{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:23:47Z","timestamp":1792520627731,"version":"4.5.0"},"reference-count":102,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:00:00Z","timestamp":1653523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["P50 AA024333"],"award-info":[{"award-number":["P50 AA024333"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["U01 AA026938"],"award-info":[{"award-number":["U01 AA026938"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["P01 HL147823"],"award-info":[{"award-number":["P01 HL147823"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK120679"],"award-info":[{"award-number":["R01 DK120679"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK130227"],"award-info":[{"award-number":["R01 DK130227"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jlr.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.jlr.2022.100234","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T02:05:16Z","timestamp":1653617116000},"page":"100234","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Membrane-bound O-acyltransferase 7 (MBOAT7)-driven phosphatidylinositol remodeling in advanced liver disease"],"prefix":"10.1016","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4557-9840","authenticated-orcid":false,"given":"Venkateshwari","family":"Varadharajan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2087-6048","authenticated-orcid":false,"given":"William J.","family":"Massey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2708-7487","authenticated-orcid":false,"given":"J. Mark","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jlr.2022.100234_bib1","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1038\/ng.3417","article-title":"A\u00a0genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis","volume":"47","author":"Buch","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jlr.2022.100234_bib2","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s12072-018-9889-3","article-title":"Single-nucleotide rs738409 polymorphisms in the PNPLA3 gene are strongly associated with alcoholic liver disease in Han Chinese males","volume":"12","author":"Zhang","year":"2018","journal-title":"Hepatol. Int."},{"key":"10.1016\/j.jlr.2022.100234_bib3","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1038\/s41395-018-0041-8","article-title":"Genetic variants in PNPLA3 and TM6SF2 predispose to the development of hepatocellular carcinoma in individuals with alcohol-related cirrhosis","volume":"113","author":"Stickel","year":"2018","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.jlr.2022.100234_bib4","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/acer.14581","article-title":"Role of candidate gene variants in modulating the risk and severity of alcoholic hepatitis","volume":"45","author":"Beaudoin","year":"2021","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.jlr.2022.100234_bib5","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.jhep.2020.02.020","article-title":"Update on NAFLD genetics: from new variants to the clinic","volume":"72","author":"Tr\u00e9po","year":"2020","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.jlr.2022.100234_bib6","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cmet.2019.12.002","article-title":"Leveraging human genetics to identify potential new treatments for fatty liver disease","volume":"31","author":"Romeo","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.jlr.2022.100234_bib7","doi-asserted-by":"crossref","first-page":"2","DOI":"10.21037\/tgh.2019.09.06","article-title":"Genetic and epigenetic disease modifiers: non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD)","volume":"6","author":"Choudhary","year":"2021","journal-title":"Transl. Gastroentero. Hepatol."},{"key":"10.1016\/j.jlr.2022.100234_bib8","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1053\/j.gastro.2016.01.032","article-title":"The MBOAT7-TMC4 variant rs641738 increases risk of Nonalcoholic Fatty Liver Disease in individuals of European descent","volume":"150","author":"Mancina","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jlr.2022.100234_bib9","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.jhep.2016.07.045","article-title":"The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans","volume":"65","author":"Luukkonen","year":"2016","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.jlr.2022.100234_bib10","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1016\/j.soard.2016.06.004","article-title":"PNPLA3 p.I148M variant is associated with greater reduction of liver fat content after bariatric surgery","volume":"12","author":"Krawczyk","year":"2016","journal-title":"Surg. Obes. Relat. Dis."