{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T13:04:26Z","timestamp":1775999066734,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Molecular Biology"],"published-print":{"date-parts":[[2006,6]]},"DOI":"10.1016\/j.jmb.2006.04.072","type":"journal-article","created":{"date-parts":[[2006,5,16]],"date-time":"2006-05-16T11:12:43Z","timestamp":1147777963000},"page":"145-156","source":"Crossref","is-referenced-by-count":23,"title":["Self-association of the Transmembrane Domain of an Anthrax Toxin Receptor"],"prefix":"10.1016","volume":"360","author":[{"given":"Mandy Y.","family":"Go","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanguk","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony W.","family":"Partridge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman A.","family":"Melnyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arianna","family":"Rath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles M.","family":"Deber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Mogridge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmb.2006.04.072_bib1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s10254-004-0028-2","article-title":"Anthrax toxins","volume":"152","author":"Mourez","year":"2004","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"10.1016\/j.jmb.2006.04.072_bib2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.tim.2004.12.004","article-title":"Anthrax toxin: the long and winding road that leads to the kill","volume":"13","author":"Abrami","year":"2005","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.jmb.2006.04.072_bib3","doi-asserted-by":"crossref","first-page":"10277","DOI":"10.1073\/pnas.89.21.10277","article-title":"Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin","volume":"89","author":"Klimpel","year":"1992","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.jmb.2006.04.072_bib4","doi-asserted-by":"crossref","first-page":"16396","DOI":"10.1016\/S0021-9258(18)42016-9","article-title":"Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen","volume":"267","author":"Molloy","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2006.04.072_bib5","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1021\/bi015860m","article-title":"Stoichiometry of anthrax toxin complexes","volume":"41","author":"Mogridge","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.jmb.2006.04.072_bib6","doi-asserted-by":"crossref","first-page":"16409","DOI":"10.1073\/pnas.0508259102","article-title":"A model of anthrax toxin lethal factor bound to protective antigen","volume":"102","author":"Lacy","year":"2005","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.jmb.2006.04.072_bib7","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1083\/jcb.200211018","article-title":"Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process","volume":"160","author":"Abrami","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jmb.2006.04.072_bib8","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1046\/j.1462-5822.2000.00052.x","article-title":"Proteolytic activation of receptor-bound anthrax protective antigen on macrophages promotes its internalization","volume":"2","author":"Beauregard","year":"2000","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.jmb.2006.04.072_bib9","doi-asserted-by":"crossref","first-page":"10432","DOI":"10.1021\/bi990792d","article-title":"Anthrax protective antigen: prepore-to-pore conversion","volume":"38","author":"Miller","year":"1999","journal-title":"Biochemistry"},{"key":"10.1016\/j.jmb.2006.04.072_bib10","doi-asserted-by":"crossref","first-page":"13147","DOI":"10.1073\/pnas.0405405101","article-title":"Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation","volume":"101","author":"Lacy","year":"2004","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.jmb.2006.04.072_bib11","doi-asserted-by":"crossref","first-page":"13278","DOI":"10.1073\/pnas.0505865102","article-title":"Receptor-specific requirements for anthrax toxin delivery into cells","volume":"102","author":"Rainey","year":"2005","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.jmb.2006.04.072_bib12","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1126\/science.1113380","article-title":"A phenylalanine clamp catalyzes protein translocation through the anthrax toxin pore","volume":"309","author":"Krantz","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.jmb.2006.04.072_bib13","doi-asserted-by":"crossref","first-page":"16756","DOI":"10.1073\/pnas.0405754101","article-title":"Evidence that translocation of anthrax toxin's lethal factor is initiated by entry of its N terminus into the protective antigen channel","volume":"101","author":"Zhang","year":"2004","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.jmb.2006.04.072_bib14","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1083\/jcb.200507067","article-title":"Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis","volume":"172","author":"Abrami","year":"2006","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jmb.2006.04.072_bib15","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/n35101999","article-title":"Identification of the cellular receptor for anthrax