{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T19:59:57Z","timestamp":1780862397753,"version":"3.54.1"},"reference-count":78,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:00:00Z","timestamp":1774656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01- HD09551201A1"],"award-info":[{"award-number":["R01- HD09551201A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jlr.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jlr.2026.101031","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T15:01:13Z","timestamp":1774882873000},"page":"101031","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Androgen excess uncouples circulating and hepatic lipid homeostasis in females on a high-calorie diet"],"prefix":"10.1016","volume":"67","author":[{"given":"Serene","family":"Joseph","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaibhave","family":"Ubba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2775-5063","authenticated-orcid":false,"given":"Raniya","family":"Kalim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7713-0069","authenticated-orcid":false,"given":"Selin","family":"Gunaydin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7888-1728","authenticated-orcid":false,"given":"Mehak","family":"Dass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Waheed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalton","family":"Hilovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Hartsell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Shpargel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juncheng","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jlr.2026.101031_bib1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nrendo.2010.217","article-title":"Polycystic ovary syndrome: etiology, pathogenesis and diagnosis","volume":"7","author":"Goodarzi","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.jlr.2026.101031_bib2","article-title":"Polycystic ovarian syndrome: exploring hypertension and cardiometabolic implications","volume":"16","author":"Brice\u00f1o Silva","year":"2024","journal-title":"Cureus"},{"key":"10.1016\/j.jlr.2026.101031_bib3","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/cen.14988","article-title":"Nonclassical congenital adrenal hyperplasia: Metabolic and hormonal profile","volume":"100","author":"Pir\u00f3g","year":"2024","journal-title":"Clin. Endocrinol. (Oxf)"},{"key":"10.1016\/j.jlr.2026.101031_bib4","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jacl.2022.11.010","article-title":"Lipid profiles and hypertriglyceridemia among transgender and gender diverse adults on gender-affirming hormone therapy","volume":"17","author":"Leemaqz","year":"2023","journal-title":"J. Clin. Lipidol."},{"key":"10.1016\/j.jlr.2026.101031_bib5","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/945053","article-title":"Alterations in lipids and adipocyte hormones in female-to-male transsexuals","volume":"2010","author":"Chandra","year":"2010","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.jlr.2026.101031_bib6","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1053\/meta.2000.6261","article-title":"Lipid profile in congenital adrenal hyperplasia","volume":"49","author":"Botero","year":"2000","journal-title":"Metabolism"},{"key":"10.1016\/j.jlr.2026.101031_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.steroids.2024.109424","article-title":"Dehydroepiandrosterone with a high-fat diet treatment at inducing polycystic ovary syndrome in rat model","volume":"206","author":"He","year":"2024","journal-title":"Steroids"},{"key":"10.1016\/j.jlr.2026.101031_bib8","doi-asserted-by":"crossref","first-page":"4425","DOI":"10.1210\/en.2008-1612","article-title":"A unique rodent model of cardiometabolic risk associated with the metabolic syndrome and polycystic ovary syndrome","volume":"150","author":"Shi","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.jlr.2026.101031_bib9","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1210\/en.2014-1196","article-title":"Characterization of reproductive, metabolic, and endocrine features of polycystic ovary syndrome in female hyperandrogenic mouse models","volume":"155","author":"Caldwell","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.jlr.2026.101031_bib10","doi-asserted-by":"crossref","first-page":"299","DOI":"10.12998\/wjcc.v11.i2.299","article-title":"Liver function in transgender persons: challenges in the COVID-19 era","volume":"11","author":"Milionis","year":"2023","journal-title":"World J. Clin. Cases"},{"key":"10.1016\/j.jlr.2026.101031_bib11","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1530\/EJE-09-0412","article-title":"Safety aspects of 36 months of administration of long-acting intramuscular testosterone undecanoate for treatment of female-to-male transgender individuals","volume":"161","author":"Jacobeit","year":"2009","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.jlr.2026.101031_bib12","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.dsx.2018.12.020","article-title":"Insulin resistance and hyperandrogenemia independently predict nonalcoholic fatty liver disease in women with polycystic ovary syndrome","volume":"13","author":"Harsha Varma","year":"2019","journal-title":"Diabetes Metab. Syndr."