{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:39:29Z","timestamp":1791157169765,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2003,10,1]],"date-time":"2003-10-01T00:00:00Z","timestamp":1064966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Molecular Biology"],"published-print":{"date-parts":[[2003,10]]},"DOI":"10.1016\/j.jmb.2003.08.041","type":"journal-article","created":{"date-parts":[[2003,10,11]],"date-time":"2003-10-11T07:27:44Z","timestamp":1065857264000},"page":"307-319","source":"Crossref","is-referenced-by-count":46,"title":["In Vivo and in Vitro Evidence that the Four Essential Intermediate Filament (IF) Proteins A1, A2, A3 and B1 of the Nematode Caenorhabditis elegans Form an Obligate Heteropolymeric IF System"],"prefix":"10.1016","volume":"333","author":[{"given":"Anton","family":"Karabinos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekkehard","family":"Schulze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Sch\u00fcnemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.D.","family":"Parry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmb.2003.08.041_BIB1","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1242\/jcs.114.14.2569","article-title":"Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18","volume":"4","author":"Hesse","year":"2001","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.jmb.2003.08.041_BIB2","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev.bi.63.070194.002021","article-title":"Intermediate filaments: structure, dynamics, function and disease","volume":"63","author":"Fuchs","year":"1994","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.jmb.2003.08.041_BIB3","series-title":"Intermediate Filament Structure","author":"Parry","year":"1995"},{"key":"10.1016\/j.jmb.2003.08.041_BIB4","first-page":"83","article-title":"Functional complexity of intermediate filament cytoskeletons: from structure to assembly to gene ablation","volume":"83","author":"Herrmann","year":"2003","journal-title":"Int. Rev. Cytol."},{"key":"10.1016\/j.jmb.2003.08.041_BIB5","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1046\/j.1365-2133.1999.02810.x","article-title":"Human keratin diseases: the increasing spectrum of disease and subtlety of the phenotype-genotype correlation","volume":"140","author":"Irvine","year":"1999","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jmb.2003.08.041_BIB6","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/1300","article-title":"Missense mutations in desmin associated with familial cardiac and skeletal myopathy","volume":"19","author":"Goldfarb","year":"1998","journal-title":"Nature Genet."},{"key":"10.1016\/j.jmb.2003.08.041_BIB7","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/83679","article-title":"Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease","volume":"27","author":"Brenner","year":"2001","journal-title":"Nature Genet."},{"key":"10.1016\/j.jmb.2003.08.041_BIB8","doi-asserted-by":"crossref","first-page":"7659","DOI":"10.1073\/pnas.151247898","article-title":"Worms reveal essential functions for intermediate filaments","volume":"98","author":"Goldman","year":"2001","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.jmb.2003.08.041_BIB9","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1006\/jmbi.2001.5298","article-title":"Tissue-specific coexpression and in vitro heteropolymer formation of the two small Branchiostoma intermediate filament proteins A3 and B2","volume":"316","author":"Karabinos","year":"2002","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jmb.2003.08.041_BIB10","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1078\/0171-9335-00069","article-title":"The epidermal intermediate filament proteins of tunicates are distant keratins; a polymerisation-competent hetero coiled coil of the Styela D protein and Xenopus keratin 8","volume":"79","author":"Wang","year":"2000","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.jmb.2003.08.041_BIB11","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1078\/0171-9335-00246","article-title":"Cytoplasmic intermediate filament protein expression in tunicate development; a specific marker for the test cells","volume":"81","author":"Wang","year":"2002","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.jmb.2003.08.041_BIB12","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1002\/j.1460-2075.1989.tb08481.x","article-title":"Cytoplasmic intermediate filament proteins of invertebrates are closer to nuclear lamins than are vertebrate intermediate filament proteins; sequence characterization of two muscle proteins of a nematode","volume":"8","author":"Weber","year":"1989","journal-title":"EMBO J."},{"key":"10.1016\/j.jmb.2003.08.041_BIB13","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/PL00006434","article-title":"Molecular phylogeny of metazoan intermediate filament proteins","volume":"47","author":"Erber","year":"1998","journal-title":"J. Mol. Evol."