{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T20:01:14Z","timestamp":1785009674357,"version":"3.55.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003793","name":"The Swedish Heart Lung Foundation","doi-asserted-by":"publisher","award":["20220271"],"award-info":[{"award-number":["20220271"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"The Swedish Heart Lung Foundation","doi-asserted-by":"publisher","award":["20241339"],"award-info":[{"award-number":["20241339"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003186","name":"Fredrik and Ingrid Thurings Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003186","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004348","name":"Region Stockholm","doi-asserted-by":"publisher","award":["K0138-2015"],"award-info":[{"award-number":["K0138-2015"]}],"id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004348","name":"Region Stockholm","doi-asserted-by":"publisher","award":["20160337"],"award-info":[{"award-number":["20160337"]}],"id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004348","name":"Region Stockholm","doi-asserted-by":"publisher","award":["FOUI-962738"],"award-info":[{"award-number":["FOUI-962738"]}],"id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018713","name":"Center for Innovative Medicine","doi-asserted-by":"publisher","award":["FoUI-963234"],"award-info":[{"award-number":["FoUI-963234"]}],"id":[{"id":"10.13039\/501100018713","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jlr.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jlr.2026.101076","type":"journal-article","created":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T14:25:18Z","timestamp":1780842318000},"page":"101076","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The impact of sex hormones and sex chromosomes on the HDL anti-inflammatory capacity in transgender individuals"],"prefix":"10.1016","volume":"67","author":[{"given":"Ana","family":"Vankova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Tillander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margery A.","family":"Connelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Arver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5896-7244","authenticated-orcid":false,"given":"Anna","family":"Wiik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1559-4206","authenticated-orcid":false,"given":"Thomas","family":"Gustafsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe J.F.","family":"Tietge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jlr.2026.101076_bib1","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1016\/S0140-6736(24)00367-2","article-title":"Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990\u20132021: a systematic analysis for the global Burden of Disease Study 2021","volume":"403","author":"Naghavi","year":"2024","journal-title":"Lancet."},{"key":"10.1016\/j.jlr.2026.101076_bib2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41572-019-0106-z","article-title":"Atherosclerosis","volume":"5","author":"Libby","year":"2019","journal-title":"Nat. Rev. Dis. Primers."},{"key":"10.1016\/j.jlr.2026.101076_bib3","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1161\/CIRCRESAHA.117.311978","article-title":"Trials and tribulations of CETP inhibitors","volume":"122","author":"Tall","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.jlr.2026.101076_bib4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrcardio.2017.115","article-title":"HDL and atherosclerotic cardiovascular disease: genetic insights into complex biology","volume":"15","author":"Rosenson","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.jlr.2026.101076_bib5","doi-asserted-by":"crossref","first-page":"457","DOI":"10.2217\/bmm.13.35","article-title":"Assessing the functional properties of high-density lipoproteins: an emerging concept in cardiovascular research","volume":"7","author":"Triolo","year":"2013","journal-title":"Biomark. Med."},{"key":"10.1016\/j.jlr.2026.101076_bib6","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1093\/eurheartj\/ehac605","article-title":"High-density lipoprotein revisited: biological functions and clinical relevance","volume":"44","author":"von Eckardstein","year":"2023","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.jlr.2026.101076_bib7","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1161\/CIRCULATIONAHA.120.044221","article-title":"HDL in the 21st century","volume":"143","author":"Rohatgi","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.jlr.2026.101076_bib8","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3390\/antiox13010057","article-title":"Antioxidant and anti-inflammatory functions of high-density lipoprotein in type 1 and type 2 diabetes","volume":"13","author":"Denimal","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.jlr.2026.101076_bib9","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1161\/CIRCULATIONAHA.120.050808","article-title":"High-Density lipoprotein anti-inflammatory capacity and incident cardiovascular events","volume":"143","author":"Jia","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.jlr.2026.101076_bib10","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0140-6736(20)30543-2","article-title":"Variations between women and men in risk factors, treatments, cardiovascular disease incidence, and death in 27 high-income, middle-income, and low-income countries (PURE): a prospective cohort study","volume":"396","author":"Walli-Attaei","year":"2020","journal-title":"Lancet."