{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:10:59Z","timestamp":1790187059355,"version":"4.1.0"},"reference-count":103,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T00:00:00Z","timestamp":1637280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30 DK041301"],"award-info":[{"award-number":["P30 DK041301"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007185","name":"University of California, Los Angeles","doi-asserted-by":"publisher","award":["IK2CX001717"],"award-info":[{"award-number":["IK2CX001717"]}],"id":[{"id":"10.13039\/100007185","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007197","name":"U.S. Public Health Service","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","award":["1R01 HL148286"],"award-info":[{"award-number":["1R01 HL148286"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jlr.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.jlr.2021.100153","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T21:18:42Z","timestamp":1637356722000},"page":"100153","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Oxidized phospholipids cause changes in jejunum mucus that induce dysbiosis and systemic inflammation"],"prefix":"10.1016","volume":"63","author":[{"given":"Pallavi","family":"Mukherjee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnab","family":"Chattopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Grijalva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasrin","family":"Dorreh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6500-8255","authenticated-orcid":false,"given":"Venu","family":"Lagishetty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4698-0254","authenticated-orcid":false,"given":"Jonathan P.","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethan L.","family":"Clifford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7642-5046","authenticated-orcid":false,"given":"Thomas","family":"Vallim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9239-8436","authenticated-orcid":false,"given":"Julia J.","family":"Mack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Navab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivasa T.","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan M.","family":"Fogelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jlr.2021.100153_bib1","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1194\/jlr.M033555","article-title":"A\u00a0novel approach to oral apoA-I mimetic therapy","volume":"54","author":"Chattopadhyay","year":"2013","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2021.100153_bib2","doi-asserted-by":"crossref","first-page":"3403","DOI":"10.1194\/jlr.M042051","article-title":"Transgenic 6F tomatoes act on the small intestine to prevent systemic inflammation and dyslipidemia caused by Western Diet and intestinally derived lysophosphatidic acid","volume":"54","author":"Navab","year":"2013","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2021.100153_bib3","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1194\/jlr.M056614","article-title":"Source and role of intestinally derived lysophosphatidic acid in dyslipidemia and atherosclerosis","volume":"56","author":"Navab","year":"2015","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2021.100153_bib4","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.154","article-title":"Efficacy of tomato concentrates in mouse models of dyslipidemia and cancer","volume":"3","author":"Chattopadhyay","year":"2015","journal-title":"Pharmacol. Res. Perspect."},{"key":"10.1016\/j.jlr.2021.100153_bib5","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1194\/jlr.M064352","article-title":"Tg6F ameliorates the increase in oxidized phospholipids in the jejunum of mice fed unsaturated LysoPC or WD","volume":"57","author":"Chattopadhyay","year":"2016","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2021.100153_bib6","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1194\/jlr.M076554","article-title":"Transgenic tomatoes expressing the 6F peptide and ezetimibe prevent diet-induced increases of IFN-\u03b2 and cholesterol 25-hydroxylase in jejunum","volume":"58","author":"Mukherjee","year":"2017","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2021.100153_bib7","doi-asserted-by":"crossref","first-page":"9032","DOI":"10.1038\/s41598-018-26755-0","article-title":"Treating the intestine with oral apoA-I mimetic Tg6F reduces tumor burden in mouse models of metastatic lung cancer","volume":"8","author":"Chattopadhyay","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jlr.2021.100153_bib8","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1194\/jlr.M083527","article-title":"Role of enterocyte stearoyl-Co-A desaturase-1 in LDLR-null mice","volume":"59","author":"Mukherjee","year":"2018","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2021.100153_bib9","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1172\/JCI123700","article-title":"Apolipoprotein A-I mimetics mitigate intestinal inflammation in COX2-dependent inflammatory bowel disease model","volume":"130","author":"Meriwether","year":"2019","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.jlr.2021.100153_bib10","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1194\/jlr.M049262","article-title":"In\u00a0vivo efficacy of HDL-like nanolipid particles containing multivalent peptide mimetics of apolipoprotein A-I","volume":"55","author":"Zhao","year":"2014","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2021.100153_bib11","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1194\/jlr.E053538","article-title":"Mimetic peptides of human apoA-I helix 10 get together to lower lipids and ameliorate atherosclerosis: