{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:00:38Z","timestamp":1787061638019,"version":"build-2736575974"},"reference-count":46,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92157107"],"award-info":[{"award-number":["92157107"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92254308"],"award-info":[{"award-number":["92254308"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004147","name":"Tsinghua University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004147","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA0806502"],"award-info":[{"award-number":["2022YFA0806502"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFA0801701"],"award-info":[{"award-number":["2019YFA0801701"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jlr.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.jlr.2023.100440","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T03:17:08Z","timestamp":1696994228000},"page":"100440","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Metabolic switch from glycogen to lipid in the liver maintains glucose homeostasis in neonatal mice"],"prefix":"10.1016","volume":"64","author":[{"given":"Liangkui","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuchao","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenshan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengting","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jlr.2023.100440_bib1","article-title":"Principal substrates of fetal metabolism: fuel and growth requirements of the ovine fetus","author":"Battaglia","year":"1978","journal-title":"Ciba Found. Symp."},{"key":"10.1016\/j.jlr.2023.100440_bib2","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1086\/415761","article-title":"An introduction to fetal Physiology.by Frederick C. Battaglia; Giacomo Meschia","volume":"63","author":"Duee","year":"1988","journal-title":"Q.\u00a0Rev. Biol."},{"key":"10.1016\/j.jlr.2023.100440_bib3","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.siny.2005.04.001","article-title":"Metabolic adaptation at birth","volume":"10","author":"Ward Platt","year":"2005","journal-title":"Semin. Fetal Neonatal Med."},{"key":"10.1016\/j.jlr.2023.100440_bib4","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1177\/0009922819875540","article-title":"Neonatal hypoglycemia: a review","volume":"58","author":"Alsaleem","year":"2019","journal-title":"Clin. Pediatr. (Phila)"},{"key":"10.1016\/j.jlr.2023.100440_bib5","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1136\/bmj.297.6659.1304","article-title":"Adverse neurodevelopmental outcome of moderate neonatal hypoglycaemia","volume":"297","author":"Lucas","year":"1988","journal-title":"Br. Med. J."},{"key":"10.1016\/j.jlr.2023.100440_bib6","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1542\/peds.2012-0079","article-title":"Neonatal morbidities and developmental delay in moderately preterm-born children","volume":"130","author":"Kerstjens","year":"2012","journal-title":"Pediatrics"},{"key":"10.1016\/j.jlr.2023.100440_bib7","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/S0022-3476(99)70209-X","article-title":"Long-term effects of neonatal hypoglycemia on brain growth and psychomotor development in small-for-gestational-age preterm infants","volume":"134","author":"Duvanel","year":"1999","journal-title":"J.\u00a0Pediatr."},{"key":"10.1016\/j.jlr.2023.100440_bib8","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.atg.2013.06.001","article-title":"Maternal regulation of offspring development in mammals is an ancient adaptation tied to lactation","volume":"2","author":"Power","year":"2013","journal-title":"Appl. Transl. Genomics."},{"key":"10.1016\/j.jlr.2023.100440_bib9","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1558-5646.1977.tb00995.x","article-title":"The significance of lactation in the evolution of mammals","volume":"31","author":"Pond","year":"1977","journal-title":"Evolution"},{"key":"10.1016\/j.jlr.2023.100440_bib10","doi-asserted-by":"crossref","first-page":"223","DOI":"10.15567\/mljekarstvo.2015.0401","article-title":"The overall and fat composition of milk of various species","volume":"65","author":"Gantner","year":"2015","journal-title":"Mljekarstvo"},{"key":"10.1016\/j.jlr.2023.100440_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2020.577759","article-title":"Composition, structure, and digestive dynamics of milk from different species-a review","volume":"7","author":"Roy","year":"2020","journal-title":"Front. Nutr."},{"key":"10.1016\/j.jlr.2023.100440_bib12","first-page":"107","article-title":"Mare\u2019s milk: composition and protein fraction in comparison with different milk species","volume":"61","author":"Kre\u0161imir","year":"2011","journal-title":"Mljekarstvo"},{"key":"10.1016\/j.jlr.2023.100440_bib13","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1017\/S0022029918000274","article-title":"Focusing on fatty acid profile in milk from different species after in\u00a0vitro digestion","volume":"85","author":"Santillo","year":"2018","journal-title":"J.\u00a0Dairy Res."