{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:38:15Z","timestamp":1793295495013,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jlr.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jlr.2026.101161","type":"journal-article","created":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T14:34:04Z","timestamp":1791729244000},"page":"101161","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Wnt-PPAR\u03b3 Seesaw Mechanism Mediates the Perilipin 2-to-1 Dominance Shift in Engineered Adipose Tissue Regeneration"],"prefix":"10.1016","author":[{"given":"Xing","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaili","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaijun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4782-1677","authenticated-orcid":false,"given":"Guangpeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"20","key":"10.1016\/j.jlr.2026.101161_bib1","doi-asserted-by":"crossref","first-page":"5809","DOI":"10.1007\/s00266-025-05269-x","article-title":"Autologous Fat Grafting in Facial Soft Tissue Defects: Application Status, Controversies and Future","volume":"49","author":"Zhang","year":"2025","journal-title":"Aesthetic Plast Surg"},{"key":"10.1016\/j.jlr.2026.101161_bib2","doi-asserted-by":"crossref","DOI":"10.1007\/s00266-025-05474-8","article-title":"Gluteal Augmentation Using Subfascial Silicone Implants and Selective Autologous Fat Grafting","author":"Salgado","year":"2026","journal-title":"Aesthetic Plast Surg"},{"issue":"9","key":"10.1016\/j.jlr.2026.101161_bib3","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1093\/asj\/sjw105","article-title":"Autologous Fat Grafting in Cosmetic Breast Augmentation: A Systematic Review on Radiological Safety, Complications, Volume Retention, and Patient\/Surgeon Satisfaction","volume":"36","author":"Groen","year":"2016","journal-title":"Aesthet Surg J"},{"key":"10.1016\/j.jlr.2026.101161_bib4","doi-asserted-by":"crossref","DOI":"10.1093\/asj\/sjag048","article-title":"Comparative Efficacy and Safety of Different Assisted-fat Transplantation Methods: A Network Meta-analysis of Randomized Controlled Trials","author":"Li","year":"2026","journal-title":"Aesthet Surg J"},{"issue":"3","key":"10.1016\/j.jlr.2026.101161_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/biom16030362","article-title":"Adipose Tissue Engineering Biomaterials: Smart Scaffolds, Vascularization, and Clinical Frontiers","volume":"16","author":"Zhao","year":"2026","journal-title":"Biomolecules"},{"issue":"19","key":"10.1016\/j.jlr.2026.101161_bib6","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202501473R","article-title":"Creatine Supplementation Enhances Fat Graft Survival by Mitochondrial Protection and Revascularization Promotion","volume":"39","author":"Zhang","year":"2025","journal-title":"Faseb j"},{"issue":"5","key":"10.1016\/j.jlr.2026.101161_bib7","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1097\/PRS.0b013e31824a2b19","article-title":"The fate of adipocytes after nonvascularized fat grafting: evidence of early death and replacement of adipocytes","volume":"129","author":"Eto","year":"2012","journal-title":"Plast Reconstr Surg"},{"issue":"6","key":"10.1016\/j.jlr.2026.101161_bib8","doi-asserted-by":"crossref","first-page":"Np646","DOI":"10.1093\/asj\/sjaa360","article-title":"Perilipin2 is an Earlier Marker Than Perilipin1 for Identifying Adipocyte Regeneration in Fat Grafts","volume":"41","author":"Zhang","year":"2021","journal-title":"Aesthet Surg J"},{"key":"10.1016\/j.jlr.2026.101161_bib9","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1146\/annurev-nutr-071813-105410","article-title":"The Perilipins: Major Cytosolic Lipid Droplet-Associated Proteins and Their Roles in Cellular Lipid Storage, Mobilization, and Systemic Homeostasis","volume":"36","author":"Kimmel","year":"2016","journal-title":"Annu Rev Nutr"},{"issue":"1","key":"10.1016\/j.jlr.2026.101161_bib10","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1038\/s41467-022-29279-4","article-title":"Tissue extracellular matrix hydrogels as alternatives to Matrigel for culturing gastrointestinal organoids","volume":"13","author":"Kim","year":"2022","journal-title":"Nat Commun"},{"issue":"5","key":"10.1016\/j.jlr.2026.101161_bib11","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/j.celrep.2019.04.010","article-title":"Identification of Metabolically Distinct Adipocyte