},{"key":"10.1016\/j.jlr.2026.101076_bib11","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1161\/ATVBAHA.122.318247","article-title":"Sex-Specific differences in lipoprotein production and clearance","volume":"43","author":"Conlon","year":"2023","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jlr.2026.101076_bib12","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1161\/ATVBAHA.113.301468","article-title":"Small, dense high-density lipoprotein-3 particles are enriched in negatively charged phospholipids","volume":"33","author":"Camont","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jlr.2026.101076_bib13","doi-asserted-by":"crossref","first-page":"3914","DOI":"10.1210\/jc.2017-01643","article-title":"Sex steroids and cardiovascular outcomes in transgender individuals","volume":"102","author":"Maraka","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jlr.2026.101076_bib14","doi-asserted-by":"crossref","first-page":"e805","DOI":"10.1210\/clinem\/dgz247","article-title":"Muscle strength, size, and composition following 12 months of gender-affirming treatment in transgender individuals","volume":"105","author":"Wiik","year":"2020","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jlr.2026.101076_bib15","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.019123","article-title":"Impaired high-density lipoprotein function in patients with heart failure","volume":"10","author":"Emmens","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.jlr.2026.101076_bib16","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1056\/NEJMoa1409065","article-title":"HDL cholesterol efflux capacity and incident cardiovascular events","volume":"371","author":"Rohatgi","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jlr.2026.101076_bib17","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1210\/clinem\/dgab075","article-title":"HDL particle subspecies and their Association with incident type 2 diabetes","volume":"106","author":"Sokooti","year":"2021","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jlr.2026.101076_bib18","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jlr.2026.101076_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2024.100678","article-title":"Untargeted lipidomics reveals novel HDL metabotypes and lipid-clinical correlates","volume":"65","author":"Karmaus","year":"2024","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jlr.2026.101076_bib20","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1038\/s41591-019-0643-8","article-title":"Sex differences in cardiometabolic disorders","volume":"25","author":"Gerdts","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.jlr.2026.101076_bib21","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1161\/CIRCULATIONAHA.118.038584","article-title":"Occurrence of acute cardiovascular events in transgender individuals receiving hormone therapy","volume":"139","author":"Nota","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.jlr.2026.101076_bib22","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1210\/js.2017-00465","article-title":"Health and cardiometabolic disease in transgender adults in the United States","volume":"2","author":"Nokoff","year":"2018","journal-title":"J. Endocr. Soc."},{"key":"10.1016\/j.jlr.2026.101076_bib23","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCOUTCOMES.119.005597","article-title":"Cardiovascular disease risk factors and myocardial infarction in the transgender population","volume":"12","author":"Alzahrani","year":"2019","journal-title":"Circ. Cardiovasc. Qual. Outcomes"},{"key":"10.1016\/j.jlr.2026.101076_bib24","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1194\/jlr.R036095","article-title":"Thematic review series: high density lipoprotein structure, function, and metabolism","volume":"54","author":"Kontush","year":"2013","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jlr.2026.101076_bib25","doi-asserted-by":"crossref","DOI":"10.1096\/fj.201800810R","article-title":"Phosphatidylserine enhances anti-inflammatory effects of reconstituted HDL","volume":"36","author":"Darabi","year":"2022","journal-title":"FASEB J."},{"key":"10.1016\/j.jlr.2026.101076_bib26","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.cmet.2014.09.004","article-title":"The arachidonic acid metabolome serves as a conserved regulator of cholesterol metabolism","volume":"20","author":"Demetz","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.jlr.2026.101076_bib27","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s00011-019-01231-1","article-title":"Self-regulation of the inflammatory response by peroxisome proliferator-activated receptors","volume":"68","author":"Korbecki","year":"2019","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.jlr.2026.101076_bib28","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1161\/01.RES.0000205846.46812.be","article-title":"High-density lipoprotein hydrolysis by endothelial lipase activates PPAR\u03b1","volume":"98","author":"Ahmed","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.jlr.2026.101076_bib29","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.molmet.2014.02.002","article-title":"Integrated physiology and systems biology of PPAR\u03b1","volume":"3","author":"Kersten","year":"2014","journal-title":"Mol. Metab."},{"key":"10.1016\/j.jlr.2026.101076_bib30","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.bbalip.2006.06.008","article-title":"Distinctiveness of secretory phospholipase A2 groups IIA and V","volume":"1761","author":"Rosengren","year":"2006","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.jlr.2026.101076_bib31","article-title":"Endothelial lipase concentrations are increased in metabolic syndrome","volume":"3","author":"Badellino","year":"2006","journal-title":"Plos Med."