{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T08:06:10Z","timestamp":1791533170126,"version":"4.3.4"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21J40043"],"award-info":[{"award-number":["JP21J40043"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21K14472"],"award-info":[{"award-number":["JP21K14472"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22H01883"],"award-info":[{"award-number":["JP22H01883"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22H04993"],"award-info":[{"award-number":["JP22H04993"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22H05185"],"award-info":[{"award-number":["JP22H05185"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22K08627"],"award-info":[{"award-number":["JP22K08627"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22K18924"],"award-info":[{"award-number":["JP22K18924"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004096","name":"Kyushu University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004096","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jlr.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.jlr.2023.100492","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T13:34:30Z","timestamp":1703079270000},"page":"100492","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Wide-scope targeted analysis of bioactive lipids in human plasma by LC\/MS\/MS"],"prefix":"10.1016","volume":"65","author":[{"given":"Kohta","family":"Nakatani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4608-4652","authenticated-orcid":false,"given":"Yoshihiro","family":"Izumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4293-287X","authenticated-orcid":false,"given":"Hironobu","family":"Umakoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maki","family":"Yokomoto-Umakoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Nakaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6998-1917","authenticated-orcid":false,"given":"Hiroki","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Nakao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutaka","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Bamba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jlr.2023.100492_bib1","article-title":"Metabolomics for biomarker discovery: moving to the clinic","volume":"2015","author":"Zhang","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.jlr.2023.100492_bib2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jmsacl.2023.02.003","article-title":"Small molecule biomarker discovery: proposed workflow for LC-MS-based clinical research projects","volume":"28","author":"Rischke","year":"2023","journal-title":"J.\u00a0Mass Spectrom. Adv. Clin. Lab."},{"key":"10.1016\/j.jlr.2023.100492_bib3","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3390\/metabo10060224","article-title":"Current status of metabolomic biomarker discovery: impact of study design and demographic characteristics","volume":"10","author":"Tolstikov","year":"2020","journal-title":"Metabolites"},{"key":"10.1016\/j.jlr.2023.100492_bib4","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.18632\/aging.101837","article-title":"Longitudinal plasma metabolomics of aging and sex","volume":"11","author":"Darst","year":"2019","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.jlr.2023.100492_bib5","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3390\/metabo9090184","article-title":"Targeted clinical metabolite profiling platform for the stratification of diabetic patients","volume":"9","author":"Ahonen","year":"2019","journal-title":"Metabolites"},{"key":"10.1016\/j.jlr.2023.100492_bib6","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/pcn.12638","article-title":"Plasma metabolome analysis of patients with major depressive disorder","volume":"72","author":"Kawamura","year":"2018","journal-title":"Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.jlr.2023.100492_bib7","article-title":"Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review","volume":"194","author":"Schiffer","year":"2020","journal-title":"J.\u00a0Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jlr.2023.100492_bib8","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/j.jacc.2017.01.052","article-title":"Prevalence and clinical manifestations of primary aldosteronism encountered in primary care practice","volume":"69","author":"Monticone","year":"2017","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.jlr.2023.100492_bib9","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/cen.14320","article-title":"Significance of aldosterone gradient within left adrenal vein in diagnosing unilateral subtype of primary aldosteronism","volume":"94","author":"Ogata","year":"2021","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"10.1016\/j.jlr.2023.100492_bib10","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0140-6736(14)61375-1","article-title":"Cushing's syndrome","volume":"386","author":"Lacroix","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.jlr.2023.100492_bib11","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/jdi.13653","article-title":"Association between cortisol and left ventricular diastolic dysfunction in patients with diabetes mellitus","volume":"13","author":"Sagara","year":"2022","journal-title":"J.\u00a0Diabetes Investig."},{"key":"10.1016\/j.jlr.2023.100492_bib12","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/s41574-019-0221-7","article-title":"Adrenocortical carcinoma - towards genomics guided clinical care","volume":"15","author":"Crona","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.jlr.2023.100492_bib13","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1097\/gme.0b013e3181aa192d","article-title":"Progesterone and ovulation across stages of the transition to menopause","volume":"16","author":"O'Connor","year":"2009","journal-title":"Menopause"},{"key":"10.1016\/j.jlr.2023.100492_bib14","doi-asserted-by":"crossref","first-page":"4737","DOI":"10.1021\/bi00135a001","article-title":"Bile acid biosynthesis","volume":"31","author":"Russell","year":"1992","journal-title":"Biochemistry"},{"key":"10.1016\/j.jlr.2023.100492_bib15","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.3390\/nu14142964","article-title":"New insights into bile acids related signaling pathways in the onset of colorectal cancer","volume":"14","author":"Caliceti","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.jlr.2023.100492_bib16","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1042\/EBC20190083","article-title":"Eicosanoids","volume":"64","author":"Calder","year":"2020","journal-title":"Essays Biochem."