"1","key":"10.1016\/j.jlb.2026.100506_bib21","doi-asserted-by":"crossref","first-page":"50","DOI":"10.21037\/tlcr.2018.02.03","article-title":"Targeting DNA damage repair in small cell lung cancer and the biomarker landscape","volume":"7","author":"Sen","year":"2018","journal-title":"Transl Lung Cancer Res"},{"issue":"5","key":"10.1016\/j.jlb.2026.100506_bib22","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.jtho.2020.01.009","article-title":"STING pathway expression identifies NSCLC with an immune-responsive phenotype","volume":"15","author":"Della Corte","year":"2020","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.jlb.2026.100506_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlb.2025.100307","article-title":"Novel applications of liquid biopsy: comprehensive methodology for circulating biomarker exploration in peripheral blood","volume":"9","author":"De Rosa","year":"2025","journal-title":"J Liq Biopsy"}],"container-title":["The Journal of Liquid Biopsy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950195426000524?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950195426000524?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:59:40Z","timestamp":1793073580000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2950195426000524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":23,"alternative-id":["S2950195426000524"],"URL":"https:\/\/doi.org\/10.1016\/j.jlb.2026.100506","relation":{},"ISSN":["2950-1954"],"issn-type":[{"value":"2950-1954","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NK cell immune fitness stratifies small cell lung cancer into four functional states associated with clinical response","name":"articletitle","label":"Article Title"},{"value":"The Journal of Liquid Biopsy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jlb.2026.100506","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of The International Society of Liquid Biopsy.","name":"copyright","label":"Copyright"}],"article-number":"100506"}}