toxin","volume":"414","author":"Bradley","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2006.04.072_bib16","doi-asserted-by":"crossref","first-page":"5170","DOI":"10.1073\/pnas.0431098100","article-title":"Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor","volume":"100","author":"Scobie","year":"2003","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.jmb.2006.04.072_bib17","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1158\/0008-5472.CAN-03-2408","article-title":"Croix, TEM8 interacts with the cleaved C5 domain of collagen alpha 3(VI)","volume":"64","author":"Nanda","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.jmb.2006.04.072_bib18","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.yexcr.2004.12.025","article-title":"TEM8 expression stimulates endothelial cell adhesion and migration by regulating cell-matrix interactions on collagen","volume":"305","author":"Hotchkiss","year":"2005","journal-title":"Expt. Cell Res."},{"key":"10.1016\/j.jmb.2006.04.072_bib19","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1242\/jcs.114.15.2755","article-title":"Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling","volume":"114","author":"Bell","year":"2001","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.jmb.2006.04.072_bib20","doi-asserted-by":"crossref","first-page":"49342","DOI":"10.1074\/jbc.M307900200","article-title":"Binding of anthrax toxin to its receptor is similar to alpha integrin-ligand interactions","volume":"278","author":"Bradley","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2006.04.072_bib21","doi-asserted-by":"crossref","first-page":"6367","DOI":"10.1073\/pnas.0401506101","article-title":"Crystal structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor","volume":"101","author":"Lacy","year":"2004","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.jmb.2006.04.072_bib22","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/nature02763","article-title":"Crystal structure of a complex between anthrax toxin and its host cell receptor","volume":"430","author":"Santelli","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2006.04.072_bib23","doi-asserted-by":"crossref","first-page":"23349","DOI":"10.1074\/jbc.M401292200","article-title":"Binding stoichiometry and kinetics of the interaction of a human anthrax toxin receptor, CMG2, with protective antigen","volume":"279","author":"Wigelsworth","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2006.04.072_bib24","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1146\/annurev.biophys.28.1.319","article-title":"Membrane protein folding and stability: physical properties","volume":"28","author":"White","year":"1999","journal-title":"Annu. Rev. Biophy. Biomol. Struct."},{"key":"10.1016\/j.jmb.2006.04.072_bib25","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1146\/annurev.biochem.69.1.881","article-title":"Helical membrane protein folding, stability, and evolution","volume":"69","author":"Popot","year":"2000","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.jmb.2006.04.072_bib26","doi-asserted-by":"crossref","first-page":"9265","DOI":"10.1074\/jbc.274.14.9265","article-title":"A heptad motif of leucine residues found in membrane proteins can drive self-assembly of artificial transmembrane segments","volume":"274","author":"Gurezka","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2006.04.072_bib27","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S0022-2836(03)00521-7","article-title":"A simple method for modeling transmembrane helix oligomers","volume":"329","author":"Kim","year":"2003","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jmb.2006.04.072_bib28","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nsmb895","article-title":"Pivotal role of the glycine-rich TM3 helix in gating the MscS mechanosensitive channel","volume":"12","author":"Edwards","year":"2005","journal-title":"Nature Struct. Mol. Biol."},{"key":"10.1016\/j.jmb.2006.04.072_bib29","doi-asserted-by":"crossref","first-page":"5988","DOI":"10.1073\/pnas.0308694101","article-title":"Membrane channel structure of Helicobacter pylori vacuolating toxin: role of multiple GXXXG motifs in cylindrical channels","volume":"101","author":"Kim","year":"2004","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.jmb.2006.04.072_bib30","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1529\/biophysj.103.039396","article-title":"A model of the closed form of the nicotinic acetylcholine receptor m2 channel pore","volume":"87","author":"Kim","year":"2004","journal-title":"Biophys. J."},{"key":"10.1016\/j.jmb.2006.04.072_bib31","doi-asserted-by":"crossref","first-page":"16591","DOI":"10.1074\/jbc.M313936200","article-title":"The affinity of GXXXG motifs in transmembrane helix-helix interactions is modulated by long-range communication","volume":"279","author":"Melnyk","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2006.04.072_bib32","doi-asserted-by":"crossref","first-page":"7294","DOI":"10.1074\/jbc.M412701200","article-title":"Transmembrane domain helix packing stabilizes integrin alphaIIbbeta3 in the low affinity state","volume":"280","author":"Partridge","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2006.04.072_bib33","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1110\/ps.30301","article-title":"TM Finder: a prediction program for transmembrane protein segments using a combination of hydrophobicity and nonpolar phase helicity scales","volume":"10","author":"Deber","year":"2001","journal-title":"Protein Sci."