{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:25:47Z","timestamp":1791087947522,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Molecular Biology"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1016\/j.jmb.2008.08.008","type":"journal-article","created":{"date-parts":[[2008,8,10]],"date-time":"2008-08-10T08:09:50Z","timestamp":1218355790000},"page":"122-132","source":"Crossref","is-referenced-by-count":34,"title":["Segregation of Type I Collagen Homo- and Heterotrimers in Fibrils"],"prefix":"10.1016","volume":"383","author":[{"given":"Sejin","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"McBride","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Losert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Leikin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmb.2008.08.008_bib1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1146\/annurev.bi.64.070195.002155","article-title":"Collagens: molecular biology, diseases, and potentials for therapy","volume":"64","author":"Prockop","year":"1995","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.jmb.2008.08.008_bib2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0076-6879(82)82062-4","article-title":"Characterization of fibrous forms of collagen","volume":"82 Pt. A","author":"Brodsky","year":"1982","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jmb.2008.08.008_bib3","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/S0021-9258(19)35449-3","article-title":"Fibril-forming collagens in lamprey","volume":"263","author":"Kelly","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2008.08.008_bib4","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/0006-291X(77)91441-3","article-title":"Identification of collagen alpha1(I) trimer in embryonic chick tendons and calvaria","volume":"78","author":"Jimenez","year":"1977","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jmb.2008.08.008_bib5","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0003-9861(77)90280-6","article-title":"Identification of collagen alpha1(I) trimer and normal type I collagen in a polyoma virus-induced mouse tumor","volume":"182","author":"Moro","year":"1977","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.jmb.2008.08.008_bib6","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/S0016-5085(79)80170-5","article-title":"Collagen types in normal and cirrhotic liver","volume":"76","author":"Rojkind","year":"1979","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jmb.2008.08.008_bib7","first-page":"513","article-title":"Collagen polymorphism in cultured rat kidney mesangial cells","volume":"57","author":"Haralson","year":"1987","journal-title":"Lab. Invest."},{"key":"10.1016\/j.jmb.2008.08.008_bib8","first-page":"316","article-title":"Synthesis of type I homotrimer collagen molecules by cultured human lung adenocarcinoma cells","volume":"133","author":"Rupard","year":"1988","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jmb.2008.08.008_bib9","first-page":"279","article-title":"Direct adhesion to type I and homotrimer collagens by breast carcinoma and embryonic epithelial cells in culture: a comparative study","volume":"50","author":"Ghersi","year":"1989","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.jmb.2008.08.008_bib10","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3109\/03008209909005281","article-title":"Characterization of the collagen phenotype of rabbit proximal tubule cells in culture","volume":"40","author":"Gibbs","year":"1999","journal-title":"Connect Tissue Res."},{"key":"10.1016\/j.jmb.2008.08.008_bib11","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1136\/jmg.21.4.257","article-title":"The clinical features of homozygous alpha 2(I) collagen deficient osteogenesis imperfecta","volume":"21","author":"Nicholls","year":"1984","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.jmb.2008.08.008_bib12","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1001\/archderm.1987.01660250082024","article-title":"Ehlers\u2013Danlos syndrome. A variant characterized by the deficiency of pro alpha 2 chain of type I procollagen","volume":"123","author":"Sasaki","year":"1987","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.jmb.2008.08.008_bib13","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1432-1033.1988.tb14087.x","article-title":"Existence of malfunctioning pro alpha2(I) collagen genes in a patient with a pro alpha 2(I)-chain-defective variant of Ehlers\u2013Danlos syndrome","volume":"174","author":"Hata","year":"1988","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.jmb.2008.08.008_bib14","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1086\/420794","article-title":"Rare