{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:13:45Z","timestamp":1791328425813,"version":"4.3.1"},"reference-count":47,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30DK020572"],"award-info":[{"award-number":["P30DK020572"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U54DK137314"],"award-info":[{"award-number":["U54DK137314"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30DK089503"],"award-info":[{"award-number":["P30DK089503"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30DK081943"],"award-info":[{"award-number":["P30DK081943"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["R 56HL156829"],"award-info":[{"award-number":["R 56HL156829"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jlr.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jlr.2026.101072","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:14:21Z","timestamp":1780067661000},"page":"101072","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Plasma acylcarnitine profiling reveals heart failure-specific fatty acid oxidation signature in chronic kidney disease"],"prefix":"10.1016","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3051-3141","authenticated-orcid":false,"given":"Farsad","family":"Afshinnia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thekkelnaycke M.","family":"Rajendiran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaeman","family":"Byun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3628-6883","authenticated-orcid":false,"given":"Subramaniam","family":"Pennathur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jlr.2026.101072_bib1","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/937398","article-title":"Heart failure in patients with chronic kidney disease: a systematic integrative review","volume":"2014","author":"Segall","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.jlr.2026.101072_bib2","doi-asserted-by":"crossref","DOI":"10.15420\/ecr.2022.64","article-title":"Gaps in modern heart failure and chronic kidney disease research","volume":"18","author":"Parmar","year":"2023","journal-title":"Eur. Cardiol."},{"key":"10.1016\/j.jlr.2026.101072_bib3","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1016\/j.jacc.2019.02.071","article-title":"Burden and outcomes of heart failure hospitalizations in adults with chronic kidney disease","volume":"73","author":"Bansal","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jlr.2026.101072_bib4","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.cardfail.2004.06.435","article-title":"Anemia and new-onset congestive heart failure in the general Medicare population","volume":"11","author":"Sandgren","year":"2005","journal-title":"J. Card Fail."},{"key":"10.1016\/j.jlr.2026.101072_bib5","doi-asserted-by":"crossref","first-page":"18","DOI":"10.7812\/TPP\/18.273","article-title":"Prognostic impact of chronic kidney disease in patients with heart failure","volume":"23","author":"Hakopian","year":"2019","journal-title":"Perm J."},{"key":"10.1016\/j.jlr.2026.101072_bib6","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.005336","article-title":"Risk factors for heart failure in patients with chronic kidney disease: the CRIC (chronic renal insufficiency cohort) Study","volume":"6","author":"He","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.jlr.2026.101072_bib7","article-title":"Fatty acid beta-oxidation in kidney diseases: perspectives on pathophysiological mechanisms and therapeutic opportunities","volume":"13","author":"Gao","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jlr.2026.101072_bib8","doi-asserted-by":"crossref","first-page":"615","DOI":"10.3390\/metabo13050615","article-title":"Integrated control of fatty acid metabolism in heart failure","volume":"13","author":"Li","year":"2023","journal-title":"Metabolites"},{"key":"10.1016\/j.jlr.2026.101072_bib9","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3390\/metabo11010051","article-title":"L-Carnitine and acylcarnitines: mitochondrial biomarkers for precision medicine","volume":"11","author":"McCann","year":"2021","journal-title":"Metabolites"},{"key":"10.1016\/j.jlr.2026.101072_bib10","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.1002\/ehf2.14449","article-title":"Increased acylcarnitines in infant heart failure indicate fatty acid oxidation inhibition: towards therapeutic options?","volume":"10","author":"Issa","year":"2023","journal-title":"ESC Heart Fail."},{"key":"10.1016\/j.jlr.2026.101072_bib11","article-title":"Even chained acylcarnitines predict long-term cardiovascular prognosis in patients with chest pain and non-obstructive coronary artery disease","volume":"14","author":"Storesund","year":"2022","journal-title":"Int. J. Cardiol. Cardiovasc. Risk Prev."