{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:40:28Z","timestamp":1791355228160,"version":"4.3.1"},"reference-count":64,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,5]],"date-time":"2022-06-05T00:00:00Z","timestamp":1654387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009479","name":"Kungl. Vetenskaps- och Vitterhets-Samh\u00e4llet i G\u00f6teborg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014437","name":"Wenner-Gren Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014437","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008310","name":"Lisa and Johan Gronberg Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008310","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016406","name":"Dr Felix Neubergh Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016406","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008546","name":"Diabetesf\u00f6rbundet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008546","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008584","name":"Foundation L\u00e4ngmanska Cultural Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008584","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003743","name":"Adlerbertska Foundations","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003743","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003745","name":"Wilhelm och Martina Lundgrens Stiftelser","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003745","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007435","name":"\u00c5ke Wiberg Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007435","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009800","name":"Professor Nanna Svartz Foundation Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009800","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007436","name":"Erling Persson Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007436","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003849","name":"IngaBritt and Arne Lundberg Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003849","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jlr.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.jlr.2022.100238","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T20:03:59Z","timestamp":1654545839000},"page":"100238","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Inhibition of MAP4K4 signaling initiates metabolic reprogramming to protect hepatocytes from lipotoxic damage"],"prefix":"10.1016","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3719-0744","authenticated-orcid":false,"given":"Sumit Kumar","family":"Anand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3362-9062","authenticated-orcid":false,"given":"Mara","family":"Caputo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8133-5413","authenticated-orcid":false,"given":"Ying","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7382-9045","authenticated-orcid":false,"given":"Emma","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1589-3596","authenticated-orcid":false,"given":"Emmelie","family":"Cansby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sima","family":"Kumari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4202-0339","authenticated-orcid":false,"given":"Marcus","family":"Henricsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rando","family":"Porosk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0570-8596","authenticated-orcid":false,"given":"Katharina Susanne","family":"Keuenhof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna Louise","family":"H\u00f6\u00f6g","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8470-2162","authenticated-orcid":false,"given":"Syam","family":"Nair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7347-3085","authenticated-orcid":false,"given":"Hanns-Ulrich","family":"Marschall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Bl\u00fcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8740-8874","authenticated-orcid":false,"given":"Margit","family":"Mahlapuu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jlr.2022.100238_bib1","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1136\/gutjnl-2020-323202","article-title":"From the origin of NASH to the future of metabolic fatty liver disease","volume":"70","author":"Geier","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.jlr.2022.100238_bib2","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/S0140-6736(20)32511-3","article-title":"Non-alcoholic fatty liver disease","volume":"397","author":"Powell","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.jlr.2022.100238_bib3","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1001\/jama.2020.2298","article-title":"Nonalcoholic Steatohepatitis: a review","volume":"323","author":"Sheka","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.jlr.2022.100238_bib4","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41575-019-0145-7","article-title":"From NASH to HCC: current concepts and future challenges","volume":"16","author":"Anstee","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jlr.2022.100238_bib5","doi-asserted-by":"crossref","first-page":"101115","DOI":"10.1016\/j.molmet.2020.101115","article-title":"Hepatic lipid droplets: a balancing act between energy storage and metabolic dysfunction in NAFLD","volume":"50","author":"Mashek","year":"2020","journal-title":"Mol. Metab."},{"key":"10.1016\/j.jlr.2022.100238_bib6","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1096\/fj.14-264937","article-title":"Protein kinase STK25 regulates hepatic lipid partitioning and progression of liver steatosis and NASH","volume":"29","author":"Amrutkar","year":"2015","journal-title":"FASEB J."},{"key":"10.1016\/j.jlr.2022.100238_bib7","doi-asserted-by":"crossref","first-page":"3628","DOI":"10.1096\/fj.201600562R","article-title":"STK25 is a critical determinant in nonalcoholic steatohepatitis","volume":"30","author":"Amrutkar","year":"2016","journal-title":"FASEB J."