{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T04:33:16Z","timestamp":1793075596883,"version":"4.5.0"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R03 DE030550"],"award-info":[{"award-number":["R03 DE030550"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["K23 DE029811"],"award-info":[{"award-number":["K23 DE029811"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["T32DC000020"],"award-info":[{"award-number":["T32DC000020"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofliquidbiopsy.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Liquid Biopsy"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.jlb.2026.100668","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:23:33Z","timestamp":1790897013000},"page":"100668","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Prognostic utility of copy number variations in circulating tumor DNA in head and neck cancer"],"prefix":"10.1016","volume":"14","author":[{"given":"Edward S.","family":"Sim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Ruiz-Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shidong","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam S.","family":"Fisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross D.","family":"Merkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan J.","family":"Paly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L.","family":"Faden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jlb.2026.100668_bib1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s41523-025-00739-6","article-title":"Enabling sensitive and precise detection of ctDNA through somatic copy number aberrations in breast cancer","volume":"11","author":"Scandino","year":"2025","journal-title":"NPJ Breast Cancer"},{"key":"10.1016\/j.jlb.2026.100668_bib2","article-title":"Circulating tumor DNA-based copy-number profiles enable monitoring treatment effects during therapy in high-grade serous carcinoma","volume":"168","author":"Nguyen","year":"2023","journal-title":"Biomed Pharmacother Biomedecine Pharmacother"},{"key":"10.1016\/j.jlb.2026.100668_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.938985","article-title":"Copy number variation of circulating tumor DNA (ctDNA) detected using NIPT in neoadjuvant chemotherapy-treated ovarian cancer patients","volume":"13","author":"Sharbatoghli","year":"2022","journal-title":"Front Genet"},{"key":"10.1016\/j.jlb.2026.100668_bib4","article-title":"Detection of copy-number variation in circulating cell-free DNA in patients with uveal melanoma","volume":"8","author":"T","year":"2024","journal-title":"JCO Precis Oncol"},{"key":"10.1016\/j.jlb.2026.100668_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.720727","article-title":"Circulating cell-free DNA-based detection of tumor suppressor gene copy number loss and its clinical implication in metastatic prostate cancer","volume":"11","author":"Dong","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.jlb.2026.100668_bib6","article-title":"Plasma cell-free DNA profiling of PTEN-PI3K-AKT pathway aberrations in metastatic castration-resistant prostate cancer","volume":"5","author":"Kwan","year":"2021","journal-title":"JCO Precis Oncol"},{"key":"10.1016\/j.jlb.2026.100668_bib7","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.eururo.2021.08.011","article-title":"Avelumab combined with stereotactic ablative body radiotherapy in metastatic castration-resistant prostate cancer: the phase 2 ICE-PAC clinical trial","volume":"81","author":"Kwan","year":"2022","journal-title":"Eur Urol"},{"key":"10.1016\/j.jlb.2026.100668_bib8","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1158\/1078-0432.CCR-22-2177","article-title":"Genomic complexity predicts resistance to endocrine therapy and CDK4\/6 inhibition in hormone receptor\u2013positive (HR+)\/HER2-Negative metastatic breast cancer","volume":"29","author":"Davis","year":"2023","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jlb.2026.100668_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104738","article-title":"BRCA-deficient metastatic prostate cancer has an adverse prognosis and distinct genomic phenotype","volume":"95","author":"Fettke","year":"2023","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jlb.2026.100668_bib10","doi-asserted-by":"crossref","first-page":"247","DOI":"10.48083\/WJMB7232","article-title":"Utilizing cell-free urinary and plasma tumor DNA to predict pathologic stage at radical cystectomy","volume":"4","author":"Murthy","year":"2023","journal-title":"Soci\u00e9t\u00e9 Int D\u2019Urologie J"},{"key":"10.1016\/j.jlb.2026.100668_bib11","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/path.6166","article-title":"Integrated longitudinal circulating tumor DNA profiling predicts immunotherapy response of metastatic urothelial carcinoma in the POLARIS-03 trial","volume":"261","author":"Zang","year":"2023","journal-title":"J Pathol"},{"key":"10.1016\/j.jlb.2026.100668_bib12","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.eururo.2023.09.017","article-title":"Novel use of circulating tumor DNA to identify muscle-invasive and non\u2013organ-confined upper tract urothelial carcinoma","volume":"85","author":"Huelster","year":"2024","journal-title":"Eur Urol"},{"key":"10.1016\/j.jlb.2026.100668_bib13","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jtho.2024.09.1385","article-title":"High-dose furmonertinib in patients with EGFR-mutated NSCLC and leptomeningeal metastases: a prospective real-world study","volume":"20","author":"Chen","year":"2025","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.jlb.2026.100668_bib14","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1158\/1078-0432.CCR-24-1814","article-title":"Longitudinal glioma monitoring via cerebrospinal fluid cell-free DNA","volume":"31","author":"Riviere-Cazaux","year":"2025","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jlb.2026.100668_bib15","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/s41467-017-00965-y","article-title":"Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors","volume":"8","author":"Adalsteinsson","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.jlb.2026.100668_bib16","doi-asserted-by":"crossref","first-page":"6833","DOI":"10.1038\/s41467-024-51271-3","article-title":"Clinical outcomes and ctDNA correlates for CAPOX BETR: a phase II trial of capecitabine, oxaliplatin, bevacizumab, trastuzumab in previously untreated advanced HER2+ gastroesophageal adenocarcinoma","volume":"15","author":"Singh","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.jlb.2026.100668_bib17","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nrc.2018.11","article-title":"The molecular landscape of head and neck cancer","volume":"18","author":"Leemans","year":"2018","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.jlb.2026.100668_bib18","doi-asserted-by":"crossref","first-page":"9060","DOI":"10.1038\/s41467-024-53390-3","article-title":"Hallmarks of a genomically distinct subclass of head and neck cancer","volume":"15","author":"Muijlwijk","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.jlb.2026.100668_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/s41698-026-01689-3","article-title":"Machine learning integration of multi-dimensional fragmentomic features of cell-free DNA for early detection of head and neck squamous cell carcinoma","author":"Mou","year":"2026","journal-title":"npj Precis Oncol"},{"key":"10.1016\/j.jlb.2026.100668_bib20","doi-asserted-by":"crossref","first-page":"4230","DOI":"10.1158\/1078-0432.CCR-21-0110","article-title":"Tumor-na\u00efve multimodal profiling of circulating tumor DNA in head and neck squamous cell carcinoma","volume":"27","author":"Burgener","year":"2021","journal-title":"Clin Cancer Res"}],"container-title":["The Journal of Liquid Biopsy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950195426002146?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950195426002146?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T04:01:19Z","timestamp":1793073679000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2950195426002146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":20,"alternative-id":["S2950195426002146"],"URL":"https:\/\/doi.org\/10.1016\/j.jlb.2026.100668","relation":{},"ISSN":["2950-1954"],"issn-type":[{"value":"2950-1954","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prognostic utility of copy number variations in circulating tumor DNA in head and neck cancer","name":"articletitle","label":"Article Title"},{"value":"The Journal of Liquid Biopsy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jlb.2026.100668","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of The International Society of Liquid Biopsy.","name":"copyright","label":"Copyright"}],"article-number":"100668"}}