{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:02:54Z","timestamp":1791018174147,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Molecular Biology"],"published-print":{"date-parts":[[2006,2]]},"DOI":"10.1016\/j.jmb.2005.11.045","type":"journal-article","created":{"date-parts":[[2005,12,2]],"date-time":"2005-12-02T07:24:27Z","timestamp":1133508267000},"page":"1026-1036","source":"Crossref","is-referenced-by-count":79,"title":["Functional Analysis of the Post-transcriptional Regulator RsmA Reveals a Novel RNA-binding Site"],"prefix":"10.1016","volume":"355","author":[{"given":"Stephan","family":"Heeb","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"Kuehne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Bycroft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorana","family":"Crivii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Haas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"C\u00e1mara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmb.2005.11.045_bib1","doi-asserted-by":"crossref","first-page":"4744","DOI":"10.1128\/jb.175.15.4744-4755.1993","article-title":"Identification and molecular characterization of csrA, a pleiotropic gene from Escherichia coli that affects glycogen biosynthesis, gluconeogenesis, cell size, and surface properties","volume":"175","author":"Romeo","year":"1993","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jmb.2005.11.045_bib2","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1128\/jb.178.4.1012-1017.1996","article-title":"Coordinate genetic regulation of glycogen catabolism and biosynthesis in Escherichia coli via the CsrA gene product","volume":"178","author":"Yang","year":"1996","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jmb.2005.11.045_bib3","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1046\/j.1365-2958.2001.02380.x","article-title":"Positive regulation of motility and flhDC expression by the RNA-binding protein CsrA of Escherichia coli","volume":"40","author":"Wei","year":"2001","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jmb.2005.11.045_bib4","doi-asserted-by":"crossref","first-page":"5108","DOI":"10.1128\/jb.177.17.5108-5115.1995","article-title":"Identification of a global repressor gene, rsmA, of Erwinia carotovora subsp. carotovora that controls extracellular enzymes, N-(3-oxohexanoyl)-l-homoserine lactone, and pathogenicity in soft-rotting Erwinia spp","volume":"177","author":"Cui","year":"1995","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jmb.2005.11.045_bib5","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1128\/AEM.61.5.1959-1967.1995","article-title":"Inactivation of rsmA leads to overproduction of extracellular pectinases, cellulases, and proteases in Erwinia carotovora subsp. carotovora in the absence of the starvation\/cell density-sensing signal, N-(3-oxohexanoyl)-l-homoserine lactone","volume":"61","author":"Chatterjee","year":"1995","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.jmb.2005.11.045_bib6","doi-asserted-by":"crossref","first-page":"6676","DOI":"10.1128\/JB.183.22.6676-6683.2001","article-title":"The global posttranscriptional regulator RsmA modulates production of virulence determinants and N-acylhomoserine lactones in Pseudomonas aeruginosa","volume":"183","author":"Pessi","year":"2001","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jmb.2005.11.045_bib7","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1128\/JB.186.10.2936-2945.2004","article-title":"Positive control of swarming and lipase production by the post-transcriptional RsmA\/RsmZ system in Pseudomonas aeruginosa PAO1","volume":"186","author":"Heurlier","year":"2004","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jmb.2005.11.045_bib8","doi-asserted-by":"crossref","first-page":"14073","DOI":"10.1073\/pnas.96.24.14073","article-title":"Global GacA-steered control of cyanide and exoprotease production in Pseudomonas fluorescens involves specific ribosome binding sites","volume":"96","author":"Blumer","year":"1999","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.jmb.2005.11.045_bib9","doi-asserted-by":"crossref","first-page":"6790","DOI":"10.1128\/IAI.68.12.6790-6797.2000","article-title":"Regulation of Salmonella enterica serovar Typhimurium invasion genes by csrA","volume":"68","author":"Altier","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jmb.2005.11.045_bib10","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1078\/1438-4221-00141","article-title":"Overexpresssion of a Legionella pneumophila homologue of the E.coli regulator csrA affects cell size, flagellation, and pigmentation","volume":"291","author":"Fettes","year":"2001","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.jmb.2005.11.045_bib11","first-page":"160","article-title":"The role of RsmA in the regulation of swarming motility in Serratia