Progenitor Cells in Human Adipose Tissues","volume":"27","author":"Raajendiran","year":"2019","journal-title":"Cell Rep"},{"issue":"1","key":"10.1016\/j.jlr.2026.101161_bib12","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1186\/s12964-023-01355-2","article-title":"Inhibition of Dickkopf-1 enhances the anti-tumor efficacy of sorafenib via inhibition of the PI3K\/Akt and Wnt\/\u03b2-catenin pathways in hepatocellular carcinoma","volume":"21","author":"Seo","year":"2023","journal-title":"Cell Commun Signal"},{"issue":"6","key":"10.1016\/j.jlr.2026.101161_bib13","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.3892\/or.2013.2704","article-title":"Effects of rosiglitazone on the growth and lymphangiogenesis of human gastric cancer transplanted in nude mice","volume":"30","author":"Chen","year":"2013","journal-title":"Oncol Rep"},{"key":"10.1016\/j.jlr.2026.101161_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2026.178974","article-title":"Fisetin alleviates osteoporosis by promoting osteogenesis and suppressing adipogenesis via the Wnt\/\u03b2-catenin signaling pathway in mice","volume":"1030","author":"Zhang","year":"2026","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"10.1016\/j.jlr.2026.101161_bib15","doi-asserted-by":"crossref","first-page":"9475","DOI":"10.1038\/s41467-024-53750-z","article-title":"CLSTN3B promotes lipid droplet maturation and lipid storage in mouse adipocytes","volume":"15","author":"Zhang","year":"2024","journal-title":"Nat Commun"},{"issue":"45","key":"10.1016\/j.jlr.2026.101161_bib16","doi-asserted-by":"crossref","first-page":"30941","DOI":"10.1074\/jbc.M109.013995","article-title":"Diacylglycerol enrichment of endoplasmic reticulum or lipid droplets recruits perilipin 3\/TIP47 during lipid storage and mobilization","volume":"284","author":"Skinner","year":"2009","journal-title":"J Biol Chem"},{"issue":"25","key":"10.1016\/j.jlr.2026.101161_bib17","doi-asserted-by":"crossref","first-page":"9163","DOI":"10.1073\/pnas.1318791111","article-title":"Perilipins 2 and 3 lack a carboxy-terminal domain present in perilipin 1 involved in sequestering ABHD5 and suppressing basal lipolysis","volume":"111","author":"Patel","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"10.1016\/j.jlr.2026.101161_bib18","doi-asserted-by":"crossref","first-page":"5833","DOI":"10.1021\/acsbiomaterials.0c01035","article-title":"Sensing Traction Force on the Matrix Induces Cell-Cell Distant Mechanical Communications for Self-Assembly","volume":"6","author":"Ouyang","year":"2020","journal-title":"ACS Biomater Sci Eng"},{"issue":"18","key":"10.1016\/j.jlr.2026.101161_bib19","doi-asserted-by":"crossref","first-page":"9508","DOI":"10.7150\/thno.120300","article-title":"Advances and challenges in decellularized adipose tissue based composite hydrogels for adipose tissue regeneration: a review over the last fifteen years","volume":"15","author":"Cui","year":"2025","journal-title":"Theranostics"},{"issue":"44","key":"10.1016\/j.jlr.2026.101161_bib20","article-title":"Bioengineered Skin Grafts from Patient-Derived Decellularized Extracellular Matrix and Autologous Cells for Personalized Regenerative","volume":"12","author":"Kang","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.jlr.2026.101161_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101355","article-title":"Deletion of narfl leads to increased oxidative stress mediated abnormal angiogenesis and digestive organ defects in zebrafish","volume":"28","author":"Luo","year":"2020","journal-title":"Redox Biol"},{"issue":"29","key":"10.1016\/j.jlr.2026.101161_bib22","article-title":"Hydrogel Bioadhesives with Extreme Acid-Tolerance for Gastric Perforation Repairing","volume":"32","author":"Chen","year":"2022","journal-title":"Advanced Functional Materials"},{"issue":"1","key":"10.1016\/j.jlr.2026.101161_bib23","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s12195-025-00883-w","article-title":"FGF-2-Overexpressing Adipose-Derived Stem Cells as a Paracrine Platform for Angiogenesis-Driven Tissue Regeneration","volume":"19","author":"Seki","year":"2026","journal-title":"Cell Mol Bioeng"},{"issue":"7","key":"10.1016\/j.jlr.2026.101161_bib24","doi-asserted-by":"crossref","first-page":"5423","DOI":"10.1021\/acsnano.5c07071","article-title":"Neonatal Spinal-Cord-Like Scaffold with Hierarchical Structural and Neurogenetic Microenvironments for Spinal Cord Injury