},{"key":"10.1016\/j.jlr.2026.101031_bib13","doi-asserted-by":"crossref","first-page":"3709","DOI":"10.1210\/jc.2012-1382","article-title":"Polycystic ovary syndrome with hyperandrogenism is characterized by an increased risk of hepatic steatosis compared to nonhyperandrogenic PCOS phenotypes and healthy controls, independent of obesity and insulin resistance","volume":"97","author":"Jones","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jlr.2026.101031_bib14","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1093\/humrep\/dep380","article-title":"Increased androgen bioavailability is associated with non-alcoholic fatty liver disease in women with polycystic ovary syndrome","volume":"25","author":"Vassilatou","year":"2010","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jlr.2026.101031_bib15","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1093\/humrep\/dew076","article-title":"Non-alcoholic fatty liver disease is associated with insulin resistance and lipid accumulation product in women with polycystic ovary syndrome","volume":"31","author":"Macut","year":"2016","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jlr.2026.101031_bib16","doi-asserted-by":"crossref","first-page":"199","DOI":"10.14310\/horm.2002.1236","article-title":"In overweight\/obese but not in normal-weight women, polycystic ovary syndrome is associated with elevated liver enzymes compared to controls","volume":"8","author":"Economou","year":"2009","journal-title":"Hormones (Athens)"},{"key":"10.1016\/j.jlr.2026.101031_bib17","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.molmed.2025.03.011","article-title":"Adolescent polycystic ovary syndrome: an endocrine-metabolic mode in response to ectopic fat","volume":"31","author":"Garcia-Beltran","year":"2025","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.jlr.2026.101031_bib18","doi-asserted-by":"crossref","first-page":"E1373","DOI":"10.1152\/ajpendo.00421.2012","article-title":"Maternal androgen excess reduces placental and fetal weights, increases placental steroidogenesis, and leads to long-term health effects in their female offspring","volume":"303","author":"Sun","year":"2012","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.jlr.2026.101031_bib19","doi-asserted-by":"crossref","first-page":"bvab060","DOI":"10.1210\/jendso\/bvab060","article-title":"Pathogenesis of reproductive and metabolic PCOS traits in a mouse model","volume":"5","author":"Rodriguez Paris","year":"2021","journal-title":"J. Endocr. Soc."},{"key":"10.1016\/j.jlr.2026.101031_bib20","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1095\/biolreprod.114.120063","article-title":"High-fat diet induces significant metabolic disorders in a mouse model of polycystic ovary Syndrome1","volume":"91","author":"Lai","year":"2014","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jlr.2026.101031_bib21","doi-asserted-by":"crossref","first-page":"E1076","DOI":"10.1152\/ajpendo.00182.2014","article-title":"Diet-induced obesity exacerbates metabolic and behavioral effects of polycystic ovary syndrome in a rodent model","volume":"308","author":"Ressler","year":"2015","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.jlr.2026.101031_bib22","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqac127","article-title":"Androgen-mediated perturbation of the hepatic circadian system through epigenetic modulation promotes NAFLD in PCOS mice","volume":"163","author":"Roy","year":"2022","journal-title":"Endocrinology"},{"key":"10.1016\/j.jlr.2026.101031_bib23","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1210\/en.2017-00460","article-title":"Developmental programming: impact of gestational steroid and metabolic milieus on mediators of insulin sensitivity in prenatal testosterone-treated female sheep","volume":"158","author":"Puttabyatappa","year":"2017","journal-title":"Endocrinology"},{"key":"10.1016\/j.jlr.2026.101031_bib24","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202100961R","article-title":"Androgen-induced insulin resistance is ameliorated by deletion of hepatic androgen receptor in females","volume":"35","author":"Andrisse","year":"2021","journal-title":"FASEB J."},{"key":"10.1016\/j.jlr.2026.101031_bib25","doi-asserted-by":"crossref","first-page":"e00301","DOI":"10.1128\/MCB.00301-17","article-title":"Feminization of Male mouse liver by persistent growth hormone stimulation: activation of sex-biased transcriptional networks and dynamic changes in chromatin states","volume":"37","author":"Lau-Corona","year":"2017","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jlr.2026.101031_bib26","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1210\/me.2005-0328","article-title":"Codependence of growth hormone-responsive, sexually dimorphic hepatic gene expression on signal transducer and activator of transcription 5b and hepatic nuclear factor 4alpha","volume":"20","author":"Holloway","year":"2006","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.jlr.2026.101031_bib27","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.jlr.2026.101031_bib28","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqaf071","article-title":"Ovarian-specific Cyp17A1 overexpression in female mice: a novel model of endogenous testosterone excess","volume":"166","author":"Joseph","year":"2025","journal-title":"Endocrinology"},{"key":"10.1016\/j.jlr.2026.101031_bib29","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1124\/mol.109.056705","article-title":"Sex