{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:15:41Z","timestamp":1792066541779,"version":"4.4.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T00:00:00Z","timestamp":1697760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["17GRNT33670590"],"award-info":[{"award-number":["17GRNT33670590"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK111052"],"award-info":[{"award-number":["DK111052"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK116496"],"award-info":[{"award-number":["DK116496"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000963","name":"American Diabetes Association Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["1-18-IBS-346"],"award-info":[{"award-number":["1-18-IBS-346"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jlr.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.jlr.2023.100462","type":"journal-article","created":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T02:30:42Z","timestamp":1697855442000},"page":"100462","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cooperation of acylglycerol hydrolases in neuronal lipolysis"],"prefix":"10.1016","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5186-9182","authenticated-orcid":false,"given":"Liqing","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jlr.2023.100462_bib1","doi-asserted-by":"crossref","first-page":"44507","DOI":"10.1074\/jbc.M207712200","article-title":"The surface of lipid droplets is a phospholipid monolayer with a unique fatty Acid composition","volume":"277","author":"Tauchi-Sato","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jlr.2023.100462_bib2","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1074\/jbc.R111.309088","article-title":"Packaging of fat: an evolving model of lipid droplet assembly and expansion","volume":"287","author":"Brasaemle","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jlr.2023.100462_bib3","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1146\/annurev-cellbio-100616-060608","article-title":"Lipid droplet biogenesis","volume":"33","author":"Walther","year":"2017","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.jlr.2023.100462_bib4","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/s41574-023-00845-0","article-title":"Lipid droplet biogenesis and functions in health and disease","volume":"19","author":"Zadoorian","year":"2023","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.jlr.2023.100462_bib5","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.cmet.2006.03.005","article-title":"Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome","volume":"3","author":"Lass","year":"2006","journal-title":"Cell Metab."},{"key":"10.1016\/j.jlr.2023.100462_bib6","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202102136","article-title":"Lipid droplets in the nervous system","volume":"220","author":"Ralhan","year":"2021","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.jlr.2023.100462_bib7","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.devcel.2018.05.002","article-title":"Emerging links between lipid droplets and motor neuron diseases","volume":"45","author":"Pennetta","year":"2018","journal-title":"Dev. Cell"},{"key":"10.1016\/j.jlr.2023.100462_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.863907","article-title":"Functions of stress-induced lipid droplets in the nervous system","volume":"10","author":"Islimye","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.jlr.2023.100462_bib9","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1038\/s42255-021-00493-6","article-title":"Lipolysis: cellular mechanisms for lipid mobilization from fat stores","volume":"3","author":"Grabner","year":"2021","journal-title":"Nat. Metab."},{"key":"10.1016\/j.jlr.2023.100462_bib10","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.ajhg.2012.10.017","article-title":"Mutations in DDHD2, encoding an intracellular phospholipase A(1), cause a recessive form of complex hereditary spastic paraplegia","volume":"91","author":"Schuurs-Hoeijmakers","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jlr.2023.100462_bib11","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1038\/ejhg.2013.29","article-title":"Mutations in phospholipase DDHD2 cause autosomal recessive hereditary spastic paraplegia (SPG54)","volume":"21","author":"Gonzalez","year":"2013","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.jlr.2023.100462_bib12","first-page":"373","article-title":"Mutations in CYP2U1, DDHD2 and GBA2 genes are rare causes of complicated forms of hereditary spastic paraparesis","volume":"261","author":"Citterio","year":"2014","journal-title":"J.\u00a0Neurol."},{"key":"10.1016\/j.jlr.2023.100462_bib13","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1002\/acn3.51850","article-title":"Biallelic DDHD2 mutations in patients with adult-onset complex hereditary spastic paraplegia","volume":"10","author":"Chou","year":"2023","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.jlr.2023.100462_bib14","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1111\/j.1471-4159.2011.07498.x","article-title":"Adipose triglyceride lipase affects triacylglycerol metabolism at brain barriers","volume":"119","author":"Etschmaier","year":"2011","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.jlr.2023.100462_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101174","article-title":"Hypothalamic hormone-sensitive lipase regulates appetite and energy homeostasis","volume":"47","author":"Hundahl","year":"2021","journal-title":"Mol. Metab."