{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:26:31Z","timestamp":1789392391130,"version":"build-2803163510"},"reference-count":53,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009673","name":"Gun Och Bertil Stohnes Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009673","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008599","name":"Alzheimerfonden","doi-asserted-by":"publisher","award":["AF-1011030"],"award-info":[{"award-number":["AF-1011030"]}],"id":[{"id":"10.13039\/501100008599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007435","name":"\u00c5ke Wiberg Foundation","doi-asserted-by":"publisher","award":["M24-0221"],"award-info":[{"award-number":["M24-0221"]}],"id":[{"id":"10.13039\/100007435","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007435","name":"\u00c5ke Wiberg Foundation","doi-asserted-by":"publisher","award":["M22-0170"],"award-info":[{"award-number":["M22-0170"]}],"id":[{"id":"10.13039\/100007435","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RF1AG079149"],"award-info":[{"award-number":["RF1AG079149"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010815","name":"Stiftelsen F\u00f6r Gamla Tj\u00e4narinnor","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010815","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006129","name":"King Gustaf V and Queen Victoria's Masonic Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018713","name":"Center for Innovative Medicine","doi-asserted-by":"publisher","award":["FoUI-1002840"],"award-info":[{"award-number":["FoUI-1002840"]}],"id":[{"id":"10.13039\/501100018713","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018713","name":"Center for Innovative Medicine","doi-asserted-by":"publisher","award":["FoUI-963369"],"award-info":[{"award-number":["FoUI-963369"]}],"id":[{"id":"10.13039\/501100018713","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["75N92021D00005"],"award-info":[{"award-number":["75N92021D00005"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["75N92021D00003"],"award-info":[{"award-number":["75N92021D00003"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["75N92021D00001"],"award-info":[{"award-number":["75N92021D00001"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["75N92021D00004"],"award-info":[{"award-number":["75N92021D00004"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["75N92021D00002"],"award-info":[{"award-number":["75N92021D00002"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2024-03440"],"award-info":[{"award-number":["2024-03440"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2022- 01428"],"award-info":[{"award-number":["2022- 01428"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jlr.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jlr.2025.100938","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T21:00:52Z","timestamp":1762462852000},"page":"100938","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Exploring biomarkers of neurodegenerative risk: associations of oxysterols, sex hormones, and reproductive characteristics in older women"],"prefix":"10.1016","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1927-2818","authenticated-orcid":false,"given":"Michelle M.","family":"Dunk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1840-1710","authenticated-orcid":false,"given":"Ljerka","family":"Delac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen R.","family":"Rapp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira","family":"Driscoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8434-3822","authenticated-orcid":false,"given":"Maria","family":"Latorre-Leal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie V.","family":"Farland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6109-431X","authenticated-orcid":false,"given":"Bernhard","family":"Haring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly R.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Yon","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JoAnn E.","family":"Manson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather M.","family":"Ochs-Balcom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aladdin H.","family":"Shadyab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3960-7275","authenticated-orcid":false,"given":"Julie C.","family":"Weitlauf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7266-3431","authenticated-orcid":false,"given":"Hong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Westman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9577-0803","authenticated-orcid":false,"given":"Silvia","family":"Maioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jlr.2025.100938_bib1","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1042\/EBC20200162","article-title":"Estrogen receptors and the aging brain","volume":"65","author":"Maioli","year":"2021","journal-title":"Essays Biochem."},{"key":"10.1016\/j.jlr.2025.100938_bib2","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1186\/s12916-023-03159-0","article-title":"Male- and female-specific reproductive risk factors across the lifespan for dementia or cognitive decline: a systematic review and meta-analysis","volume":"21","author":"Han","year":"2023","journal-title":"BMC Med."