{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:52:32Z","timestamp":1790304752518,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Molecular Biology"],"published-print":{"date-parts":[[2007,8]]},"DOI":"10.1016\/j.jmb.2007.05.038","type":"journal-article","created":{"date-parts":[[2007,5,19]],"date-time":"2007-05-19T20:23:17Z","timestamp":1179606197000},"page":"210-221","source":"Crossref","is-referenced-by-count":44,"title":["A Novel Loop Domain in Superantigens Extends their T Cell Receptor Recognition Site"],"prefix":"10.1016","volume":"371","author":[{"given":"Sebastian","family":"G\u00fcnther","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok K.","family":"Varma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beenu","family":"Moza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine J.","family":"Kasper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron W.","family":"Wyatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penny","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.K.M. Nur-ur","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yili","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy A.","family":"Mariuzza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John K.","family":"McCormick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.","family":"Sundberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmb.2007.05.038_bib1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1146\/annurev.micro.55.1.77","article-title":"Toxic shock syndrome and bacterial superantigens: an update","volume":"55","author":"McCormick","year":"2001","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.jmb.2007.05.038_bib2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0952-7915(01)00296-5","article-title":"So many ways of getting in the way: diversity in the molecular architecture of superantigen-dependent T-cell signaling complexes","volume":"14","author":"Sundberg","year":"2002","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.jmb.2007.05.038_bib3","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1086\/515199","article-title":"Intravenous immunoglobulin therapy for streptococcal toxic shock syndrome \u2013 a comparative observational study. The Canadian Streptococcal Study Group","volume":"28","author":"Kaul","year":"1999","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.jmb.2007.05.038_bib4","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1128\/AAC.45.2.460-463.2001","article-title":"Human antibodies to bacterial superantigens and their ability to inhibit T-cell activation and lethality","volume":"45","author":"LeClaire","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jmb.2007.05.038_bib5","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1074-7613(01)00092-9","article-title":"Crystal structure of a superantigen bound to the high-affinity, zinc-dependent site on MHC class II","volume":"14","author":"Li","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.jmb.2007.05.038_bib6","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/368711a0","article-title":"Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen","volume":"368","author":"Jardetzky","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2007.05.038_bib7","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1126\/science.7997880","article-title":"Toxic shock syndrome toxin-1 complexed with a class II major histocompatibility molecule HLA-DR1","volume":"266","author":"Kim","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.jmb.2007.05.038_bib8","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0969-2126(02)00759-1","article-title":"Structures of two streptococcal superantigens bound to TCR beta chains reveal diversity in the architecture of T cell signaling complexes","volume":"10","author":"Sundberg","year":"2002","journal-title":"Structure"},{"key":"10.1016\/j.jmb.2007.05.038_bib9","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/sj.emboj.7601531","article-title":"Structural basis of T cell receptor specificity and activation by the bacterial superantigen TSST-1","volume":"26","author":"Moza","year":"2007","journal-title":"EMBO J."},{"key":"10.1016\/j.jmb.2007.05.038_bib10","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S1074-7613(00)80646-9","article-title":"Three-dimensional structure of the complex between a T cell receptor beta chain and the superantigen staphylococcal enterotoxin B","volume":"9","author":"Li","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.jmb.2007.05.038_bib11","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1046\/j.1365-2249.2003.02203.x","article-title":"Bacterial superantigens","volume":"133","author":"Proft","year":"2003","journal-title":"Clin. Expt. Immunol."},{"key":"10.1016\/j.jmb.2007.05.038_bib12","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.jmb.2007.01.024","article-title":"Crystal structure of the streptococcal superantigen SpeI and functional role of a novel loop domain in T cell activation by Group V superantigens","volume":"367","author":"Brouillard","year":"2007","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jmb.2007.05.038_bib13","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1084\/jem.183.3.1083","article-title":"Major histocompatibility complex class II-associated peptides control the presentation of bacterial superantigens to T cells","volume":"183","author":"Wen","year":"1996","journal-title":"J. Expt. Med."},{"key":"10.1016\/j.jmb.2007.05.038_bib14","doi-asserted-by":"crossref","first-page":"9867","DOI":"10.1073\/pnas.0600220103","article-title":"Long-range cooperative binding effects in a T cell receptor variable domain","volume":"103","author":"Moza","year":"2006","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.jmb.2007.05.038_bib15","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/384188a0","article-title":"Crystal structure of a T-cell receptor beta-chain complexed with a superantigen","volume":"384","author":"Fields","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2007.05.038_bib16","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.1002\/j.1460-2075.1995.tb07300.x","article-title":"Characterization of two distinct MHC class II binding sites in the superantigen staphylococcal enterotoxin A","volume":"14","author":"Abrahmsen","year":"1995","journal-title":"EMBO J."},{"key":"10.1016\/j.jmb.2007.05.038_bib17","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1084\/jem.182.3.711","article-title":"Staphylococcal enterotoxin A has two cooperative binding sites on major histocompatibility complex class II","volume":"182","author":"Hudson","year":"1995","journal-title":"J. Expt. Med."