},{"key":"10.1016\/j.jlr.2023.100440_bib14","doi-asserted-by":"crossref","first-page":"632","DOI":"10.3168\/jds.2008-1563","article-title":"Technical note: milk composition in mice\u2014methodological aspects and effects of mouse strain and lactation day","volume":"92","author":"G\u00f6rs","year":"2009","journal-title":"J.\u00a0Dairy Sci."},{"key":"10.1016\/j.jlr.2023.100440_bib15","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nm.2614","article-title":"Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids","volume":"18","author":"Wang","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.jlr.2023.100440_bib16","doi-asserted-by":"crossref","first-page":"16314","DOI":"10.1073\/pnas.0808517105","article-title":"PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation","volume":"104","author":"Bobrovnikova-Marjon","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jlr.2023.100440_bib17","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1101\/gad.1032702","article-title":"The housekeeping gene xanthine oxidoreductase is necessary for milk fat droplet enveloping and secretion: gene sharing in the lactating mammary gland","volume":"16","author":"Vorbach","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.jlr.2023.100440_bib18","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1038\/s41467-018-04363-w","article-title":"Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate","volume":"9","author":"Li","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jlr.2023.100440_bib19","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1194\/jlr.M500556-JLR200","article-title":"Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium","volume":"47","author":"Beigneux","year":"2006","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2023.100440_bib20","doi-asserted-by":"crossref","first-page":"473","DOI":"10.21037\/atm.2018.10.57","article-title":"Fatty acid oxidation disorders","volume":"6","author":"Merritt","year":"2018","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.jlr.2023.100440_bib21","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1046\/j.1432-1033.2003.03949.x","article-title":"MINIREVIEW: genetic defects in fatty acid b-oxidation and acyl-CoA dehydrogenases","volume":"271","author":"Gregersen","year":"2004","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.jlr.2023.100440_bib22","series-title":"Carnitine Palmitoyltransferase 1A Deficiency. GeneReviews((R))","author":"Bennett","year":"1993"},{"key":"10.1016\/j.jlr.2023.100440_bib23","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1002\/hep4.1426","article-title":"Liver glycogen phosphorylase deficiency leads to Profibrogenic phenotype in a murine model of glycogen storage disease type VI","volume":"3","author":"Wilson","year":"2019","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.jlr.2023.100440_bib24","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cmet.2011.06.003","article-title":"Hormonal regulation of hepatic glucose production in health and disease","volume":"14","author":"Lin","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.jlr.2023.100440_bib25","doi-asserted-by":"crossref","first-page":"5559","DOI":"10.1016\/j.cell.2021.10.001","article-title":"Glycogen accumulation and phase separation drives liver tumor initiation","volume":"184","author":"Liu","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jlr.2023.100440_bib26","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/ng1225","article-title":"Cidea-deficient mice have lean phenotype and are resistant to obesity","volume":"35","author":"Zhou","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jlr.2023.100440_bib27","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.cmet.2006.10.011","article-title":"Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation","volume":"4","author":"Boxer","year":"2006","journal-title":"Cell Metab."},{"key":"10.1016\/j.jlr.2023.100440_bib28","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1083\/jcb.201704184","article-title":"Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions","volume":"217","author":"Xu","year":"2018","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.jlr.2023.100440_bib29","doi-asserted-by":"crossref","first-page":"5949","DOI":"10.1038\/ncomms6949","article-title":"Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27-deficient mice","volume":"6","author":"Zhou","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jlr.2023.100440_bib30","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.talanta.2017.09.046","article-title":"Assessment of potential false positives via orbitrap-based untargeted lipidomics from rat tissues","volume":"178","author":"Xu","year":"2018","journal-title":"Talanta"},{"key":"10.1016\/j.jlr.2023.100440_bib31","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.talanta.2016.04.051","article-title":"Establishment of local searching methods for orbitrap-based high throughput metabolomics