is the action in the gut?","volume":"55","author":"Wool","year":"2014","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2021.100153_bib12","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1194\/jlr.M013144","article-title":"Intestine may be a major site of action for the apoA-I mimetic peptide 4F whether administered subcutaneously or orally","volume":"52","author":"Navab","year":"2011","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2021.100153_bib13","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1194\/jlr.M067025","article-title":"Transintestinal transport of the anti-inflammatory drug 4F and the modulation of transintestinal efflux","volume":"57","author":"Meriwether","year":"2016","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2021.100153_bib14","doi-asserted-by":"crossref","first-page":"15064","DOI":"10.1073\/pnas.0803124105","article-title":"The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria","volume":"105","author":"Johansson","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jlr.2021.100153_bib15","doi-asserted-by":"crossref","first-page":"4659","DOI":"10.1073\/pnas.1006451107","article-title":"The two mucus layers of colon are organized by the Muc2 mucin, whereas the outer layer is a legislator of host-microbial interactions","volume":"108","author":"Johansson","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jlr.2021.100153_bib16","doi-asserted-by":"crossref","first-page":"G341","DOI":"10.1152\/ajpgi.00046.2013","article-title":"Studies of mucus in mouse stomach, small intestine and colon. I. Gastrointestinal mucus layers have different properties depending on location as well as over the Peyer\u2019s patches","volume":"305","author":"Ermund","year":"2013","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.jlr.2021.100153_bib17","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1194\/jlr.M059485","article-title":"Apolipoprotein A-I mimetic peptide 4F blocks sphingomyelinase-induced LDL aggregation","volume":"56","author":"Nguyen","year":"2015","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2021.100153_bib18","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1172\/JCI71612","article-title":"Emerging lymphatic imaging technologies for mouse and man","volume":"124","author":"Sevick-Muraca","year":"2014","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.jlr.2021.100153_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2016.e00219","article-title":"Sphingsine-1-phosphate in the lymphatic fluid determined by novel methods","volume":"2","author":"Nagahashi","year":"2016","journal-title":"Heliyon"},{"key":"10.1016\/j.jlr.2021.100153_bib20","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.3631","article-title":"Mouse adipose tissue protein extraction","volume":"10","author":"An","year":"2020","journal-title":"Bio. Protocol."},{"key":"10.1016\/j.jlr.2021.100153_bib21","doi-asserted-by":"crossref","first-page":"100235","DOI":"10.1016\/j.xpro.2020.100235","article-title":"Profiling of mouse macrophage lipidome using direct infusion shotgun mass spectrometry","volume":"2","author":"Hsieh","year":"2020","journal-title":"STAR Protoc."},{"key":"10.1016\/j.jlr.2021.100153_bib22","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1053\/j.gastro.2004.04.007","article-title":"A\u00a0novel, noninvasive method for the measurement of intestinal fat absorption","volume":"127","author":"Jandacek","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jlr.2021.100153_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19490976.2016.1257469","article-title":"Microbial, metabolomic, immunologic dynamics in a relapsing genetic mouse model of colitis induced by T-synthase deficiency","volume":"8","author":"Jacobs","year":"2017","journal-title":"Gut Microbes"},{"key":"10.1016\/j.jlr.2021.100153_bib24","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: high-resolution sample inference from Illumina amplicon data","volume":"13","author":"Callahan","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jlr.2021.100153_bib25","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1099\/00221287-148-1-257","article-title":"Determination of bacterial load by real-time PCR using a broad-range (universal) probe and primers set","volume":"148","author":"Nadkarni","year":"2002","journal-title":"Microbiology"},{"key":"10.1016\/j.jlr.2021.100153_bib26","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.jlr.2021.100153_bib27","doi-asserted-by":"crossref","first-page":"9440","DOI":"10.1073\/pnas.1530509100","article-title":"Statistical significance for genomewide studies","volume":"100","author":"Storey","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jlr.2021.100153_bib28","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.cell.2014.06.037","article-title":"Conducting a microbiome study","volume":"158","author":"Goodrich","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.jlr.2021.100153_bib29","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.4014\/jmb.1709.09027","article-title":"Deciphering diversity indices for a better understanding of microbial communities","volume":"27","author":"Kim","year":"2017","journal-title":"J.\u00a0Microbiol. Biotechnol."