{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:52:11Z","timestamp":1786992731792,"version":"build-2736575974"},"reference-count":45,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01-DK099110"],"award-info":[{"award-number":["R01-DK099110"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01-DK055758"],"award-info":[{"award-number":["R01-DK055758"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007925","name":"Huazhong Agricultural University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35-140851"],"award-info":[{"award-number":["R35-140851"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jlr.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.jlr.2025.100898","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T02:35:46Z","timestamp":1757644546000},"page":"100898","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Advanced alcoholic liver disease driven by a proferroptotic diet"],"prefix":"10.1016","volume":"66","author":[{"given":"Yonggang","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanchao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4968-2529","authenticated-orcid":false,"given":"Megan","family":"Virostek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8991-9413","authenticated-orcid":false,"given":"Ann","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5686-0315","authenticated-orcid":false,"given":"Bret","family":"Evers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1570-4142","authenticated-orcid":false,"given":"Jeffrey G.","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0680-3392","authenticated-orcid":false,"given":"Philipp E.","family":"Scherer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6034-7351","authenticated-orcid":false,"given":"Shaojie","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3179-4777","authenticated-orcid":false,"given":"Jin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jlr.2025.100898_bib1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41575-022-00688-6","article-title":"Global epidemiology of alcohol-associated cirrhosis and HCC: trends, projections and risk factors","volume":"20","author":"Huang","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jlr.2025.100898_bib2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41572-018-0014-7","article-title":"Alcoholic liver disease","volume":"4","author":"Seitz","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.jlr.2025.100898_bib3","doi-asserted-by":"crossref","first-page":"8018","DOI":"10.3748\/wjg.v20.i25.8018","article-title":"Liver fibrosis markers in alcoholic liver disease","volume":"20","author":"Chrostek","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jlr.2025.100898_bib4","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nprot.2013.032","article-title":"Mouse model of chronic and binge ethanol feeding (the NIAAA model)","volume":"8","author":"Bertola","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jlr.2025.100898_bib5","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1002\/hep.23837","article-title":"Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: role of signal transducer and activator of transcription 3","volume":"52","author":"Ki","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.jlr.2025.100898_bib6","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.1016\/j.molcel.2023.09.025","article-title":"Identification of hyperoxidized PRDX3 as a ferroptosis marker reveals ferroptotic damage in chronic liver diseases","volume":"83","author":"Cui","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jlr.2025.100898_bib7","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jlr.2025.100898_bib8","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.jlr.2025.100898_bib9","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.chembiol.2018.11.016","article-title":"Exogenous monounsaturated fatty acids promote a ferroptosis-resistant cell state","volume":"26","author":"Magtanong","year":"2019","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.jlr.2025.100898_bib10","doi-asserted-by":"crossref","first-page":"31189","DOI":"10.1073\/pnas.2017152117","article-title":"Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis","volume":"117","author":"Yi","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jlr.2025.100898_bib11","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1016\/j.cell.2023.05.003","article-title":"Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones","volume":"186","author":"Liang","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.jlr.2025.100898_bib12","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nchembio.2238","article-title":"Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis","volume":"13","author":"Kagan","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jlr.2025.100898_bib13","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.25015","article-title":"Expression of SREBP-1c requires SREBP-2-mediated gneration of a serol ligand for LXR in livers of mice","volume":"6","author":"Rong","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.jlr.2025.100898_bib14","doi-asserted-by":"crossref","first-page":"4471","DOI":"10.1016\/j.molcel.2024.11.001","article-title":"5H7c: a rabbit monoclonal antibody detecting ferroptotic cells","volume":"84","author":"Cui","year":"2024","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jlr.2025.100898_bib15","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1194\/jlr.D090795","article-title":"Three-phase liquid extraction: a simple and fast method for lipidomic workflows","volume":"60","author":"Vale","year":"2019","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jlr.2025.100898_bib16","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1111\/j.1572-0241.1999.01377.x","article-title":"Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions","volume":"94","author":"Brunt","year":"1999","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.jlr.2025.100898_bib17","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1111\/acer.13840","article-title":"The Lieber-DeCarli diet\u2014A flagship model for experimental alcoholic liver disease","volume":"42","author":"Guo","year":"2018","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.jlr.2025.100898_bib18","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1002\/hep.510260622","article-title":"Dietary saturated fatty acids down-regulate cyclooxygenase-2 and tumor necrosis factor alfa and reverse fibrosis in alcohol-induced liver disease in the rat","volume":"26","author":"Nanji","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.jlr.2025.100898_bib19","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2107189119","article-title":"FAF1 blocks ferroptosis by inhibiting peroxidation of polyunsaturated fatty acids","volume":"119","author":"Cui","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jlr.2025.100898_bib20","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jhep.2012.04.004","article-title":"EASL clinical practical guidelines: management of acoholic liver disease","volume":"57","year":"2012","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jlr.2025.100898_bib21","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/(SICI)1096-9896(199809)186:1<82::AID-PATH151>3.0.CO;2-D","article-title":"Distinct patterns of chemokine expression are associated with leukocyte recruitment in alcoholic hepatitis and alcoholic cirrhosis","volume":"186","author":"Afford","year":"1998","journal-title":"J. Pathol."