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Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jlr.2022.100323_bib81","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.602252","article-title":"From Inert Storage to Biological Activity-In Search of Identity for Oxidized Cholesteryl Esters","volume":"11","author":"Gonen","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.jlr.2022.100323_bib82","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1023\/A:1007912809965","article-title":"Inclusion of Ring A of Cholesterol Inside the \u03b2-Cyclodextrin Cavity: evidence from Oxidation Reactions and Structural Studies","volume":"30","author":"Ravichandran","year":"1998","journal-title":"J.\u00a0Incl. Phenom. Mol. Recogn. 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