},{"key":"10.1016\/j.jlr.2022.100234_bib11","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1194\/jlr.P067454","article-title":"Combined effects of the PNPLA3 rs738409, TM6SF2 rs58542926, and MBOAT7 rs641738 variants on NAFLD severity: a multicenter biopsy-based study","volume":"58","author":"Krawczyk","year":"2017","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2022.100234_bib12","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/s10038-018-0420-4","article-title":"Could inherited predisposition drive non-obese fatty liver disease? Results from German tertiary referral centers","volume":"63","author":"Krawczyk","year":"2018","journal-title":"J.\u00a0Hum. Genet."},{"key":"10.1016\/j.jlr.2022.100234_bib13","doi-asserted-by":"crossref","first-page":"4492","DOI":"10.1038\/s41598-017-04991-0","article-title":"MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals","volume":"7","author":"Donati","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jlr.2022.100234_bib14","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/joim.12719","article-title":"Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver","volume":"283","author":"Dongiovanni","year":"2018","journal-title":"J.\u00a0Intern. Med."},{"key":"10.1016\/j.jlr.2022.100234_bib15","doi-asserted-by":"crossref","first-page":"3702","DOI":"10.1038\/s41598-018-21939-0","article-title":"Evaluation of polygenic determinants of non-alcoholic fatty liver disease (NAFLD) by a candidate genes resequencing strategy","volume":"8","author":"Di Costanzo","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jlr.2022.100234_bib16","doi-asserted-by":"crossref","first-page":"734847","DOI":"10.3389\/fmed.2021.734847","article-title":"PNPLA3, TM6SF2, and MBOAT7 influence on nutraceutical therapy response for non-alcoholic fatty liver disease: a randomized controlled trial","volume":"8","author":"Dallio","year":"2021","journal-title":"Front. Med."},{"key":"10.1016\/j.jlr.2022.100234_bib17","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.cgh.2021.05.056","article-title":"A\u00a0polygenic risk score to refine risk stratification and prediction for Severe Liver Disease by clinical fibrosis scores","volume":"20","author":"De Vincentis","year":"2022","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jlr.2022.100234_bib18","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.jhep.2020.11.024","article-title":"Non-invasive stratification of hepatocellular carcinoma risk in non-alcoholic fatty liver using polygenic risk scores","volume":"74","author":"Bianco","year":"2021","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.jlr.2022.100234_bib19","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/nrgastro.2011.273","article-title":"Pedatric Nonalcoholic Fatty Liver Disease: a multidisciplinary approach","volume":"9","author":"Alisi","year":"2012","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jlr.2022.100234_bib20","doi-asserted-by":"crossref","DOI":"10.1111\/ijpo.12849","article-title":"Recent advances in the epidemiology of Nonalcoholic Fatty Liver Disease in children","volume":"16","author":"Shapiro","year":"2021","journal-title":"Pediatr. Obes."},{"key":"10.1016\/j.jlr.2022.100234_bib21","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/pr.2016.139","article-title":"Association of MBOAT7 gene variant with plasma ALT levels in children: the PANIC study","volume":"80","author":"Viitasalo","year":"2016","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.jlr.2022.100234_bib22","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/MPG.0000000000001979","article-title":"The membrane-bound O-Acyltransferase7 rs641738 variant in pediatric Nonalcoholic Fatty Liver Disease","volume":"67","author":"Di Sessa","year":"2018","journal-title":"J.\u00a0Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.jlr.2022.100234_bib23","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/ajg.2018.1","article-title":"The rs626283 variant in the MBOAT7 gene is associated with insulin resistance and fatty liver in Caucasian obese youth","volume":"113","author":"Umano","year":"2018","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.jlr.2022.100234_bib24","doi-asserted-by":"crossref","first-page":"5097","DOI":"10.1038\/s41598-018-23453-9","article-title":"Lack of evidence supporting a role of TMC4-rs641738 missense variant-MBOAT7- intergenic downstream variant-in the susceptibility to Nonalcoholic Fatty Liver Disease","volume":"8","author":"Sookoian","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jlr.2022.100234_bib25","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1016\/j.cgh.2019.09.017","article-title":"Association between a polymorphism in MBOAT7 and Chronic Kidney Disease in patients with Biopsy-confirmed Nonalcoholic Fatty Liver Disease","volume":"18","author":"Koo","year":"2020","journal-title":"Clin. Gastoenterol. Hepatol."},{"key":"10.1016\/j.jlr.2022.100234_bib26","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1111\/jgh.14056","article-title":"Additive effects of PNPLA3 and TM6SF2 on the histological severity of non-alcoholic fatty liver disease","volume":"33","author":"Koo","year":"2018","journal-title":"J.