{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T15:40:06Z","timestamp":1756482006550,"version":"3.44.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG3N0081-83"],"award-info":[{"award-number":["CMRPG3N0081-83"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jlr.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.jlr.2025.100864","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T15:55:14Z","timestamp":1753113314000},"page":"100864","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lipoprotein dynamics in neuromyelitis optica spectrum disorder"],"prefix":"10.1016","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1378-824X","authenticated-orcid":false,"given":"Tsai-Wei","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei-Ling","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiung-Mei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long-Sun","family":"Ro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4972-9823","authenticated-orcid":false,"given":"Kuo-Hsuan","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jlr.2025.100864_bib1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1136\/jnnp-2016-313300","article-title":"Neurodegeneration in multiple sclerosis and neuromyelitis optica","volume":"88","author":"Kawachi","year":"2017","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jlr.2025.100864_bib2","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1016\/S0140-6736(04)17551-X","article-title":"A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis","volume":"364","author":"Lennon","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.jlr.2025.100864_bib3","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1084\/jem.20050304","article-title":"IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel","volume":"202","author":"Lennon","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jlr.2025.100864_bib4","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1001\/archneur.64.6.899","article-title":"Neuromyelitis optica is distinct from multiple sclerosis","volume":"64","author":"Weinshenker","year":"2007","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.jlr.2025.100864_bib5","doi-asserted-by":"crossref","first-page":"12970","DOI":"10.3390\/ijms131012970","article-title":"Molecular pathogenesis of neuromyelitis optica","volume":"13","author":"Bukhari","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jlr.2025.100864_bib6","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1146\/annurev.bi.47.070178.003535","article-title":"The plasma lipoproteins: structure and metabolism","volume":"47","author":"Smith","year":"1978","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.jlr.2025.100864_bib7","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.ecl.2022.02.008","article-title":"Lipid and lipoprotein metabolism","volume":"51","author":"Feingold","year":"2022","journal-title":"Endocrinol. Metab. Clin. North Am."},{"key":"10.1016\/j.jlr.2025.100864_bib8","doi-asserted-by":"crossref","first-page":"836","DOI":"10.3390\/biomedicines9070836","article-title":"High-density lipoprotein subfractions: much Ado about nothing or clinically important?","volume":"9","author":"Lappegard","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.jlr.2025.100864_bib9","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S0022-2275(20)39765-0","article-title":"Development and application of a multicompartmental model to study very low density lipoprotein subfraction metabolism","volume":"36","author":"Packard","year":"1995","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jlr.2025.100864_bib10","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1194\/jlr.R200004-JLR200","article-title":"Metabolic origins and clinical significance of LDL heterogeneity","volume":"43","author":"Berneis","year":"2002","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jlr.2025.100864_bib11","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1093\/eurheartj\/ehx144","article-title":"Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel","volume":"38","author":"Ference","year":"2017","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.jlr.2025.100864_bib12","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.molmed.2011.05.013","article-title":"Biological activities of HDL subpopulations and their relevance to cardiovascular disease","volume":"17","author":"Camont","year":"2011","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.jlr.2025.100864_bib13","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1034\/j.1600-0404.2002.01334.x","article-title":"Blood cholesterol and MRI activity in first clinical episode suggestive of multiple sclerosis","volume":"106","author":"Giubilei","year":"2002","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.jlr.2025.100864_bib14","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/1742-2094-8-127","article-title":"Serum lipid profiles are associated with disability and MRI outcomes in multiple sclerosis","volume":"8","author":"Weinstock-Guttman","year":"2011","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jlr.2025.100864_bib15","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1136\/jnnp-2013-307106","article-title":"Apolipoproteins are associated with new MRI lesions and deep grey matter atrophy in clinically isolated syndromes","volume":"85","author":"Browne","year":"2014","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jlr.2025.100864_bib16","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1177\/1352458514533162","article-title":"An adverse lipid profile is associated with disability and progression in disability, in people with MS","volume":"20","author":"Tettey","year":"2014","journal-title":"Mult. Scler."