{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:52:34Z","timestamp":1786992754086,"version":"build-2736575974"},"reference-count":69,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["jlr.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jlr.2024.100728","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T01:20:39Z","timestamp":1733966439000},"page":"100728","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["The role of high-density lipoproteins in sepsis"],"prefix":"10.1016","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3686-3807","authenticated-orcid":false,"given":"Liam R.","family":"Brunham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jlr.2024.100728_bib1","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1056\/NEJMoa1107579","article-title":"Niacin in patients with low hdl cholesterol levels receiving intensive statin therapy","volume":"365","author":"Boden","year":"2011","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.jlr.2024.100728_bib2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1056\/NEJMoa1300955","article-title":"Effects of extended-release niacin with laropiprant in high-risk patients","volume":"371","author":"Group","year":"2014","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.jlr.2024.100728_bib3","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1056\/NEJMoa0706628","article-title":"Effects of torcetrapib in patients at high risk for coronary events","volume":"357","author":"Barter","year":"2007","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.jlr.2024.100728_bib4","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1056\/NEJMoa1206797","article-title":"Effects of dalcetrapib in patients with a recent acute coronary syndrome","volume":"367","author":"Schwartz","year":"2012","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.jlr.2024.100728_bib5","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1056\/NEJMoa1609581","article-title":"Evacetrapib and cardiovascular outcomes in high-risk vascular disease","volume":"376","author":"Lincoff","year":"2017","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.jlr.2024.100728_bib6","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1056\/NEJMoa1706444","article-title":"Effects of anacetrapib in patients with atherosclerotic vascular disease","volume":"377","author":"Group","year":"2017","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.jlr.2024.100728_bib7","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1056\/NEJMoa2400969","article-title":"Apolipoprotein a1 infusions and cardiovascular outcomes after acute myocardial infarction","volume":"390","author":"Gibson","year":"2024","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.jlr.2024.100728_bib8","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1128\/IAI.71.6.3280-3284.2003","article-title":"Distribution and kinetics of lipoprotein-bound lipoteichoic acid","volume":"71","author":"Levels","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jlr.2024.100728_bib9","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1128\/IAI.69.5.2821-2828.2001","article-title":"Distribution and kinetics of lipoprotein-bound endotoxin","volume":"69","author":"Levels","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jlr.2024.100728_bib10","doi-asserted-by":"crossref","first-page":"17947","DOI":"10.1074\/jbc.M112.442699","article-title":"High density lipoprotein protects against polymicrobe-induced sepsis in mice","volume":"288","author":"Guo","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jlr.2024.100728_bib11","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.cmet.2016.10.013","article-title":"High-density lipoproteins exert pro-inflammatory effects on macrophages via passive cholesterol depletion and pkc-nf-kappab\/stat1-irf1 signaling","volume":"25","author":"van der Vorst","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.jlr.2024.100728_bib12","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/ni.2784","article-title":"High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator atf3","volume":"15","author":"De Nardo","year":"2014","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jlr.2024.100728_bib13","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1161\/ATVBAHA.106.136325","article-title":"High-density lipoprotein attenuates inflammation and coagulation response on endotoxin challenge in humans","volume":"27","author":"Birjmohun","year":"2007","journal-title":"Arterioscler Thromb. Vasc. Biol."},{"key":"10.1016\/j.jlr.2024.100728_bib14","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s13054-020-02860-3","article-title":"High-density lipoproteins during sepsis: from bench to bedside","volume":"24","author":"Tanaka","year":"2020","journal-title":"Crit. Care"},{"key":"10.1016\/j.jlr.2024.100728_bib15","doi-asserted-by":"crossref","first-page":"12965","DOI":"10.3390\/ijms232112965","article-title":"Impact of high-density lipoproteins on sepsis","volume":"23","author":"De Geest","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jlr.2024.100728_bib16","doi-asserted-by":"crossref","first-page":"R592","DOI":"10.1016\/j.cub.2019.04.057","article-title":"The phylogeny and evolutionary history of arthropods","volume":"29","author":"Giribet","year":"2019","journal-title":"Curr. Biol."