\u00a0Gastroenterol. Hepatol."},{"key":"10.1016\/j.jlr.2022.100234_bib27","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1016\/j.cgh.2020.02.011","article-title":"Development and validation of a scoring system, based on genetic and clinical factors, to determine risk of Steatohepatitis in Asian patients with Nonalcoholic Fatty Liver Disease","volume":"18","author":"Koo","year":"2020","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jlr.2022.100234_bib28","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.3390\/ijms20061277","article-title":"TM6SF2 and MBOAT7 gene variants in Liver Fibrosis and Cirrhosis","volume":"20","author":"Basyte-Bacevice","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jlr.2022.100234_bib29","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1080\/00365513.2019.1700428","article-title":"Metabolic syndrome but not genetic polymorphisms known to induce NAFLD predicts increased total mortality in subjects with NAFLD (OPERA study)","volume":"80","author":"Karajamaki","year":"2020","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1016\/j.jlr.2022.100234_bib30","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/apt.16392","article-title":"The impact of genetic risk on liver fibrosis in non-alcoholic fatty liver disease as assessed by magnetic resonance elastography","volume":"54","author":"Ajmera","year":"2021","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.jlr.2022.100234_bib31","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.jhep.2020.04.003","article-title":"Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterized cohort","volume":"73","author":"Anstee","year":"2020","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.jlr.2022.100234_bib32","doi-asserted-by":"crossref","first-page":"455","DOI":"10.5223\/pghn.2021.24.5.455","article-title":"The PNPLA3 rs738409 variant but not MBOAT7 rs641738 is a risk factor for Nonalcoholic Fatty Liver Disease in Obese U.S. children of hispanic ethnicity","volume":"24","author":"Mansoor","year":"2021","journal-title":"Pediatr. Gastroenterol. Hepatol. Nutr."},{"key":"10.1016\/j.jlr.2022.100234_bib33","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1016\/j.numecd.2021.01.020","article-title":"Association between MBOAT7 rs641738 polymorphism and non-alcoholic fatty liver in overweight or obese children","volume":"31","author":"Zusi","year":"2021","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"10.1016\/j.jlr.2022.100234_bib34","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/s41390-019-0303-1","article-title":"Genetic and metabolic predictors of hepatic fat content in a cohort of Italian children with obesity","volume":"85","author":"Di Costanzo","year":"2019","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.jlr.2022.100234_bib35","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1111\/liv.13689","article-title":"Genetic determinants of hepatic steatosis and serum cytokeratin-18 fragment levels in Taiwanese children","volume":"38","author":"Lin","year":"2018","journal-title":"Liver Int."},{"key":"10.1016\/j.jlr.2022.100234_bib36","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jhep.2020.08.027","article-title":"rs641738C>T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD: a meta-analysis","volume":"74","author":"Teo","year":"2021","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.jlr.2022.100234_bib37","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.49882","article-title":"Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease","volume":"8","author":"Helsley","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.jlr.2022.100234_bib38","doi-asserted-by":"crossref","first-page":"102658","DOI":"10.1016\/j.ebiom.2020.102658","article-title":"Mboat7 down-regulation by hyper-insulinemia induces fat accumulation in hepatocytes","volume":"52","author":"Meroni","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jlr.2022.100234_bib39","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1136\/gutjnl-2020-320646","article-title":"LPIAT1\/MBOAT7 depletion increases triglyceride synthesis fueled by high phosphatidylinositol turnover","volume":"70","author":"Tanaka","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.jlr.2022.100234_bib40","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1136\/gutjnl-2020-320853","article-title":"Loss of hepatic Mboat7 leads to liver fibrosis","volume":"70","author":"Thangapandi","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.jlr.2022.100234_bib41","doi-asserted-by":"crossref","first-page":"100031","DOI":"10.1194\/jlr.RA120000856","article-title":"Hepatic deletion of Mboat7 (LPIAT1) causes activation of SREBP-1c and fatty