{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T17:53:46Z","timestamp":1784138026490,"version":"3.55.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2701903"],"award-info":[{"award-number":["2021YFC2701903"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2701900"],"award-info":[{"award-number":["2021YFC2701900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170869"],"award-info":[{"award-number":["82170869"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100915"],"award-info":[{"award-number":["82100915"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008233","name":"School of Medicine, Shanghai Jiao Tong University","doi-asserted-by":"publisher","award":["TRYJ2024LC03"],"award-info":[{"award-number":["TRYJ2024LC03"]}],"id":[{"id":"10.13039\/501100008233","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jlr.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jlr.2025.100914","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T02:09:17Z","timestamp":1758938957000},"page":"100914","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["1-Linoleoylglycerophosphocholine stimulates UCP1-dependent thermogenesis and mitochondrial respiration to combat obesity"],"prefix":"10.1016","volume":"66","author":[{"given":"Rui","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianfu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxian","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengke","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xirong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jlr.2025.100914_bib1","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/s41366-021-01035-6","article-title":"Obesity and infectious diseases: pathophysiology and epidemiology of a double pandemic condition","volume":"46","author":"Pugliese","year":"2022","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.jlr.2025.100914_bib2","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/s41576-021-00414-z","article-title":"The genetics of obesity: from discovery to biology","volume":"23","author":"Loos","year":"2021","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.jlr.2025.100914_bib3","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.metabol.2018.09.005","article-title":"The epidemiology of obesity","volume":"92","author":"Chooi","year":"2019","journal-title":"Metabolism"},{"key":"10.1016\/j.jlr.2025.100914_bib4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cmet.2021.12.012","article-title":"Why does obesity cause diabetes?","volume":"34","author":"Klein","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.jlr.2025.100914_bib5","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.cmet.2021.11.003","article-title":"Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation","volume":"34","author":"Mills","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.jlr.2025.100914_bib6","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/obr.12796","article-title":"Mechanisms underlying UCP1 dependent and independent adipocyte thermogenesis","volume":"20","author":"Chang","year":"2018","journal-title":"Obes. Rev."},{"key":"10.1016\/j.jlr.2025.100914_bib7","doi-asserted-by":"crossref","first-page":"e353","DOI":"10.1038\/emm.2017.70","article-title":"Induction of thermogenic adipocytes: molecular targets and thermogenic small molecules","volume":"49","author":"Song","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.jlr.2025.100914_bib8","doi-asserted-by":"crossref","first-page":"796","DOI":"10.3390\/nu11040796","article-title":"A lipophilic fucoxanthin-rich Phaeodactylum tricornutum extract ameliorates effects of diet-induced obesity in C57BL\/6J mice","volume":"11","author":"Gille","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.jlr.2025.100914_bib9","doi-asserted-by":"crossref","first-page":"E346","DOI":"10.1152\/ajpendo.00485.2015","article-title":"Bile acids induce uncoupling protein 1-dependent thermogenesis and stimulate energy expenditure at thermoneutrality in mice","volume":"310","author":"Zietak","year":"2016","journal-title":"Am. J. Physiology-Endocrinology Metab."},{"key":"10.1016\/j.jlr.2025.100914_bib10","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.cmet.2012.01.019","article-title":"PPAR\u03b3 agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein","volume":"15","author":"Ohno","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.jlr.2025.100914_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2020.101068","article-title":"Emerging roles of lysophospholipids in health and disease","volume":"80","author":"Tan","year":"2020","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.jlr.2025.100914_bib12","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.bbalip.2016.11.006","article-title":"Schistosomal-derived lysophosphatidylcholine triggers M2 polarization of macrophages through PPAR\u03b3 dependent mechanisms","volume":"1862","author":"Assun\u00e7\u00e3o","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.jlr.2025.100914_bib13","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/jb\/mvv044","article-title":"Lysophosphatidylcholine promotes SREBP-2 activation via rapid cholesterol efflux and SREBP-2-independent cytokine release in human endothelial cells","volume":"158","author":"Morita","year":"2015","journal-title":"J. Biochem."