},{"key":"10.1016\/j.jlr.2025.100898_bib22","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1006\/cyto.1999.0495","article-title":"Increased monocyte MCP-1 production in acute alcoholic hepatitis","volume":"11","author":"Devalaraja","year":"1999","journal-title":"Cytokine"},{"key":"10.1016\/j.jlr.2025.100898_bib23","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/0304-4165(77)90154-4","article-title":"The influence of dietary selenium and vitamin E on glutathione peroxidase and glutathione in the rat","volume":"497","author":"Scott","year":"1977","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jlr.2025.100898_bib24","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.alcohol.2005.04.004","article-title":"Alcohol and liver cancer","volume":"35","author":"McKillop","year":"2005","journal-title":"Alcohol"},{"key":"10.1016\/j.jlr.2025.100898_bib25","doi-asserted-by":"crossref","first-page":"25892","DOI":"10.1074\/jbc.274.36.25892","article-title":"Fish oil feeding decreases mature sterol regulatory element-binding protein 1 (SREBP-1) by down-regulation of SREBP-1c mRNA in mouse liver: a possible mechanism for down-regulation of lipogenic enzyme mRNAs","volume":"274","author":"Kim","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jlr.2025.100898_bib26","doi-asserted-by":"crossref","first-page":"12027","DOI":"10.1073\/pnas.1534923100","article-title":"Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes","volume":"100","author":"Horton","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jlr.2025.100898_bib27","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.cmet.2011.12.017","article-title":"The Scap\/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals","volume":"15","author":"Moon","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.jlr.2025.100898_bib28","doi-asserted-by":"crossref","first-page":"9520","DOI":"10.1074\/jbc.M111421200","article-title":"Diminished hepatic response to fasting\/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c","volume":"277","author":"Liang","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jlr.2025.100898_bib29","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.3390\/nu11122941","article-title":"The secrets of the Mediterranean diet. Does [Only] olive oil matter?","volume":"11","author":"Mazzocchi","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.jlr.2025.100898_bib30","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1177\/026010600902000105","article-title":"Fish oil and the management of hypertriglyceridemia","volume":"20","author":"Mattar","year":"2009","journal-title":"Nutr. Health"},{"key":"10.1016\/j.jlr.2025.100898_bib31","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/s41467-023-44412-7","article-title":"Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance","volume":"15","author":"Lee","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jlr.2025.100898_bib32","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1152\/physrev.00031.2024","article-title":"Ferroptosis: when metabolism meets cell death","volume":"105","author":"Conrad","year":"2025","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jlr.2025.100898_bib33","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.cell.2015.09.020","article-title":"Antioxidant role for lipid droplets in a stem cell niche of drosophila","volume":"163","author":"Bailey","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.jlr.2025.100898_bib34","doi-asserted-by":"crossref","first-page":"4327","DOI":"10.1038\/s41467-022-31963-4","article-title":"Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer","volume":"13","author":"Bartolacci","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jlr.2025.100898_bib35","doi-asserted-by":"crossref","DOI":"10.1530\/REM-22-0024","article-title":"Triglyceride peroxidation progression in lipid droplets of hepatocytes in nonalcoholic steatohepatitis","volume":"2023","author":"Saito","year":"2023","journal-title":"Redox Exp. Med."},{"key":"10.1016\/j.jlr.2025.100898_bib36","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1002\/hep.32675","article-title":"Adipose lipolysis is important for ethanol to induce fatty liver in the National Institute on Alcohol Abuse and Alcoholism murine model of chronic and binge ethanol feeding","volume":"77","author":"Mathur","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.jlr.2025.100898_bib37","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jcmgh.2022.10.002","article-title":"Ethanol and its nonoxidative metabolites promote acute liver injury by inducing ER stress, adipocyte death, and lipolysis","volume":"15","author":"Park","year":"2023","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jlr.2025.100898_bib38","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/ajg.2015.137","article-title":"PNPLA3 gene polymorphism is associated with predisposition to and severity of alcoholic liver disease","volume":"110","author":"Salameh","year":"2015","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.jlr.2025.100898_bib39","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1002\/hep.31535","article-title":"Genome-wide association study and meta-analysis on alcohol-associated liver cirrhosis identifies genetic risk factors","volume":"73","author":"Schwantes-An","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.jlr.2025.100898_bib40","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1038\/ng.3417","article-title":"A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis","volume":"47","author":"Buch","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jlr.2025.100898_bib41","doi-asserted-by":"crossref","first-page":"6706","DOI":"10.1074\/jbc.M109.064501","article-title":"A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis","volume":"285","author":"He","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jlr.2025.100898_bib42","doi-asserted-by":"crossref","first-page":"4130","DOI":"10.1172\/JCI65179","article-title":"Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis","volume":"122","author":"Li","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jlr.2025.100898_bib43","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1002\/hep.29273","article-title":"The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation","volume":"66","author":"BasuRay","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.jlr.2025.100898_bib44","doi-asserted-by":"crossref","first-page":"9521","DOI":"10.1073\/pnas.1901974116","article-title":"Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis","volume":"116","author":"BasuRay","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jlr.2025.100898_bib45","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.jhep.2009.11.004","article-title":"The expression level of non-alcoholic fatty liver disease-related gene PNPLA3 in hepatocytes is highly influenced by hepatic lipid status","volume":"52","author":"Hoekstra","year":"2010","journal-title":"J. Hepatol."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227525001609?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227525001609?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T08:39:06Z","timestamp":1761727146000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227525001609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":45,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S0022227525001609"],"URL":"https:\/\/doi.org\/10.1016\/j.jlr.2025.100898","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advanced alcoholic liver disease driven by a proferroptotic diet","name":"articletitle","label":"Article Title"},{"value":"Journal of Lipid Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jlr.2025.100898","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology\u00e9","name":"copyright","label":"Copyright"}],"article-number":"100898"}}