liver","volume":"62","author":"Xia","year":"2021","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2022.100234_bib42","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/s41575-019-0186-y","article-title":"A\u00a0global view of hepatocellular carcinoma: trends, risk, prevention and management","volume":"16","author":"Yang","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jlr.2022.100234_bib43","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nrgastro.2011.57","article-title":"Managing patients with hepatitis-B-related or hepatitis-C-related decompensated cirrhosis","volume":"8","author":"Fink","year":"2011","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jlr.2022.100234_bib44","doi-asserted-by":"crossref","first-page":"12757","DOI":"10.1038\/ncomms12757","article-title":"MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C","volume":"7","author":"Thabet","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jlr.2022.100234_bib45","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1002\/hep.29064","article-title":"The membrane-bound O-acyltransferase domain-containing 7 variant rs641738 increases inflammation and fibrosis in chronic hepatitis B","volume":"65","author":"Thabet","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.jlr.2022.100234_bib46","doi-asserted-by":"crossref","first-page":"12247","DOI":"10.1038\/s41598-018-30824-9","article-title":"Effect of MBOAT7 variant on hepatitis B and C infections in Moroccan patients","volume":"8","author":"Ezzikouri","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jlr.2022.100234_bib47","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00535-018-01533-x","article-title":"Independent and additive effects of PNPLA3 and TM6SF2 polymorphisms on the development of non-B, non-C hepatocellular carcinoma","volume":"54","author":"Raksayot","year":"2019","journal-title":"J.\u00a0Gastroenterol."},{"key":"10.1016\/j.jlr.2022.100234_bib48","doi-asserted-by":"crossref","DOI":"10.1136\/bmjgast-2018-000241","article-title":"PNPLA3 gene predicts clinical recovery after sustained virological response in decompensated hepatitis C cirrhosis","volume":"6","author":"Dunn","year":"2019","journal-title":"BMJ Open Gastroenterol."},{"key":"10.1016\/j.jlr.2022.100234_bib49","doi-asserted-by":"crossref","first-page":"146235","DOI":"10.1016\/j.gene.2022.146235","article-title":"Evaluation of the association of a variant in PNPLA3 and TM6SF2 with fibrosis progression in patients with chronic hepatitis C infection after eradication: a retrospective study","volume":"820","author":"Kang","year":"2022","journal-title":"Gene"},{"key":"10.1016\/j.jlr.2022.100234_bib50","doi-asserted-by":"crossref","first-page":"639438","DOI":"10.3389\/fonc.2021.639438","article-title":"MBOAT7-TMC4 rs641738 is not associated with the Risk of Hepatocellular Carcinoma or Persistent Hepatitis B Infection","volume":"11","author":"Wang","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.jlr.2022.100234_bib51","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.clinre.2019.12.006","article-title":"The MBOAT7 rs641738 variant is associated with an improved outcome in primary sclerosing cholangitis","volume":"44","author":"Freund","year":"2020","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"10.1016\/j.jlr.2022.100234_bib52","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.clinre.2019.12.007","article-title":"The MBOAT7 rs641738 variant in primary sclerosing cholangitis: a novel biomarker for prognostication","volume":"44","author":"Rahal","year":"2020","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"10.1016\/j.jlr.2022.100234_bib53","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1111\/apt.16252","article-title":"Variants in PCSK7, PNPLA3 and TM6SF2 are risk factors for the development of cirrhosis in hereditary haemochromatosis","volume":"53","author":"Buch","year":"2021","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.jlr.2022.100234_bib54","doi-asserted-by":"crossref","first-page":"4329","DOI":"10.1038\/s41467-019-11954-8","article-title":"Genetic architecture of human plasma lipidome and its link to cardiovascular disease","volume":"10","author":"Tabassum","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jlr.2022.100234_bib55","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1053\/j.gastro.2016.12.020","article-title":"PNPLA3, TM6SF2, and MBOAT7 genotypes and Coronary Artery Disease","volume":"152","author":"Simons","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jlr.2022.100234_bib56","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1002\/hep4.1319","article-title":"Relationship between Nonalcoholic Fatty Liver Disease susceptibility genes and Coronary Artery Disease","volume":"3","author":"Brouwers","year":"2019","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.jlr.2022.100234_bib57","doi-asserted-by":"crossref","first-page":"5057","DOI":"10.1002\/cam4.1719","article-title":"Evidence for PTGER4, PSCA, and MBOAT7 as risk genes for gastric cancer on the genome and transcriptome level","volume":"7","author":"Heinrichs","year":"2018","journal-title":"Cancer Med."