differences in the expression of hepatic drug metabolizing enzymes","volume":"76","author":"Waxman","year":"2009","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.jlr.2026.101031_bib30","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/0092-8674(84)90030-8","article-title":"Secretory rhythm of growth hormone regulates sexual differentiation of mouse liver","volume":"36","author":"Norstedt","year":"1984","journal-title":"Cell"},{"key":"10.1016\/j.jlr.2026.101031_bib31","doi-asserted-by":"crossref","first-page":"5036","DOI":"10.1021\/acs.jproteome.1c00542","article-title":"Vitamin C differentially impacts the serum proteome profile in female and Male mice","volume":"20","author":"Aumailley","year":"2021","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jlr.2026.101031_bib32","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1210\/edrv-6-2-128","article-title":"Sexual dimorphism in the control of growth hormone secretion","volume":"6","author":"Jansson","year":"1985","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.jlr.2026.101031_bib33","doi-asserted-by":"crossref","first-page":"13262","DOI":"10.1074\/jbc.270.22.13262","article-title":"Intermittent plasma growth hormone triggers tyrosine phosphorylation and nuclear translocation of a liver-expressed, Stat 5-related DNA binding protein. Proposed role as an intracellular regulator of male-specific liver gene transcription","volume":"270","author":"Waxman","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jlr.2026.101031_bib34","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/S1096-6374(00)80002-7","article-title":"Pulsatility of growth hormone (GH) signalling in liver cells: role of the JAK-STAT5b pathway in GH action","volume":"10 Suppl B","author":"Choi","year":"2000","journal-title":"Growth Horm. IGF Res."},{"key":"10.1016\/j.jlr.2026.101031_bib35","doi-asserted-by":"crossref","first-page":"4599","DOI":"10.1210\/endo.142.11.8480","article-title":"Temporal relationship between the sexually dimorphic spontaneous GH secretory profiles and hepatic STAT5 activity","volume":"142","author":"Tannenbaum","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.jlr.2026.101031_bib36","doi-asserted-by":"crossref","first-page":"5126","DOI":"10.1210\/endo.140.11.7106","article-title":"Growth hormone, but not prolactin, maintains, low-level activation of STAT5a and STAT5b in female rat liver","volume":"140","author":"Choi","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.jlr.2026.101031_bib37","first-page":"807","article-title":"Relative contributions of sex hormones, sex chromosomes, and gonads to sex differences in tissue gene regulation","volume":"32","author":"Blencowe","year":"2022","journal-title":"Genome Res."},{"issue":"Pt B","key":"10.1016\/j.jlr.2026.101031_bib38","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.fct.2016.10.019","article-title":"Gene expression kinetics of renal transporters induced by ochratoxin A in male and female F344 rats","volume":"98","author":"Pastor","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jlr.2026.101031_bib39","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1210\/en.2003-0874","article-title":"Female-predominant expression of fatty acid translocase\/CD36 in rat and human liver","volume":"145","author":"St\u00e5hlberg","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.jlr.2026.101031_bib40","doi-asserted-by":"crossref","first-page":"35331","DOI":"10.1074\/jbc.274.50.35331","article-title":"STAT5b-deficient mice are growth hormone pulse-resistant. Role of STAT5b in sex-specific liver p450 expression","volume":"274","author":"Davey","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jlr.2026.101031_bib41","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1210\/me.2006-0007","article-title":"Growth hormone regulation of sex-dependent liver gene expression","volume":"20","author":"Waxman","year":"2006","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.jlr.2026.101031_bib42","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/0305-0491(84)90051-8","article-title":"Alpha-1-antitrypsin from mouse serum isolation and characterization","volume":"78","author":"Minnich","year":"1984","journal-title":"Comp. Biochem. Physiol. B"},{"key":"10.1016\/j.jlr.2026.101031_bib43","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1210\/en.2010-0537","article-title":"GH-dependent STAT5 signaling plays an important role in hepatic lipid metabolism","volume":"152","author":"Barclay","year":"2011","journal-title":"Endocrinology"},{"key":"10.1016\/j.jlr.2026.101031_bib44","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/hepr.12816","article-title":"Signal transducer and activator of transcription 5 plays a crucial role in hepatic lipid metabolism through regulation of CD36 expression","volume":"47","author":"Hosui","year":"2017","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.jlr.2026.101031_bib45","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/j.cmet.2024.04.014","article-title":"Obesity disrupts the pituitary-hepatic UPR communication leading to NAFLD progression","volume":"36","author":"Qian","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.jlr.2026.101031_bib46","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1128\/MCB.06312-11","article-title":"Dynamic, sex-differential