},{"key":"10.1016\/j.jlr.2026.101072_bib12","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jacc.2015.10.079","article-title":"Prognostic implications of long-chain acylcarnitines in heart failure and reversibility with mechanical circulatory support","volume":"67","author":"Ahmad","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jlr.2026.101072_bib13","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s12944-021-01576-9","article-title":"Medium & long-chain acylcarnitine's relation to lipid metabolism as potential predictors for diabetic cardiomyopathy: a metabolomic study","volume":"20","author":"Zheng","year":"2021","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.jlr.2026.101072_bib14","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/s12933-021-01353-z","article-title":"Circulating long chain acylcarnitines and outcomes in diabetic heart failure: an HF-ACTION clinical trial substudy","volume":"20","author":"Truby","year":"2021","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.jlr.2026.101072_bib15","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1681\/ASN.2017030350","article-title":"Impaired \u03b2-Oxidation and altered complex lipid fatty acid partitioning with advancing CKD","volume":"29","author":"Afshinnia","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.jlr.2026.101072_bib16","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.jlr.2026.101072_bib17","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/0002-9149(86)90771-X","article-title":"Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings","volume":"57","author":"Devereux","year":"1986","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.jlr.2026.101072_bib18","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.130317","article-title":"Increased lipogenesis and impaired beta-oxidation predict type 2 diabetic kidney disease progression in American Indians","volume":"4","author":"Afshinnia","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.jlr.2026.101072_bib19","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.2337\/dc21-0737","article-title":"Circulating free fatty acid and Phospholipid signature predicts early rapid kidney function decline in patients with type 1 diabetes","volume":"44","author":"Afshinnia","year":"2021","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jlr.2026.101072_bib20","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J. Chronic Dis."},{"key":"10.1016\/j.jlr.2026.101072_bib21","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1053\/j.ajkd.2006.10.021","article-title":"Left ventricular geometry and renal function in hypertensive patients with diastolic heart failure","volume":"49","author":"Afshinnia","year":"2007","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.jlr.2026.101072_bib22","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3747\/pdi.2014.00264","article-title":"Reverse epidemiology of blood pressure in peritoneal dialysis associated with dynamic deterioration of left ventricular function","volume":"36","author":"Afshinnia","year":"2016","journal-title":"Perit Dial Int."},{"key":"10.1016\/j.jlr.2026.101072_bib23","doi-asserted-by":"crossref","first-page":"e003190","DOI":"10.1161\/JAHA.115.003190","article-title":"Metabolomic profiling identifies novel circulating biomarkers of mitochondrial dysfunction differentially elevated in heart failure with preserved versus reduced ejection fraction: evidence for shared metabolic impairments in clinical heart failure","volume":"5","author":"Hunter","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.jlr.2026.101072_bib24","doi-asserted-by":"crossref","first-page":"H768","DOI":"10.1152\/ajpheart.00820.2016","article-title":"Circulating acylcarnitine profile in human heart failure: a surrogate of fatty acid metabolic dysregulation in mitochondria and beyond","volume":"313","author":"Ruiz","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.jlr.2026.101072_bib25","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1001\/jamacardio.2017.4873","article-title":"Association of acylcarnitines with left ventricular remodeling in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement","volume":"3","author":"Elmariah","year":"2018","journal-title":"JAMA Cardiol."},{"key":"10.1016\/j.jlr.2026.101072_bib26","series-title":"Heart Failure","author":"Bauersachs","year":"2017"},{"key":"10.1016\/j.jlr.2026.101072_bib27","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1096\/fj.12-216689","article-title":"Carnitine palmitoyltransferase 2 and carnitine\/acylcarnitine translocase are involved in the mitochondrial synthesis and export of acylcarnitines","volume":"27","author":"Violante","year":"2013","journal-title":"FASEB J."},{"key":"10.1016\/j.jlr.2026.101072_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2337\/db12-0466","article-title":"Acylcarnitines: reflecting or inflicting insulin resistance?","volume":"62","author":"Schooneman","year":"2013","journal-title":"Diabetes"},{"issue":"Suppl","key":"10.1016\/j.jlr.2026.101072_bib29","doi-asserted-by":"crossref","first-page":"S138","DOI":"10.1194\/jlr.R800079-JLR200","article-title":"Fatty acid metabolism: target for metabolic syndrome","volume":"50","author":"Wakil","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jlr.2026.101072_bib30","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.drudis.2016.02.010","article-title":"Targeting fatty acid metabolism in heart failure: is it a suitable therapeutic approach?","volume":"21","author":"Arumugam","year":"2016","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.jlr.2026.101072_bib31","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/cvr\/cvr038","article-title":"Modulating fatty acid oxidation in heart failure","volume":"90","author":"Lionetti","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.jlr.2026.101072_bib32","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1086\/679608","article-title":"Cardiac energy metabolic alterations in pressure overload-induced left and right heart failure (2013 Grover Conference Series)","volume":"5","author":"Sankaralingam","year":"2015","journal-title":"Pulm. Circ."