},{"key":"10.1016\/j.jmb.2006.04.072_bib34","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/bip.10595","article-title":"Polar residue tagging of transmembrane peptides","volume":"71","author":"Melnyk","year":"2003","journal-title":"Biopolymers"},{"key":"10.1016\/j.jmb.2006.04.072_bib35","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/S0960-9822(01)00018-5","article-title":"Self assembly of the transmembrane domain promotes signal transduction through the erythropoietin receptor","volume":"11","author":"Kubatzky","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/j.jmb.2006.04.072_bib36","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1073\/pnas.96.3.863","article-title":"TOXCAT: a measure of transmembrane helix association in a biological membrane","volume":"96","author":"Russ","year":"1999","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.jmb.2006.04.072_bib37","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1083\/jcb.147.1.175","article-title":"Plasma membrane microdomains act as concentration platforms to facilitate intoxication by aerolysin","volume":"147","author":"Abrami","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jmb.2006.04.072_bib38","doi-asserted-by":"crossref","first-page":"11106","DOI":"10.1021\/bi010642e","article-title":"Retention of native-like oligomerization states in transmembrane segment peptides: application to the Escherichia coli aspartate receptor","volume":"40","author":"Melnyk","year":"2001","journal-title":"Biochemistry"},{"key":"10.1016\/j.jmb.2006.04.072_bib39","doi-asserted-by":"crossref","first-page":"22056","DOI":"10.1074\/jbc.M210685200","article-title":"A transmembrane segment mimic derived from Escherichia coli diacylglycerol kinase inhibits protein activity","volume":"278","author":"Partridge","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2006.04.072_bib40","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1006\/jmbi.2001.5214","article-title":"Transmembrane domain mediated self-assembly of major coat protein subunits from Ff bacteriophage","volume":"315","author":"Melnyk","year":"2002","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jmb.2006.04.072_bib41","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/S0022-2836(02)00781-7","article-title":"Oligomerization of a peptide derived from the transmembrane region of the sodium pump gamma subunit: effect of the pathological mutation G41R","volume":"322","author":"Therien","year":"2002","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jmb.2006.04.072_bib42","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1074\/jbc.M309311200","article-title":"The interface between self-assembling erythropoietin receptor transmembrane segments corresponds to a membrane-spanning leucine zipper","volume":"279","author":"Ruan","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2006.04.072_bib43","doi-asserted-by":"crossref","first-page":"45580","DOI":"10.1074\/jbc.M105362200","article-title":"In vitro selection of membrane-spanning leucine zipper protein-protein interaction motifs using POSSYCCAT","volume":"276","author":"Gurezka","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2006.04.072_bib44","doi-asserted-by":"crossref","first-page":"5941","DOI":"10.1074\/jbc.271.10.5941","article-title":"A leucine zipper stabilizes the pentameric membrane domain of phospholamban and forms a coiled-coil pore structure","volume":"271","author":"Simmerman","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2006.04.072_bib45","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1006\/jmbi.1997.0926","article-title":"Prediction of protein side-chain rotamers from a backbone-dependent rotamer library: a new homology modeling tool","volume":"267","author":"Bower","year":"1997","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jmb.2006.04.072_bib46","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1002\/pro.5560041120","article-title":"How to measure and predict the molar absorption coefficient of a protein","volume":"4","author":"Pace","year":"1995","journal-title":"Protein Sci."},{"key":"10.1016\/j.jmb.2006.04.072_bib47","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1006\/jmbi.1999.3489","article-title":"The GxxxG motif: a framework for transmembrane helix-helix association","volume":"296","author":"Russ","year":"2000","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jmb.2006.04.072_bib48","doi-asserted-by":"crossref","first-page":"51950","DOI":"10.1074\/jbc.M308429200","article-title":"Sequence-specific dimerization of the transmembrane domain of the \u201cBH3-only\u201d protein BNIP3 in membranes and detergent","volume":"278","author":"Sulistijo","year":"2003","journal-title":"J. Biol. Chem."}],"container-title":["Journal of Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283606005663?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283606005663?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T08:24:09Z","timestamp":1627374249000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022283606005663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["S0022283606005663"],"URL":"https:\/\/doi.org\/10.1016\/j.jmb.2006.04.072","relation":{},"ISSN":["0022-2836"],"issn-type":[{"value":"0022-2836","type":"print"}],"subject":[],"published":{"date-parts":[[2006,6]]}}}