},{"key":"10.1016\/j.jlr.2025.100864_bib17","doi-asserted-by":"crossref","first-page":"188-e184","DOI":"10.1111\/ene.14055","article-title":"Cholesterol and neurodegeneration: longitudinal changes in serum cholesterol biomarkers are associated with new lesions and gray matter atrophy in multiple sclerosis over 5 years of follow-up","volume":"27","author":"Murali","year":"2020","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.jlr.2025.100864_bib18","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1365-2990.1994.tb01174.x","article-title":"Low density lipoprotein uptake by macrophages in multiple sclerosis plaques- implications for pathogenesis","volume":"20","author":"Newcombe","year":"1994","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.jlr.2025.100864_bib19","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1212\/WNL.0000000000001729","article-title":"International consensus diagnostic criteria for neuromyelitis optica spectrum disorders","volume":"85","author":"Wingerchuk","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.jlr.2025.100864_bib20","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(17)30470-2","article-title":"Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria","volume":"17","author":"Thompson","year":"2018","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jlr.2025.100864_bib21","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1212\/WNL.33.11.1444","article-title":"Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS)","volume":"33","author":"Kurtzke","year":"1983","journal-title":"Neurology"},{"key":"10.1016\/j.jlr.2025.100864_bib22","doi-asserted-by":"crossref","first-page":"11962","DOI":"10.1021\/acs.analchem.8b02412","article-title":"Quantitative lipoprotein subclass and low molecular weight metabolite analysis in human serum and plasma by 1H NMR spectroscopy in a multilaboratory trial","volume":"90","author":"Jim\u00e9nez","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jlr.2025.100864_bib23","doi-asserted-by":"crossref","first-page":"4428","DOI":"10.1021\/acs.jproteome.0c00537","article-title":"Quantitative in-vitro diagnostic NMR spectroscopy for lipoprotein and metabolite measurements in plasma and serum: recommendations for analytical artifact minimization with special reference to COVID-19\/SARS-CoV-2 samples","volume":"19","author":"Loo","year":"2020","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jlr.2025.100864_bib24","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5585521","article-title":"Changing perspectives on HDL: from simple quantity measurements to functional quality assessment","volume":"2021","author":"Thakkar","year":"2021","journal-title":"J. Lipids"},{"key":"10.1016\/j.jlr.2025.100864_bib25","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3390\/cells12030385","article-title":"Alternations of lipoprotein profiles in the plasma as biomarkers of huntington's disease","volume":"12","author":"Chang","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.jlr.2025.100864_bib26","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1016\/S0022-2275(20)37453-8","article-title":"Apolipoprotein-mediated removal of cellular cholesterol and phospholipids","volume":"37","author":"Oram","year":"1996","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jlr.2025.100864_bib27","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1161\/CIRCULATIONAHA.107.704031","article-title":"Apolipoprotein A-II is inversely associated with risk of future coronary artery disease","volume":"116","author":"Birjmohun","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jlr.2025.100864_bib28","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.3390\/biomedicines10071578","article-title":"Apolipoprotein A-II, a player in multiple processes and diseases","volume":"10","author":"Florea","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.jlr.2025.100864_bib29","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.clnu.2004.08.004","article-title":"Dyslipidemia and inflammation: an evolutionary conserved mechanism","volume":"24","author":"Esteve","year":"2005","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.jlr.2025.100864_bib30","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.clineuro.2010.03.017","article-title":"Serum lipoprotein levels in patients with neuromyelitis optica elevated but had little correlation with clinical presentations","volume":"112","author":"Li","year":"2010","journal-title":"Clin. Neurol. Neurosurg."},{"key":"10.1016\/j.jlr.2025.100864_bib31","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/1476-511X-12-150","article-title":"Distinct serum apolipoprotein AI levels in neuromyelitis optica and acute transverse myelitis","volume":"12","author":"Zhong","year":"2013","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.jlr.2025.100864_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2020.101981","article-title":"Low high-density lipoprotein cholesterol and high triglycerides lipid profile in neuromyelitis optica spectrum disorder: associations with disease activity and disability","volume":"40","author":"Cho","year":"2020","journal-title":"Mult. Scler. Relat. Disord."