{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:40:03Z","timestamp":1792471203437,"version":"4.5.0"},"reference-count":76,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["F31 DK142470"],"award-info":[{"award-number":["F31 DK142470"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK130971"],"award-info":[{"award-number":["R01 DK130971"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jlr.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jlr.2026.101159","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:14:36Z","timestamp":1790205276000},"page":"101159","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Loss of ceramide synthases 5 and 6 exacerbate myristate-induced colonic IRE1\u03b1 activation"],"prefix":"10.1016","volume":"67","author":[{"given":"Chelsea L.","family":"Doll","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0348-9197","authenticated-orcid":false,"given":"Mary R.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Padilla-Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8255-6972","authenticated-orcid":false,"given":"Eugene","family":"Jap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4993-6735","authenticated-orcid":false,"given":"Paul A.","family":"Boasiako","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3367-9644","authenticated-orcid":false,"given":"Marilyn T.","family":"Marron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2718-3986","authenticated-orcid":false,"given":"Brandon K.","family":"Dahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8514-1600","authenticated-orcid":false,"given":"Keila S.","family":"Espinoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drew M.","family":"Seiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel J.","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curtis A.","family":"Thorne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin M.","family":"Snider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1515-4171","authenticated-orcid":false,"given":"Ashley J.","family":"Snider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jlr.2026.101159_bib1","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1053\/j.gastro.2023.05.050","article-title":"Global burden of digestive diseases: a systematic analysis of the global burden of diseases study, 1990 to 2019","volume":"165","author":"Wang","year":"2023","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jlr.2026.101159_bib2","article-title":"Global, regional, and national burden of 10 digestive diseases in 204 countries and territories from 1990 to 2019","volume":"11","author":"Wang","year":"2023","journal-title":"Front. Public Health"},{"key":"10.1016\/j.jlr.2026.101159_bib3","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1053\/j.gastro.2024.11.004","article-title":"Prevalence of pediatric inflammatory bowel disease in the United States: pooled estimates from three administrative claims data sources","volume":"168","author":"Kappelman","year":"2025","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jlr.2026.101159_bib4","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1016\/j.cgh.2019.10.009","article-title":"Risk factors associated with early-onset colorectal cancer","volume":"18","author":"Gausman","year":"2020","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jlr.2026.101159_bib5","first-page":"347","article-title":"Increased incidence of inflammatory bowel disease in association with dietary transition (Westernization) in Japan","volume":"4","author":"Chiba","year":"2021","journal-title":"JMA J."},{"key":"10.1016\/j.jlr.2026.101159_bib6","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1007\/s10620-025-09543-5","article-title":"Pain and IBD: the contributing role of diet and nutrition","volume":"71","author":"Kuang","year":"2025","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.jlr.2026.101159_bib7","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s11894-024-00949-1","article-title":"Synergistic benefits of dietary strategies in the management of IBD","volume":"27","author":"Dryden","year":"2025","journal-title":"Curr. Gastroenterol. Rep."},{"key":"10.1016\/j.jlr.2026.101159_bib8","article-title":"Nutritional composition of diets for inducing and maintaining remission in inflammatory bowel diseases: from bedside to plate","volume":"86","author":"Godny","year":"2025","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.jlr.2026.101159_bib9","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nrm.2017.107","article-title":"Sphingolipids and their metabolism in physiology and disease","volume":"19","author":"Hannun","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jlr.2026.101159_bib10","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1096\/fj.08-118109","article-title":"A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis","volume":"23","author":"Snider","year":"2009","journal-title":"FASEB J."},{"key":"10.1016\/j.jlr.2026.101159_bib11","doi-asserted-by":"crossref","first-page":"5724","DOI":"10.1096\/fj.201800141R","article-title":"Myristate-induced endoplasmic reticulum stress requires ceramide synthases 5\/6 and generation of C14-ceramide in intestinal epithelial cells","volume":"32","author":"Choi","year":"2018","journal-title":"FASEB J."