},{"key":"10.1016\/j.jlr.2026.101076_bib32","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/s12944-019-1175-4","article-title":"Sex hormones affect endothelial lipase-mediated lipid metabolism","volume":"18","author":"Wang","year":"2019","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.jlr.2026.101076_bib33","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1161\/01.ATV.0000157933.19424.b7","article-title":"Serum levels of type II secretory phospholipase A2 and coronary artery disease risk","volume":"25","author":"Boekholdt","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jlr.2026.101076_bib34","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jped.2018.01.002","article-title":"Tracking of secretory phospholipase A2 activity from childhood to adulthood","volume":"95","author":"Chung","year":"2019","journal-title":"J. Pediatr. Rio J."},{"key":"10.1016\/j.jlr.2026.101076_bib35","doi-asserted-by":"crossref","DOI":"10.1161\/ATVBAHA.125.318266","article-title":"ABCA1-Mediated structural diversity of HDL subspecies and their proposed roles in cardioprotection","volume":"46","author":"Heinecke","year":"2026","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jlr.2026.101076_bib36","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1172\/JCI200523915","article-title":"Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I","volume":"115","author":"Timmins","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jlr.2026.101076_bib37","first-page":"1","article-title":"Impact of phospholipid transfer protein in lipid metabolism and cardiovascular diseases","volume":"276","author":"Jiang","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.jlr.2026.101076_bib38","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1080\/14789450.2025.2534397","article-title":"HDL proteome: from its characterization to quantitative measurements in particle subspecies and functional associations","volume":"22","author":"Vaisar","year":"2025","journal-title":"Expert Rev. Proteomics"},{"key":"10.1016\/j.jlr.2026.101076_bib39","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.1038\/ncomms4292","article-title":"HDL-transferred microRNA-223 regulates ICAM-1 expression in endothelial cells","volume":"5","author":"Tabet","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jlr.2026.101076_bib40","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1074\/mcp.M115.054528","article-title":"Targeted proteomics identifies Paraoxonase\/Arylesterase 1 (PON1) and apolipoprotein Cs as potential risk factors for hypoalphalipoproteinemia in diabetic subjects treated with fenofibrate and rosiglitazone","volume":"15","author":"Ronsein","year":"2016","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.jlr.2026.101076_bib41","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jprot.2014.04.010","article-title":"The human HDL proteome displays high inter-individual variability and is altered dynamically in response to angioplasty-induced atheroma plaque rupture","volume":"106","author":"Jorge","year":"2014","journal-title":"J. Proteomics"},{"key":"10.1016\/j.jlr.2026.101076_bib42","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1161\/CIRCULATIONAHA.120.045713","article-title":"Associations between high-density lipoprotein particles and ischemic events","volume":"142","author":"Singh","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.jlr.2026.101076_bib43","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1161\/01.ATV.18.9.1450","article-title":"Factors influencing the ability of HDL to inhibit expression of vascular cell adhesion molecule-1 in endothelial cells","volume":"18","author":"Ashby","year":"1998","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jlr.2026.101076_bib44","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1161\/ATVBAHA.117.309275","article-title":"A shift in ApoM\/S1P between HDL-Particles in women with type 1 diabetes mellitus is associated with impaired anti-inflammatory effects of the ApoM\/S1P complex","volume":"37","author":"Frej","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jlr.2026.101076_bib45","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1161\/ATVBAHA.119.312645","article-title":"HDL (High-Density lipoprotein) cholesterol efflux capacity is associated with incident cardiovascular disease in the general population","volume":"39","author":"Ebtehaj","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jlr.2026.101076_bib46","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S2213-8587(15)00126-6","article-title":"Association of HDL cholesterol efflux capacity with incident coronary heart disease events: a prospective case-control study","volume":"3","author":"Saleheen","year":"2015","journal-title":"Lancet Diabetes Endocrinol."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227526001021?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227526001021?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T19:23:41Z","timestamp":1785007421000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227526001021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":46,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S0022227526001021"],"URL":"https:\/\/doi.org\/10.1016\/j.jlr.2026.101076","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The impact of sex hormones and sex chromosomes on the HDL anti-inflammatory capacity in transgender individuals","name":"articletitle","label":"Article Title"},{"value":"Journal of Lipid Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jlr.2026.101076","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"101076"}}