},{"key":"10.1016\/j.jlr.2025.100938_bib3","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/alz.12638","article-title":"2022 Alzheimer's disease facts and figures","volume":"18","year":"2022","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.jlr.2025.100938_bib4","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1212\/WNL.0000000000000033","article-title":"Age at surgical menopause influences cognitive decline and Alzheimer pathology in older women","volume":"82","author":"Bove","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.jlr.2025.100938_bib5","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1001\/jamaneurol.2023.0455","article-title":"Association of age at menopause and hormone therapy use with tau and beta-amyloid positron emission tomography","volume":"80","author":"Coughlan","year":"2023","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.jlr.2025.100938_bib6","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.3390\/ijms24043205","article-title":"Is hormone replacement therapy a risk factor or a therapeutic option for Alzheimer\u2019s disease?","volume":"24","author":"Mills","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jlr.2025.100938_bib7","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/ana.24135","article-title":"Sex modifies the APOE-related risk of developing Alzheimer disease","volume":"75","author":"Altmann","year":"2014","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jlr.2025.100938_bib8","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1001\/jamaneurol.2023.2169","article-title":"Associations of sex, race, and apolipoprotein E alleles with multiple domains of cognition among older adults","volume":"80","author":"Walters","year":"2023","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.jlr.2025.100938_bib9","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1001\/jamaneurol.2017.2188","article-title":"Apolipoprotein E genotype and sex risk factors for Alzheimer disease","volume":"74","author":"Neu","year":"2017","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.jlr.2025.100938_bib10","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.tins.2022.01.002","article-title":"Brain cell type-specific cholesterol metabolism and implications for learning and memory","volume":"45","author":"Li","year":"2022","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.jlr.2025.100938_bib11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41514-021-00064-9","article-title":"Abnormal brain cholesterol homeostasis in Alzheimer's disease-a targeted metabolomic and transcriptomic study","volume":"7","author":"Varma","year":"2021","journal-title":"NPJ Aging Mech. Dis."},{"key":"10.1016\/j.jlr.2025.100938_bib12","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.3233\/JAD-140954","article-title":"Midlife vascular risk factors and the risk of Alzheimer's disease: a systematic review and meta-analysis","volume":"42","author":"Meng","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.jlr.2025.100938_bib13","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0140-6736(24)01296-0","article-title":"Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission","volume":"404","author":"Livingston","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.jlr.2025.100938_bib14","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/j.1365-2796.2006.01725.x","article-title":"Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain","volume":"260","author":"Bj\u00f6rkhem","year":"2006","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.jlr.2025.100938_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.prostaglandins.2019.106381","article-title":"Oxysterols as lipid mediators: their biosynthetic genes, enzymes and metabolites","volume":"147","author":"Griffiths","year":"2020","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"10.1016\/j.jlr.2025.100938_bib16","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.tem.2011.01.003","article-title":"27-Hydroxycholesterol: the first identified endogenous SERM","volume":"22","author":"Umetani","year":"2011","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.jlr.2025.100938_bib17","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adj1354","article-title":"CYP46A1-mediated cholesterol turnover induces sex-specific changes in cognition and counteracts memory loss in ovariectomized mice","volume":"10","author":"Latorre-Leal","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jlr.2025.100938_bib18","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.biocel.2008.05.029","article-title":"24(S),25-Epoxycholesterol: a messenger for cholesterol homeostasis","volume":"41","author":"Brown","year":"2009","journal-title":"Int. J. Biochem. Cell Biol"},{"key":"10.1016\/j.jlr.2025.100938_bib19","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.redox.2016.09.001","article-title":"Changes in brain oxysterols at different stages of Alzheimer's disease: their involvement in neuroinflammation","volume":"10","author":"Testa","year":"2016","journal-title":"Redox Biol."