},{"key":"10.1016\/j.jlr.2024.100728_bib17","series-title":"Subcellular Biochem","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-030-41769-7","article-title":"Vertebrate and invertebrate respiratory proteins, lipoproteins and other body fluid proteins","author":"Hoeger","year":"2020"},{"key":"10.1016\/j.jlr.2024.100728_bib18","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S0022-2275(20)34780-5","article-title":"Animal lipoproteins: chemistry, structure, and comparative aspects","volume":"21","author":"Chapman","year":"1980","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2024.100728_bib19","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1093\/eurheartj\/ehac605","article-title":"High-density lipoprotein revisited: biological functions and clinical relevance","volume":"44","author":"von Eckardstein","year":"2023","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.jlr.2024.100728_bib20","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1093\/eurheartj\/ehx665","article-title":"U-shaped relationship of hdl and risk of infectious disease: two prospective population-based cohort studies","volume":"39","author":"Madsen","year":"2018","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.jlr.2024.100728_bib21","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.jcrc.2016.11.041","article-title":"Decreased high-density lipoprotein cholesterol level is an early prognostic marker for organ dysfunction and death in patients with suspected sepsis","volume":"38","author":"Cirstea","year":"2017","journal-title":"J.\u00a0Crit. Care"},{"key":"10.1016\/j.jlr.2024.100728_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.104981","article-title":"Low circulatory levels of total cholesterol, hdl-c and ldl-c are associated with death of patients with sepsis and critical illness: systematic review, meta-analysis, and perspective of observational studies","volume":"100","author":"Taylor","year":"2024","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jlr.2024.100728_bib23","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1161\/ATVBAHA.108.179317","article-title":"Proteomics of apolipoproteins and associated proteins from plasma high-density lipoproteins","volume":"30","author":"Davidsson","year":"2010","journal-title":"Arterioscler Thromb. Vasc. Biol."},{"key":"10.1016\/j.jlr.2024.100728_bib24","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1161\/ATVBAHA.113.301468","article-title":"Small, dense high-density lipoprotein-3 particles are enriched in negatively charged phospholipids: relevance to cellular cholesterol efflux, antioxidative, antithrombotic, anti-inflammatory, and antiapoptotic functionalities","volume":"33","author":"Camont","year":"2013","journal-title":"Arterioscler Thromb. Vasc. Biol."},{"key":"10.1016\/j.jlr.2024.100728_bib25","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/ncpcardio0500","article-title":"Antiatherogenic small, dense hdl--guardian angel of the arterial wall?","volume":"3","author":"Kontush","year":"2006","journal-title":"Nat. Clin. Pract. Cardiovasc. Med."},{"key":"10.1016\/j.jlr.2024.100728_bib26","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s13613-019-0541-8","article-title":"High-density lipoprotein (hdl) particle size and concentration changes in septic shock patients","volume":"9","author":"Tanaka","year":"2019","journal-title":"Ann. Intensive Care"},{"key":"10.1016\/j.jlr.2024.100728_bib27","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1093\/cvr\/cvac194","article-title":"Lower levels of small hdl particles associated with increased infectious disease morbidity and mortality: a population-based cohort study of 30 195 individuals","volume":"119","author":"Harslof","year":"2023","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.jlr.2024.100728_bib28","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1186\/s13054-023-04589-1","article-title":"Low levels of small hdl particles predict but do not influence risk of sepsis","volume":"27","author":"Hamilton","year":"2023","journal-title":"Crit. Care"},{"key":"10.1016\/j.jlr.2024.100728_bib29","first-page":"E49","article-title":"Tissue specific deletion of enterocyte abca1 identifies the intestine as a significant source of plasma hdl cholesterol in\u00a0vivo","volume":"25","author":"Brunham","year":"2005","journal-title":"Arteriosclerosis Thromb. Vasc. Biol."},{"key":"10.1016\/j.jlr.2024.100728_bib30","doi-asserted-by":"crossref","DOI":"10.1126\/science.abe6729","article-title":"Enterically derived high-density lipoprotein restrains liver injury through the portal vein","volume":"373","author":"Han","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.jlr.2024.100728_bib31","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1002\/sim.3034","article-title":"Mendelian randomization: using genes as instruments for making causal inferences in epidemiology","volume":"27","author":"Lawlor","year":"2008","journal-title":"Stat. Med."},{"key":"10.1016\/j.jlr.2024.100728_bib32","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1161\/ATVBAHA.119.313381","article-title":"Causal inference for genetically determined levels of high-density lipoprotein cholesterol and risk of infectious disease","volume":"40","author":"Trinder","year":"2020","journal-title":"Arterioscler Thromb. Vasc. Biol."},{"key":"10.1016\/j.jlr.2024.100728_bib33","doi-asserted-by":"crossref","first-page":"12040","DOI":"10.1073\/pnas.90.24.12040","article-title":"In\u00a0vivo protection against endotoxin by plasma high density lipoprotein","volume":"90","author":"Levine","year":"1993","journal-title":"Proc. Natl. Acad Sci. U. S. A."