STAT5 and BCL6 binding to sex-biased, growth hormone-regulated genes in adult mouse liver","volume":"32","author":"Zhang","year":"2012","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jlr.2026.101031_bib47","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1080\/08977190410001715172","article-title":"Role of hepatocyte nuclear factors in growth hormone-regulated, sexually dimorphic expression of liver cytochromes P450","volume":"22","author":"Wiwi","year":"2004","journal-title":"Growth Factors"},{"key":"10.1016\/j.jlr.2026.101031_bib48","first-page":"95","article-title":"Quantification and mechanisms of oleic acid-induced steatosis in HepG2 cells","volume":"2","author":"Cui","year":"2010","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.jlr.2026.101031_bib49","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1073\/pnas.0630588100","article-title":"Triglyceride accumulation protects against fatty acid-induced lipotoxicity","volume":"100","author":"Listenberger","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jlr.2026.101031_bib50","doi-asserted-by":"crossref","first-page":"30132","DOI":"10.1074\/jbc.M005488200","article-title":"The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1","volume":"275","author":"Miyazaki","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jlr.2026.101031_bib51","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqac046","article-title":"Constitutively active STAT5b feminizes mouse liver gene expression","volume":"163","author":"Lau-Corona","year":"2022","journal-title":"Endocrinology"},{"key":"10.1016\/j.jlr.2026.101031_bib52","doi-asserted-by":"crossref","first-page":"e0135502","DOI":"10.1371\/journal.pone.0135502","article-title":"Metabolic and behavioural phenotypes in nestin-cre mice are caused by hypothalamic expression of human growth hormone","volume":"10","author":"Declercq","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jlr.2026.101031_bib53","doi-asserted-by":"crossref","first-page":"19937","DOI":"10.1074\/jbc.M109.014308","article-title":"Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism","volume":"284","author":"Fan","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jlr.2026.101031_bib54","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1080\/19768354.2020.1778080","article-title":"Treatment of growth hormone attenuates hepatic steatosis in hyperlipidemic mice via downregulation of hepatic CD36 expression","volume":"24","author":"Jang","year":"2020","journal-title":"Anim. Cells Syst. (Seoul)"},{"key":"10.1016\/j.jlr.2026.101031_bib55","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1007\/s00125-009-1402-z","article-title":"Growth hormone improves body composition, fasting blood glucose, glucose tolerance and liver triacylglycerol in a mouse model of diet-induced obesity and type 2 diabetes","volume":"52","author":"List","year":"2009","journal-title":"Diabetologia"},{"key":"10.1016\/j.jlr.2026.101031_bib56","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/1476-511X-9-78","article-title":"Preventive effects of chronic exogenous growth hormone levels on diet-induced hepatic steatosis in rats","volume":"9","author":"Qin","year":"2010","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.jlr.2026.101031_bib57","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1210\/en.2010-0953","article-title":"Growth hormone-dependent pathogenesis of human hepatic steatosis in a novel mouse model bearing a human hepatocyte-repopulated liver","volume":"152","author":"Tateno","year":"2011","journal-title":"Endocrinology"},{"key":"10.1016\/j.jlr.2026.101031_bib58","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/00041433-200104000-00008","article-title":"Very-low-density lipoprotein assembly and secretion","volume":"12","author":"Shelness","year":"2001","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.jlr.2026.101031_bib59","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/hep4.1822","article-title":"TM6SF2: a novel genetic player in nonalcoholic fatty liver and cardiovascular disease","volume":"6","author":"Luo","year":"2022","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.jlr.2026.101031_bib60","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/s13238-017-0437-z","article-title":"Carboxylesterases in lipid metabolism: from mouse to human","volume":"9","author":"Lian","year":"2018","journal-title":"Protein Cell"},{"key":"10.1016\/j.jlr.2026.101031_bib61","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1002\/hep.25881","article-title":"Liver specific inactivation of carboxylesterase 3\/triacylglycerol hydrolase decreases blood lipids without causing severe steatosis in mice","volume":"56","author":"Lian","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.jlr.2026.101031_bib62","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.cmet.2010.02.005","article-title":"Loss of TGH\/Ces3 in mice decreases blood lipids, improves glucose tolerance, and increases energy expenditure","volume":"11","author":"Wei","year":"2010","journal-title":"Cell Metab."