{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:41:14Z","timestamp":1790185274566,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000233","name":"Genome British Columbia","doi-asserted-by":"publisher","award":["365MET"],"award-info":[{"award-number":["365MET"]}],"id":[{"id":"10.13039\/501100000233","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000233","name":"Genome British Columbia","doi-asserted-by":"publisher","award":["375MET"],"award-info":[{"award-number":["375MET"]}],"id":[{"id":"10.13039\/501100000233","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019114","name":"Fondation de l\u2019H\u00f4pital Saint-Boniface","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019114","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004411","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jlr.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.jlr.2025.100830","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T02:40:48Z","timestamp":1747881648000},"page":"100830","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Conjugated bile acids are elevated in severe calcific aortic valve stenosis"],"prefix":"10.1016","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8123-4785","authenticated-orcid":false,"given":"Hannah","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negar","family":"Atefi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Surendran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Goodlett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davinder S.","family":"Jassal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6663-1225","authenticated-orcid":false,"given":"Amir","family":"Ravandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jlr.2025.100830_bib1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1056\/NEJM199907153410302","article-title":"Association of aortic-valve sclerosis with cardiovascular mortality and morbidity in the elderly","volume":"341","author":"Otto","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jlr.2025.100830_bib2","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S0735-1097(96)00563-3","article-title":"Study for the CH Clinical factors associated with calcific aortic valve disease fn1fn1This study was supported in part by contracts NO1-HC85079 through HC-850086 from the National heart, lung, and blood institute","volume":"29","author":"Stewart","year":"1997","journal-title":"Natl. Institutes Health Bethesda, Md. J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jlr.2025.100830_bib3","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1161\/CIRCULATIONAHA.104.486738","article-title":"Spectrum of calcific aortic valve disease","volume":"111","author":"Freeman","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jlr.2025.100830_bib4","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/0735-1097(94)90606-8","article-title":"Accumulation of T lymphocytes and expression of interleukin-2 receptors in nonrheumatic stenotic aortic valves","volume":"23","author":"Olsson","year":"1994","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jlr.2025.100830_bib5","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1161\/01.ATV.16.4.523","article-title":"Apolipoproteins B, (a), and E accumulate in the morphologically early lesion of \u2018degenerative\u2019 valvular aortic stenosis","volume":"16","author":"O\u2019Brien","year":"1996","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jlr.2025.100830_bib6","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1161\/01.ATV.19.5.1218","article-title":"Presence of oxidized low density lipoprotein in nonrheumatic stenotic aortic valves","volume":"19","author":"Olsson","year":"1999","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jlr.2025.100830_bib7","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1136\/heart.88.4.348","article-title":"T lymphocyte infiltration in non-rheumatic aortic stenosis: a comparative descriptive study between tricuspid and bicuspid aortic valves","volume":"88","author":"Wallby","year":"2002","journal-title":"Heart"},{"key":"10.1016\/j.jlr.2025.100830_bib8","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.123.015247","article-title":"Unlocking the secrets of subclinical calcific aortic valve disease and heart failure","volume":"16","author":"Sharma","year":"2023","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"10.1016\/j.jlr.2025.100830_bib9","first-page":"1163","article-title":"Metabolomic signature of human aortic valve stenosis","volume":"5","author":"Surendran","year":"2020","journal-title":"Jacc: Basic Transl. Sci."},{"key":"10.1016\/j.jlr.2025.100830_bib10","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1002\/j.2040-4603.2013.tb00517.x","article-title":"Bile acid metabolism and signalling","volume":"3","author":"Chiang","year":"2013","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.jlr.2025.100830_bib11","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.2147\/CIA.S431220","article-title":"Bile acid network and vascular calcification-associated diseases: unraveling the intricate connections and therapeutic potential","volume":"18","author":"Wang","year":"2023","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.jlr.2025.100830_bib12","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1161\/CIR.0000000000000029","article-title":"2014 AHA\/ACC guideline for the management of patients with valvular heart disease: executive summary","volume":"129","author":"Nishimura","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.jlr.2025.100830_bib13","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/cpf.12166","article-title":"Aortic valve type and calcification as assessed by transthoracic and transoesophageal echocardiography","volume":"35","author":"Yousry","year":"2015","journal-title":"Clin. Physiol. Funct. Imaging"},{"key":"10.1016\/j.jlr.2025.100830_bib14","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/j.1475-097X.2012.01153.x","article-title":"Real-time imaging required for optimal echocardiographic assessment of aortic valve calcification","volume":"32","author":"Yousry","year":"2012","journal-title":"Clin. Physiol. Funct. Imaging"},{"key":"10.1016\/j.jlr.2025.100830_bib15","article-title":"Association of fontan pathophysiology with plasma bile acids","volume":"4","author":"Shah","year":"2025","journal-title":"JACC: Adv."},{"key":"10.1016\/j.jlr.2025.100830_bib16","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1021\/ac503816u","article-title":"Metabolic profiling of bile acids in human and mouse blood by LC\u2013MS\/MS in combination with phospholipid-depletion solid-phase extraction","volume":"87","author":"Han","year":"2015","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jlr.2025.100830_bib17","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1111\/liv.13714","article-title":"Comprehensive bile acid profiling in hereditary intrahepatic cholestasis: genetic and clinical correlations","volume":"38","author":"Liu","year":"2018","journal-title":"Liver Int."