{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:35:19Z","timestamp":1792204519510,"version":"4.4.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T00:00:00Z","timestamp":1663027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF15OC0016798"],"award-info":[{"award-number":["NNF15OC0016798"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jlr.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.jlr.2022.100280","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T02:42:06Z","timestamp":1663209726000},"page":"100280","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Adipose Tissue, Bile Acids, and Gut Microbiome Species Associated With Gallstones After Bariatric Surgery"],"prefix":"10.1016","volume":"63","author":[{"given":"M.S.S.","family":"Guman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.B.","family":"Hoozemans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7668-9164","authenticated-orcid":false,"given":"S.","family":"Haal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2980-8444","authenticated-orcid":false,"given":"P.A.","family":"de Jonge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6.","family":"Aydin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6336-2680","authenticated-orcid":false,"given":"D.","family":"Lappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.S.","family":"Meijnikman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Westerink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Acherman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"B\u00e4ckhed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"de Brauw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Nieuwdorp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.K.","family":"Groen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0493-4399","authenticated-orcid":false,"given":"V.E.A.","family":"Gerdes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jlr.2022.100280_bib1","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1001\/jama.2020.12567","article-title":"Benefits and risks of bariatric surgery in adults: a review","volume":"324","author":"Arterburn","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.jlr.2022.100280_bib2","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1016\/j.soard.2020.05.025","article-title":"Long-term incidence of gallstone disease after bariatric surgery: results from the nonrandomized controlled Swedish Obese Subjects study","volume":"16","author":"Anveden","year":"2020","journal-title":"Surg. Obes. Relat. Dis."},{"key":"10.1016\/j.jlr.2022.100280_bib3","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.soard.2009.03.221","article-title":"Incidence of postoperative gallstone disease after antiobesity surgery: population-based study from Sweden","volume":"6","author":"Jonas","year":"2010","journal-title":"Surg. Obes. Relat. Dis."},{"key":"10.1016\/j.jlr.2022.100280_bib4","first-page":"1000","article-title":"Gallstone formation after rapid weight loss: a prospective study in patients undergoing gastric bypass surgery for treatment of morbid obesity","volume":"86","author":"Shiffman","year":"1991","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.jlr.2022.100280_bib5","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/MOG.0000000000000423","article-title":"An update on the pathogenesis of cholesterol gallstone disease","volume":"34","author":"Di Ciaula","year":"2018","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.jlr.2022.100280_bib6","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1186\/1471-2164-14-669","article-title":"Gut microbiota dysbiosis and bacterial community assembly associated with cholesterol gallstones in large-scale study","volume":"14","author":"Wu","year":"2013","journal-title":"BMC Genomics"},{"key":"10.1016\/j.jlr.2022.100280_bib7","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.cmet.2013.01.003","article-title":"Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist","volume":"17","author":"Sayin","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.jlr.2022.100280_bib8","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s40168-021-01101-1","article-title":"Review: microbial transformations of human bile acids","volume":"9","author":"Guzior","year":"2021","journal-title":"Microbiome"},{"key":"10.1016\/j.jlr.2022.100280_bib9","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s12876-020-01195-1","article-title":"Intestinal flora imbalance affects bile acid metabolism and is associated with gallstone formation","volume":"20","author":"Wang","year":"2020","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.jlr.2022.100280_bib10","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12876-017-0629-2","article-title":"Alteration of gut microbiota in association with cholesterol gallstone formation in mice","volume":"17","author":"Wang","year":"2017","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.jlr.2022.100280_bib11","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1111\/1758-2229.12319","article-title":"Interactions between the intestinal microbiota and bile acids in gallstones patients","volume":"7","author":"Keren","year":"2015","journal-title":"Environ. Microbiol. Rep."},{"key":"10.1016\/j.jlr.2022.100280_bib12","doi-asserted-by":"crossref","first-page":"6677","DOI":"10.1038\/s41598-021-86247-6","article-title":"Carrying asymptomatic gallstones is not associated with changes in intestinal microbiota composition and diversity but cholecystectomy with significant dysbiosis","volume":"11","author":"Frost","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jlr.2022.100280_bib13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3390\/jpm11010013","article-title":"Gallstone Disease, Obesity and the firmicutes\/bacteroidetes ratio as a possible biomarker of gut Dysbiosis","volume":"11","author":"Grigor'eva","year":"2020","journal-title":"J.