},{"key":"10.1016\/j.jlr.2026.101159_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.prostaglandins.2020.106423","article-title":"Sphingosine kinase 1 is required for myristate-induced TNFalpha expression in intestinal epithelial cells","volume":"149","author":"Choi","year":"2020","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"10.1016\/j.jlr.2026.101159_bib13","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1096\/fj.201700585R","article-title":"Loss of acid ceramidase in myeloid cells suppresses intestinal neutrophil recruitment","volume":"32","author":"Espaillat","year":"2018","journal-title":"FASEB J."},{"key":"10.1016\/j.jlr.2026.101159_bib14","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.prostaglandins.2017.03.006","article-title":"Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis","volume":"130","author":"Pulkoski-Gross","year":"2017","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"10.1016\/j.jlr.2026.101159_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113998","article-title":"Distinct roles for hematopoietic and extra-hematopoietic sphingosine kinase-1 in inflammatory bowel disease","volume":"9","author":"Snider","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jlr.2026.101159_bib16","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.prostaglandins.2012.08.003","article-title":"Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease","volume":"99","author":"Snider","year":"2012","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"10.1016\/j.jlr.2026.101159_bib17","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1042\/BJ20111626","article-title":"Ceramide synthases at the centre of sphingolipid metabolism and biology","volume":"441","author":"Mullen","year":"2012","journal-title":"Biochem. J."},{"key":"10.1016\/j.jlr.2026.101159_bib18","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.cmet.2014.08.002","article-title":"Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance","volume":"20","author":"Turpin","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.jlr.2026.101159_bib19","doi-asserted-by":"crossref","first-page":"6989","DOI":"10.1074\/jbc.M115.691212","article-title":"Ceramide synthase 5 is essential to maintain C16:0-Ceramide pools and contributes to the development of diet-induced obesity","volume":"291","author":"Gosejacob","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jlr.2026.101159_bib20","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s00018-022-04401-3","article-title":"Contribution of specific ceramides to obesity-associated metabolic diseases","volume":"79","author":"Hammerschmidt","year":"2022","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.jlr.2026.101159_bib21","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.3389\/fimmu.2018.02649","article-title":"Inflammatory links between high fat diets and diseases","volume":"9","author":"Duan","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jlr.2026.101159_bib22","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nature17173","article-title":"High-fat diet enhances stemness and tumorigenicity of intestinal progenitors","volume":"531","author":"Beyaz","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jlr.2026.101159_bib23","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/advances\/nmz061","article-title":"Negative effects of a high-fat diet on intestinal permeability: a review","volume":"11","author":"Rohr","year":"2020","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.jlr.2026.101159_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111641","article-title":"A dietary change to a high-fat diet initiates a rapid adaptation of the intestine","volume":"41","author":"Enriquez","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.jlr.2026.101159_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109212","article-title":"High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity","volume":"35","author":"Mana","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.jlr.2026.101159_bib26","doi-asserted-by":"crossref","first-page":"6207","DOI":"10.1210\/jc.2019-00160","article-title":"Overeating saturated fat promotes fatty liver and ceramides compared with polyunsaturated fat: a randomized trial","volume":"104","author":"Rosqvist","year":"2019","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jlr.2026.101159_bib27","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/j.cgh.2016.12.036","article-title":"High dietary intake of specific fatty acids increases risk of flares in patients with ulcerative colitis in remission during treatment with aminosalicylates","volume":"15","author":"Barnes","year":"2017","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jlr.2026.101159_bib28","article-title":"Examination of food consumption in United States adults and the prevalence of inflammatory bowel disease using National Health Interview Survey 2015","volume":"15","author":"Han","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.jlr.2026.101159_bib29","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.advnut.2023.05.008","article-title":"The association between total protein, animal