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A."},{"key":"10.1016\/j.jlr.2026.101133_bib82","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.talanta.2014.03.051","article-title":"Lipoxin A4: problems with its determination using reversed phase chromatography-tandem mass spectrometry and confirmation with chiral chromatography","volume":"127","author":"Ferreiros","year":"2014","journal-title":"Talanta"},{"key":"10.1016\/j.jlr.2026.101133_bib83","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2502640122","article-title":"12\/15-lipoxygenase orchestrates murine wound healing via PPARgamma-activating oxylipins acting holistically to dampen inflammation","volume":"122","author":"Thomas","year":"2025","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jlr.2026.101133_bib84","article-title":"On the biosynthesis of specialized pro-resolving mediators in human neutrophils and the influence of cell integrity","volume":"1867","author":"Mainka","year":"2022","journal-title":"Biochim. Biophys. 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Care Med."},{"key":"10.1016\/j.jlr.2026.101133_bib115","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1096\/fj.13-227728","article-title":"The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype","volume":"27","author":"Dalli","year":"2013","journal-title":"FASEB J."},{"key":"10.1016\/j.jlr.2026.101133_bib116","doi-asserted-by":"crossref","DOI":"10.1016\/j.prostaglandins.2023.106726","article-title":"Formation of lipoxins and resolvins in human leukocytes","volume":"166","author":"Kahnt","year":"2023","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"10.1016\/j.jlr.2026.101133_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115932","article-title":"Identification of selective 5-LOX and FLAP inhibitors as novel anti-inflammatory agents by ligand-based virtual screening","volume":"263","author":"Cerchia","year":"2024","journal-title":"Eur. 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Toxicol."},{"key":"10.1016\/j.jlr.2026.101133_bib131","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.1039\/D6OB00371K","article-title":"Macrocyclic oxygen transfer in the conversion of fatty acid hydroperoxide to a single species of triol in physiological saline","volume":"24","author":"Choi","year":"2026","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.jlr.2026.101133_bib132","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1006\/bbrc.1995.1183","article-title":"5-15-diHETE and lipoxins generated by neutrophils from endogenous arachidonic acid as asthma biomarkers","volume":"207","author":"Chavis","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jlr.2026.101133_bib133","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S0022-2275(20)42779-8","article-title":"Platelet-neutrophil interactions. 12S,20- and 5S,12S-dihydroxyeicosapentaenoic acids: two novel neutrophil metabolites from platelet-derived 12S-hydroxyeicosapentaenoic acid","volume":"31","author":"von Schacky","year":"1990","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jlr.2026.101133_bib134","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1073\/pnas.81.3.689","article-title":"Enzyme with dual lipoxygenase activities catalyzes leukotriene A4 synthesis from arachidonic acid","volume":"81","author":"Shimizu","year":"1984","journal-title":"Proc. Natl. Acad. Sci. U. S. 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A."},{"key":"10.1016\/j.jlr.2026.101133_bib137","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.87031","article-title":"A broad-spectrum lipidomics screen of antiinflammatory drug combinations in human blood","volume":"1","author":"Mazaleuskaya","year":"2016","journal-title":"JCI Insight"},{"key":"10.1016\/j.jlr.2026.101133_bib138","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.107422","article-title":"Integrated analysis of whole blood oxylipin and cytokine responses after bacterial, viral, and T cell stimulation reveals new immune networks","volume":"26","author":"Villain","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.jlr.2026.101133_bib139","doi-asserted-by":"crossref","first-page":"4680","DOI":"10.1016\/S0021-9258(18)34575-7","article-title":"Albumin stabilizes Leukotriene A4","volume":"257","author":"Fitzpatrick","year":"1982","journal-title":"J. Biol. 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Pharmacol."},{"key":"10.1016\/j.jlr.2026.101133_bib143","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3001571","article-title":"5-Lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of omega-3 polyunsaturated fatty acids","volume":"3","author":"Sapieha","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jlr.2026.101133_bib144","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0022-2275(20)37802-0","article-title":"Autooxidation of docosahexaenoic acid: analysis of ten isomers of hydroxydocosahexaenoate","volume":"25","author":"VanRollins","year":"1984","journal-title":"J. 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Med."},{"key":"10.1016\/j.jlr.2026.101133_bib153","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2022.101597","article-title":"E-series resolvin metabolome, biosynthesis and critical role of stereochemistry of specialized pro-resolving mediators (SPMs) in inflammation-resolution: preparing SPMs for long COVID-19, human clinical trials, and targeted precision nutrition","volume":"59","author":"Serhan","year":"2022","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.jlr.2026.101133_bib154","doi-asserted-by":"crossref","first-page":"12912","DOI":"10.1016\/S0021-9258(18)31472-8","article-title":"Formation of 19(S)-19(R)-and 18(R)-hydroxyeicosatetraenoic acids by alcohol-inducible cytochrome P450 2E1","volume":"268","author":"Laethem","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jlr.2026.101133_bib155","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/343282a0","article-title":"Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis","volume":"343","author":"Dixon","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.jlr.2026.101133_bib156","doi-asserted-by":"crossref","first-page":"32842","DOI":"10.1074\/jbc.273.49.32842","article-title":"Cellular oxygenation of 12-hydroxyeicosatetraenoic acid and 15-hydroxyeicosatetraenoic acid by 5-lipoxygenase is stimulated by 5-lipoxygenase-activating protein","volume":"273","author":"Mancini","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jlr.2026.101133_bib157","doi-asserted-by":"crossref","first-page":"22048","DOI":"10.1016\/S0021-9258(18)41633-X","article-title":"Reversible membrane association of neutrophil 5-lipoxygenase is accompanied by retention of activity and a change in substrate specificity","volume":"267","author":"Hill","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jlr.2026.101133_bib158","doi-asserted-by":"crossref","first-page":"911","DOI":"10.2147\/JIR.S345510","article-title":"Shifting the biosynthesis of leukotrienes toward specialized pro-resolving mediators by the 5-Lipoxygenase-Activating protein (FLAP) antagonist BRP-201","volume":"15","author":"Kretzer","year":"2022","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.jlr.2026.101133_bib159","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0094836","article-title":"Generation and dietary modulation of anti-inflammatory electrophilic omega-3 fatty acid derivatives","volume":"9","author":"Cipollina","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jlr.2026.101133_bib160","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1161\/01.RES.85.10.950","article-title":"Formation of nitric oxide-derived oxidants by myeloperoxidase in monocytes: pathways for monocyte-mediated protein nitration and lipid peroxidation in vivo","volume":"85","author":"Hazen","year":"1999","journal-title":"Circ. Res."},{"key":"10.1016\/j.jlr.2026.101133_bib161","doi-asserted-by":"crossref","first-page":"14530","DOI":"10.1073\/pnas.1410851111","article-title":"Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway","volume":"111","author":"Fredman","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jlr.2026.101133_bib162","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1084\/jem.178.6.1935","article-title":"5-Lipoxygenase and 5-lipoxygenase activating protein are localized in the nuclear envelope of activated human leukocytes","volume":"178","author":"Woods","year":"1994","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jlr.2026.101133_bib163","doi-asserted-by":"crossref","first-page":"9475","DOI":"10.1073\/pnas.92.21.9475","article-title":"Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions","volume":"92","author":"Claria","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jlr.2026.101133_bib164","doi-asserted-by":"crossref","first-page":"9323","DOI":"10.1074\/jbc.M609212200","article-title":"Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation","volume":"282","author":"Sun","year":"2007","journal-title":"J. Biol. 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