analysis","volume":"156-157","author":"Tang","year":"2016","journal-title":"Talanta"},{"key":"10.1016\/j.jlr.2023.100440_bib32","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/nprot.2012.024","article-title":"A\u00a0positive\/negative ion-switching, targeted mass spectrometry-based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue","volume":"7","author":"Yuan","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jlr.2023.100440_bib33","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/s41596-018-0102-x","article-title":"Ex\u00a0vivo and in\u00a0vivo stable isotope labelling of central carbon metabolism and related pathways with analysis by LC-MS\/MS","volume":"14","author":"Yuan","year":"2019","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jlr.2023.100440_bib34","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.cell.2018.08.070","article-title":"The Mevalonate pathway is a Druggable target for vaccine adjuvant discovery","volume":"175","author":"Xia","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.jlr.2023.100440_bib35","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.cmet.2013.06.001","article-title":"A\u00a0noncanonical, GSK3-independent pathway controls postprandial hepatic glycogen deposition","volume":"18","author":"Wan","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.jlr.2023.100440_bib36","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1172\/JCI107519","article-title":"Fuels, hormones, and liver metabolism at term and during the early postnatal period in the rat","volume":"52","author":"Girard","year":"1973","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.jlr.2023.100440_bib37","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1101\/gad.1553207","article-title":"A\u00a0role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease","volume":"21","author":"Cheng","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.jlr.2023.100440_bib38","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/s41422-019-0163-6","article-title":"Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress","volume":"29","author":"Zong","year":"2019","journal-title":"Cell Res."},{"key":"10.1016\/j.jlr.2023.100440_bib39","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0022-3476(87)80303-7","article-title":"Serum glucose levels in term neonates during the first 48 hours of life","volume":"110","author":"Heck","year":"1987","journal-title":"J.\u00a0Pediatr."},{"key":"10.1016\/j.jlr.2023.100440_bib40","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0022-3476(86)80588-1","article-title":"Plasma glucose values in normal neonates: a new look","volume":"109","author":"Srinivasan","year":"1986","journal-title":"J.\u00a0Pediatr."},{"key":"10.1016\/j.jlr.2023.100440_bib41","series-title":"Role of the Insulin\/Glucagon Ratio in the Changes of Hepatic Metabolism During Development of the Rat","author":"Girard","year":"1977"},{"key":"10.1016\/j.jlr.2023.100440_bib42","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1515\/jpem-2020-0173","article-title":"Glycogen storage disease type VI can progress to cirrhosis: ten Chinese patients with GSD VI and a literature review","volume":"33","author":"Lu","year":"2020","journal-title":"J.\u00a0Pediatr. Endocrinol. Metab."},{"key":"10.1016\/j.jlr.2023.100440_bib43","first-page":"151","article-title":"Carbohydrate, metabolism II: gluconeogenesis, glycogen synthesis and breakdown, and alternative pathways","volume":"14","author":"Ha","year":"2011","journal-title":"Essentials Med. Biochem."},{"key":"10.1016\/j.jlr.2023.100440_bib44","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41421-022-00447-6","article-title":"Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming","volume":"8","author":"Chong","year":"2022","journal-title":"Cell Discov."},{"key":"10.1016\/j.jlr.2023.100440_bib45","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/s42255-021-00342-6","article-title":"Murine neonatal ketogenesis preserves mitochondrial energetics by preventing protein hyperacetylation","volume":"3","author":"Arima","year":"2021","journal-title":"Nat. Metab."},{"key":"10.1016\/j.jlr.2023.100440_bib46","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.cmet.2021.11.013","article-title":"TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver","volume":"34","author":"Wang","year":"2022","journal-title":"Cell Metab."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002222752300113X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002222752300113X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:11:34Z","timestamp":1777417894000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002222752300113X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":46,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["S002222752300113X"],"URL":"https:\/\/doi.org\/10.1016\/j.jlr.2023.100440","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolic switch from glycogen to lipid in the liver maintains glucose homeostasis in neonatal mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Lipid Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jlr.2023.100440","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"100440"}}