{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T21:17:01Z","timestamp":1768079821096,"version":"3.49.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL63034"],"award-info":[{"award-number":["HL63034"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["0565226B"],"award-info":[{"award-number":["0565226B"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular Biology"],"published-print":{"date-parts":[[2008,9]]},"DOI":"10.1016\/j.jmb.2008.05.076","type":"journal-article","created":{"date-parts":[[2008,6,6]],"date-time":"2008-06-06T04:12:59Z","timestamp":1212725579000},"page":"559-568","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Blockade of NF-\u03baB Using I\u03baB\u03b1 Dominant-Negative Mice Ameliorates Cardiac Hypertrophy in Myotrophin-Overexpressed Transgenic Mice"],"prefix":"10.1016","volume":"381","author":[{"given":"David","family":"Young","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoran B.","family":"Popovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. Keith","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudhiranjan","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmb.2008.05.076_bib1","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1146\/annurev.ph.49.030187.002441","article-title":"Cardiocyte adaptation to chronically altered load","volume":"49","author":"Cooper","year":"1987","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.jmb.2008.05.076_bib2","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1006\/jmcc.2001.1340","article-title":"The molecular genetic basis for hypertrophic cardiomyopathy","volume":"33","author":"Marian","year":"2001","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.jmb.2008.05.076_bib3","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1056\/NEJM199005313222203","article-title":"Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study","volume":"322","author":"Levy","year":"1990","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jmb.2008.05.076_bib4","doi-asserted-by":"crossref","first-page":"16635","DOI":"10.1016\/S0021-9258(17)46269-7","article-title":"Myotrophin: purification of a novel peptide from spontaneously hypertensive rat heart that influences myocardial growth","volume":"265","author":"Sen","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2008.05.076_bib5","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1161\/01.RES.73.1.98","article-title":"Myotrophin in human cardiomyopathic heart","volume":"73","author":"Sil","year":"1993","journal-title":"Circ. Res."},{"key":"10.1016\/j.jmb.2008.05.076_bib6","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1161\/01.RES.76.6.1020","article-title":"Quantification of myotrophin from spontaneously hypertensive and normal rat hearts","volume":"76","author":"Sil","year":"1995","journal-title":"Circ. Res."},{"key":"10.1016\/j.jmb.2008.05.076_bib7","doi-asserted-by":"crossref","first-page":"20422","DOI":"10.1074\/jbc.M308488200","article-title":"Cardiac expression of myotrophin triggers myocardial hypertrophy and heart failure in transgenic mice: changes in gene expression profiles during initiation of hypertrophy and during heart failure measured by DNA microarray analysis","volume":"279","author":"Sarkar","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2008.05.076_bib8","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.jmb.2007.10.006","article-title":"Prevention of cardiac hypertrophy and heart failure by silencing of NF-kappaB","volume":"375","author":"Gupta","year":"2008","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jmb.2008.05.076_bib9","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1161\/01.CIR.98.17.1707","article-title":"Nuclear factor-kappaB is selectively and markedly activated in humans with unstable angina pectoris","volume":"98","author":"Ritchie","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.jmb.2008.05.076_bib10","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0003-4975(99)00646-3","article-title":"An essential role for NF-kappaB in the cardioadaptive response to ischemia","volume":"68","author":"Morgan","year":"1999","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.jmb.2008.05.076_bib11","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1083\/jcb.200207149","article-title":"Activation of nuclear factor-kappaB is necessary for myotrophin-induced cardiac hypertrophy","volume":"159","author":"Gupta","year":"2002","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jmb.2008.05.076_bib12","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/s00109-005-0691-z","article-title":"Role of the NF-kappaB signaling cascade and NF-kappaB-targeted genes in failing human hearts","volume":"83","author":"Gupta","year":"2005","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.jmb.2008.05.076_bib13","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.immunol.14.1.649","article-title":"The NF-\u03baB and I-\u03baB proteins: new discoveries and insights","volume":"14","author":"Baldwin","year":"1996","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jmb.2008.05.076_bib14","first-page":"3301","article-title":"Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation","volume":"13","author":"Beg","year":"1993","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.jmb.2008.05.076_bib15","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1080\/07853890510007232","article-title":"Inflammatory and anti-inflammatory cytokines in chronic heart failure: potential therapeutic implications","volume":"37","author":"Aukrust","year":"2005","journal-title":"Ann. Med."