},{"key":"10.1016\/j.jmb.2007.05.038_bib18","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/S0969-2126(02)00895-X","article-title":"Crystal structure of a SEA variant in complex with MHC class II reveals the ability of SEA to crosslink MHC molecules","volume":"10","author":"Petersson","year":"2002","journal-title":"Structure"},{"key":"10.1016\/j.jmb.2007.05.038_bib19","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1093\/emboj\/20.13.3306","article-title":"Crystal structure of a superantigen bound to MHC class II displays zinc and peptide dependence","volume":"20","author":"Petersson","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.jmb.2007.05.038_bib20","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1074-7613(01)00092-9","article-title":"Crystal structure of a superantigen bound to the high-affinity, zinc-dependent site on MHC class II","volume":"14","author":"Li","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.jmb.2007.05.038_bib21","doi-asserted-by":"crossref","first-page":"25356","DOI":"10.1074\/jbc.M603969200","article-title":"Crystal structure of staphylococcal enterotoxin I (SEI) in complex with a human major histocompatibility complex class II molecule","volume":"281","author":"Fernandez","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2007.05.038_bib22","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.1038\/sj.emboj.7600771","article-title":"Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule","volume":"24","author":"Li","year":"2005","journal-title":"EMBO J."},{"key":"10.1016\/j.jmb.2007.05.038_bib23","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.jmb.2005.08.041","article-title":"Characterization of T cell receptors engineered for high affinity against toxic shock syndrome toxin-1","volume":"353","author":"Buonpane","year":"2005","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jmb.2007.05.038_bib24","doi-asserted-by":"crossref","first-page":"8595","DOI":"10.4049\/jimmunol.177.12.8595","article-title":"Molecular basis of TCR selectivity, cross-reactivity, and allelic discrimination by a bacterial superantigen: integrative functional and energetic mapping of the SpeC-Vbeta2.1 molecular interface","volume":"177","author":"Rahman","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.jmb.2007.05.038_bib25","doi-asserted-by":"crossref","first-page":"669","DOI":"10.4049\/jimmunol.166.1.669","article-title":"egc, a highly prevalent operon of enterotoxin gene, forms a putative nursery of superantigens in Staphylococcus aureus","volume":"166","author":"Jarraud","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.jmb.2007.05.038_bib26","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1128\/IAI.69.1.360-366.2001","article-title":"Biochemical and biological properties of staphylococcal enterotoxin K","volume":"69","author":"Orwin","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jmb.2007.05.038_bib27","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1006\/jaut.1996.0023","article-title":"Analysis of function, specificity and T cell receptor expression of cloned mucosal T cell lines in Crohn's disease","volume":"9","author":"Prindiville","year":"1996","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jmb.2007.05.038_bib28","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1600-0765.1996.tb00457.x","article-title":"Biased T cell receptor V gene usage in tissues with periodontal disease","volume":"31","author":"Nakajima","year":"1996","journal-title":"J. Periodontal Res."},{"key":"10.1016\/j.jmb.2007.05.038_bib29","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/art.1780380114","article-title":"The role of T cell receptor beta chain genes in susceptibility to rheumatoid arthritis","volume":"38","author":"McDermott","year":"1995","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jmb.2007.05.038_bib30","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.immuni.2006.04.012","article-title":"Bacterial superantigens bypass Lck-dependent T cell receptor signaling by activating a Galpha11-dependent, PLC-beta-mediated pathway","volume":"25","author":"Bueno","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.jmb.2007.05.038_bib31","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","article-title":"Processing X-ray diffraction data collected in oscillation mode","volume":"276","author":"Otwinowski","year":"1997","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jmb.2007.05.038_bib32","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1107\/S0907444903028956","article-title":"Likelihood-enhanced fast rotation functions","volume":"60","author":"Storoni","year":"2004","journal-title":"Acta Crystallog. sect. D"},{"key":"10.1016\/j.jmb.2007.05.038_bib33","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1107\/S0907444996012255","article-title":"Refinement of macromolecular structures by the maximum-likelihood method","volume":"53","author":"Murshudov","year":"1997","journal-title":"Acta Crystallog. sect. D"},{"key":"10.1016\/j.jmb.2007.05.038_bib34","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1107\/S0907444998003254","article-title":"Crystallography and NMR system: a new software suite for macromolecular structure determination","volume":"54","author":"Brunger","year":"1998","journal-title":"Acta Crystallog. sect. D"},{"key":"10.1016\/j.jmb.2007.05.038_bib35","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","article-title":"Coot: model-building tools for molecular graphics","volume":"60","author":"Emsley","year":"2004","journal-title":"Acta Crystallog. sect. D"},{"key":"10.1016\/j.jmb.2007.05.038_bib36","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1084\/jem.160.5.1284","article-title":"Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line","volume":"160","author":"Weiss","year":"1984","journal-title":"J. Expt. Med."},{"key":"10.1016\/j.jmb.2007.05.038_bib37","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/316606a0","article-title":"Reconstitution of an active surface T3\/T-cell antigen receptor by DNA transfer","volume":"316","author":"Ohashi","year":"1985","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2007.05.038_bib38","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0378-1119(99)00045-1","article-title":"Efficient control of tetracycline-responsive gene expression from an autoregulated bi-directional expression vector","volume":"229","author":"Strathdee","year":"1999","journal-title":"Gene"}],"container-title":["Journal of Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283607006742?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283607006742?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,28]],"date-time":"2019-04-28T05:36:13Z","timestamp":1556429773000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022283607006742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["S0022283607006742"],"URL":"https:\/\/doi.org\/10.1016\/j.jmb.2007.05.038","relation":{},"ISSN":["0022-2836"],"issn-type":[{"value":"0022-2836","type":"print"}],"subject":[],"published":{"date-parts":[[2007,8]]}}}