},{"key":"10.1016\/j.jlr.2021.100153_bib30","doi-asserted-by":"crossref","first-page":"4170","DOI":"10.1073\/pnas.1718635115","article-title":"Microbes vs. chemistry in the origin of the anaerobic gut lumen","volume":"115","author":"Friedman","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jlr.2021.100153_bib31","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1136\/gutjnl-2020-322260","article-title":"Mucus barrier, mucins and gut microbiota: the expected slimy partners?","volume":"69","author":"Paone","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.jlr.2021.100153_bib32","doi-asserted-by":"crossref","first-page":"988","DOI":"10.3390\/nu10080988","article-title":"The potential of gut commensals in reinforcing intestinal barrier function and alleviating inflammation","volume":"10","author":"Hiippala","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.jlr.2021.100153_bib33","doi-asserted-by":"crossref","first-page":"9066","DOI":"10.1073\/pnas.1219451110","article-title":"Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity","volume":"110","author":"Everard","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jlr.2021.100153_bib34","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nm.4236","article-title":"A\u00a0purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice","volume":"23","author":"Plovier","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.jlr.2021.100153_bib35","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1161\/CIRCULATIONAHA.115.019645","article-title":"Akkermansia muciniphila protects against atherosclerosis by preventing metabolic endotoxemia-induced inflammation in Apoe-\/- mice","volume":"133","author":"Li","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.jlr.2021.100153_bib36","doi-asserted-by":"crossref","first-page":"13329","DOI":"10.1038\/ncomms13329","article-title":"Akkermansia muciniphila mediates negative effects of IFN\u03b3 on glucose metabolism","volume":"7","author":"Greer","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jlr.2021.100153_bib37","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1080\/19490976.2020.1737307","article-title":"Pasteurized Akkermansia muciniphila increases whole-body energy expenditure and fecal energy excretion in diet-induced obese mice","volume":"11","author":"Depommier","year":"2020","journal-title":"Gut Microbes"},{"key":"10.1016\/j.jlr.2021.100153_bib38","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1128\/AEM.04050-14","article-title":"Akkermansia muciniphila adheres to enterocytes and strengthens the integrity of the epithelial cell layer","volume":"81","author":"Reunanen","year":"2015","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.jlr.2021.100153_bib39","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/s41591-019-0495-2","article-title":"Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study","volume":"25","author":"Depommier","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.jlr.2021.100153_bib40","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/jat.4044","article-title":"Toxicological safety evaluation of pasteurized Akkermansia muciniphila","volume":"41","author":"Druart","year":"2021","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.jlr.2021.100153_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0173004","article-title":"Pili-like proteins of Akkermansia muciniphila modulate host immune responses and gut barrier function","volume":"12","author":"Ottman","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jlr.2021.100153_bib42","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1136\/gutjnl-2014-308778","article-title":"Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology","volume":"65","author":"Dao","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.jlr.2021.100153_bib43","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3390\/microorganisms6030075","article-title":"Akkermansia muciniphila in the human gastrointestinal tract: when, where, and how?","volume":"6","author":"Geerlings","year":"2018","journal-title":"Microorganisms"},{"key":"10.1016\/j.jlr.2021.100153_bib44","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1126\/science.1127119","article-title":"Symbiotic bacteria direct expression of an intestinal bactericidal lectin","volume":"313","author":"Cash","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.jlr.2021.100153_bib45","doi-asserted-by":"crossref","first-page":"118111","DOI":"10.1016\/j.lfs.2020.118111","article-title":"Ginkgolide-A attenuates bacterial translocation through activating PXR and improving antimicrobial peptide Reg 3A in experimental cirrhosis","volume":"257","author":"Mohandas","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.jlr.2021.100153_bib46","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.celrep.2015.12.070","article-title":"The gut epithelial receptor LRRC19 promotes the recruitment of immune cells and gut inflammation","volume":"14","author":"Cao","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.jlr.2021.100153_bib47","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.chom.2016.01.003","article-title":"Intestinal REG3 lectins protect against steatohepatitis by reducing mucosa-associated microbiota and preventing bacterial translocation","volume":"19","author":"Wang","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jlr.2021.100153_bib48","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1128\/IAI.06165-11","article-title":"Intestinally secreted C-type lectin Reg3b attenuates salmonellosis but not listeriosis in mice","volume":"80","author":"van Ampting","year":"2012","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jlr.2021.100153_bib49","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1126\/science.1209791","article-title":"The antibacterial lectin RegIII\u03b3 promotes the spatial segregation of microbiota and host in the intestine","volume":"334","author":"Vaishnava","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.jlr.2021.100153_bib50","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.smim.2007.04.002","article-title":"Paneth cells, defensins, and the commensal microbiota: a hypothesis on