},{"key":"10.1016\/j.jlr.2022.100234_bib58","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1038\/s41388-020-1196-5","article-title":"The ACSL3-LPIAT1 signaling drives prostaglandin synthesis in non-small cell lung cancer","volume":"39","author":"Saliakoura","year":"2020","journal-title":"Oncogene"},{"key":"10.1016\/j.jlr.2022.100234_bib59","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.molmet.2020.01.011","article-title":"MBOAT7-driven phosphatidylinositol remodeling promotes the progression of clear cell renal carcinoma","volume":"34","author":"Neumann","year":"2020","journal-title":"Mol. Metab."},{"key":"10.1016\/j.jlr.2022.100234_bib60","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.ajhg.2016.07.019","article-title":"Mutations in MBOAT7, encoding lysophosphatidylinositol acyltransferase I, lead to Intellectual Disability accompanied by Epilepsy and Autistic Features","volume":"99","author":"Johansen","year":"2016","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jlr.2022.100234_bib61","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/ajmg.b.32749","article-title":"Expanding the phenotypic spectrum of MBOAT7-related intellectual disability","volume":"180","author":"Jacher","year":"2019","journal-title":"Am. J. Med. Genet. B. Neuropsychiatr. Genet."},{"key":"10.1016\/j.jlr.2022.100234_bib62","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/s12881-019-0907-7","article-title":"Homozygous variants in the HEXB and MBOAT7 genes underlie neurological diseases in consanguineous families","volume":"20","author":"Khan","year":"2019","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.jlr.2022.100234_bib63","doi-asserted-by":"crossref","first-page":"4072","DOI":"10.1016\/j.ygeno.2020.07.008","article-title":"Identification of novel loss of function variants in MBOAT7 resulting in intellectual disability","volume":"112","author":"Heidari","year":"2020","journal-title":"Genomics"},{"key":"10.1016\/j.jlr.2022.100234_bib64","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/jimd.12016","article-title":"Expanding the phenotype of phospholipid remodelling disease due to MBOAT7 gene defect","volume":"42","author":"Yalnizglu","year":"2019","journal-title":"J.\u00a0Inherit. Metab. Disord."},{"key":"10.1016\/j.jlr.2022.100234_bib65","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1111\/liv.14732","article-title":"Genetic insight into COVID-19 related liver injury: a note on MBOAT7","volume":"41","author":"Machill","year":"2021","journal-title":"Liver Int."},{"key":"10.1016\/j.jlr.2022.100234_bib66","doi-asserted-by":"crossref","first-page":"4689","DOI":"10.1091\/mbc.e12-09-0673","article-title":"LPIAT1 regulates arachidonic acid content in phosphatidylinositol and is required for cortical lamination in mice","volume":"23","author":"Lee","year":"2012","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.jlr.2022.100234_bib67","article-title":"Lysophosphatidylinositol-acyltransferase-1 (LPIAT1) is required to maintain physiological levels of PtdIns and PtdInsP(2) in the mouse","volume":"8","author":"Anderson","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jlr.2022.100234_bib68","doi-asserted-by":"crossref","first-page":"30235","DOI":"10.1074\/jbc.M806194200","article-title":"Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils","volume":"283","author":"Gij\u00f3n","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jlr.2022.100234_bib69","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.prostaglandins.2014.08.003","article-title":"Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils","volume":"113-115","author":"Zarini","year":"2014","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"10.1016\/j.jlr.2022.100234_bib70","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jsb.2019.04.006","article-title":"MBOAT7 is anchored to endomembranes by six transmembrane domains","volume":"206","author":"Caddeo","year":"2019","journal-title":"J.\u00a0Struct. Biol."