marcescens","volume":"8","author":"Ang","year":"2001","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.jmb.2005.11.045_bib12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1099\/jmm.0.05024-0","article-title":"Role of RsmA in the regulation of swarming motility and virulence factor expression in Proteus mirabilis","volume":"52","author":"Liaw","year":"2003","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.jmb.2005.11.045_bib13","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1111\/j.1365-2958.2004.04439.x","article-title":"Environmental and genetic regulation of the phosphorylcholine epitope of Haemophilus influenzae lipooligosaccharide","volume":"55","author":"Wong","year":"2005","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jmb.2005.11.045_bib14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1046\/j.1365-2958.2003.03788.x","article-title":"Global regulation of virulence and the stress response by CsrA in the highly adapted human gastric pathogen Helicobacter pylori","volume":"51","author":"Barnard","year":"2004","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jmb.2005.11.045_bib15","doi-asserted-by":"crossref","first-page":"4639","DOI":"10.1128\/jb.179.14.4639-4642.1997","article-title":"The global regulator CsrA of Escherichia coli is a specific mRNA-binding protein","volume":"179","author":"Liu","year":"1997","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jmb.2005.11.045_bib16","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1128\/jb.177.10.2663-2672.1995","article-title":"The product of the pleiotropic Escherichia coli gene csrA modulates glycogen biosynthesis via effects on mRNA stability","volume":"177","author":"Liu","year":"1995","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jmb.2005.11.045_bib17","doi-asserted-by":"crossref","first-page":"4450","DOI":"10.1128\/JB.185.15.4450-4460.2003","article-title":"CsrA regulates translation of the Escherichia coli carbon starvation gene, cstA, by blocking ribosome access to the cstA transcript","volume":"185","author":"Dubey","year":"2003","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jmb.2005.11.045_bib18","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1046\/j.1365-2958.2002.02982.x","article-title":"CsrA regulates glycogen biosynthesis by preventing translation of glgC in Escherichia coli","volume":"44","author":"Baker","year":"2002","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jmb.2005.11.045_bib19","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1046\/j.1365-2958.1998.00924.x","article-title":"Characterization of a novel RNA regulator of Erwinia carotovora subsp. carotovora that controls production of extracellular enzymes and secondary metabolites","volume":"29","author":"Liu","year":"1998","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jmb.2005.11.045_bib20","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1128\/JB.183.6.1870-1880.2001","article-title":"Molecular characterization of global regulatory RNA species that control pathogenicity factors in Erwinia amylovora and Erwinia herbicola pv. gypsophilae","volume":"183","author":"Ma","year":"2001","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jmb.2005.11.045_bib21","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1128\/jb.184.4.1046-1056.2002","article-title":"Regulatory RNA as mediator in GacA\/RsmA-dependent global control of exoproduct formation in Pseudomonas fluorescens CHA0","volume":"184","author":"Heeb","year":"2002","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jmb.2005.11.045_bib22","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1046\/j.1365-2958.2003.03774.x","article-title":"RsmY, a small regulatory RNA, is required in concert with RsmZ for GacA-dependent expression of biocontrol traits in Pseudomonas fluorescens CHA0","volume":"50","author":"Valverde","year":"2003","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jmb.2005.11.045_bib23","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1046\/j.1365-2958.2003.03459.x","article-title":"A novel sRNA component of the carbon storage regulatory system of Escherichia coli","volume":"48","author":"Weilbacher","year":"2003","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jmb.2005.11.045_bib24","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.resmic.2004.07.004","article-title":"Characterisation of the regulatory RNA RsmB from Pseudomonas aeruginosa PAO1","volume":"156","author":"Burrowes","year":"2005","journal-title":"Res. Microbiol."},{"key":"10.1016\/j.jmb.2005.11.045_bib25","first-page":"239","article-title":"Post-transcriptional regulation in Pseudomonas spp. via the Gac\/Rsm regulatory network","volume":"vol. 2","author":"Heeb","year":"2004"},{"key":"10.1016\/j.jmb.2005.11.045_bib26","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1128\/JB.187.1.276-285.2005","article-title":"Posttranscriptional repression of GacS\/GacA-controlled genes by the RNA-binding protein RsmE acting together with RsmA in the biocontrol strain Pseudomonas fluorescens CHA0","volume":"187","author":"Reimmann","year":"2005","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jmb.2005.11.045_bib27","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0969-2126(99)80025-2","article-title":"Crystal structures of Nova-1 and Nova-2 K-homology RNA-binding domains","volume":"7","author":"Lewis","year":"1999","journal-title":"Struct. Fold. Des."