},{"key":"10.1016\/j.jmb.2008.05.076_bib16","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1146\/annurev.med.52.1.15","article-title":"Pathophysiological role of cytokines in congestive heart failure","volume":"52","author":"Blum","year":"2001","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.jmb.2008.05.076_bib17","first-page":"H20","article-title":"Inhibition of NF-kappaB induces regression of cardiac hypertrophy, independent of blood pressure control, in spontaneously hypertensive rats","volume":"289","author":"Gupta","year":"2005","journal-title":"Am. J. Physiol.: Heart Circ. Physiol."},{"key":"10.1016\/j.jmb.2008.05.076_bib18","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/376167a0","article-title":"Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B","volume":"376","author":"Beg","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2008.05.076_bib19","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/373531a0","article-title":"Expression of relB is required for the development of thymic medulla and dendritic cells","volume":"373","author":"Burkly","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2008.05.076_bib20","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1101\/gad.9.16.1965","article-title":"Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression","volume":"9","author":"Kontgen","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/j.jmb.2008.05.076_bib21","doi-asserted-by":"crossref","first-page":"183","DOI":"10.4049\/jimmunol.156.1.183","article-title":"B cells from p50\/NF-kappa B knockout mice have selective defects in proliferation, differentiation, germ-line CH transcription, and Ig class switching","volume":"156","author":"Snapper","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.jmb.2008.05.076_bib22","first-page":"H466","article-title":"Cardiac-specific blockade of NF-kappaB in cardiac pathophysiology: differences between acute and chronic stimuli in vivo","volume":"289","author":"Brown","year":"2005","journal-title":"Am. J. Physiol.: Heart Circ. Physiol."},{"key":"10.1016\/j.jmb.2008.05.076_bib23","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1161\/01.RES.81.5.664","article-title":"Increased expression of interleukin-1 beta and monocyte chemotactic and activating factor\/monocyte chemoattractant protein-1 in the hypertrophied and failing heart with pressure overload","volume":"81","author":"Shioi","year":"1997","journal-title":"Circ. Res."},{"key":"10.1016\/j.jmb.2008.05.076_bib24","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1006\/jmcc.1996.0285","article-title":"Plasma levels of the monocyte chemotactic and activating factor\/monocyte chemoattractant protein-1 are elevated in patients with acute myocardial infarction","volume":"29","author":"Matsumori","year":"1997","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.jmb.2008.05.076_bib25","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.cardiores.2006.06.013","article-title":"Bone marrow-derived cells contribute to infarct remodelling","volume":"71","author":"Mollmann","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.jmb.2008.05.076_bib26","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.carpath.2007.03.002","article-title":"Cryoinjury: a model of myocardial regeneration","volume":"17","author":"van Amerongen","year":"2008","journal-title":"Cardiovasc. Pathol."},{"key":"10.1016\/j.jmb.2008.05.076_bib27","first-page":"H590","article-title":"Cardioprotection afforded by NF-kappaB ablation is associated with activation of Akt in mice overexpressing TNF-alpha","volume":"290","author":"Higuchi","year":"2006","journal-title":"Am. J. Physiol.: Heart Circ. Physiol."},{"key":"10.1016\/j.jmb.2008.05.076_bib28","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0092-8674(00)80406-7","article-title":"The I\u03baB kinase complex (IKK) contains two kinase subunits, IKK\u03b1 and IKK\u03b2, necessary for I\u03baB phosphorylation and NF-\u03baB activation","volume":"91","author":"Zandi","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.jmb.2008.05.076_bib29","first-page":"H2248","article-title":"IKKbeta inhibition attenuates myocardial injury and dysfunction following acute ischemia\u2013reperfusion injury","volume":"293","author":"Moss","year":"2007","journal-title":"Am. J. Physiol.: Heart Circ. Physiol."},{"key":"10.1016\/j.jmb.2008.05.076_bib30","first-page":"H1264","article-title":"Early activation of IKKbeta during in vivo myocardial ischemia","volume":"280","author":"Li","year":"2001","journal-title":"Am. J. Physiol.: Heart Circ. Physiol."},{"key":"10.1016\/j.jmb.2008.05.076_bib31","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1161\/01.CIR.98.2.100","article-title":"Induction of cyclooxygenase-2 and activation of nuclear factor-kappaB in myocardium of patients with congestive heart failure","volume":"98","author":"Wong","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.jmb.2008.05.076_bib32","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.cardiores.2005.02.007","article-title":"Blockade of NF-kappaB improves cardiac function and survival without affecting inflammation in TNF-alpha-induced cardiomyopathy","volume":"66","author":"Kawamura","year":"2005","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.jmb.2008.05.076_bib33","first-page":"H1337","article-title":"Blockade of NF-{kappa}B improves cardiac function and survival after myocardial infarction","volume":"291","author":"Kawano","year":"1998","journal-title":"Am. J. Physiol.: Heart Circ. Physiol."