\u00a0Pers Med."},{"key":"10.1016\/j.jlr.2022.100280_bib14","doi-asserted-by":"crossref","first-page":"5101","DOI":"10.1038\/s41467-018-07460-y","article-title":"Genome-wide association meta-analysis yields 20 loci associated with gallstone disease","volume":"9","author":"Ferkingstad","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jlr.2022.100280_bib15","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1053\/j.gastro.2016.04.007","article-title":"Four susceptibility loci for gallstone disease identified in a meta-analysis of genome-wide association studies","volume":"151","author":"Joshi","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jlr.2022.100280_bib16","doi-asserted-by":"crossref","first-page":"682","DOI":"10.3390\/metabo11100682","article-title":"Gallstone formation follows a different trajectory in bariatric patients compared to nonbariatric patients","volume":"11","author":"Haal","year":"2021","journal-title":"Metabolites"},{"key":"10.1016\/j.jlr.2022.100280_bib17","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/joim.13157","article-title":"A\u00a0systems biology approach to understand gut microbiota and host metabolism in morbid obesity: design of the BARIA Longitudinal Cohort Study","volume":"289","author":"Van Olden","year":"2021","journal-title":"J.\u00a0Intern. Med."},{"key":"10.1016\/j.jlr.2022.100280_bib18","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jlr.2022.100280_bib19","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/nbt0816-888d","article-title":"Erratum: Near-optimal probabilistic RNA-seq quantification","volume":"34","author":"Bray","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jlr.2022.100280_bib20","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jlr.2022.100280_bib21","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nmeth.3885","article-title":"Data-driven hypothesis weighting increases detection power in genome-scale multiple testing","volume":"13","author":"Ignatiadis","year":"2016","journal-title":"Nat. Met."},{"key":"10.1016\/j.jlr.2022.100280_bib22","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Met."},{"key":"10.1016\/j.jlr.2022.100280_bib23","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1111\/j.1654-1103.2003.tb02228.x","article-title":"VEGAN, a package of R functions for community ecology","volume":"14","author":"Dixon","year":"2003","journal-title":"J.\u00a0Veg Sci."},{"key":"10.1016\/j.jlr.2022.100280_bib24","doi-asserted-by":"crossref","first-page":"e61217","DOI":"10.1371\/journal.pone.0061217","article-title":"phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data","volume":"8","author":"McMurdie","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jlr.2022.100280_bib25","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.jlr.2022.100280_bib26","doi-asserted-by":"crossref","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: a comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.jlr.2022.100280_bib27","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate - a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J.\u00a0R. Stat. Soc. B"},{"key":"10.1016\/j.jlr.2022.100280_bib28","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.soard.2016.12.004","article-title":"Cholecystectomy after gastric bypass-incidence and complications","volume":"13","author":"Wanjura","year":"2017","journal-title":"Surg. Obes. Relat. Dis."},{"key":"10.1016\/j.jlr.2022.100280_bib29","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.cmet.2019.08.018","article-title":"Fatty liver disease caused by high-alcohol-producing klebsiella pneumoniae","volume":"30","author":"Yuan","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.jlr.2022.100280_bib30","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3389\/fmicb.2016.00047","article-title":"Ethanol production by selected intestinal microorganisms and lactic acid bacteria growing under different nutritional conditions","volume":"7","author":"Elshaghabee","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jlr.2022.100280_bib31","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1097\/MEG.0000000000000803","article-title":"Alcohol consumption and risk of gallstone disease: a meta-analysis","volume":"29","author":"Wang","year":"2017","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jlr.2022.100280_bib32","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/toxsci\/kfn268","article-title":"Bile Acid sulfation: a pathway of bile acid elimination and detoxification","volume":"108","author":"Alnouti","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.jlr.2022.100280_bib33","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1080\/19490976.2020.1748261","article-title":"Metagenomic analysis of the human microbiome reveals the association between the abundance of gut bile salt hydrolases and host health","volume":"11","author":"Jia","year":"2020","journal-title":"Gut Microbes"},{"key":"10.1016\/j.jlr.2022.100280_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23051157","article-title":"A\u00a0Comprehensive Genome Survey Provides Novel Insights into Bile Salt Hydrolase (BSH) in Lactobacillaceae","volume":"23","author":"Liang","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.jlr.2022.100280_bib35","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/s41467-021-27758-8","article-title":"Gut microbiota promotes cholesterol gallstone formation by modulating bile acid composition and biliary cholesterol secretion","volume":"13","author":"Hu","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jlr.2022.100280_bib36","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1093\/ajcn\/80.1.38","article-title":"Prospective study of abdominal adiposity and gallstone disease in US men","volume":"80","author":"Tsai","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jlr.2022.100280_bib37","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1136\/gut.2005.076133","article-title":"Central