{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:08:48Z","timestamp":1790723328580,"version":"4.1.0"},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T00:00:00Z","timestamp":1626307200000},"content-version":"vor","delay-in-days":195,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jlr.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2021]]},"DOI":"10.1016\/j.jlr.2021.100096","type":"journal-article","created":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T03:34:01Z","timestamp":1626492841000},"page":"100096","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["PCSK9 is not secreted from mature differentiated intestinal\u00a0cells"],"prefix":"10.1016","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4217-8264","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Moreau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Th\u00e9drez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Gar\u00e7on","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Ayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibaud","family":"Sotin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wieneke","family":"Dijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Blanchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilliane","family":"Chadeuf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Arnaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Croyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7408-3521","authenticated-orcid":false,"given":"Laurianne","family":"Van Landeghem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Touvron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Prieur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Roubtsova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabil","family":"Seidah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annik","family":"Prat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Cariou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7554-792X","authenticated-orcid":false,"given":"Cedric","family":"Le May","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jlr.2021.100096_bib1","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1073\/pnas.0335507100","article-title":"The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation","volume":"100","author":"Seidah","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jlr.2021.100096_bib2","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/ng1161","article-title":"Mutations in PCSK9 cause autosomal dominant hypercholesterolemia","volume":"34","author":"Abifadel","year":"2003","journal-title":"Nat.Genet."},{"key":"10.1016\/j.jlr.2021.100096_bib3","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/s41569-018-0107-8","article-title":"PCSK9 inhibitors: clinical evidence and implementation","volume":"16","author":"Sabatine","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.jlr.2021.100096_bib4","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/MOL.0000000000000180","article-title":"Role of PCSK9 beyond liver involvement","volume":"26","author":"Cariou","year":"2015","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.jlr.2021.100096_bib5","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/s41574-018-0110-5","article-title":"Inhibiting PCSK9 - biology beyond LDL control","volume":"15","author":"Stoekenbroek","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.jlr.2021.100096_bib6","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/hep.22354","article-title":"Proprotein convertase subtilisin\/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration","volume":"48","author":"Zaid","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.jlr.2021.100096_bib7","doi-asserted-by":"crossref","first-page":"6429","DOI":"10.3748\/wjg.v12.i40.6429","article-title":"Emerging roles of the intestine in control of cholesterol metabolism","volume":"12","author":"Kruit","year":"2006","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jlr.2021.100096_bib8","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1161\/ATVBAHA.108.181586","article-title":"Proprotein convertase subtilisin kexin type 9 null mice are protected from postprandial triglyceridemia","volume":"29","author":"Le May","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jlr.2021.100096_bib9","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1161\/ATVBAHA.112.300263","article-title":"Transintestinal cholesterol excretion is an active metabolic process modulated by PCSK9 and statin involving ABCB1","volume":"33","author":"Le May","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jlr.2021.100096_bib10","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1161\/ATVBAHA.120.314194","article-title":"Circulating rather than intestinal PCSK9 (proprotein convertase subtilisin kexin Type 9) regulates postprandial lipemia in mice","volume":"40","author":"Garcon","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jlr.2021.100096_bib11","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.atherosclerosis.2013.01.023","article-title":"PCSK9 plays a significant role in cholesterol homeostasis and lipid transport in intestinal epithelial cells","volume":"227","author":"Levy","year":"2013","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jlr.2021.100096_bib12","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/s41467-017-02107-w","article-title":"Parallel derivation of isogenic human primed and naive induced pluripotent stem cells","volume":"9","author":"Kilens","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jlr.2021.100096_bib13","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jlr.2021.100096_bib14","doi-asserted-by":"crossref","first-page":"G1111","DOI":"10.1152\/ajpgi.00519.2011","article-title":"Activation of two distinct Sox9-EGFP-expressing intestinal stem cell populations during crypt regeneration after irradiation","volume":"302","author":"Van Landeghem","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.jlr.2021.100096_bib15","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1111\/pedi.12490","article-title":"Obesity and type 2 diabetes are associated with elevated PCSK9 levels in young women","volume":"18","author":"Levenson","year":"2017","journal-title":"Pediatr. Diabetes"},{"key":"10.1016\/j.jlr.2021.100096_bib16","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.00444","article-title":"SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion","volume":"2","author":"Chen","year":"2013","journal-title":"Elife"},{"key":"10.1016\/j.jlr.2021.100096_bib17","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1016\/j.celrep.2015.11.006","article-title":"GRP94 regulates circulating cholesterol levels through blockade of PCSK9-induced LDLR degradation","volume":"13","author":"Poirier","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.jlr.2021.100096_bib18","doi-asserted-by":"crossref","first-page":"31791","DOI":"10.1074\/jbc.M805971200","article-title":"Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels","volume":"283","author":"Mayer","year":"2008","journal-title":"J.\u00a0Biol. Chem."}],"updated-by":[{"DOI":"10.1016\/j.jlr.2022.100186","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000}}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002222752100078X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002222752100078X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T10:01:52Z","timestamp":1645092112000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002222752100078X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":18,"alternative-id":["S002222752100078X"],"URL":"https:\/\/doi.org\/10.1016\/j.jlr.2021.100096","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.jlr.2022.100186","asserted-by":"object"}]},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PCSK9 is not secreted from mature differentiated intestinal\u00a0cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Lipid Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jlr.2021.100096","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"100096"}}