autosomal recessive cardiac valvular form of Ehlers\u2013Danlos syndrome results from mutations in the COL1A2 gene that activate the nonsense-mediated RNA decay pathway","volume":"74","author":"Schwarze","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jmb.2008.08.008_bib15","doi-asserted-by":"crossref","first-page":"16061","DOI":"10.1074\/jbc.M801982200","article-title":"Defective C-propeptides of the Pro{alpha}2(I) chain of type I procollagen impede molecular assembly and result in osteogenesis imperfecta","volume":"283","author":"Pace","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2008.08.008_bib16","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0022-2836(02)00703-9","article-title":"The role of the alpha2 chain in the stabilization of the collagen type I heterotrimer: a study of the type I homotrimer in oim mouse tissues","volume":"321","author":"Miles","year":"2002","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jmb.2008.08.008_bib17","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0022-2836(03)00715-0","article-title":"Changes in thermal stability and microunfolding pattern of collagen helix resulting from the loss of alpha2(I) chain in osteogenesis imperfecta murine","volume":"331","author":"Kuznetsova","year":"2003","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jmb.2008.08.008_bib18","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1006\/jmbi.2001.4682","article-title":"Osteogenesis imperfecta murine: interaction between type I collagen homotrimers","volume":"309","author":"Kuznetsova","year":"2001","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jmb.2008.08.008_bib19","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S0934-8832(11)80077-6","article-title":"Self-assembly into fibrils of a homotrimer of type I collagen","volume":"12","author":"McBride","year":"1992","journal-title":"Matrix"},{"key":"10.1016\/j.jmb.2008.08.008_bib20","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1006\/jmbi.1997.1106","article-title":"Altered collagen structure in mouse tail tendon lacking the alpha 2(I) chain","volume":"270","author":"McBride","year":"1997","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jmb.2008.08.008_bib21","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1172\/JCI119519","article-title":"Collagen from the osteogenesis imperfecta mouse model (oim) shows reduced resistance against tensile stress","volume":"100","author":"Misof","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jmb.2008.08.008_bib22","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/0309-1651(88)90053-7","article-title":"Collagen biosynthesis by a breast carcinoma cell strain and biopsy fragments of the primary tumour","volume":"12","author":"Minafra","year":"1988","journal-title":"Cell Biol. Int. Rep."},{"key":"10.1016\/j.jmb.2008.08.008_bib23","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0309-1651(84)90184-X","article-title":"Collagen composition in the ductal infiltrating carcinoma of human breast","volume":"8","author":"Minafra","year":"1984","journal-title":"Cell Biol. Int. Rep."},{"key":"10.1016\/j.jmb.2008.08.008_bib24","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/oxfordjournals.jbchem.a134809","article-title":"FBJ virus-induced osteosarcoma contains type I, type I trimer, type III as well as type V collagens","volume":"96","author":"Yamagata","year":"1984","journal-title":"J. Biochem."},{"key":"10.1016\/j.jmb.2008.08.008_bib25","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1172\/JCI10347","article-title":"A COL1A1 Sp1 binding site polymorphism predisposes to osteoporotic fracture by affecting bone density and quality","volume":"107","author":"Mann","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jmb.2008.08.008_bib26","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/ng1096-203","article-title":"Reduced bone density and osteoporosis associated with a polymorphic Sp1 binding site in the collagen type I alpha 1 gene","volume":"14","author":"Grant","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jmb.2008.08.008_bib27","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/S8756-3282(03)00087-5","article-title":"Meta-analysis of COL1A1 Sp1 polymorphism in relation to bone mineral density and osteoporotic fracture","volume":"32","author":"Mann","year":"2003","journal-title":"Bone"},{"key":"10.1016\/j.jmb.2008.08.008_bib28","doi-asserted-by":"crossref","first-page":"e90","DOI":"10.1371\/journal.pmed.0030090","article-title":"Large-scale evidence for the effect of the COLIA1 Sp1 polymorphism on osteoporosis outcomes: the GENOMOS study","volume":"3","author":"Ralston","year":"2006","journal-title":"PLoS Med."