},{"key":"10.1016\/j.jmb.2008.05.076_bib34","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1161\/01.RES.0000130526.20854.fa","article-title":"Inflammatory cytokines and postmyocardial infarction remodeling","volume":"94","author":"Nian","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.jmb.2008.05.076_bib35","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1165\/ajrcmb.17.1.f132","article-title":"The role of nuclear factor-kappa B in cytokine gene regulation","volume":"17","author":"Blackwell","year":"1997","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.jmb.2008.05.076_bib36","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1161\/01.CIR.0000147233.10318.23","article-title":"Excessive tumor necrosis factor activation after infarction contributes to susceptibility of myocardial rupture and left ventricular dysfunction","volume":"110","author":"Sun","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jmb.2008.05.076_bib37","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1023\/B:HREV.0000011390.44039.b7","article-title":"MMP induction and inhibition in myocardial infarction","volume":"9","author":"Lindsey","year":"2004","journal-title":"Heart Failure Rev."},{"key":"10.1016\/j.jmb.2008.05.076_bib38","doi-asserted-by":"crossref","first-page":"31092","DOI":"10.1074\/jbc.272.49.31092","article-title":"Transcriptional regulation of the human monocyte chemoattractant protein-1 gene. Cooperation of two NF-kappaB sites and NF-kappaB\/Rel subunit specificity","volume":"272","author":"Ueda","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2008.05.076_bib39","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1161\/01.CIR.0000092890.29552.22","article-title":"Anti-monocyte chemoattractant protein-1 gene therapy attenuates left ventricular remodeling and failure after experimental myocardial infarction","volume":"108","author":"Hayashidani","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jmb.2008.05.076_bib40","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1385\/CT:5:2:183","article-title":"NF-kappaB in cardiovascular disease: diverse and specific effects of a \u201cgeneral\u201d transcription factor?","volume":"5","author":"Jones","year":"2005","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.jmb.2008.05.076_bib41","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0167-5699(90)90035-8","article-title":"Human monocyte chemoattractant protein-1 (MCP-1)","volume":"11","author":"Leonard","year":"1990","journal-title":"Immunol. Today"},{"key":"10.1016\/j.jmb.2008.05.076_bib42","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1093\/cvr\/28.8.1258","article-title":"Expression of intercellular adhesion molecule-1 on rat cardiac myocytes by monocyte chemoattractant protein-1","volume":"28","author":"Ban","year":"1994","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.jmb.2008.05.076_bib43","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0165-2478(98)00116-3","article-title":"Macrophage-restricted molecules: role in differentiation and activation","volume":"65","author":"Gordon","year":"1999","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.jmb.2008.05.076_bib44","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1056\/NEJM199704173361603","article-title":"Apoptosis in the failing human heart","volume":"336","author":"Olivetti","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jmb.2008.05.076_bib45","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1378\/chest.112.5.1358","article-title":"Apoptosis and the heart","volume":"112","author":"Narula","year":"1997","journal-title":"Chest"},{"key":"10.1016\/j.jmb.2008.05.076_bib46","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1161\/01.RES.82.11.1111","article-title":"Apoptosis: basic mechanisms and implications for cardiovascular disease","volume":"82","author":"Haunstetter","year":"1998","journal-title":"Circ. Res."},{"key":"10.1016\/j.jmb.2008.05.076_bib47","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0735-1097(02)02958-3","article-title":"Myocyte apoptosis: programming ventricular remodeling","volume":"41","author":"Mani","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jmb.2008.05.076_bib48","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1161\/01.RES.88.3.262","article-title":"Nuclear factor-kappaB and cell survival: IAPs call for support","volume":"88","author":"Lee","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.jmb.2008.05.076_bib49","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1006\/jmcc.2001.1385","article-title":"Effect of NF-kappa B inhibition on TNF-alpha-induced apoptosis and downstream pathways in cardiomyocytes","volume":"33","author":"Bergmann","year":"2001","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.jmb.2008.05.076_bib50","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/0076-6879(83)01039-3","article-title":"Eukaryotic gene transcription with purified components","volume":"101","author":"Dignam","year":"1983","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jmb.2008.05.076_bib51","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal. Biochem."}],"container-title":["Journal of Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283608006694?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283608006694?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T21:05:21Z","timestamp":1758315921000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022283608006694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["S0022283608006694"],"URL":"https:\/\/doi.org\/10.1016\/j.jmb.2008.05.076","relation":{},"ISSN":["0022-2836"],"issn-type":[{"value":"0022-2836","type":"print"}],"subject":[],"published":{"date-parts":[[2008,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Blockade of NF-\u03baB Using I\u03baB\u03b1 Dominant-Negative Mice Ameliorates Cardiac Hypertrophy in Myotrophin-Overexpressed Transgenic Mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmb.2008.05.076","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}