},{"key":"10.1016\/j.jlr.2025.100938_bib20","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3233\/JAD-150734","article-title":"Cholesterol, 24-hydroxycholesterol, and 27-hydroxycholesterol as surrogate biomarkers in cerebrospinal fluid in mild cognitive impairment and Alzheimer\u2019s disease: a meta-analysis","volume":"51","author":"Wang","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.jlr.2025.100938_bib21","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3233\/JAD-2012-111460","article-title":"Markers of cholesterol metabolism in the brain show stronger associations with cerebrovascular disease than Alzheimer's disease","volume":"30","author":"Hughes","year":"2012","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.jlr.2025.100938_bib22","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1002\/alz.13811","article-title":"Plasma oxysterols are associated with serum lipids and dementia risk in older women","volume":"20","author":"Dunk","year":"2024","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.jlr.2025.100938_bib23","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0197-2456(97)00078-0","article-title":"Design of the Women's Health Initiative clinical trial and observational study. The Women's Health Initiative Study Group","volume":"19","year":"1998","journal-title":"Control Clin. Trials"},{"key":"10.1016\/j.jlr.2025.100938_bib24","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1001\/jama.288.3.321","article-title":"Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial","volume":"288","author":"Rossouw","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.jlr.2025.100938_bib25","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1001\/jama.291.14.1701","article-title":"Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial","volume":"291","author":"Anderson","year":"2004","journal-title":"JAMA"},{"issue":"9 Suppl","key":"10.1016\/j.jlr.2025.100938_bib26","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1016\/S1047-2797(03)00043-7","article-title":"Implementation of the Women's Health Initiative study design","volume":"13","author":"Anderson","year":"2003","journal-title":"Ann. Epidemiol."},{"key":"10.1016\/j.jlr.2025.100938_bib27","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/jbmr.3576","article-title":"27-hydroxycholesterol, an endogenous SERM, and risk of fracture in postmenopausal women: a nested case-cohort study in the Women's Health Initiative","volume":"34","author":"Chang","year":"2019","journal-title":"J. Bone Miner Res."},{"key":"10.1016\/j.jlr.2025.100938_bib28","doi-asserted-by":"crossref","first-page":"v1399","DOI":"10.1194\/jlr.D022285","article-title":"A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma","volume":"53","author":"McDonald","year":"2012","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jlr.2025.100938_bib29","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.steroids.2015.07.009","article-title":"A chromatography\/tandem mass spectrometry method for the simultaneous profiling of ten endogenous steroids, including progesterone, adrenal precursors, androgens and estrogens, using low serum volume","volume":"104","author":"Caron","year":"2015","journal-title":"Steroids"},{"key":"10.1016\/j.jlr.2025.100938_bib30","doi-asserted-by":"crossref","first-page":"7813","DOI":"10.1021\/ac070494j","article-title":"Quantitative measurement of endogenous estrogens and estrogen metabolites in human serum by liquid chromatography-tandem mass spectrometry","volume":"79","author":"Xu","year":"2007","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jlr.2025.100938_bib31","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/0022-4731(82)90038-3","article-title":"Calculation of free and bound fractions of testosterone and estradiol-17 beta to human plasma proteins at body temperature","volume":"16","author":"S\u00f6derg\u00e5rd","year":"1982","journal-title":"J. Steroid Biochem."},{"key":"10.1016\/j.jlr.2025.100938_bib32","first-page":"314","article-title":"The Modified Mini-Mental State (3MS) examination","volume":"48","author":"Teng","year":"1987","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jlr.2025.100938_bib33","doi-asserted-by":"crossref","DOI":"10.1177\/2045894020952023","article-title":"Obesity, estrogens and adipose tissue dysfunction - implications for pulmonary arterial hypertension","volume":"10","author":"Mair","year":"2020","journal-title":"Pulm. Circ."},{"issue":"Pt B","key":"10.1016\/j.jlr.2025.100938_bib34","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.chemphyslip.2017.08.003","article-title":"Oxysterols and phytosterols in human health","volume":"207","author":"Massaad","year":"2017","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.jlr.2025.100938_bib35","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.3390\/jcm13102983","article-title":"Association between female reproductive factors and risk of dementia","volume":"13","author":"Pszczo\u0142owska","year":"2024","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.jlr.2025.100938_bib36","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.maturitas.2017.07.014","article-title":"27-Hydroxycholesterol, an endogenous selective estrogen receptor modulator","volume":"104","author":"He","year":"2017","journal-title":"Maturitas"},{"key":"10.1016\/j.jlr.2025.100938_bib37","first-page":"181","article-title":"Association between lifestyle, dietary, reproductive, and anthropometric factors and circulating 27-hydroxycholesterol in EPIC-Heidelberg","volume":"31","author":"Le Cornet","year":"2020","journal-title":"CCC"},{"key":"10.1016\/j.jlr.2025.100938_bib38","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/nrendo.2015.82","article-title":"Perimenopause as a neurological transition state","volume":"11","author":"Brinton","year":"2015","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.jlr.2025.100938_bib39","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1001\/jamaneurol.2023.3599","article-title":"APOE genotype and alzheimer disease risk across Age, sex, and population ancestry","volume":"80","author":"Belloy","year":"2023","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.jlr.2025.100938_bib40","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3389\/fnagi.2020.00150","article-title":"APOE alleles and diet in brain aging and alzheimer\u2019s disease","volume":"12","author":"Yassine","year":"2020","journal-title":"Front Aging Neurosci."