},{"key":"10.1016\/j.jlr.2025.100914_bib14","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/SHK.0000000000001012","article-title":"Stearoyl lysophosphatidylcholine inhibits endotoxin-induced caspase-11 activation","volume":"50","author":"Li","year":"2018","journal-title":"Shock"},{"key":"10.1016\/j.jlr.2025.100914_bib15","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.atherosclerosis.2012.07.038","article-title":"Acyl chain-dependent effect of lysophosphatidylcholine on cyclooxygenase (COX)-2 expression in endothelial cells","volume":"224","author":"Brki\u0107","year":"2012","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jlr.2025.100914_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202200568","article-title":"Are phosphatidylcholine and lysophosphatidylcholine body levels potentially reliable biomarkers in obesity? A review of human studies","volume":"67","author":"Bellot","year":"2023","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.jlr.2025.100914_bib17","doi-asserted-by":"crossref","first-page":"3511","DOI":"10.2147\/DMSO.S371370","article-title":"Lysophosphatidylcholine (17:0) improves HFD-Induced hyperglycemia & insulin resistance: a mechanistic mice model Study","volume":"15","author":"Bao","year":"2022","journal-title":"Diabetes Metab. Syndr. Obes. Targets Ther."},{"key":"10.1016\/j.jlr.2025.100914_bib18","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/s42255-022-00589-7","article-title":"AgRP neurons control feeding behaviour at cortical synapses via peripherally derived lysophospholipids","volume":"4","author":"Endle","year":"2022","journal-title":"Nat. Metab."},{"key":"10.1016\/j.jlr.2025.100914_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104760","article-title":"Obesity and NRF2-mediated cytoprotection: where is the missing link?","volume":"156","author":"Vasileva","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jlr.2025.100914_bib20","doi-asserted-by":"crossref","first-page":"6973","DOI":"10.3390\/ijms21186973","article-title":"The role of the Nrf2 signaling in obesity and insulin resistance","volume":"21","author":"Li","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jlr.2025.100914_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102951","article-title":"NRF2 is essential for adaptative browning of white adipocytes","volume":"68","author":"Bauz\u00e1-Thorbr\u00fcgge","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.jlr.2025.100914_bib22","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201900574","article-title":"Punicalagin, a pomegranate-derived ellagitannin, suppresses obesity and obesity-induced inflammatory responses via the Nrf2\/Keap1 signaling pathway","volume":"63","author":"Kang","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.jlr.2025.100914_bib23","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.3390\/antiox11112190","article-title":"Therapeutic effects of Heterotrigona itama (Stingless Bee) bee bread in improving hepatic lipid metabolism through the activation of the Keap1\/Nrf2 signaling pathway in an obese rat model","volume":"11","author":"Zakaria","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.jlr.2025.100914_bib24","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202301166R","article-title":"Traumatic acid inhibits ACSL4 associated lipid accumulation in adipocytes to attenuate high-fat diet-induced obesity","volume":"37","author":"Gao","year":"2023","journal-title":"FASEB J."},{"key":"10.1016\/j.jlr.2025.100914_bib25","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cmet.2018.11.002","article-title":"New advances in adaptive thermogenesis: UCP1 and beyond","volume":"29","author":"Chouchani","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.jlr.2025.100914_bib26","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.3390\/antiox10111824","article-title":"Mitochondrial management of reactive oxygen species","volume":"10","author":"Napolitano","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.jlr.2025.100914_bib27","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.3390\/biomedicines9091196","article-title":"A role of stress sensor Nrf2 in stimulating thermogenesis and energy expenditure","volume":"9","author":"Chang","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.jlr.2025.100914_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.atherosclerosis.2024.118569","article-title":"Phospholipid-derived lysophospholipids in (patho)physiology","volume":"398","author":"Prabutzki","year":"2024","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jlr.2025.100914_bib29","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.prostaglandins.2016.06.003","article-title":"Linoleic acid and the pathogenesis of obesity","volume":"125","author":"Naughton","year":"2016","journal-title":"Prostaglandins Other Lipid Med"},{"key":"10.1016\/j.jlr.2025.100914_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102389","article-title":"Signal amplification in the KEAP1-NRF2-ARE antioxidant response pathway","volume":"54","author":"Liu","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.jlr.2025.100914_bib31","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13578-019-0309-8","article-title":"Brusatol, an NRF2 inhibitor for future cancer therapeutic","volume":"9","author":"Cai","year":"2019","journal-title":"Cell Biosci."},{"key":"10.1016\/j.jlr.2025.100914_bib32","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3346\/jkms.2013.28.2.268","article-title":"Lysophosphatidylcholine, oxidized low-density lipoprotein and cardiovascular disease in Korean hemodialysis patients: analysis at 5 years of follow-up","volume":"28","author":"Lee","year":"2013","journal-title":"J. Korean Med. Sci."