{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:49:01Z","timestamp":1792093741171,"version":"4.4.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012154","name":"Graduate Research and Innovation Projects of Jiangsu Province","doi-asserted-by":"publisher","award":["KYCX23_3620"],"award-info":[{"award-number":["KYCX23_3620"]}],"id":[{"id":"10.13039\/501100012154","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370517"],"award-info":[{"award-number":["82370517"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jlr.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jlr.2026.101151","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:57:42Z","timestamp":1790060262000},"page":"101151","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hypertriglyceridemia and atherosclerosis in apolipoprotein A5 mutant rabbits generated using CRISPR\/Cas9"],"prefix":"10.1016","volume":"67","author":[{"given":"Yiwen","family":"Zha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunning","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jlr.2026.101151_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2026.109010","article-title":"Clinical relevance of per-particle atherogenicity of triglyceride-rich lipoproteins, Lp(a) and LDL for cardiovascular risk","volume":"281","author":"Bj\u00f6rnson","year":"2026","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jlr.2026.101151_bib2","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/eurheartj\/ehz785","article-title":"Clinical review on triglycerides","volume":"41","author":"Laufs","year":"2020","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.jlr.2026.101151_bib3","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/MED.0000000000000530","article-title":"Triglycerides and residual risk","volume":"27","author":"Vallejo-Vaz","year":"2020","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"10.1016\/j.jlr.2026.101151_bib4","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1126\/science.1064852","article-title":"An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing","volume":"294","author":"Pennacchio","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.jlr.2026.101151_bib5","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nature13917","article-title":"Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction","volume":"518","author":"Do","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jlr.2026.101151_bib6","article-title":"A neutralizing APOA5 monoclonal antibody reduces amounts of lipoprotein lipase in capillaries and triggers hypertriglyceridemia","volume":"123","author":"Yang","year":"2026","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jlr.2026.101151_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2021.100068","article-title":"APOA5 lowers triglyceride levels via suppression of ANGPTL3\/8-mediated LPL inhibition","volume":"62","author":"Chen","year":"2021","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jlr.2026.101151_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2026.101050","article-title":"Effects of fenofibrate on angiopoietin-like 3\/4\/8 proteins and apolipoprotein A5","volume":"67","author":"Yang","year":"2026","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jlr.2026.101151_bib9","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.molmed.2025.10.003","article-title":"ANGPTL3\/8: one target, multiple lipid disorders","volume":"32","author":"Zhang","year":"2026","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.jlr.2026.101151_bib10","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1021\/bi7000533","article-title":"Apolipoprotein A-V interaction with members of the low density lipoprotein receptor gene family","volume":"46","author":"Nilsson","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.jlr.2026.101151_bib11","doi-asserted-by":"crossref","first-page":"25383","DOI":"10.1074\/jbc.M501589200","article-title":"Apolipoprotein A-V-heparin interactions: implications for plasma lipoprotein metabolism","volume":"280","author":"Lookene","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jlr.2026.101151_bib12","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1161\/ATVBAHA.118.311931","article-title":"Critical role of SREBP-1c large-VLDL pathway in environment-induced hypertriglyceridemia of Apo AV deficiency","volume":"39","author":"Takanashi","year":"2019","journal-title":"Arterioscler Thromb. Vasc. Biol."},{"key":"10.1016\/j.jlr.2026.101151_bib13","doi-asserted-by":"crossref","first-page":"213","DOI":"10.5551\/jat.RV17018","article-title":"Principles and applications of rabbit models for atherosclerosis research","volume":"25","author":"Fan","year":"2018","journal-title":"J. Atheroscler. Thromb."},{"key":"10.1016\/j.jlr.2026.101151_bib14","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.atherosclerosis.2015.12.002","article-title":"ApoE knockout rabbits: a novel model for the study of human hyperlipidemia","volume":"245","author":"Niimi","year":"2016","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jlr.2026.101151_bib15","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1161\/01.ATV.0000075947.28567.50","article-title":"Development of an animal model for spontaneous myocardial infarction (WHHLMI rabbit)","volume":"23","author":"Shiomi","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jlr.2026.101151_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70555","article-title":"Targeting APOA5-associated hypertriglyceridemia to ameliorate acute pancreatitis: insights from a knockout hamster model","volume":"6","author":"Shi","year":"2025","journal-title":"MedComm"},{"key":"10.1016\/j.jlr.2026.101151_bib17","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.7150\/thno.91084","article-title":"Depletion of APOA5 aggravates spontaneous and diet-induced nonalcoholic fatty liver disease by reducing hepatic NR1D1 in hamsters","volume":"14","author":"Guo","year":"2024","journal-title":"Theranostics"},{"issue":"Suppl","key":"10.1016\/j.jlr.2026.101151_bib18","doi-asserted-by":"crossref","first-page":"S150","DOI":"10.1194\/jlr.R800050-JLR200","article-title":"The ins (cell) and outs (plasma) of apolipoprotein A-V","volume":"50","author":"Forte","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jlr.2026.101151_bib19","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12902-024-01663-9","article-title":"Sex hormones differently regulate lipid metabolism genes in primary human hepatocytes","volume":"24","author":"Seidemann","year":"2024","journal-title":"BMC Endocr. Disord."