},{"key":"10.1016\/j.jlr.2022.100238_bib8","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00125-015-3801-7","article-title":"Protein kinase STK25 controls lipid partitioning in hepatocytes and correlates with liver fat content in humans","volume":"59","author":"Amrutkar","year":"2016","journal-title":"Diabetologia"},{"key":"10.1016\/j.jlr.2022.100238_bib9","doi-asserted-by":"crossref","first-page":"9974","DOI":"10.1096\/fj.201900356RR","article-title":"Protein kinase MST3 modulates lipid homeostasis in hepatocytes and correlates with nonalcoholic steatohepatitis in humans","volume":"33","author":"Cansby","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.jlr.2022.100238_bib10","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.jcmgh.2018.12.004","article-title":"Targeted delivery of Stk25 antisense oligonucleotides to hepatocytes protects mice against nonalcoholic fatty liver disease","volume":"7","author":"Cansby","year":"2019","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jlr.2022.100238_bib11","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1002\/hep4.1702","article-title":"STE20-type protein kinase MST4 controls NAFLD progression by regulating lipid droplet dynamics and metabolic stress in hepatocytes","volume":"5","author":"Caputo","year":"2021","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.jlr.2022.100238_bib12","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202002671RR","article-title":"Silencing of STE20-type kinase MST3 in mice with antisense oligonucleotide treatment ameliorates diet-induced nonalcoholic fatty liver disease","volume":"35","author":"Caputo","year":"2021","journal-title":"FASEB J."},{"key":"10.1016\/j.jlr.2022.100238_bib13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/hep4.1128","article-title":"Serine\/threonine protein kinase 25 antisense oligonucleotide treatment reverses glucose intolerance, insulin resistance, and nonalcoholic fatty liver disease in mice","volume":"2","author":"Nunez-Duran","year":"2018","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.jlr.2022.100238_bib14","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1194\/jlr.RA119000316","article-title":"Lipid droplet-associated kinase STK25 regulates peroxisomal activity and metabolic stress response in steatotic liver","volume":"61","author":"Nerstedt","year":"2020","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2022.100238_bib15","doi-asserted-by":"crossref","first-page":"101353","DOI":"10.1016\/j.molmet.2021.101353","article-title":"STE20-type kinase TAOK3 regulates hepatic lipid partitioning","volume":"54","author":"Xia","year":"2021","journal-title":"Mol. Metab."},{"key":"10.1016\/j.jlr.2022.100238_bib16","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0960-9822(99)80023-2","article-title":"A\u00a0Drosophila TNF-receptor-associated factor (TRAF) binds the ste20 kinase Misshapen and activates Jun kinase","volume":"9","author":"Liu","year":"1999","journal-title":"Curr. Biol."},{"key":"10.1016\/j.jlr.2022.100238_bib17","doi-asserted-by":"crossref","first-page":"3775","DOI":"10.1073\/pnas.0600040103","article-title":"A\u00a0small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase","volume":"103","author":"Collins","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jlr.2022.100238_bib18","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1093\/emboj\/16.6.1279","article-title":"NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK\/JNK cascade via a conserved regulatory domain","volume":"16","author":"Su","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.jlr.2022.100238_bib19","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.celrep.2019.01.019","article-title":"MAP4K4 activation mediates motor neuron degeneration in amyotrophic lateral sclerosis","volume":"26","author":"Wu","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.jlr.2022.100238_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0047647","article-title":"Association of common genetic variants in the MAP4K4 locus with prediabetic traits in humans","volume":"7","author":"Sartorius","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jlr.2022.100238_bib21","doi-asserted-by":"crossref","first-page":"268","DOI":"10.2337\/db08-0931","article-title":"Genome-wide linkage and admixture mapping of type 2 diabetes in African American families from the American Diabetes Association GENNID (Genetics of NIDDM) study cohort","volume":"58","author":"Elbein","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.jlr.2022.100238_bib22","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1128\/MCB.00150-15","article-title":"Inducible deletion of protein kinase Map4k4 in obese mice improves insulin sensitivity in liver and adipose tissues","volume":"35","author":"Danai","year":"2015","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.jlr.2022.100238_bib23","first-page":"1","article-title":"Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis","volume":"6","author":"Flach","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jlr.2022.100238_bib24","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1158\/1078-0432.CCR-10-0331","article-title":"ShRNA-targeted MAP4K4 inhibits hepatocellular carcinoma growth","volume":"17","author":"Liu","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jlr.2022.100238_bib25","doi-asserted-by":"crossref","first-page":"7043","DOI":"10.1158\/1078-0432.CCR-08-0381","article-title":"Expression of MAP4K4 is associated with worse prognosis in patients with stage II pancreatic ductal adenocarcinoma","volume":"14","author":"Liang","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jlr.2022.100238_bib26","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1158\/1535-7163.MCT-13-0296","article-title":"miRNA-141, downregulated in pancreatic cancer, inhibits cell proliferation and invasion by directly targeting MAP4K4","volume":"12","author":"Zhao","year":"2013","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.jlr.2022.100238_bib27","doi-asserted-by":"crossref","first-page":"11457","DOI":"10.1007\/s13277-016-5022-1","article-title":"MAP4K4 promotes epithelial-mesenchymal transition and metastasis in hepatocellular carcinoma","volume":"37","author":"Feng","year":"2016","journal-title":"Tumor Biol."