},{"key":"10.1016\/j.jlr.2025.100914_bib33","article-title":"Plasma lysophosphatidylcholine levels are reduced in obesity and type 2 diabetes","volume":"7","author":"Waki","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jlr.2025.100914_bib34","article-title":"Alterations of plasma lysophosphatidylcholine species in obesity and weight Loss","volume":"9","author":"Vajreswari","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jlr.2025.100914_bib35","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1093\/gerona\/gly100","article-title":"Targeted metabolomics shows low plasma lysophosphatidylcholine 18:2 predicts greater decline of gait speed in older adults: the baltimore longitudinal study of aging","volume":"74","author":"Gonzalez-Freire","year":"2019","journal-title":"J. Gerontol. Ser. A"},{"key":"10.1016\/j.jlr.2025.100914_bib36","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2337\/db11-0649","article-title":"The l-\u03b1-lysophosphatidylinositol-GPR55 system and its potential role in human obesity","volume":"61","author":"Moreno-Navarrete","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.jlr.2025.100914_bib37","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.cmet.2018.05.003","article-title":"Cardiolipin synthesis in brown and beige fat mitochondria is essential for systemic energy homeostasis","volume":"28","author":"Sustarsic","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.jlr.2025.100914_bib38","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ade7864","article-title":"Mitochondrial phosphatidylethanolamine modulates to promote brown adipose thermogenesis","volume":"9","author":"Johnson","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jlr.2025.100914_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000412","article-title":"The lipidome of primary murine white, brite, and brown adipocytes-impact of beta-adrenergic stimulation","volume":"17","author":"Schweizer","year":"2019","journal-title":"PLoS Biol."},{"key":"10.1016\/j.jlr.2025.100914_bib40","doi-asserted-by":"crossref","first-page":"22080","DOI":"10.1073\/pnas.2003877117","article-title":"Allosteric regulation of thioesterase superfamily member 1 by lipid sensor domain binding fatty acids and lysophosphatidylcholine","volume":"117","author":"Tillman","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jlr.2025.100914_bib41","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.freeradbiomed.2021.01.023","article-title":"Exosomes from adipose-derived stem cells alleviate the inflammation and oxidative stress via regulating Nrf2\/HO-1 axis in macrophages","volume":"165","author":"Shen","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jlr.2025.100914_bib42","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ejphar.2009.08.022","article-title":"Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-Imidazolide","volume":"620","author":"Shin","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jlr.2025.100914_bib43","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.2337\/db16-0662","article-title":"Glucoraphanin ameliorates obesity and insulin resistance through adipose tissue browning and reduction of metabolic endotoxemia in mice","volume":"66","author":"Nagata","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.jlr.2025.100914_bib44","doi-asserted-by":"crossref","first-page":"419","DOI":"10.5483\/BMBRep.2021.54.8.023","article-title":"Nrf2 induces Ucp1 expression in adipocytes in response to \u03b23-AR stimulation and enhances oxygen consumption in high-fat diet-fed obese mice","volume":"54","author":"Chang","year":"2021","journal-title":"BMB Rep."},{"key":"10.1016\/j.jlr.2025.100914_bib45","first-page":"1","article-title":"The Nrf2\/PGC1\u03b1 pathway regulates antioxidant and proteasomal activity to alter cisplatin sensitivity in ovarian cancer","volume":"2020","author":"Deng","year":"2020","journal-title":"Oxidative Med. Cell Longev."},{"key":"10.1016\/j.jlr.2025.100914_bib46","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nature17399","article-title":"Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1","volume":"532","author":"Chouchani","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jlr.2025.100914_bib47","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.jnutbio.2012.03.005","article-title":"The Nrf2-antioxidant response element pathway: a target for regulating energy metabolism","volume":"23","author":"Vomhof-DeKrey","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.jlr.2025.100914_bib48","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.fsi.2022.05.046","article-title":"Nrf2 pathway in vegetable oil-induced inflammation of large yellow croaker (Larimichthys crocea)","volume":"127","author":"Tan","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.jlr.2025.100914_bib49","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.prostaglandins.2018.02.003","article-title":"Modulation of oxidative stress response by flaxseed oil: role of lipid peroxidation and underlying mechanisms","volume":"135","author":"Yadav","year":"2018","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1016\/j.jlr.2025.100914_bib50","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1021\/ja057076l","article-title":"Metadynamics simulation of prion protein: \u03b2-structure stability and the early stages of misfolding","volume":"128","author":"Barducci","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jlr.2025.100914_bib51","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1110\/ps.4140102","article-title":"Analysis of the factors that stabilize a designed two-stranded antiparallel \u03b2-sheet","volume":"11","author":"Espinosa","year":"2009","journal-title":"Protein Sci."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227525001762?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227525001762?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T08:54:28Z","timestamp":1764147268000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227525001762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":51,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S0022227525001762"],"URL":"https:\/\/doi.org\/10.1016\/j.jlr.2025.100914","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"1-Linoleoylglycerophosphocholine stimulates UCP1-dependent thermogenesis and mitochondrial respiration to combat obesity","name":"articletitle","label":"Article Title"},{"value":"Journal of Lipid Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jlr.2025.100914","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology\u00e9","name":"copyright","label":"Copyright"}],"article-number":"100914"}}