adiposity, regional fat distribution, and the risk of cholecystectomy in women","volume":"55","author":"Tsai","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.jlr.2022.100280_bib38","article-title":"Association between different combination of measures for obesity and new-onset gallstone disease","volume":"13","author":"Liu","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jlr.2022.100280_bib39","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0022-2275(20)37830-5","article-title":"Adipose tissue and cholesterol metabolism","volume":"25","author":"Krause","year":"1984","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2022.100280_bib40","first-page":"5936","article-title":"Biliary cholesterol secretion: more than a simple ABC","volume":"16","author":"Dikkers","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jlr.2022.100280_bib41","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/MOL.0000000000000260","article-title":"Dietary cholesterol effects on adipose tissue inflammation","volume":"27","author":"Chung","year":"2016","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.jlr.2022.100280_bib42","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.gtc.2010.02.007","article-title":"Lith genes and genetic analysis of cholesterol gallstone formation","volume":"39","author":"Wang","year":"2010","journal-title":"Gastroenterol. Clin. North Am."},{"key":"10.1016\/j.jlr.2022.100280_bib43","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.livres.2017.05.005","article-title":"New insights into the role of Lith genes in the formation of cholesterol-supersaturated bile","volume":"1","author":"Wang","year":"2017","journal-title":"Liver Res."},{"key":"10.1016\/j.jlr.2022.100280_bib44","doi-asserted-by":"crossref","first-page":"G303","DOI":"10.1152\/ajpgi.00385.2019","article-title":"Reabsorption of bile acids regulated by FXR-OATP1A2 is the main factor for the formation of cholesterol gallstone","volume":"319","author":"Cai","year":"2020","journal-title":"Am. J. Physiol. Gastr. L."},{"key":"10.1016\/j.jlr.2022.100280_bib45","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1194\/jlr.S091199","article-title":"Gallbladder bile supersaturated with cholesterol in gallstone patients preferentially develops from shortage of bile acids","volume":"60","author":"Rudling","year":"2019","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2022.100280_bib46","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1002\/hep.1840150314","article-title":"Effect of complete sulfation of bile acids on bile formation: role of conjugation and number of sulfate groups","volume":"15","author":"Yousef","year":"1992","journal-title":"Hepatology"},{"key":"10.1016\/j.jlr.2022.100280_bib47","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1111\/jcmm.13599","article-title":"Folic acid delays development of atherosclerosis in low-density lipoprotein receptor-deficient mice","volume":"22","author":"Pan","year":"2018","journal-title":"J.\u00a0Cell Mol. Med."},{"key":"10.1016\/j.jlr.2022.100280_bib48","doi-asserted-by":"crossref","first-page":"615","DOI":"10.15288\/jsad.2009.70.615","article-title":"Beneficial role of dietary folic acid on cholesterol and bile acid metabolism in ethanol-fed rats","volume":"70","author":"Delgado-Villa","year":"2009","journal-title":"J.\u00a0Stud. Alcohol. Drugs"},{"key":"10.1016\/j.jlr.2022.100280_bib49","doi-asserted-by":"crossref","first-page":"108554","DOI":"10.1016\/j.jnutbio.2020.108554","article-title":"High folic acid intake increases methylation-dependent expression of Lsr and dysregulates hepatic cholesterol homeostasis","volume":"88","author":"Leclerc","year":"2021","journal-title":"J.\u00a0Nutr. Biochem."},{"key":"10.1016\/j.jlr.2022.100280_bib50","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/S2468-1253(21)00301-0","article-title":"Ursodeoxycholic acid for the prevention of symptomatic gallstone disease after bariatric surgery (UPGRADE): a multicentre, double-blind, randomised, placebo-controlled superiority trial","volume":"6","author":"Haal","year":"2021","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10.1016\/j.jlr.2022.100280_bib51","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.cell.2018.09.055","article-title":"Microbially produced imidazole propionate impairs insulin signaling through mTORC1","volume":"175","author":"Koh","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.jlr.2022.100280_bib52","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nmeth.3901","article-title":"The Perseus computational platform for comprehensive analysis of (prote)omics data","volume":"13","author":"Tyanova","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jlr.2022.100280_bib53","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nbt.3960","article-title":"Towards standards for human fecal sample processing in metagenomic studies","volume":"35","author":"Costea","year":"2017","journal-title":"Nat. Biotechnol."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227522001134?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227522001134?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T05:31:21Z","timestamp":1762666281000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227522001134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":53,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["S0022227522001134"],"URL":"https:\/\/doi.org\/10.1016\/j.jlr.2022.100280","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adipose Tissue, Bile Acids, and Gut Microbiome Species Associated With Gallstones After Bariatric Surgery","name":"articletitle","label":"Article Title"},{"value":"Journal of Lipid Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jlr.2022.100280","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"100280"}}