},{"key":"10.1016\/j.jmb.2003.08.041_BIB14","doi-asserted-by":"crossref","first-page":"3937","DOI":"10.1091\/mbc.11.11.3937","article-title":"Essential roles for Caenorhabditis elegans lamin gene in nuclear organization, cell cycle progression, and spatial organization of nuclear pore complexes","volume":"11","author":"Liu","year":"2000","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.jmb.2003.08.041_BIB15","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/35042517","article-title":"Functional genomic analysis of C.elegans chromosome I by systematic RNA interference","volume":"408","author":"Fraser","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2003.08.041_BIB16","doi-asserted-by":"crossref","first-page":"7863","DOI":"10.1073\/pnas.121169998","article-title":"Essential roles for four cytoplasmic intermediate filament proteins in Caenorhabditis elegans development","volume":"98","author":"Karabinos","year":"2001","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.jmb.2003.08.041_BIB17","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1083\/jcb.114.3.465","article-title":"Muscle cell attachement in Caenorhabditis elegans","volume":"114","author":"Francis","year":"1991","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jmb.2003.08.041_BIB18","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1083\/jcb.124.4.491","article-title":"Assembly of body wall muscle and muscle cell attachment structures in Caenorhabditis elegans","volume":"124","author":"Hresko","year":"1994","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jmb.2003.08.041_BIB19","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1083\/jcb.146.3.659","article-title":"Myotactin, a novel hypodermal protein involved in muscle-cell adhesion in Caenorhabditis elegans","volume":"146","author":"Hresko","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jmb.2003.08.041_BIB20","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0925-4773(02)00192-2","article-title":"Expression profiles of the essential intermediate filament (IF) protein A2 and the IF protein C2 in the nematode Caenorhabditis elegans","volume":"117","author":"Karabinos","year":"2002","journal-title":"Mech. Dev."},{"key":"10.1016\/j.jmb.2003.08.041_BIB21","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0378-1119(00)00579-5","article-title":"Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans","volume":"263","author":"Timmons","year":"2001","journal-title":"Gene"},{"key":"10.1016\/j.jmb.2003.08.041_BIB22","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1002\/j.1460-2075.1994.tb06553.x","article-title":"Eight genes and alternative RNA processing pathways generate an unexpectedly large diversity of cytoplasmic intermediate filament proteins in the nematode Caenorhabditis elegans","volume":"13","author":"Dodemont","year":"1994","journal-title":"EMBO J."},{"key":"10.1016\/j.jmb.2003.08.041_BIB23","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1006\/jsbi.2000.4284","article-title":"Human and Xenopus cingulin a modular organization of the coiled-coil rod domain: predictions for intra- and intermolecular assembly","volume":"131","author":"Citi","year":"2000","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.jmb.2003.08.041_BIB24","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1083\/jcb.153.3.503","article-title":"Insights into the dynamic properties of keratin intermediate filaments in living epithelial cells","volume":"153","author":"Yoon","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jmb.2003.08.041_BIB25","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature01278","article-title":"Systematic functional analysis of the Caenorhabditis elegans genome using RNAi","volume":"421","author":"Kamath","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2003.08.041_BIB26","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0955-0674(99)00060-5","article-title":"Intermediate filaments and their associates: multi-talented structural elements specifying cytoarchitecture and cytodynamics","volume":"12","author":"Herrmann","year":"2000","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.jmb.2003.08.041_BIB27","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/bies.10246","article-title":"Molecular architecture of intermediate filaments","volume":"25","author":"Strelkov","year":"2003","journal-title":"BioEssays"},{"key":"10.1016\/j.jmb.2003.08.041_BIB28","series-title":"The Nematode Caenorhabditis elegans","first-page":"587","article-title":"Methods","author":"Sulston","year":"1988"},{"key":"10.1016\/j.jmb.2003.08.041_BIB29","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1093\/genetics\/157.3.1217","article-title":"Creation of low-copy integrated transgenic lines in Caenorhabditis elegans","volume":"157","author":"Praitis","year":"2001","journal-title":"Genetics"},{"key":"10.1016\/j.jmb.2003.08.041_BIB30","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0022-2836(87)90122-7","article-title":"Cytokeratin domains involved in heterotypic complex formation determined by in vitro binding assays","volume":"197","author":"Hatzfeld","year":"1987","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jmb.2003.08.041_BIB31","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0022-2836(02)01240-8","article-title":"The single nuclear lamin of Caenorhabditis elegans forms in vitro stable intermediate filaments and paracrystals with a reduced axial periodicity","volume":"325","author":"Karabinos","year":"2003","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jmb.2003.08.041_BIB32","first-page":"234","article-title":"Specification of male development in Caenorhabditis elegans: the fem genes","volume":"105","author":"Kirby","year":"1990","journal-title":"Dev. Biol."}],"container-title":["Journal of Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283603010830?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283603010830?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T22:22:36Z","timestamp":1623450156000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022283603010830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,10]]}},"alternative-id":["S0022283603010830"],"URL":"https:\/\/doi.org\/10.1016\/j.jmb.2003.08.041","relation":{},"ISSN":["0022-2836"],"issn-type":[{"value":"0022-2836","type":"print"}],"subject":[],"published":{"date-parts":[[2003,10]]}}}