},{"key":"10.1016\/j.jlr.2022.100234_bib71","doi-asserted-by":"crossref","first-page":"158891","DOI":"10.1016\/j.bbalip.2021.158891","article-title":"LPIAT1\/MBOAT7 contains a catalytic dyad transferring polyunsaturated fatty acids to lysophosphatidylinositol","volume":"1866","author":"Caddeo","year":"2021","journal-title":"Biochim. Biophys. Acta Mol. Cell. Biol. Lipids"},{"key":"10.1016\/j.jlr.2022.100234_bib72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1074\/jbc.R800046200","article-title":"Acyl-CoA:lysophospholipid acyltransferases","volume":"284","author":"Shindou","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"issue":"l","key":"10.1016\/j.jlr.2022.100234_bib73","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1194\/jlr.R800035-JLR200","article-title":"Recent progress of acyl CoA: lysophospholipid acyltransferase research","volume":"50","author":"Shindou","year":"2009","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2022.100234_bib74","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1194\/jlr.R700019-JLR200","article-title":"Phosphatidylcholine and choline homeostasis","volume":"49","author":"Li","year":"2008","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2022.100234_bib75","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1093\/hmg\/ddaa162","article-title":"Insights into genetic variants associated with NASH-fibrosis from metabolite profiling","volume":"29","author":"Mann","year":"2020","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jlr.2022.100234_bib76","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1124\/pr.58.3.8","article-title":"Eicosanoid transcellular biosynthesis: from cell-cell interactions to in\u00a0vivo responses","volume":"58","author":"Folco","year":"2006","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.jlr.2022.100234_bib77","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nmeth.1564","article-title":"Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry","volume":"8","author":"Clark","year":"2011","journal-title":"Nat. Met."},{"key":"10.1016\/j.jlr.2022.100234_bib78","doi-asserted-by":"crossref","first-page":"6026","DOI":"10.1021\/bi0621617","article-title":"Lipid profiling reveals glycerophospholipid remodeling in zymosan-stimulated macrophages","volume":"46","author":"Rouzer","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.jlr.2022.100234_bib79","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41568-019-0216-7","article-title":"The PI3K-AKT network at the interface of oncogenic signaling and cancer metabolism","volume":"20","author":"Hoxhaj","year":"2020","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jlr.2022.100234_bib80","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/nrm2335","article-title":"Lipid signaling in disease","volume":"9","author":"Wymann","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jlr.2022.100234_bib81","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/tra.12709","article-title":"Integrated regulation of phosphatidylinositol cycle and phosphoinositide-driven lipid transport at ER-PM contact sites","volume":"21","author":"Pemberton","year":"2020","journal-title":"Traffic"},{"key":"10.1016\/j.jlr.2022.100234_bib82","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.cell.2017.07.029","article-title":"The PI3K pathway in human disease","volume":"170","author":"Fruman","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jlr.2022.100234_bib83","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/jb\/mvaa089","article-title":"Emerging roles of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate as regulators of multiple steps in autophagy","volume":"168","author":"Baba","year":"2020","journal-title":"J.\u00a0Biochem."},{"key":"10.1016\/j.jlr.2022.100234_bib84","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1146\/annurev-cellbio-111315-125349","article-title":"Phosphoinositides in control of membrane dynamics","volume":"32","author":"Schink","year":"2016","journal-title":"Annu. Rev. Cell. Dev. Biol."},{"key":"10.1016\/j.jlr.2022.100234_bib85","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev-physiol-020518-114444","article-title":"Phospholipid remodeling in physiology and disease","volume":"81","author":"Wang","year":"2019","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.jlr.2022.100234_bib86","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/S0022-2275(20)34276-0","article-title":"Membrane lipid composition and cellular function","volume":"26","author":"Spector","year":"1985","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2022.100234_bib87","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.molmed.2005.12.001","article-title":"Emerging medicinal roles for lysophospholipid signaling","volume":"12","author":"Gardell","year":"2006","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.jlr.2022.100234_bib88","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.biochi.2012.10.009","article-title":"Novel bioactive glycerol-based lysophospholipids: new data\u2013 new insights into their function","volume":"95","author":"Grzelczyk","year":"2013","journal-title":"Biochimie"},{"key":"10.1016\/j.jlr.2022.100234_bib89","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/j.bbalip.2018.09.003","article-title":"Lysophosphatidylinositols in inflammation and macrophage activation: altered levels and anti-inflammatory effects","volume":"1863","author":"Masquelier","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell. Biol. Lipids"},{"key":"10.1016\/j.jlr.2022.100234_bib90","doi-asserted-by":"crossref","first-page":"773473","DOI":"10.3389\/fcvm.2021.773473","article-title":"Novel knowledge-based transcriptional profiling of lipid lysophatidylinositol-induced endothelial cell activation","volume":"8","author":"Xu","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.jlr.2022.100234_bib91","article-title":"Lysophoshatidylinositol, especially albumin-bound form, induces inflammatory cytokines in macrophages","volume":"36","author":"Li","year":"2021","journal-title":"FASEB J."