},{"key":"10.1016\/j.jlr.2024.100728_bib34","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1126\/science.271.5248.518","article-title":"Identification of scavenger receptor sr-bi as a high density lipoprotein receptor","volume":"271","author":"Acton","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.jlr.2024.100728_bib35","doi-asserted-by":"crossref","first-page":"16888","DOI":"10.1073\/pnas.0602126103","article-title":"Cla-1 and its splicing variant cla-2 mediate bacterial adhesion and cytosolic bacterial invasion in mammalian cells","volume":"103","author":"Vishnyakova","year":"2006","journal-title":"Proc. Natl. Acad Sci. U. S. A"},{"key":"10.1016\/j.jlr.2024.100728_bib36","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1172\/JCI31539","article-title":"Sr-bi protects against endotoxemia in mice through its roles in glucocorticoid production and hepatic clearance","volume":"118","author":"Cai","year":"2008","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.jlr.2024.100728_bib37","doi-asserted-by":"crossref","first-page":"19826","DOI":"10.1074\/jbc.M109.020933","article-title":"Scavenger receptor bi protects against septic death through its role in modulating inflammatory response","volume":"284","author":"Guo","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jlr.2024.100728_bib38","doi-asserted-by":"crossref","first-page":"14666","DOI":"10.1074\/jbc.M113.537258","article-title":"Hepatic scavenger receptor bi protects against polymicrobial-induced sepsis through promoting lps clearance in mice","volume":"289","author":"Guo","year":"2014","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jlr.2024.100728_bib39","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1146\/annurev-physiol-021317-121550","article-title":"Sr-b1: a unique multifunctional receptor for cholesterol influx and efflux","volume":"80","author":"Shen","year":"2018","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.jlr.2024.100728_bib40","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/jb\/mvn176","article-title":"Signalling pathway involving gulp, mapk and rac1 for sr-bi-induced phagocytosis of apoptotic cells","volume":"145","author":"Osada","year":"2009","journal-title":"J.\u00a0Biochem."},{"key":"10.1016\/j.jlr.2024.100728_bib41","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0021-9150(01)00447-6","article-title":"The impact of phospholipid transfer protein (pltp) on hdl metabolism","volume":"155","author":"Huuskonen","year":"2001","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jlr.2024.100728_bib42","article-title":"The binding capability of plasma phospholipid transfer protein, but not hdl pool size, is critical to repress lps induced inflammation","volume":"6","author":"Yu","year":"2016","journal-title":"Scientific Rep."},{"key":"10.1016\/j.jlr.2024.100728_bib43","doi-asserted-by":"crossref","first-page":"H866","DOI":"10.1152\/ajpheart.01232.2008","article-title":"Apolipoprotein a-i mimetic peptide treatment inhibits inflammatory responses and improves survival in septic rats","volume":"297","author":"Zhang","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.jlr.2024.100728_bib44","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.abl9322","article-title":"Replenishing hdl with synthetic hdl has multiple protective effects against sepsis in mice","volume":"15","author":"Guo","year":"2022","journal-title":"Sci. Signaling"},{"key":"10.1016\/j.jlr.2024.100728_bib45","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1001\/archsurg.1994.01420260089012","article-title":"Reconstituted high density lipoprotein inhibits physiologic and tumor necrosis factor alpha responses to lipopolysaccharide in rabbits","volume":"129","author":"Cue","year":"1994","journal-title":"Arch. Surg."},{"key":"10.1016\/j.jlr.2024.100728_bib46","first-page":"14","article-title":"A\u00a0reconstituted, apolipoprotein a-i containing lipoprotein reduces tumor necrosis factor release and attenuates shock in endotoxemic rabbits","volume":"40","author":"Hubsch","year":"1993","journal-title":"Circ. Shock"},{"key":"10.1016\/j.jlr.2024.100728_bib47","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1097\/ALN.0000000000003155","article-title":"Reconstituted high-density lipoprotein therapy improves survival in mouse models of sepsis","volume":"132","author":"Tanaka","year":"2020","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jlr.2024.100728_bib48","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1164\/rccm.201806-1157OC","article-title":"Cholesteryl ester transfer protein influences high-density lipoprotein levels and survival in sepsis","volume":"199","author":"Trinder","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jlr.2024.100728_bib49","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1161\/CIRCULATIONAHA.120.048568","article-title":"Inhibition of cholesteryl ester transfer protein preserves high-density lipoprotein cholesterol and improves survival in sepsis","volume":"143","author":"Trinder","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.jlr.2024.100728_bib50","article-title":"Cetp genetic variant rs1800777 (allele a) is associated with abnormally low hdl-c levels and increased risk of aki during sepsis","volume":"8","author":"Genga","year":"2018","journal-title":"Scientific Rep."},{"key":"10.1016\/j.jlr.2024.100728_bib51","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40635-016-0096-z","article-title":"Sepsis modeling in mice: ligation length is a major severity factor in cecal ligation and puncture","volume":"4","author":"Ruiz","year":"2016","journal-title":"Intensive Care Med. Exp."