intimate interplay at the intestinal mucosa","volume":"19","author":"Salzman","year":"2007","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.jlr.2021.100153_bib51","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.1128\/IAI.67.7.3542-3547.1999","article-title":"Mouse \u03b2-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs","volume":"67","author":"Bals","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jlr.2021.100153_bib52","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1365-2249.2010.04282.x","article-title":"Chronic colitis induces expression of \u03b2-defensins in murine intestinal epithelial cells","volume":"163","author":"Rahman","year":"2011","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jlr.2021.100153_bib53","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1365-2249.2004.02543.x","article-title":"\u03b2-defensin-3 and-4 in intestinal epithelial cells display increased mRNA expression in ulcerative colitis","volume":"137","author":"Fahlgren","year":"2004","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jlr.2021.100153_bib54","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1136\/gut.16.7.553","article-title":"The paneth cell: A source of intestinal lysozyme","volume":"16","author":"Peeters","year":"1975","journal-title":"Gut"},{"key":"10.1016\/j.jlr.2021.100153_bib55","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1073\/pnas.0712140105","article-title":"Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition","volume":"105","author":"Goldberg","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jlr.2021.100153_bib56","doi-asserted-by":"crossref","first-page":"7525","DOI":"10.1128\/MCB.23.21.7525-7530.2003","article-title":"Accelerated fat absorption in intestinal alkaline phosphatase knockout mice","volume":"23","author":"Narisawa","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jlr.2021.100153_bib57","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1177\/1753425910368447","article-title":"Gp-340\/DMBT1 in mucosal innate immunity","volume":"16","author":"Madsen","year":"2010","journal-title":"Innate Immun."},{"key":"10.1016\/j.jlr.2021.100153_bib58","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1002\/ibd.21473","article-title":"DMBT1 is a novel gene induced by IL-22 in ulcerative colitis","volume":"17","author":"Fukui","year":"2011","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.jlr.2021.100153_bib59","doi-asserted-by":"crossref","first-page":"8203","DOI":"10.4049\/jimmunol.178.12.8203","article-title":"Regulation of DMBT1 via NOD2 and TLR4 in intestinal epithelial cells modulates bacterial recognition and invasion","volume":"178","author":"Rosenstiel","year":"2007","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jlr.2021.100153_bib60","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/imr.12182","article-title":"The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system","volume":"260","author":"Pelaseyed","year":"2014","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jlr.2021.100153_bib61","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/mi.2017.111","article-title":"Epithelial Hes1 maintains gut homeostasis by preventing microbial dysbiosis","volume":"11","author":"Guo","year":"2018","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.jlr.2021.100153_bib62","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1093\/abbs\/36.6.419","article-title":"Role of apolipoprotein A-I in protecting against endotoxin toxicity","volume":"36","author":"Ma","year":"2004","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.jlr.2021.100153_bib63","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1177\/0968051907078611","article-title":"Effects of human apolipoprotein A-I on endotoxin-induced leukocyte adhesion on endothelial cells in\u00a0vivo and on the growth of Escherichia coli in\u00a0vitro","volume":"13","author":"Thaveeratitham","year":"2007","journal-title":"J.\u00a0Endotoxin Res."},{"key":"10.1016\/j.jlr.2021.100153_bib64","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/j.bbamem.2013.02.009","article-title":"Apolipoprotien A-I binding to anionic vesicles and lipopolysaccharides: role for lysine residues in antimicrobial properties","volume":"1828","author":"Beck","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jlr.2021.100153_bib65","doi-asserted-by":"crossref","first-page":"12162","DOI":"10.1074\/jbc.270.20.12162","article-title":"Pulmonary surfactant A (SP-A) is expressed by epithelial cells of small and large intestine","volume":"270","author":"Rubio","year":"1995","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jlr.2021.100153_bib66","first-page":"G425","article-title":"Isolation and characterization of surfactant-like particles in rat and human colon","volume":"272","author":"Eliakim","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.jlr.2021.100153_bib67","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1172\/JCI16889","article-title":"Surfactant proteins A and D inhibit the growth of gram-negative bacteria by increasing membrane permeability","volume":"111","author":"Wu","year":"2003","journal-title":"J.