},{"key":"10.1016\/j.jlr.2022.100238_bib28","doi-asserted-by":"crossref","first-page":"4541","DOI":"10.3748\/wjg.v16.i36.4541","article-title":"Lowered HGK expression inhibits cell invasion and adhesion in hepatocellular carcinoma cell line HepG2","volume":"16","author":"Han","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jlr.2022.100238_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-50160-w","article-title":"Targeted genomic CRISPR-Cas9 screen identifies MAP4K4 as essential for glioblastoma invasion","volume":"9","author":"Prolo","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jlr.2022.100238_bib30","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s00125-014-3490-7","article-title":"Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance","volume":"58","author":"Kannt","year":"2015","journal-title":"Diabetologia"},{"key":"10.1016\/j.jlr.2022.100238_bib31","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1111\/j.1572-0241.1999.01377.x","article-title":"Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions","volume":"94","author":"Brunt","year":"1999","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.jlr.2022.100238_bib32","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3109\/13813455.2012.683442","article-title":"The human hepatocyte cell lines IHH and HepaRG: models to study glucose, lipid and lipoprotein metabolism","volume":"118","author":"Samanez","year":"2012","journal-title":"Arch. Physiol. Biochem."},{"key":"10.1016\/j.jlr.2022.100238_bib33","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1021\/acsmedchemlett.5b00215","article-title":"Discovery of an in\u00a0vivo tool to establish proof-of-concept for MAP4K4-based antidiabetic treatment","volume":"6","author":"Ammirati","year":"2015","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.jlr.2022.100238_bib34","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0091-679X(10)96028-7","article-title":"\"Tips and Tricks\" for high-pressure freezing of model systems","volume":"96","author":"McDonald","year":"2010","journal-title":"Met. Cell Biol."},{"key":"10.1016\/j.jlr.2022.100238_bib35","doi-asserted-by":"crossref","first-page":"jcs258325","DOI":"10.1242\/jcs.258325","article-title":"Large organellar changes occur during mild heat shock in yeast","volume":"135","author":"Keuenhof","year":"2022","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.jlr.2022.100238_bib36","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2020997118","article-title":"Nuclear envelope budding is a response to cellular stress","volume":"118","author":"Panagaki","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jlr.2022.100238_bib37","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1194\/jlr.D023036","article-title":"The BUME method: a novel automated chloroform-free 96-well total lipid extraction method for blood plasma","volume":"53","author":"Lofgren","year":"2012","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2022.100238_bib38","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0378-4347(97)00651-8","article-title":"Rapid separation and quantitation of combined neutral and polar lipid classes by high-performance liquid chromatography and evaporative light-scattering mass detection","volume":"708","author":"Homan","year":"1998","journal-title":"J.\u00a0Chromatogr. B Biomed. Sci. Appl."},{"key":"10.1016\/j.jlr.2022.100238_bib39","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/j.bbalip.2013.07.009","article-title":"Dyslipidemia, but not hyperglycemia and insulin resistance, is associated with marked alterations in the HDL lipidome in type 2 diabetic subjects in the DIWA cohort: impact on small HDL particles","volume":"1831","author":"Stahlman","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jlr.2022.100238_bib40","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1089\/omi.2017.0143","article-title":"Metabolomics of the Wolfram Syndrome 1 gene (Wfs1) deficient mice","volume":"21","author":"Porosk","year":"2017","journal-title":"Omics"},{"key":"10.1016\/j.jlr.2022.100238_bib41","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1074\/jbc.274.4.2118","article-title":"A\u00a0novel human STE20-related protein kinase, HGK, that specifically activates the c-Jun N-terminal kinase signaling pathway","volume":"274","author":"Yao","year":"1999","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jlr.2022.100238_bib42","doi-asserted-by":"crossref","first-page":"15711","DOI":"10.1074\/jbc.C300542200","article-title":"Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase","volume":"279","author":"Machida","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jlr.2022.100238_bib43","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.devcel.2014.10.025","article-title":"Microtubules regulate focal adhesion dynamics through MAP4K4","volume":"31","author":"Yue","year":"2014","journal-title":"Dev. Cell"},{"key":"10.1016\/j.jlr.2022.100238_bib44","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1002\/hep.30206","article-title":"Trimming the fat: acetyl-CoA carboxylase inhibition for the management of NAFLD","volume":"68","author":"Imai","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.jlr.2022.100238_bib45","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.cmet.2005.05.004","article-title":"Metabolic control through the PGC-1 family of transcription coactivators","volume":"1","author":"Lin","year":"2005","journal-title":"Cell Metab."