},{"key":"10.1016\/j.jlr.2026.101031_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2025.100887","article-title":"Loss of hepatic carboxylesterase 3 prevents the development of MASLD in mice","volume":"66","author":"Batayneh","year":"2025","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jlr.2026.101031_bib64","doi-asserted-by":"crossref","first-page":"C570","DOI":"10.1152\/ajpcell.00436.2008","article-title":"Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters","volume":"296","author":"Leuthold","year":"2009","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.jlr.2026.101031_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2025.100757","article-title":"Liver specific transgenic expression of CYP7B1 attenuates early western diet-induced MASLD progression","volume":"66","author":"Kakiyama","year":"2025","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jlr.2026.101031_bib66","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1530\/JOE-21-0040","article-title":"DHT causes liver steatosis via transcriptional regulation of SCAP in normal weight female mice","volume":"250","author":"Seidu","year":"2021","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.jlr.2026.101031_bib67","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.3390\/ijerph17082620","article-title":"Sex hormone-dependent physiology and diseases of liver","volume":"17","author":"Kur","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.jlr.2026.101031_bib68","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1002\/hep.30626","article-title":"Sex differences in nonalcoholic fatty liver disease: state of the art and identification of research gaps","volume":"70","author":"Lonardo","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.jlr.2026.101031_bib69","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1210\/en.2016-1553","article-title":"Low-Dose Dihydrotestosterone Drives Metabolic Dysfunction via Cytosolic and Nuclear Hepatic Androgen Receptor Mechanisms","volume":"158","author":"Andrisse","year":"2017","journal-title":"Endocrinology"},{"key":"10.1016\/j.jlr.2026.101031_bib70","doi-asserted-by":"crossref","first-page":"bqad141","DOI":"10.1210\/endocr\/bqad141","article-title":"Neuronal AR Regulates Glucose Homeostasis and Energy Expenditure in Lean Female Mice With Androgen Excess","volume":"164","author":"Ubba","year":"2023","journal-title":"Endocrinology"},{"key":"10.1016\/j.jlr.2026.101031_bib71","doi-asserted-by":"crossref","first-page":"R733","DOI":"10.1152\/ajpregu.00153.2019","article-title":"Loss of hepatic PPAR\u03b1 promotes inflammation and serum hyperlipidemia in diet[1]induced obesity","volume":"317","author":"Stec","year":"2019","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.jlr.2026.101031_bib72","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/s41419-019-1458-8","article-title":"PPAR\u03b4 attenuates hepatic steatosis through autophagy-mediated fatty acid oxidation","volume":"10","author":"Tong","year":"2019","journal-title":"Cell Death & Disease"},{"key":"10.1016\/j.jlr.2026.101031_bib73","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1194\/jlr.D500019-JLR200","article-title":"Determining hepatic triglyceride production in mice: comparison of poloxamer 407 with Triton WR-1339","volume":"46","author":"Millar","year":"2005","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jlr.2026.101031_bib74","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nm.3450","article-title":"Mfge8 promotes obesity by mediating the uptake of dietary fats and serum fatty acids","volume":"20","author":"Khalifeh-Soltani","year":"2014","journal-title":"Nat Med"},{"key":"10.1016\/j.jlr.2026.101031_bib75","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1053\/j.gastro.2010.03.033","article-title":"A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis","volume":"139","author":"Lee","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jlr.2026.101031_bib76","article-title":"Reproductive Profile of Neuronal Androgen Receptor Knockout Female Mice with Low Dose of DHT","author":"Ubba","year":"2023","journal-title":"Endocrinology"},{"key":"10.1016\/j.jlr.2026.101031_bib77","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/bioinformatics\/btt703","article-title":"Causal analysis approaches in Ingenuity Pathway Analysis","volume":"30","author":"Kr\u00e4mer","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jlr.2026.101031_bib78","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s11306-024-02113-2","article-title":"Data-dependent and -independent acquisition lipidomics analysis reveals the tissue-dependent effect of metformin on lipid metabolism","volume":"20","author":"Scheidemantle","year":"2024","journal-title":"Metabolomics"}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002222752600057X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002222752600057X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T19:51:47Z","timestamp":1780861907000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002222752600057X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":78,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S002222752600057X"],"URL":"https:\/\/doi.org\/10.1016\/j.jlr.2026.101031","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Androgen excess uncouples circulating and hepatic lipid homeostasis in females on a high-calorie diet","name":"articletitle","label":"Article Title"},{"value":"Journal of Lipid Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jlr.2026.101031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"101031"}}