\u00a0Clin. Invest"},{"key":"10.1016\/j.jlr.2021.100153_bib68","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s00418-009-0572-6","article-title":"Lipopolysaccharide-binding protein: localization in secretory granules of paneth cells in mouse small intestine","volume":"131","author":"Hansen","year":"2009","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.jlr.2021.100153_bib69","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.4049\/jimmunol.165.8.4561","article-title":"Lipopolysaccharide-binding protein is vectorially secreted and transported by cultured intestinal epithelial cells and is present in the intestinal mucus of mice","volume":"165","author":"Vreugdenhil","year":"2000","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jlr.2021.100153_bib70","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0173629","article-title":"The potential role of osteopontin in the maintenance of commensal bacteria homeostasis in the intestine","volume":"12","author":"Ito","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jlr.2021.100153_bib71","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.4049\/jimmunol.1901168","article-title":"Osteopontin and iCD8\u03b1 cells promote intestinal intraepithelial lymphocyte homeostasis","volume":"204","author":"Nazmi","year":"2020","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jlr.2021.100153_bib72","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1002\/ibd.22929","article-title":"Healing of intestinal inflammation by IL-22","volume":"18","author":"Mizoguchi","year":"2012","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.jlr.2021.100153_bib73","doi-asserted-by":"crossref","first-page":"13942","DOI":"10.1073\/pnas.1323852111","article-title":"Homeostatic IL-23 receptor signaling limits Th17 response through Il-22-mediated containment of commensal microbiota","volume":"111","author":"Shih","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jlr.2021.100153_bib74","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3389\/fcell.2015.00085","article-title":"Interleukin-22 signaling in the regulation of intestinal health and disease","volume":"3","author":"Parks","year":"2016","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.jlr.2021.100153_bib75","doi-asserted-by":"crossref","first-page":"E5076","DOI":"10.1073\/pnas.1718902115","article-title":"A\u00a0cytokine network involving IL-36\u03b3, IL-23, and IL-22 promotes antimicrobial defense and recovery from intestinal barrier damage","volume":"115","author":"Ngo","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jlr.2021.100153_bib76","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.immuni.2018.09.011","article-title":"An interleukin-23-interleukin-22 axis regulates intestinal microbial homeostasis to protect from diet-induced atherosclerosis","volume":"49","author":"Fatkhullina","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.jlr.2021.100153_bib77","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.stemcr.2020.05.010","article-title":"Rapid crypt remodeling regenerates the intestinal stem cell niche after Notch inhibition","volume":"15","author":"Bohin","year":"2020","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.jlr.2021.100153_bib78","doi-asserted-by":"crossref","first-page":"8965","DOI":"10.1073\/pnas.1201652109","article-title":"Functional intestinal stem cells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1)","volume":"109","author":"Durand","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jlr.2021.100153_bib79","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1242\/dev.070763","article-title":"Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells","volume":"139","author":"VanDussen","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.jlr.2021.100153_bib80","doi-asserted-by":"crossref","first-page":"4791","DOI":"10.1113\/JP271667","article-title":"Notch regulation of gastrointestinal stems cells","volume":"594","author":"Demitrack","year":"2016","journal-title":"J.\u00a0Phyisol"},{"key":"10.1016\/j.jlr.2021.100153_bib81","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1101\/gad.1353905","article-title":"Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation","volume":"19","author":"Shroyer","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.jlr.2021.100153_bib82","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.yexcr.2009.09.020","article-title":"SAM pointed domain ETS factor (SPDEF) regulates terminal differentiation and maturation of intestinal goblet cells","volume":"316","author":"Noah","year":"2010","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.jlr.2021.100153_bib83","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/nyas.13360","article-title":"Intestinal epithelial claudins: expression and regulation in homeostasis and inflammation","volume":"1397","author":"Garcia-Hernandez","year":"2017","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jlr.2021.100153_bib84","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s12276-018-0126-x","article-title":"Mechanisms regulating intestinal barrier integrity and its pathological implications","volume":"50","author":"Chelakkot","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.jlr.2021.100153_bib85","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1194\/jlr.M800156-JLR200","article-title":"Chylomicrons promote intestinal absorption of lipopolysaccharides","volume":"50","author":"Ghoshal","year":"2009","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2021.100153_bib86","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1194\/jlr.E800018-JLR200","article-title":"Endotoxin in the gut and chylomicrons: translocation or transportation?","volume":"50","author":"Grunfeld","year":"2009","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2021.100153_bib87","article-title":"Obesogenic diet-induced gut barrier dysfunction and pathobiont expansion aggravate experimental colitis","volume":"12","author":"Lee","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jlr.2021.100153_bib88","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1084\/jem.20150603","article-title":"Endothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis","volume":"212","author":"Briot","year":"2015","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.jlr.2021.100153_bib89","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/S0022-2275(20)31599-6","article-title":"Effects