},{"key":"10.1016\/j.jlr.2022.100238_bib46","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/s41467-020-20303-z","article-title":"Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH","volume":"12","author":"Dong","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jlr.2022.100238_bib47","first-page":"585","article-title":"Hypoxia via ERK Signaling Inhibits Hepatic PPAR alpha to Promote Fatty Liver","volume":"12","author":"Mooli","year":"2021","journal-title":"Cell Mol. Gastroenter."},{"key":"10.1016\/j.jlr.2022.100238_bib48","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1053\/j.gastro.2020.02.020","article-title":"Metabolic inflammation-A role for hepatic inflammatory pathways as drivers of comorbidities in nonalcoholic fatty liver disease?","volume":"158","author":"Gehrke","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jlr.2022.100238_bib49","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.jlr.2022.100238_bib50","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41575-019-0144-8","article-title":"Past, present and future perspectives in nonalcoholic fatty liver disease","volume":"16","author":"Sanyal","year":"2019","journal-title":"Nat. Rev. Gastro Hepat."},{"key":"10.1016\/j.jlr.2022.100238_bib51","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.cmet.2019.02.011","article-title":"Mitochondria bound to lipid droplets: where mitochondrial dynamics regulate lipid storage and utilization","volume":"29","author":"Benador","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.jlr.2022.100238_bib52","doi-asserted-by":"crossref","first-page":"618322","DOI":"10.3389\/fcell.2020.618322","article-title":"Two types of contact between lipid droplets and mitochondria","volume":"8","author":"Cui","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.jlr.2022.100238_bib53","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/s41580-020-0210-7","article-title":"The cell biology of mitochondrial membrane dynamics","volume":"21","author":"Giacomello","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jlr.2022.100238_bib54","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cell.2016.12.039","article-title":"Understanding the intersections between metabolism and cancer biology","volume":"168","author":"Vander Heiden","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jlr.2022.100238_bib55","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0132148","article-title":"Cellular MicroRNA Let-7a suppresses KSHV replication through targeting MAP4K4 signaling pathways","volume":"10","author":"Tan","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jlr.2022.100238_bib56","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/bs.ai.2015.09.006","article-title":"MAP4K Family Kinases in Immunity and Inflammation","volume":"129","author":"Chuang","year":"2016","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.jlr.2022.100238_bib57","doi-asserted-by":"crossref","first-page":"11074","DOI":"10.1523\/JNEUROSCI.0905-17.2017","article-title":"The Ste20 family kinases MAP4K4, MINK1, and TNIK converge to regulate stress-induced JNK signaling in neurons","volume":"37","author":"Larhammar","year":"2017","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.jlr.2022.100238_bib58","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1194\/jlr.M038802","article-title":"Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling","volume":"54","author":"Danai","year":"2013","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2022.100238_bib59","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1128\/MCB.00618-12","article-title":"Identification of Map4k4 as a novel suppressor of skeletal muscle differentiation","volume":"33","author":"Wang","year":"2013","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.jlr.2022.100238_bib60","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1042\/BCJ20210003","article-title":"MAP4K4 expression in cardiomyocytes: multiple isoforms, multiple phosphorylations and interactions with striatins","volume":"478","author":"Fuller","year":"2021","journal-title":"Biochem. J."},{"key":"10.1016\/j.jlr.2022.100238_bib61","doi-asserted-by":"crossref","first-page":"7783","DOI":"10.1074\/jbc.M608602200","article-title":"MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-alpha-induced insulin resistance","volume":"282","author":"Bouzakri","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jlr.2022.100238_bib62","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.tem.2017.10.007","article-title":"Mitogen-activated protein kinase regulation in hepatic metabolism","volume":"28","author":"Lawan","year":"2017","journal-title":"Trends Endocrin. Met."},{"key":"10.1016\/j.jlr.2022.100238_bib63","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s00109-019-01765-1","article-title":"Innate immune regulatory networks in hepatic lipid metabolism","volume":"97","author":"Bai","year":"2019","journal-title":"J.\u00a0Mol. Med. (Berl)"},{"key":"10.1016\/j.jlr.2022.100238_bib64","doi-asserted-by":"crossref","first-page":"101190","DOI":"10.1016\/j.molmet.2021.101190","article-title":"Stress kinases in the development of liver steatosis and hepatocellular carcinoma","volume":"50","author":"Cicuendez","year":"2020","journal-title":"Mol. Metab."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227522000712?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227522000712?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T05:31:22Z","timestamp":1762666282000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227522000712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":64,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["S0022227522000712"],"URL":"https:\/\/doi.org\/10.1016\/j.jlr.2022.100238","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of MAP4K4 signaling initiates metabolic reprogramming to protect hepatocytes from lipotoxic damage","name":"articletitle","label":"Article Title"},{"value":"Journal of Lipid Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jlr.2022.100238","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"100238"}}