},{"key":"10.1016\/j.jlr.2023.100462_bib16","doi-asserted-by":"crossref","first-page":"14924","DOI":"10.1073\/pnas.1413706111","article-title":"The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase","volume":"111","author":"Inloes","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jlr.2023.100462_bib17","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1021\/acs.biochem.7b01028","article-title":"Functional contribution of the spastic paraplegia-related triglyceride hydrolase DDHD2 to the formation and content of lipid droplets","volume":"57","author":"Inloes","year":"2018","journal-title":"Biochemistry"},{"key":"10.1016\/j.jlr.2023.100462_bib18","doi-asserted-by":"crossref","first-page":"11329","DOI":"10.1074\/jbc.M111092200","article-title":"A\u00a0novel phospholipase A1 with sequence homology to a mammalian Sec23p-interacting protein, p125","volume":"277","author":"Nakajima","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jlr.2023.100462_bib19","doi-asserted-by":"crossref","first-page":"4389","DOI":"10.1016\/j.febslet.2010.09.047","article-title":"Golgi-localized KIAA0725p regulates membrane trafficking from the Golgi apparatus to the plasma membrane in mammalian cells","volume":"584","author":"Sato","year":"2010","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jlr.2023.100462_bib20","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.bbamcr.2012.02.002","article-title":"Roles of SAM and DDHD domains in mammalian intracellular phospholipase A1 KIAA0725p","volume":"1823","author":"Inoue","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jlr.2023.100462_bib21","doi-asserted-by":"crossref","first-page":"100457","DOI":"10.1016\/j.jlr.2023.100457","article-title":"Cooperative lipolytic control of neuronal triacylglycerol by spastic paraplegia-associated enzyme DDHD2 and ATGL","volume":"64","author":"Hofer","year":"2023","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jlr.2023.100462_bib22","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202050214","article-title":"Neuronal lipolysis participates in PUFA-mediated neural function and neurodegeneration","volume":"21","author":"Yang","year":"2020","journal-title":"EMBO Rep."},{"key":"10.1016\/j.jlr.2023.100462_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000595","article-title":"A\u00a0role for triglyceride lipase brummer in the regulation of sex differences in Drosophila fat storage and breakdown","volume":"18","author":"Wat","year":"2020","journal-title":"PLoS Biol."},{"key":"10.1016\/j.jlr.2023.100462_bib24","doi-asserted-by":"crossref","first-page":"7362","DOI":"10.1038\/s41467-021-27365-7","article-title":"Lipid droplet availability affects neural stem\/progenitor cell metabolism and proliferation","volume":"12","author":"Ramosaj","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jlr.2023.100462_bib25","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.neuron.2019.10.009","article-title":"Rewiring neuronal glycerolipid metabolism determines the extent of axon regeneration","volume":"105","author":"Yang","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.jlr.2023.100462_bib26","doi-asserted-by":"crossref","first-page":"41446","DOI":"10.1074\/jbc.M112.400416","article-title":"Studies on the substrate and stereo\/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferases","volume":"287","author":"Eichmann","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jlr.2023.100462_bib27","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.1007\/s00018-015-1982-3","article-title":"DAG tales: the multiple faces of diacylglycerol--stereochemistry, metabolism, and signaling","volume":"72","author":"Eichmann","year":"2015","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.jlr.2023.100462_bib28","doi-asserted-by":"crossref","first-page":"4806","DOI":"10.1074\/jbc.M110355200","article-title":"Hormone-sensitive lipase deficiency in mice causes diglyceride accumulation in adipose tissue, muscle, and testis","volume":"277","author":"Haemmerle","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jlr.2023.100462_bib29","doi-asserted-by":"crossref","DOI":"10.1038\/srep23795","article-title":"Lipid-laden cells differentially distributed in the aging brain are functionally active and correspond to distinct phenotypes","volume":"6","author":"Shimabukuro","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jlr.2023.100462_bib30","doi-asserted-by":"crossref","first-page":"3610","DOI":"10.1210\/en.2015-1322","article-title":"Impact of reduced ATGL-mediated adipocyte lipolysis on obesity-associated insulin resistance and inflammation in male mice","volume":"156","author":"Schoiswohl","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.jlr.2023.100462_bib31","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.cmet.2017.09.002","article-title":"Lipolysis in Brown adipocytes is not essential for cold-induced thermogenesis in mice","volume":"26","author":"Shin","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.jlr.2023.100462_bib32","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.cmet.2017.09.004","article-title":"Cold-induced thermogenesis depends on ATGL-mediated lipolysis in cardiac muscle, but not Brown adipose tissue","volume":"26","author":"Schreiber","year":"2017","journal-title":"Cell Metab."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227523001359?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227523001359?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T18:33:22Z","timestamp":1758306802000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227523001359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":32,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S0022227523001359"],"URL":"https:\/\/doi.org\/10.1016\/j.jlr.2023.100462","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cooperation of acylglycerol hydrolases in neuronal lipolysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Lipid Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jlr.2023.100462","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"100462"}}