},{"key":"10.1016\/j.jlr.2026.101072_bib33","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1056\/NEJMra063052","article-title":"The failing heart--an engine out of fuel","volume":"356","author":"Neubauer","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jlr.2026.101072_bib34","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1161\/CIRCULATIONAHA.120.052671","article-title":"Short-chain fatty acids outpace ketone oxidation in the failing heart","volume":"143","author":"Carley","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.jlr.2026.101072_bib35","doi-asserted-by":"crossref","first-page":"G287","DOI":"10.1152\/ajpgi.00105.2023","article-title":"Medium-chain fatty acid oxidation is independent of l-carnitine in liver and kidney but not in heart and skeletal muscle","volume":"325","author":"Pereyra","year":"2023","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.jlr.2026.101072_bib36","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.cmet.2015.02.007","article-title":"Maximal oxidative capacity during exercise is associated with skeletal muscle fuel selection and dynamic changes in mitochondrial protein acetylation","volume":"21","author":"Overmyer","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.jlr.2026.101072_bib37","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1440-1797.2007.00817.x","article-title":"L-carnitine supplementation in the dialysis population: are Australian patients missing out?","volume":"13","author":"Reuter","year":"2008","journal-title":"Nephrology (Carlton)"},{"key":"10.1016\/j.jlr.2026.101072_bib38","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/sdi.12041","article-title":"L-carnitine supplementation in dialysis: treatment in quest of disease","volume":"26","author":"Wasserstein","year":"2013","journal-title":"Semin. Dial"},{"key":"10.1016\/j.jlr.2026.101072_bib39","doi-asserted-by":"crossref","first-page":"247","DOI":"10.2147\/DMSO.S350233","article-title":"Acylcarnitines: can they be biomarkers of diabetic nephropathy?","volume":"15","author":"Mu","year":"2022","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"10.1016\/j.jlr.2026.101072_bib40","doi-asserted-by":"crossref","first-page":"819","DOI":"10.2337\/db18-0090","article-title":"Proximal tubular cell-specific ablation of carnitine acetyltransferase causes tubular disease and secondary glomerulosclerosis","volume":"68","author":"Kruger","year":"2019","journal-title":"Diabetes"},{"key":"10.1016\/j.jlr.2026.101072_bib41","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12986-018-0328-1","article-title":"Plasma acylcarnitines could predict prognosis and evaluate treatment of IgA nephropathy","volume":"16","author":"Xia","year":"2019","journal-title":"Nutr. Metab. (Lond)"},{"key":"10.1016\/j.jlr.2026.101072_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2026.100975","article-title":"Chronic kidney disease induces distinct alterations of macrophage lipid metabolism in a mouse model of atherosclerosis","volume":"67","author":"Saum","year":"2026","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jlr.2026.101072_bib43","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1124\/pharmrev.121.000408","article-title":"Acylcarnitines: nomenclature, biomarkers, therapeutic potential, drug targets, and clinical trials","volume":"74","author":"Dambrova","year":"2022","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.jlr.2026.101072_bib44","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17797-x","article-title":"Plasma acylcarnitine concentrations reflect the acylcarnitine profile in cardiac tissues","volume":"7","author":"Makrecka-Kuka","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jlr.2026.101072_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0041686","article-title":"Long-chain acylcarnitines regulate the hERG channel","volume":"7","author":"Ferro","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jlr.2026.101072_bib46","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nrendo.2015.129","article-title":"Acylcarnitines--old actors auditioning for new roles in metabolic physiology","volume":"11","author":"McCoin","year":"2015","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.jlr.2026.101072_bib47","doi-asserted-by":"crossref","first-page":"E1378","DOI":"10.1152\/ajpendo.00656.2013","article-title":"Acylcarnitines activate proinflammatory signaling pathways","volume":"306","author":"Rutkowsky","year":"2014","journal-title":"Am. J. Physiol. Endocrinol. Metab."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227526000982?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227526000982?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T19:23:09Z","timestamp":1785007389000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227526000982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":47,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S0022227526000982"],"URL":"https:\/\/doi.org\/10.1016\/j.jlr.2026.101072","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasma acylcarnitine profiling reveals heart failure-specific fatty acid oxidation signature in chronic kidney disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Lipid Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jlr.2026.101072","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"101072"}}