},{"key":"10.1016\/j.jmb.2008.08.008_bib29","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1073\/pnas.90.5.1701","article-title":"Defective pro alpha 2(I) collagen synthesis in a recessive mutation in mice: a model of human osteogenesis imperfecta","volume":"90","author":"Chipman","year":"1993","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.jmb.2008.08.008_bib30","doi-asserted-by":"crossref","first-page":"11741","DOI":"10.1016\/S0021-9258(19)86545-6","article-title":"Collagen fibril formation in vitro. The role of the nonhelical terminal regions","volume":"254","author":"Gelman","year":"1979","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2008.08.008_bib31","doi-asserted-by":"crossref","first-page":"7118","DOI":"10.1016\/S0021-9258(19)68934-9","article-title":"Collagen self-assembly in vitro. Differentiating specific telopeptide-dependent interactions using selective enzyme modification and the addition of free amino telopeptide","volume":"256","author":"Helseth","year":"1981","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2008.08.008_bib32","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1002\/bip.1977.360161004","article-title":"The mechanism of nucleation for in vitro collagen fibril formation","volume":"16","author":"Comper","year":"1977","journal-title":"Biopolymers"},{"key":"10.1016\/j.jmb.2008.08.008_bib33","doi-asserted-by":"crossref","first-page":"36083","DOI":"10.1074\/jbc.274.51.36083","article-title":"Does the triple helical domain of type I collagen encode molecular recognition and fiber assembly while telopeptides serve as catalytic domains? Effect of proteolytic cleavage on fibrillogenesis and on collagen\u2013collagen interaction in fibers","volume":"274","author":"Kuznetsova","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2008.08.008_bib34","first-page":"113","article-title":"Collagen fibrillogenesis","volume":"Vol. I","author":"Veis","year":"1988"},{"key":"10.1016\/j.jmb.2008.08.008_bib35","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1749-6632.1990.tb17930.x","article-title":"Assembly of type I collagen fibrils de novo by the specific enzymic cleavage of pC collagen. The fibrils formed at about 37 degrees C are similar in diameter, roundness, and apparent flexibility to the collagen fibrils seen in connective tissue","volume":"580","author":"Kadler","year":"1990","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jmb.2008.08.008_bib36","doi-asserted-by":"crossref","first-page":"14901","DOI":"10.1021\/bi048788b","article-title":"Interactions of inorganic phosphate and sulfate anions with collagen","volume":"43","author":"Mertz","year":"2004","journal-title":"Biochemistry"},{"key":"10.1016\/j.jmb.2008.08.008_bib37","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1242\/jcs.01731","article-title":"Procollagen trafficking, processing and fibrillogenesis","volume":"118","author":"Canty","year":"2005","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.jmb.2008.08.008_bib38","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0174-173X(84)80036-9","article-title":"Action of mammalian collagenases on type I trimer collagen","volume":"4","author":"Narayanan","year":"1984","journal-title":"Collagen Relat. Res."},{"key":"10.1016\/j.jmb.2008.08.008_bib39","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1046\/j.1523-1755.2002.00451.x","article-title":"Novel collagen glomerulopathy in a homotrimeric type I collagen mouse (oim)","volume":"62","author":"Phillips","year":"2002","journal-title":"Kidney Int."},{"key":"10.1016\/j.jmb.2008.08.008_bib40","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1073\/pnas.032307099","article-title":"Type I collagen is thermally unstable at body temperature","volume":"99","author":"Leikina","year":"2002","journal-title":"Proc. Natl Acad. Sci. USA"}],"container-title":["Journal of Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283608009881?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283608009881?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T15:36:05Z","timestamp":1631633765000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022283608009881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["S0022283608009881"],"URL":"https:\/\/doi.org\/10.1016\/j.jmb.2008.08.008","relation":{},"ISSN":["0022-2836"],"issn-type":[{"value":"0022-2836","type":"print"}],"subject":[],"published":{"date-parts":[[2008,10]]}}}