},{"key":"10.1016\/j.jlr.2026.101151_bib20","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1158\/0008-5472.CAN-23-3966","article-title":"Estrogen induces LCAT to maintain cholesterol homeostasis and suppress hepatocellular carcinoma development","volume":"84","author":"He","year":"2024","journal-title":"Cancer Res."},{"key":"10.1016\/j.jlr.2026.101151_bib21","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1161\/ATVBAHA.114.303565","article-title":"Monocyte fate in atherosclerosis","volume":"35","author":"Hilgendorf","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jlr.2026.101151_bib22","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1161\/CIRCRESAHA.116.309692","article-title":"Neutrophil extracellular traps in atherosclerosis and atherothrombosis","volume":"120","author":"Doring","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.jlr.2026.101151_bib23","doi-asserted-by":"crossref","first-page":"4493","DOI":"10.2174\/1381612822666160607064118","article-title":"The role of platelets in cardiovascular disease: molecular mechanisms","volume":"22","author":"Papapanagiotou","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.jlr.2026.101151_bib24","doi-asserted-by":"crossref","first-page":"44512","DOI":"10.1074\/jbc.M106888200","article-title":"Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration","volume":"276","author":"van der Vliet","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jlr.2026.101151_bib25","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1096\/fj.12-225367","article-title":"Apolipoprotein A5 deficiency aggravates high-fat diet-induced obesity due to impaired central regulation of food intake","volume":"27","author":"van den Berg","year":"2013","journal-title":"FASEB J."},{"key":"10.1016\/j.jlr.2026.101151_bib26","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/s12944-021-01605-7","article-title":"CRISPR\/Cas9-mediated knockout of APOC3 stabilizes plasma lipids and inhibits atherosclerosis in rabbits","volume":"20","author":"Zha","year":"2021","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.jlr.2026.101151_bib27","article-title":"Drug target Mendelian randomization supports apolipoprotein C3-lowering for lipoprotein-lipid levels reductions and cardiovascular diseases prevention","volume":"390","author":"Gagnon","year":"2024","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jlr.2026.101151_bib28","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1161\/CIRCULATIONAHA.126.080012","article-title":"Effect of APOC3 inhibition with olezarsen on coronary atherosclerosis: Essence-TIMI 73b imaging study","volume":"153","author":"Marston","year":"2026","journal-title":"Circulation"},{"key":"10.1016\/j.jlr.2026.101151_bib29","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1210\/clinem\/dgaf701","article-title":"Approach to the adult patient with chylomicronemia","volume":"111","author":"Hegele","year":"2026","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jlr.2026.101151_bib30","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.cgh.2020.08.016","article-title":"Genetic variants associated with increased plasma levels of triglycerides, via effects on the lipoprotein lipase pathway, increase risk of acute pancreatitis","volume":"19","author":"Hansen","year":"2021","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jlr.2026.101151_bib31","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ebiom.2018.11.001","article-title":"Intensive genetic analysis for Chinese patients with very high triglyceride levels: relations of mutations to triglyceride levels and acute pancreatitis","volume":"38","author":"Jin","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jlr.2026.101151_bib32","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s44325-025-00091-5","article-title":"Characterizing lipoprotein profiles in coronary atherosclerosis development through quantitative lipidomics and proteomics approaches","volume":"2","author":"Takeda","year":"2025","journal-title":"NPJ Cardiovasc. Health"}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227526001811?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227526001811?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:23:07Z","timestamp":1792092187000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227526001811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":32,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S0022227526001811"],"URL":"https:\/\/doi.org\/10.1016\/j.jlr.2026.101151","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypertriglyceridemia and atherosclerosis in apolipoprotein A5 mutant rabbits generated using CRISPR\/Cas9","name":"articletitle","label":"Article Title"},{"value":"Journal of Lipid Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jlr.2026.101151","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"101151"}}