},{"key":"10.1016\/j.jlr.2025.100864_bib33","doi-asserted-by":"crossref","first-page":"374","DOI":"10.3390\/metabo10090374","article-title":"Metabolomic profiling in neuromyelitis optica spectrum disorder biomarker discovery","volume":"10","author":"Thoman","year":"2020","journal-title":"Metabolites"},{"key":"10.1016\/j.jlr.2025.100864_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.763793","article-title":"Monocyte to high-density lipoprotein ratio: a novel predictive marker of disease severity and prognosis in patients with neuromyelitis optica spectrum disorders","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Neurol."},{"key":"10.1016\/j.jlr.2025.100864_bib35","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s40478-017-0495-8","article-title":"Metabolomics reveals distinct, antibody-independent, molecular signatures of MS, AQP4-antibody and MOG-antibody disease","volume":"5","author":"Jurynczyk","year":"2017","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.jlr.2025.100864_bib36","doi-asserted-by":"crossref","first-page":"5L","DOI":"10.1016\/S0002-9149(00)01461-2","article-title":"The metabolic pathways of high-density lipoprotein, low-density lipoprotein, and triglycerides- A current review","volume":"86","author":"Kwiterovich","year":"2000","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.jlr.2025.100864_bib37","series-title":"MDText.com, Inc. Copyright \u00a9 2000-2025","article-title":"The effect of inflammation and infection on lipids and lipoproteins","author":"Feingold","year":"2000"},{"key":"10.1016\/j.jlr.2025.100864_bib38","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S0002-9343(02)01186-5","article-title":"Effects of antirheumatic therapy on serum lipid levels in patients with rheumatoid arthritis: a prospective study","volume":"113","author":"Park","year":"2002","journal-title":"Am. J. Med."},{"key":"10.1016\/j.jlr.2025.100864_bib39","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/0026-0495(88)90067-4","article-title":"Prednisone increases very low density lipoprotein and high density lipoprotein in healthy men","volume":"37","author":"Ettinger","year":"1988","journal-title":"Metabolism"},{"key":"10.1016\/j.jlr.2025.100864_bib40","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.semcdb.2005.01.005","article-title":"Cholesterol homeostasis in neurons and glial cells","volume":"16","author":"Vance","year":"2005","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.jlr.2025.100864_bib41","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s12974-021-02249-1","article-title":"Neuromyelitis optica spectrum disorders: from pathophysiology to therapeutic strategies","volume":"18","author":"Carnero Contentti","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jlr.2025.100864_bib42","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1186\/s12967-024-05801-8","article-title":"Integrated omics profiling reveals systemic dysregulation and potential biomarkers in the blood of patients with neuromyelitis optica spectrum disorders","volume":"22","author":"Xie","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jlr.2025.100864_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1037812","article-title":"Increased peripheral inflammatory responses in myelin oligodendrocyte glycoprotein associated disease and aquaporin-4 antibody positive neuromyelitis optica spectrum disorder","volume":"13","author":"Bauer","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jlr.2025.100864_bib44","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1159\/000494976","article-title":"Cytokines and tissue damage biomarkers in first-onset neuromyelitis optica spectrum disorders: significance of interleukin-6","volume":"25","author":"Wei","year":"2018","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.jlr.2025.100864_bib45","doi-asserted-by":"crossref","first-page":"e841","DOI":"10.1212\/NXI.0000000000000841","article-title":"Interleukin-6 in neuromyelitis optica spectrum disorder pathophysiology","volume":"7","author":"Fujihara","year":"2020","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"10.1016\/j.jlr.2025.100864_bib46","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1194\/jlr.R300019-JLR200","article-title":"Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host","volume":"45","author":"Khovidhunkit","year":"2004","journal-title":"J. Lipid Res."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227525001269?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227525001269?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T15:15:23Z","timestamp":1756480523000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227525001269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":46,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S0022227525001269"],"URL":"https:\/\/doi.org\/10.1016\/j.jlr.2025.100864","relation":{},"ISSN":["0022-2275"],"issn-type":[{"type":"print","value":"0022-2275"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lipoprotein dynamics in neuromyelitis optica spectrum disorder","name":"articletitle","label":"Article Title"},{"value":"Journal of Lipid Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jlr.2025.100864","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology\u00e9","name":"copyright","label":"Copyright"}],"article-number":"100864"}}