of increasing hydrophobicity on the physical-chemical and biological properties of a class A amphipathic helical peptide","volume":"42","author":"Datta","year":"2001","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2021.100153_bib90","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1194\/jlr.M800075-JLR200","article-title":"Anti-inflammatory apoA-I mimetic peptides bind oxidized lipids with much greater affinity than human apoA-I","volume":"49","author":"Van Lenten","year":"2008","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2021.100153_bib91","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/s41586-018-0198-8","article-title":"Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice","volume":"558","author":"Que","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jlr.2021.100153_bib92","doi-asserted-by":"crossref","first-page":"5447","DOI":"10.1038\/s41598-017-05348-3","article-title":"Inflammatory pain control by blocking oxidized phospholipid-mediated TRP channel activation","volume":"7","author":"Oehler","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jlr.2021.100153_bib93","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/QAD.0000000000002785","article-title":"ApoA-I mimetics attenuate macrophage activation in chronic treated HIV","volume":"35","author":"Mu","year":"2021","journal-title":"AIDS"},{"key":"10.1016\/j.jlr.2021.100153_bib94","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s40168-020-0785-4","article-title":"Self-reinoculation with fecal flora changes microbiota density and composition leading to an altered bile-acid profile in the mouse small intestine","volume":"8","author":"Bogatyrev","year":"2020","journal-title":"Microbiome"},{"key":"10.1016\/j.jlr.2021.100153_bib95","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/S0022-2275(20)33462-3","article-title":"Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: steps 2 and 3","volume":"41","author":"Navab","year":"2000","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2021.100153_bib96","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1053\/j.gastro.2014.07.020","article-title":"Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota","volume":"147","author":"Albenberg","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jlr.2021.100153_bib97","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1194\/jlr.M023523","article-title":"D-4F-mediated reduction in metabolites of arachidonic and linoleic acids in the small intestine is associated with decreased inflammation in low-density lipoprotein receptor-null mice","volume":"53","author":"Navab","year":"2012","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2021.100153_bib98","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1016\/S0022-2275(20)31582-0","article-title":"A\u00a0cell-free assay for detecting HDL that is dysfunctional in preventing the formation of or inactivating oxidized phospholipids","volume":"42","author":"Navab","year":"2001","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2021.100153_bib99","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.cell.2018.08.063","article-title":"Spatial reconstruction of single enterocytes uncovers broad zonation along the intestinal villus axis","volume":"175","author":"Moor","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.jlr.2021.100153_bib100","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/advances\/nmz061","article-title":"Negative effects of a high-fat diet on intestinal permeability: A review","volume":"11","author":"Rohr","year":"2020","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.jlr.2021.100153_bib101","doi-asserted-by":"crossref","first-page":"6353","DOI":"10.1073\/pnas.96.11.6353","article-title":"Monoclonal antibodies against oxidized low-density lipoprotein bind to apoptotic cells and inhibit their phagocytosis by elicited macrophages: Evidence that oxidation-specific epitopes mediate macrophage recognition","volume":"96","author":"Chang","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jlr.2021.100153_bib102","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1161\/hq0102.101525","article-title":"Oxidized membrane vesicles and blebs from apoptotic cells contain biologically active oxidized phospholipids that induce monocyte-endothelial interactions","volume":"22","author":"Huber","year":"2002","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jlr.2021.100153_bib103","doi-asserted-by":"crossref","DOI":"10.1126\/science.abe6729","article-title":"Enterically derived high-density lipoprotein restrains liver injury through the portal vein","volume":"373","author":"Han","year":"2021","journal-title":"Science"}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002222752100136X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002222752100136X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T18:30:52Z","timestamp":1758306652000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002222752100136X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":103,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S002222752100136X"],"URL":"https:\/\/doi.org\/10.1016\/j.jlr.2021.100153","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oxidized phospholipids cause changes in jejunum mucus that induce dysbiosis and systemic inflammation","name":"articletitle","label":"Article Title"},{"value":"Journal of Lipid Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jlr.2021.100153","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"100153"}}