},{"key":"10.1016\/j.jmb.2005.11.045_bib28","doi-asserted-by":"crossref","first-page":"25066","DOI":"10.1074\/jbc.M401870200","article-title":"A repeated GGA motif is critical for the activity and stability of the riboregulator RsmY of Pseudomonas fluorescens","volume":"279","author":"Valverde","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2005.11.045_bib29","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/254034a0","article-title":"Determinant of cistron specificity in bacterial ribosomes","volume":"254","author":"Shine","year":"1975","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2005.11.045_bib30","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1261\/rna.2990205","article-title":"RNA sequence and secondary structure participate in high-affinity CsrA\u2013RNA interaction","volume":"11","author":"Dubey","year":"2005","journal-title":"RNA"},{"key":"10.1016\/j.jmb.2005.11.045_bib31","doi-asserted-by":"crossref","first-page":"3496","DOI":"10.1128\/JB.187.10.3496-3501.2005","article-title":"Solution structure of the carbon storage regulator protein CsrA from Escherichia coli","volume":"187","author":"Guti\u00e9rrez","year":"2005","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jmb.2005.11.045_bib32","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1006\/jmbi.1996.0399","article-title":"Over-production of proteins in Escherichia coli: mutant hosts that allow synthesis of some membrane proteins and globular proteins at high levels","volume":"260","author":"Miroux","year":"1996","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jmb.2005.11.045_bib33","unstructured":"Leslie, A. G. W. (1992). Recent changes to the MOSFLM package for processing film and image plate data. In Joint CCP4+ESF-EAMCB Newsletter on Protein Crystallography, vol. 26, Daresbury Laboratory, Warrington, UK."},{"key":"10.1016\/j.jmb.2005.11.045_bib34","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1107\/S0907444999000839","article-title":"Automated and MAD MIR structure solution","volume":"55","author":"Terwilliger","year":"1999","journal-title":"Acta Crystallog. sect. D"},{"key":"10.1016\/j.jmb.2005.11.045_bib35","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1107\/S0907444998003254","article-title":"Crystallography & NMR system: a new software suite for macromolecular structure determination","volume":"54","author":"Br\u00fcnger","year":"1998","journal-title":"Acta Crystallog. sect. D"},{"key":"10.1016\/j.jmb.2005.11.045_bib36","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1107\/S0108767391001071","article-title":"Accurate bond and angle parameters for X-ray protein structure refinement","volume":"47","author":"Engh","year":"1991","journal-title":"Acta Crystallog. sect. A"},{"key":"10.1016\/j.jmb.2005.11.045_bib37","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/0076-6879(93)17064-C","article-title":"Polymerase chain reaction-based point mutagenesis protocol","volume":"217","author":"Zhao","year":"1993","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jmb.2005.11.045_bib38","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.femsle.2004.12.008","article-title":"Role of the stress sigma factor RpoS in GacA\/RsmA-controlled secondary metabolism and resistance to oxidative stress in Pseudomonas fluorescens CHA0","volume":"243","author":"Heeb","year":"2005","journal-title":"FEMS Microbiol. Letters"},{"key":"10.1016\/j.jmb.2005.11.045_bib39","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0378-1119(91)90365-I","article-title":"New pUC-derived cloning vectors with different selectable markers and DNA replication origins","volume":"100","author":"Vieira","year":"1991","journal-title":"Gene"},{"key":"10.1016\/j.jmb.2005.11.045_bib40","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","article-title":"PROCHECK: a program to check the stereochemical quality of protein structures","volume":"26","author":"Laskowski","year":"1993","journal-title":"J. Appl. Crystallog."}],"container-title":["Journal of Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283605014245?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283605014245?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,11]],"date-time":"2020-04-11T05:31:22Z","timestamp":1586583082000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022283605014245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["S0022283605014245"],"URL":"https:\/\/doi.org\/10.1016\/j.jmb.2005.11.045","relation":{},"ISSN":["0022-2836"],"issn-type":[{"value":"0022-2836","type":"print"}],"subject":[],"published":{"date-parts":[[2006,2]]}}}