protein, and animal protein sources with risk of inflammatory bowel diseases: a systematic review and meta-analysis of cohort studies","volume":"14","author":"Talebi","year":"2023","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.jlr.2026.101159_bib30","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.cell.2008.07.021","article-title":"XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease","volume":"134","author":"Kaser","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.jlr.2026.101159_bib31","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.dld.2014.05.013","article-title":"Endoplasmic reticulum stress and unfolded protein response are involved in paediatric inflammatory bowel disease","volume":"46","author":"Negroni","year":"2014","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.jlr.2026.101159_bib32","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1053\/j.gastro.2018.07.028","article-title":"Activated ATF6 induces intestinal dysbiosis and innate immune response to promote colorectal tumorigenesis","volume":"155","author":"Coleman","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jlr.2026.101159_bib33","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.3389\/fimmu.2019.02825","article-title":"ER stress and the UPR in shaping intestinal tissue homeostasis and immunity","volume":"10","author":"Coleman","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jlr.2026.101159_bib34","doi-asserted-by":"crossref","first-page":"5392","DOI":"10.1007\/s10620-022-07467-y","article-title":"Role of ER stress mediated unfolded protein responses and ER stress inhibitors in the pathogenesis of inflammatory bowel disease","volume":"67","author":"Deka","year":"2022","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.jlr.2026.101159_bib35","doi-asserted-by":"crossref","first-page":"4628","DOI":"10.1073\/pnas.1217611110","article-title":"Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains","volume":"110","author":"Volmer","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jlr.2026.101159_bib36","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1091\/mbc.e17-03-0144","article-title":"Generic membrane-spanning features endow IRE1alpha with responsiveness to membrane aberrancy","volume":"28","author":"Kono","year":"2017","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.jlr.2026.101159_bib37","first-page":"1","article-title":"Hepatic triglyceride accumulation via endoplasmic reticulum stress-induced SREBP-1 activation is regulated by ceramide synthases","volume":"51","author":"Kim","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.jlr.2026.101159_bib38","doi-asserted-by":"crossref","first-page":"3632","DOI":"10.1002\/1873-3468.13863","article-title":"The role of sphingolipids in endoplasmic reticulum stress","volume":"594","author":"Park","year":"2020","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jlr.2026.101159_bib39","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1038\/s41467-022-29363-9","article-title":"Long-chain ceramides are cell non-autonomous signals linking lipotoxicity to endoplasmic reticulum stress in skeletal muscle","volume":"13","author":"McNally","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jlr.2026.101159_bib40","doi-asserted-by":"crossref","first-page":"7824","DOI":"10.1038\/s41467-023-42595-7","article-title":"CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER\/mitochondrial stress and impairs glucose homeostasis in obese mice","volume":"14","author":"Hammerschmidt","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jlr.2026.101159_bib41","doi-asserted-by":"crossref","first-page":"22193","DOI":"10.1074\/jbc.M113.477786","article-title":"Sphingosine kinase 1 is regulated by peroxisome proliferator-activated receptor alpha in response to free fatty acids and is essential for skeletal muscle interleukin-6 production and signaling in diet-induced obesity","volume":"288","author":"Ross","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jlr.2026.101159_bib42","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/978-1-60761-322-0_22","article-title":"Comprehensive quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry","volume":"579","author":"Bielawski","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jlr.2026.101159_bib43","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0005-2760(88)90030-6","article-title":"Effect of harvesting methods, growth conditions and growth phase on diacylglycerol levels in cultured human adherent cells","volume":"959","author":"Van Veldhoven","year":"1988","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jlr.2026.101159_bib44","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/y59-099","article-title":"A rapid method of total lipid extraction and purification","volume":"37","author":"Bligh","year":"1959","journal-title":"Can J. Biochem. Physiol."