},{"key":"10.1016\/j.jlr.2024.100728_bib52","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the global burden of disease study","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.jlr.2024.100728_bib53","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.173205","article-title":"Cetp inhibition enhances monocyte activation and bacterial clearance and reduces streptococcus pneumonia-associated mortality in mice","volume":"9","author":"Deng","year":"2024","journal-title":"JCI Insight"},{"key":"10.1016\/j.jlr.2024.100728_bib54","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1161\/CIRCRESAHA.119.312617","article-title":"Hdl and reverse cholesterol transport","volume":"124","author":"Ouimet","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.jlr.2024.100728_bib55","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.plipres.2015.01.001","article-title":"Human genetics of hdl: insight into particle metabolism and function","volume":"58","author":"Brunham","year":"2015","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.jlr.2024.100728_bib56","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1053\/j.gastro.2007.06.019","article-title":"Direct intestinal cholesterol secretion contributes significantly to total fecal neutral sterol excretion in mice","volume":"133","author":"van der Velde","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jlr.2024.100728_bib57","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1194\/jlr.M007435","article-title":"Abca1 promotes the efflux of bacterial lps from macrophages and accelerates recovery from lps-induced tolerance","volume":"51","author":"Thompson","year":"2010","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2024.100728_bib58","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1161\/CIRCRESAHA.110.217281","article-title":"Abca1 and abcg1 protect against oxidative stress-induced macrophage apoptosis during efferocytosis","volume":"106","author":"Yvan-Charvet","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.jlr.2024.100728_bib59","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.1194\/jlr.M006486","article-title":"Macrophage abca1 reduces myd88-dependent toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol","volume":"51","author":"Zhu","year":"2010","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2024.100728_bib60","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1194\/jlr.M600428-JLR200","article-title":"Increased lipid rafts and accelerated lipopolysaccharide-induced tumor necrosis factor-alpha secretion in abca1-deficient macrophages","volume":"48","author":"Koseki","year":"2007","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2024.100728_bib61","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.tem.2012.02.001","article-title":"Crosstalk between reverse cholesterol transport and innate immunity","volume":"23","author":"Azzam","year":"2012","journal-title":"Trends in endocrinology and metabolism: TEM"},{"key":"10.1016\/j.jlr.2024.100728_bib62","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1161\/CIRCULATIONAHA.108.810721","article-title":"Inflammation impairs reverse cholesterol transport in\u00a0vivo","volume":"119","author":"McGillicuddy","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.jlr.2024.100728_bib63","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1194\/jlr.E005454","article-title":"The acute phase response inhibits reverse cholesterol transport","volume":"51","author":"Feingold","year":"2010","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2024.100728_bib64","doi-asserted-by":"crossref","first-page":"143","DOI":"10.4161\/viru.26083","article-title":"Animal models of sepsis","volume":"5","author":"Fink","year":"2014","journal-title":"Virulence"},{"key":"10.1016\/j.jlr.2024.100728_bib65","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1194\/jlr.M002295","article-title":"Assessment of cholesteryl ester transfer protein inhibitors for interaction with proteins involved in the immune response to infection","volume":"51","author":"Clark","year":"2010","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jlr.2024.100728_bib66","doi-asserted-by":"crossref","first-page":"491","DOI":"10.2165\/11599310-000000000-00000","article-title":"On- and off-target pharmacology of torcetrapib: current understanding and implications for the structure activity relationships (sar), discovery and development of cholesteryl ester-transfer protein (cetp) inhibitors","volume":"72","author":"Johns","year":"2012","journal-title":"Drugs"},{"key":"10.1016\/j.jlr.2024.100728_bib67","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1084\/jem.184.5.1601","article-title":"Antiinflammatory effects of reconstituted high-density lipoprotein during human endotoxemia","volume":"184","author":"Pajkrt","year":"1996","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.jlr.2024.100728_bib68","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1186\/s12916-023-03057-5","article-title":"Beneficial effects of recombinant cer-001 high-density lipoprotein infusion in sepsis: results from a bench to bedside translational research project","volume":"21","author":"Stasi","year":"2023","journal-title":"BMC Med."},{"key":"10.1016\/j.jlr.2024.100728_bib69","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1097\/CCM.0000000000006268","article-title":"The lipid intensive drug therapy for sepsis phase II pilot clinical trial","volume":"52","author":"Guirgis","year":"2024","journal-title":"Crit. Care Med."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227524002335?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227524002335?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T16:19:21Z","timestamp":1738081161000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227524002335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":69,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S0022227524002335"],"URL":"https:\/\/doi.org\/10.1016\/j.jlr.2024.100728","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of high-density lipoproteins in sepsis","name":"articletitle","label":"Article Title"},{"value":"Journal of Lipid Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jlr.2024.100728","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"100728"}}