},{"key":"10.1016\/j.jlr.2025.100830_bib18","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1001\/archinte.159.22.2647","article-title":"The continuing importance of bile acids in liver and intestinal disease","volume":"159","author":"Hofmann","year":"1999","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.jlr.2025.100830_bib19","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1002\/hep.25839","article-title":"Crosstalk between the hepatologist and the cardiologist: a future place for the lithocholic acid as a coronary atheroma risk factor?","volume":"56","author":"Duboc","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.jlr.2025.100830_bib20","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.atherosclerosis.2019.11.026","article-title":"Fasting serum total bile acid level is associated with coronary artery disease, myocardial infarction and severity of coronary lesions","volume":"292","author":"Li","year":"2020","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jlr.2025.100830_bib21","doi-asserted-by":"crossref","first-page":"308","DOI":"10.12998\/wjcc.v9.i2.308","article-title":"Overview of bile acid signaling in the cardiovascular system","volume":"9","author":"Zhang","year":"2021","journal-title":"World J. Clin. Cases."},{"key":"10.1016\/j.jlr.2025.100830_bib22","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1042\/BST20130279","article-title":"TGR5 in inflammation and cardiovascular disease","volume":"42","author":"Pols","year":"2014","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.jlr.2025.100830_bib23","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s11883-020-0821-7","article-title":"Calcific aortic valve stenosis and atherosclerotic calcification","volume":"22","author":"de S\u00e1","year":"2020","journal-title":"Curr. Atheroscler. Rep."},{"key":"10.1016\/j.jlr.2025.100830_bib24","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.molmed.2021.12.006","article-title":"Crosstalk between bile acid-activated receptors and microbiome in entero-hepatic inflammation","volume":"28","author":"Thibaut","year":"2022","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.jlr.2025.100830_bib25","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.cmet.2011.11.006","article-title":"TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading","volume":"14","author":"Pols","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.jlr.2025.100830_bib26","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1124\/pr.113.008201","article-title":"Bile acid signaling in metabolic disease and drug therapy","volume":"66","author":"Li","year":"2014","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.jlr.2025.100830_bib27","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3164\/jcbn.13-46","article-title":"The involvement of endoplasmic reticulum stress in bile acid-induced hepatocellular injury","volume":"54","author":"Adachi","year":"2014","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.jlr.2025.100830_bib28","doi-asserted-by":"crossref","first-page":"857","DOI":"10.34067\/KID.0007502020","article-title":"Free deoxycholic acid exacerbates vascular calcification in CKD through ER stress-mediated ATF4 activation","volume":"2","author":"Miyazaki-Anzai","year":"2021","journal-title":"Kidney360"},{"key":"10.1016\/j.jlr.2025.100830_bib29","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.kint.2020.01.032","article-title":"Lithocholic acid increases intestinal phosphate and calcium absorption in a vitamin D receptor dependent but transcellular pathway independent manner","volume":"97","author":"Hashimoto","year":"2020","journal-title":"Kidney Int."},{"key":"10.1016\/j.jlr.2025.100830_bib30","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1053\/j.ajkd.2017.06.017","article-title":"Deoxycholic acid, a metabolite of circulating bile acids, and coronary artery vascular calcification in CKD","volume":"71","author":"Jovanovich","year":"2018","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.jlr.2025.100830_bib31","doi-asserted-by":"crossref","first-page":"279","DOI":"10.34067\/KID.0004422020","article-title":"Identification of novel biomarkers and pathways for coronary artery calcification in nondiabetic patients on hemodialysis using metabolomic profiling","volume":"2","author":"Chen","year":"2021","journal-title":"Kidney360"},{"key":"10.1016\/j.jlr.2025.100830_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.xkme.2021.09.004","article-title":"Deoxycholic acid and risks of cardiovascular events, ESKD, and mortality in CKD: the CRIC study","volume":"4","author":"Frazier","year":"2022","journal-title":"Kidney Med."},{"key":"10.1016\/j.jlr.2025.100830_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0025006","article-title":"Bile acid metabolites in serum: intraindividual variation and associations with coronary heart disease, metabolic syndrome and diabetes mellitus","volume":"6","author":"Steiner","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jlr.2025.100830_bib34","doi-asserted-by":"crossref","first-page":"306","DOI":"10.5543\/tkda.2023.38141","article-title":"What is the impact of liver function to predict mortality in patients with severe aortic stenosis and reduced ejection fraction?","volume":"51","author":"\u00d6zcan","year":"2023","journal-title":"Turk Kardiyol. Dernegi Arsivi-arch. Turk. Soc. Cardiol."},{"key":"10.1016\/j.jlr.2025.100830_bib35","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1080\/00015385.2020.1853968","article-title":"Association of dietary and gut microbiota-related metabolites with calcific aortic stenosis","volume":"76","author":"Kocyigit","year":"2021","journal-title":"Acta Cardiol."},{"key":"10.1016\/j.jlr.2025.100830_bib36","doi-asserted-by":"crossref","DOI":"10.1111\/eci.14381","article-title":"A scoping review evaluating the current state of gut microbiota and its metabolites in valvular heart disease physiopathology","volume":"55","author":"Chong-Nguyen","year":"2025","journal-title":"Eur. J. Clin. Investig."},{"key":"10.1016\/j.jlr.2025.100830_bib37","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1194\/jlr.R900010-JLR200","article-title":"Bile acids: regulation of synthesis thematic review series: bile acids","volume":"50","author":"Chiang","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jlr.2025.100830_bib38","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1097\/HJH.0000000000003423","article-title":"Conjugated bile acids are nutritionally re-programmable antihypertensive metabolites","volume":"41","author":"Chakraborty","year":"2023","journal-title":"J. Hypertens."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227525000902?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227525000902?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T21:57:20Z","timestamp":1762207040000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227525000902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S0022227525000902"],"URL":"https:\/\/doi.org\/10.1016\/j.jlr.2025.100830","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Conjugated bile acids are elevated in severe calcific aortic valve stenosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Lipid Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jlr.2025.100830","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology\u00e9","name":"copyright","label":"Copyright"}],"article-number":"100830"}}