},{"key":"10.1016\/j.jlr.2026.101159_bib45","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.1038\/s41467-023-39752-3","article-title":"Endothelial cell CD36 regulates membrane ceramide formation, exosome fatty acid transfer and circulating fatty acid levels","volume":"14","author":"Peche","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jlr.2026.101159_bib46","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.1172\/JCI63888","article-title":"Ceramide synthase 5 mediates lipid-induced autophagy and hypertrophy in cardiomyocytes","volume":"122","author":"Russo","year":"2012","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.jlr.2026.101159_bib47","doi-asserted-by":"crossref","first-page":"13397","DOI":"10.1074\/jbc.M112.428185","article-title":"Myristate-derived d16:0 sphingolipids constitute a cardiac sphingolipid pool with distinct synthetic routes and functional properties","volume":"288","author":"Russo","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jlr.2026.101159_bib48","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1007\/s00125-013-2973-2","article-title":"Fatty acids differentially regulate insulin resistance through endoplasm reticulum stress-mediated induction of tribbles homologue 3: a potential link between dietary fat composition and the pathophysiological outcomes of obesity","volume":"56","author":"Geng","year":"2013","journal-title":"Diabetologia"},{"key":"10.1016\/j.jlr.2026.101159_bib49","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.74342","article-title":"Endoplasmic reticulum stress activates human IRE1alpha through reversible assembly of inactive dimers into small oligomers","volume":"11","author":"Belyy","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.jlr.2026.101159_bib50","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1042\/BJ20090699","article-title":"Disruption of ceramide synthesis by CerS2 down-regulation leads to autophagy and the unfolded protein response","volume":"424","author":"Spassieva","year":"2009","journal-title":"Biochem. J."},{"key":"10.1016\/j.jlr.2026.101159_bib51","doi-asserted-by":"crossref","first-page":"905","DOI":"10.3390\/biom13060905","article-title":"The effects of a high-fat diet on inflammatory bowel disease","volume":"13","author":"Dang","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.jlr.2026.101159_bib52","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202400830R","article-title":"The diverse roles of sphingolipids in inflammatory bowel disease","volume":"38","author":"Doll","year":"2024","journal-title":"FASEB J."},{"key":"10.1016\/j.jlr.2026.101159_bib53","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1194\/jlr.M016931","article-title":"Different fatty acids inhibit apoB100 secretion by different pathways: unique roles for ER stress, ceramide, and autophagy","volume":"52","author":"Caviglia","year":"2011","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jlr.2026.101159_bib54","doi-asserted-by":"crossref","first-page":"41479","DOI":"10.18632\/oncotarget.6286","article-title":"Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis","volume":"6","author":"Martinez","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.jlr.2026.101159_bib55","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.molmet.2018.12.008","article-title":"The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach","volume":"21","author":"Raichur","year":"2019","journal-title":"Mol. Metab."},{"key":"10.1016\/j.jlr.2026.101159_bib56","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1194\/jlr.M009142","article-title":"Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism","volume":"52","author":"Mullen","year":"2011","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jlr.2026.101159_bib57","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1096\/fj.09-135087","article-title":"Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6\/CHOP arm of ER-stress-response pathways","volume":"24","author":"Senkal","year":"2010","journal-title":"FASEB J."},{"key":"10.1016\/j.jlr.2026.101159_bib58","doi-asserted-by":"crossref","first-page":"42446","DOI":"10.1074\/jbc.M111.287383","article-title":"Alteration of ceramide synthase 6\/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER\/Golgi membrane network","volume":"286","author":"Senkal","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jlr.2026.101159_bib59","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41368-021-00118-4","article-title":"Downregulation of ceramide synthase 1 promotes oral cancer through endoplasmic reticulum stress","volume":"13","author":"Chen","year":"2021","journal-title":"Int. J. Oral. Sci."},{"key":"10.1016\/j.jlr.2026.101159_bib60","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.3390\/nu17172881","article-title":"Myristic acid remodels sphingolipid metabolism via dual pathways: canonical d18-Sphingolipid regulation and non-canonical d16-Sphingolipid synthesis","volume":"17","author":"You","year":"2025","journal-title":"Nutrients"},{"key":"10.1016\/j.jlr.2026.101159_bib61","doi-asserted-by":"crossref","first-page":"5670","DOI":"10.1111\/febs.16446","article-title":"The atypical sphingosine 1-phosphate variant, d16:1 S1P, mediates CTGF induction via S1P2 activation in renal cell carcinoma","volume":"289","author":"Glueck","year":"2022","journal-title":"FEBS J."