},{"key":"10.1016\/j.jlr.2023.100492_bib17","doi-asserted-by":"crossref","DOI":"10.1194\/jlr.TR120000954","article-title":"Docosanoid signaling modulates corneal nerve regeneration: effect on tear secretion, wound healing, and neuropathic pain","volume":"62","author":"Pham","year":"2021","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2023.100492_bib18","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1002\/pmic.201400255","article-title":"Basics of mass spectrometry based metabolomics","volume":"14","author":"Courant","year":"2014","journal-title":"Proteomics"},{"key":"10.1016\/j.jlr.2023.100492_bib19","doi-asserted-by":"crossref","first-page":"16877","DOI":"10.1021\/acs.analchem.2c03986","article-title":"Unified-hydrophilic-interaction\/anion-exchange liquid chromatography mass spectrometry (unified-HILIC\/AEX\/MS): a single-run method for comprehensive and simultaneous analysis of polar metabolome","volume":"94","author":"Nakatani","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jlr.2023.100492_bib20","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1194\/jlr.D083014","article-title":"Widely-targeted quantitative lipidomics method by supercritical fluid chromatography triple quadrupole mass spectrometry","volume":"59","author":"Takeda","year":"2018","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2023.100492_bib21","doi-asserted-by":"crossref","first-page":"11997","DOI":"10.1021\/acs.jafc.0c04723","article-title":"Dynamic metabolome analysis reveals the metabolic fate of medium-chain fatty acids in AML12 cells","volume":"68","author":"Fushimi","year":"2020","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.jlr.2023.100492_bib22","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.chroma.2015.07.008","article-title":"Evaluation of steroidomics by liquid chromatography hyphenated to mass spectrometry as a powerful analytical strategy for measuring human steroid perturbations","volume":"1430","author":"Jeanneret","year":"2016","journal-title":"J.\u00a0Chromatogr. A"},{"key":"10.1016\/j.jlr.2023.100492_bib23","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/978-1-4939-7592-1_8","article-title":"LC-MS\/MS analysis of bile acids","volume":"1730","author":"Krautbauer","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jlr.2023.100492_bib24","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.bbrc.2018.06.026","article-title":"Profiling of bioactive lipids in different dendritic cell subsets using an improved multiplex quantitative LC-MS\/MS method","volume":"504","author":"Ohba","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jlr.2023.100492_bib25","doi-asserted-by":"crossref","first-page":"D1202","DOI":"10.1093\/nar\/gkv951","article-title":"PubChem substance and compound databases","volume":"44","author":"Kim","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jlr.2023.100492_bib26","doi-asserted-by":"crossref","first-page":"12292","DOI":"10.1021\/acs.analchem.2c02117","article-title":"Benchmarking one-phase lipid extractions for plasma lipidomics","volume":"94","author":"H\u00f6ring","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jlr.2023.100492_bib27","first-page":"15","article-title":"A\u00a0practical guide to sample preparation for liquid chromatography-tandem mass spectrometry in clinical research and toxicology","volume":"30","author":"Stone","year":"2018","journal-title":"Spectrosc. Eur."},{"key":"10.1016\/j.jlr.2023.100492_bib28","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.4155\/bio.12.73","article-title":"Recent advances in bioanalytical sample preparation for LC-MS analysis","volume":"4","author":"Singleton","year":"2012","journal-title":"Bioanalysis"},{"key":"10.1016\/j.jlr.2023.100492_bib29","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s10822-011-9440-2","article-title":"Online chemical modeling environment (OCHEM): web platform for data storage, model development and publishing of chemical information","volume":"25","author":"Sushko","year":"2011","journal-title":"J.\u00a0Comput. Aided Mol. Des."},{"key":"10.1016\/j.jlr.2023.100492_bib30","doi-asserted-by":"crossref","first-page":"W388","DOI":"10.1093\/nar\/gkab382","article-title":"MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights","volume":"49","author":"Pang","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jlr.2023.100492_bib31","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/chromsci\/27.12.721","article-title":"Chromatographic characterization of silica C18 packing materials. Correlation between a preparation method and retention behavior of stationary phase","volume":"27","author":"Kimata","year":"1989","journal-title":"J.\u00a0Chromatogr. Sci."},{"key":"10.1016\/j.jlr.2023.100492_bib32","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jchromb.2015.05.015","article-title":"A\u00a0comprehensive quantification method for eicosanoids and related compounds by using liquid chromatography\/mass spectrometry with high speed continuous ionization polarity switching","volume":"995-996","author":"Yamada","year":"2015","journal-title":"J.\u00a0Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jlr.2023.100492_bib33","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1177\/1535370214554545","article-title":"Matrix effects break the LC behavior rule for analytes in LC-MS\/MS analysis of biological samples","volume":"240","author":"Fang","year":"2015","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.jlr.2023.100492_bib34","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jbiosc.2021.09.009","article-title":"Quantitative metabolomics for dynamic metabolic engineering using stable isotope labeled internal standards mixture (SILIS)","volume":"133","author":"Soma","year":"2022","journal-title":"J.\u00a0Biosci. Bioeng."},{"key":"10.1016\/j.jlr.2023.100492_bib35","doi-asserted-by":"crossref","first-page":"676","DOI":"10.3390\/ijerph18020676","article-title":"Cortisol on circadian rhythm and its effect on cardiovascular system","volume":"18","author":"Mohd Azmi","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227523001657?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227523001657?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T21:57:08Z","timestamp":1762207028000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227523001657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["S0022227523001657"],"URL":"https:\/\/doi.org\/10.1016\/j.jlr.2023.100492","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Wide-scope targeted analysis of bioactive lipids in human plasma by LC\/MS\/MS","name":"articletitle","label":"Article Title"},{"value":"Journal of Lipid Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jlr.2023.100492","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"100492"}}