},{"key":"10.1016\/j.jlr.2022.100234_bib92","doi-asserted-by":"crossref","first-page":"11033","DOI":"10.1074\/jbc.RA118.002752","article-title":"Lysophospholipids induce innate immune transdifferentiation of endothelial cells, resulting in prolonged endothelial activation","volume":"293","author":"Li","year":"2018","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jlr.2022.100234_bib93","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1096\/fj.201800171R","article-title":"GPR55 deficiency is associated with increased adiposity and impaired insulin signaling in peripheral metabolic tissues","volume":"33","author":"Lipina","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.jlr.2022.100234_bib94","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.neuroscience.2019.06.039","article-title":"GPR55-mediated effects o brain microvascular endothelial cells and the blood-brain barrier","volume":"414","author":"Leo","year":"2019","journal-title":"Neuroscience"},{"key":"10.1016\/j.jlr.2022.100234_bib95","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1124\/jpet.113.204180","article-title":"A\u00a0selective antagonist reveals a potential role of G protein-coupled receptor 55 in platelet and endothelial cell function","volume":"346","author":"Kargl","year":"2013","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.jlr.2022.100234_bib96","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1159\/000493490","article-title":"Structure-activity relationship of the GRP55 antagonist, CID16020046","volume":"102","author":"Brown","year":"2018","journal-title":"Pharmacology"},{"key":"10.1016\/j.jlr.2022.100234_bib97","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.487","article-title":"L-alpha-lysophosphatidylinositol (LPI) aggravates myocardial ischemia\/reperfusion injury via a GPR55\/ROCK-dependent pathway","volume":"7","author":"Robertson-Gray","year":"2019","journal-title":"Pharmacol. Res. Perspect."},{"key":"10.1016\/j.jlr.2022.100234_bib98","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.tem.2016.04.012","article-title":"GPR55: metabolic help of hindrance?","volume":"27","author":"Henstridge","year":"2016","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.jlr.2022.100234_bib99","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/jb\/mvp208","article-title":"Lysophosphatidylinositol induces rapid phosphorylation of p38 mitogen-activated protein kinase and activating transcription factor 2 in HEK293 cells expressing GRP55 and IM-9 lymphoblastoid cells","volume":"147","author":"Oka","year":"2010","journal-title":"J.\u00a0Biochem."},{"key":"10.1016\/j.jlr.2022.100234_bib100","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.3390\/ijms22063091","article-title":"O-1602 promotes hepatic steatosis through GPR55 and PI3 kinase\/Akt\/SREBP-1c signaling in mice","volume":"22","author":"Kang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jlr.2022.100234_bib101","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2337\/db11-0649","article-title":"The L-alpha-lysophosphatidylinositol\/GPR55 system and its potential role in human obesity","volume":"61","author":"Moreno-Navarrete","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.jlr.2022.100234_bib102","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/hep.31290","article-title":"The L-alpha lysophosphatidylinositol\/G protein-coupled receptor 55 system induces the development of nonalcoholic steatosis and steatohepatitis","volume":"73","author":"Fondevila","year":"2021","journal-title":"Hepatology"}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227522000670?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227522000670?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T18:30:58Z","timestamp":1758306658000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227522000670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":102,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["S0022227522000670"],"URL":"https:\/\/doi.org\/10.1016\/j.jlr.2022.100234","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Membrane-bound O-acyltransferase 7 (MBOAT7)-driven phosphatidylinositol remodeling in advanced liver disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Lipid Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jlr.2022.100234","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"100234"}}