Repair","volume":"20","author":"Bai","year":"2026","journal-title":"ACS Nano"},{"issue":"3","key":"10.1016\/j.jlr.2026.101161_bib25","doi-asserted-by":"crossref","first-page":"303e","DOI":"10.1097\/PRS.0000000000000066","article-title":"Degeneration, regeneration, and cicatrization after fat grafting: dynamic total tissue remodeling during the first 3 months","volume":"133","author":"Kato","year":"2014","journal-title":"Plast Reconstr Surg"},{"issue":"7903","key":"10.1016\/j.jlr.2026.101161_bib26","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/s41586-022-04518-2","article-title":"A single-cell atlas of human and mouse white adipose tissue","volume":"603","author":"Emont","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.jlr.2026.101161_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106461","article-title":"Critical review on anti-obesity effects of phytochemicals through Wnt\/\u03b2-catenin signaling pathway","volume":"184","author":"Luo","year":"2022","journal-title":"Pharmacol Res"},{"issue":"10 Pt B","key":"10.1016\/j.jlr.2026.101161_bib28","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.bbalip.2017.07.007","article-title":"Regulation of lipid droplet-associated proteins by peroxisome proliferator-activated receptors","volume":"1862","author":"de la Rosa Rodriguez","year":"2017","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"issue":"3","key":"10.1016\/j.jlr.2026.101161_bib29","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1053\/j.gastro.2012.05.048","article-title":"\u03b2-Catenin regulates hepatic mitochondrial function and energy balance in mice","volume":"143","author":"Lehwald","year":"2012","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.jlr.2026.101161_bib30","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-026-09749-x","article-title":"Netrin-1 disrupt high-fat-diet-induced adipogenesis via the PPAR\u03b3 and Wnt\/\u03b2-catenin signaling pathways","volume":"9","author":"Shi","year":"2026","journal-title":"Commun Biol"},{"issue":"1","key":"10.1016\/j.jlr.2026.101161_bib31","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.tem.2008.09.002","article-title":"Adipogenesis and WNT signalling","volume":"20","author":"Christodoulides","year":"2009","journal-title":"Trends Endocrinol Metab"},{"issue":"23","key":"10.1016\/j.jlr.2026.101161_bib32","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.189371","article-title":"Angiopoietin-like 8 governs osteoblast-adipocyte lineage commitment during skeletal aging","volume":"10","author":"Guo","year":"2025","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.jlr.2026.101161_bib33","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1210\/endrev\/bnab018","article-title":"Fat Cell Size: Measurement Methods, Pathophysiological Origins, and Relationships With Metabolic Dysregulations","volume":"43","author":"Ye","year":"2022","journal-title":"Endocr Rev"},{"issue":"5","key":"10.1016\/j.jlr.2026.101161_bib34","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1262\/jrd.2024-023","article-title":"Perilipin2 depletion causes lipid droplet enlargement in the ovarian corpus luteum in mice","volume":"70","author":"Ibayashi","year":"2024","journal-title":"J Reprod Dev"},{"issue":"6","key":"10.1016\/j.jlr.2026.101161_bib35","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1113\/JP277140","article-title":"Perilipin-2 promotes obesity and progressive fatty liver disease in mice through mechanistically distinct hepatocyte and extra-hepatocyte actions","volume":"597","author":"Orlicky","year":"2019","journal-title":"J Physiol"}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227526001914?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227526001914?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:24:13Z","timestamp":1793294653000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227526001914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":35,"alternative-id":["S0022227526001914"],"URL":"https:\/\/doi.org\/10.1016\/j.jlr.2026.101161","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Wnt-PPAR\u03b3 Seesaw Mechanism Mediates the Perilipin 2-to-1 Dominance Shift in Engineered Adipose Tissue Regeneration","name":"articletitle","label":"Article Title"},{"value":"Journal of Lipid Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jlr.2026.101161","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"101161"}}