},{"key":"10.1016\/j.jlr.2026.101159_bib62","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s13195-020-00694-3","article-title":"Immunomodulatory sphingosine-1-phosphates as plasma biomarkers of Alzheimer's disease and vascular cognitive impairment","volume":"12","author":"Chua","year":"2020","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.jlr.2026.101159_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.115054","article-title":"SPTLC3 regulates plasma membrane sphingolipid composition to facilitate hepatic gluconeogenesis","volume":"43","author":"Montefusco","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.jlr.2026.101159_bib64","doi-asserted-by":"crossref","first-page":"E1334","DOI":"10.1073\/pnas.1504555113","article-title":"ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complex","volume":"113","author":"Park","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jlr.2026.101159_bib65","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232012130","article-title":"Diverse sphingolipid species Harbor different effects on Ire1 clustering","volume":"23","author":"Bieniawski","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jlr.2026.101159_bib66","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.devcel.2018.04.023","article-title":"The UPR activator ATF6 responds to proteotoxic and lipotoxic stress by distinct mechanisms","volume":"46","author":"Tam","year":"2018","journal-title":"Dev. Cell"},{"key":"10.1016\/j.jlr.2026.101159_bib67","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1194\/jlr.D081646","article-title":"Probing de novo sphingolipid metabolism in mammalian cells utilizing mass spectrometry","volume":"59","author":"Snider","year":"2018","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jlr.2026.101159_bib68","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1007\/s10620-012-2373-3","article-title":"Dietary patterns and self-reported associations of diet with symptoms of inflammatory bowel disease","volume":"58","author":"Cohen","year":"2013","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.jlr.2026.101159_bib69","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.jada.2011.05.004","article-title":"Effects of dairy products on Crohn'S disease symptoms are influenced by fat content and disease location but not lactose content or disease activity status in a New Zealand population","volume":"111","author":"Nolan-Clark","year":"2011","journal-title":"J. Am. Diet. Assoc."},{"key":"10.1016\/j.jlr.2026.101159_bib70","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature11225","article-title":"Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-\/- mice","volume":"487","author":"Devkota","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jlr.2026.101159_bib71","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2022.2055441","article-title":"A Mediterranean-like fat blend protects against the development of severe colitis in the mucin-2 deficient murine model","volume":"14","author":"Haskey","year":"2022","journal-title":"Gut Microbes"},{"key":"10.1016\/j.jlr.2026.101159_bib72","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1093\/infdis\/jiw084","article-title":"Dietary lipid type, rather than total number of calories, alters outcomes of enteric infection in mice","volume":"213","author":"DeCoffe","year":"2016","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jlr.2026.101159_bib73","doi-asserted-by":"crossref","first-page":"4608","DOI":"10.1039\/C9FO00690G","article-title":"Milk phospholipids ameliorate mouse colitis associated with colonic goblet cell depletion via the Notch pathway","volume":"10","author":"Wang","year":"2019","journal-title":"Food Funct."},{"key":"10.1016\/j.jlr.2026.101159_bib74","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-51092-1","article-title":"Concentrates of two subsets of extracellular vesicles from cow's milk modulate symptoms and inflammation in experimental colitis","volume":"9","author":"Benmoussa","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jlr.2026.101159_bib75","article-title":"Milk fat globule membrane attenuates acute Colitis and secondary liver injury by improving the mucus barrier and regulating the gut microbiota","volume":"13","author":"Wu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jlr.2026.101159_bib76","doi-asserted-by":"crossref","first-page":"5145","DOI":"10.3390\/nu14235145","article-title":"Effects of milk polar lipids on DSS-induced colitis severity are dependent on dietary fat content","volume":"14","author":"Garcia","year":"2022","journal-title":"Nutrients"}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227526001896?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227526001896?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:19:09Z","timestamp":1792469949000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227526001896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":76,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S0022227526001896"],"URL":"https:\/\/doi.org\/10.1016\/j.jlr.2026.101159","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of ceramide synthases 5 and 6 exacerbate myristate-induced colonic IRE1\u03b1 activation","name":"articletitle","label":"Article Title"},{"value":"Journal of Lipid Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jlr.2026.101159","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"101159"}}