{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:46:24Z","timestamp":1791600384182,"version":"4.3.4"},"reference-count":15,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jlr.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.jlr.2025.100796","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T19:26:29Z","timestamp":1743881189000},"page":"100796","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["HDL meets triglyceride"],"prefix":"10.1016","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4320-222X","authenticated-orcid":false,"given":"Tugce","family":"Akcan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2468-7807","authenticated-orcid":false,"given":"Fredric B.","family":"Kraemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jlr.2025.100796_bib1","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/0002-9343(77)90874-9","article-title":"High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study","volume":"62","author":"Gordon","year":"1977","journal-title":"Am. J. Med."},{"key":"10.1016\/j.jlr.2025.100796_bib2","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/S0140-6736(77)92274-7","article-title":"The Tromso heart-study. High- density lipoprotein and coronary heart-disease: a prospective case-control study","volume":"1","author":"Miller","year":"1977","journal-title":"Lancet"},{"key":"10.1016\/j.jlr.2025.100796_bib3","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1161\/01.CIR.79.1.8","article-title":"High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies","volume":"79","author":"Gordon","year":"1989","journal-title":"Circulation"},{"key":"10.1016\/j.jlr.2025.100796_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0094585","article-title":"Effect of HDL-raising drugs on cardiovascular outcomes: a systematic review and metaregression","volume":"9","author":"Kaur","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jlr.2025.100796_bib5","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1001\/jamacardio.2022.0912","article-title":"Association between high-density lipoprotein cholesterol levels and adverse cardiovascular outcomes in high-risk populations","volume":"7","author":"Liu","year":"2022","journal-title":"JAMA Cardiol."},{"key":"10.1016\/j.jlr.2025.100796_bib6","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0140-6736(12)60312-2","article-title":"Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study","volume":"380","author":"Voight","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.jlr.2025.100796_bib7","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1161\/CIRCULATIONAHA.106.637793","article-title":"Triglycerides and the risk of coronary heart disease: 10,158 incident cases among 262,525 participants in 29 Western prospective studies","volume":"115","author":"Sarwar","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jlr.2025.100796_bib8","doi-asserted-by":"crossref","DOI":"10.1038\/srep19249","article-title":"Lipoprotein hydrophobic core lipids are partially extruded to surface in smaller HDL: \"Herniated\" HDL, a common feature in diabetes","volume":"6","author":"Amig\u00f3","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jlr.2025.100796_bib9","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.atherosclerosis.2008.07.047","article-title":"Acute hypertriglyceridaemia in humans increases the triglyceride content and decreases the anti-inflammatory capacity of high density lipoproteins","volume":"204","author":"Patel","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jlr.2025.100796_bib10","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.3390\/ijms20133151","article-title":"HDL triglycerides: a new marker of metabolic and cardiovascular risk","volume":"20","author":"Girona","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jlr.2025.100796_bib11","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1124\/pr.58.3.1","article-title":"Functionally defective high-density lipoprotein: a new therapeutic target at the crossroads of dyslipidemia, inflammation, and atherosclerosis","volume":"58","author":"Kontush","year":"2006","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.jlr.2025.100796_bib12","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0009-9120(03)00078-X","article-title":"Mechanisms of HDL lowering in insulin resistant, hypertriglyceridemic states: the combined effect of HDL triglyceride enrichment and elevated hepatic lipase activity","volume":"36","author":"Rashid","year":"2003","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.jlr.2025.100796_bib13","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1161\/CIRCULATIONAHA.120.044221","article-title":"HDL in the 21st century: a multifunctional roadmap for future HDL research","volume":"143","author":"Rohatgi","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.jlr.2025.100796_bib14","doi-asserted-by":"crossref","first-page":"802","DOI":"10.7326\/0003-4819-139-10-200311180-00007","article-title":"Use of metabolic markers to identify overweight individuals who are insulin resistant","volume":"139","author":"McLaughlin","year":"2003","journal-title":"Ann. Int. Med."},{"key":"10.1016\/j.jlr.2025.100796_bib15","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jacl.2022.02.007","article-title":"Concerns regarding NMR lipoprotein analyses performed on the Nightingale heath platform - focus on LDL subclasses","volume":"16","author":"Krauss","year":"2022","journal-title":"J. Clin. Lipidol."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227525000562?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227525000562?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T04:33:41Z","timestamp":1754973221000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227525000562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S0022227525000562"],"URL":"https:\/\/doi.org\/10.1016\/j.jlr.2025.100796","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HDL meets triglyceride","name":"articletitle","label":"Article Title"},{"value":"Journal of Lipid Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jlr.2025.100796","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.jlr.2025.100791","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology\u00e9","name":"copyright","label":"Copyright"}],"article-number":"100796"}}