},{"key":"10.1016\/j.jlr.2025.100938_bib41","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0022-2275(20)32052-6","article-title":"Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients","volume":"41","author":"L\u00fctjohann","year":"2000","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jlr.2025.100938_bib42","doi-asserted-by":"crossref","first-page":"5742","DOI":"10.1002\/alz.13358","article-title":"Associations of dietary cholesterol and fat, blood lipids, and risk for dementia in older women vary by APOE genotype","volume":"19","author":"Dunk","year":"2023","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.jlr.2025.100938_bib43","article-title":"Role of estrogen in women\u2019s Alhzeimer\u2019s disease risk as modified by APOE","volume":"35","author":"Valencia-Olvera","year":"2022","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.jlr.2025.100938_bib44","doi-asserted-by":"crossref","first-page":"5141","DOI":"10.1002\/hbm.25180","article-title":"Women's brain aging: effects of sex-hormone exposure, pregnancies, and genetic risk for Alzheimer's disease","volume":"41","author":"De Lange","year":"2020","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.jlr.2025.100938_bib45","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13195-021-00790-y","article-title":"27-hydroxycholesterol, cognition, and brain imaging markers in the FINGER randomized controlled trial","volume":"13","author":"Sandebring-Matton","year":"2021","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.jlr.2025.100938_bib46","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.jsbmb.2009.11.007","article-title":"Postmenopausal hormone therapy and cognitive outcomes: the Women\u2019s Health Initiative Memory Study (WHIMS)","volume":"118","author":"Coker","year":"2010","journal-title":"J. Steroid Biochem."},{"key":"10.1016\/j.jlr.2025.100938_bib47","article-title":"Systematic review and meta-analysis of the effects of menopausal hormone therapy on risk of Alzheimer\u2019s disease and dementia","volume":"15","author":"Narattini","year":"2023","journal-title":"Front Aging Neurosci."},{"key":"10.1016\/j.jlr.2025.100938_bib48","doi-asserted-by":"crossref","DOI":"10.1186\/s13195-022-01121-5","article-title":"Hormone replacement therapy is associated with improved cognition and larger brain volumes in at-risk APOE4 women: results from the European Prevention of Alzheimer\u2019s Disease (EPAD) cohort","volume":"15","author":"Saleh","year":"2023","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.jlr.2025.100938_bib49","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1212\/WNL.54.10.1949","article-title":"Estrogen use, APOE, and cognitive decline","volume":"54","author":"Yaffe","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.jlr.2025.100938_bib50","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1001\/archneur.60.4.510","article-title":"Reduction in levels of 24S-hydroxycholesterol by statin treatment in patients with Alzheimer disease","volume":"60","author":"Vega","year":"2003","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.jlr.2025.100938_bib51","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1177\/0091270006289851","article-title":"High-dose statin treatment does not alter plasma marker for brain cholesterol metabolism in patients with moderately elevated plasma cholesterol levels","volume":"46","author":"Thelen","year":"2006","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.jlr.2025.100938_bib52","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/WAD.0b013e3181d61fea","article-title":"Effects of simvastatin on cholesterol metabolism and Alzheimer disease biomarkers","volume":"24","author":"Serrano-Pozo","year":"2010","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.jlr.2025.100938_bib53","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2174\/1567205043480546","article-title":"The effects of gender and CYP46 and Apo E polymorphism on 24S-hydroxycholesterol levels in Alzheimers patients treated with statins","volume":"1","author":"Vega","year":"2004","journal-title":"Curr. Alzheimer Res."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227525002019?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227525002019?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T16:43:16Z","timestamp":1766076196000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227525002019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":53,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S0022227525002019"],"URL":"https:\/\/doi.org\/10.1016\/j.jlr.2025.100938","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring biomarkers of neurodegenerative risk: associations of oxysterols, sex hormones, and reproductive characteristics in older women","name":"articletitle","label":"Article Title"},{"value":"Journal of Lipid Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jlr.2025.100938","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology\u00e9","name":"copyright","label":"Copyright"}],"article-number":"100938"}}