{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T13:59:05Z","timestamp":1770991145003,"version":"3.50.1"},"reference-count":83,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 HD040661"],"award-info":[{"award-number":["R01 HD040661"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Roadmap Interdisciplinary Research Consortium","award":["UL1 DE019583"],"award-info":[{"award-number":["UL1 DE019583"]}]},{"name":"Roadmap Interdisciplinary Research Consortium","award":["RL1 AG032119"],"award-info":[{"award-number":["RL1 AG032119"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Molecular Biology"],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1016\/j.jmb.2011.01.006","type":"journal-article","created":{"date-parts":[[2011,1,13]],"date-time":"2011-01-13T09:15:04Z","timestamp":1294910104000},"page":"21-34","source":"Crossref","is-referenced-by-count":22,"title":["Initiation of Translation of the FMR1 mRNA Occurs Predominantly through 5\u2032-End-Dependent Ribosomal Scanning"],"prefix":"10.1016","volume":"407","author":[{"given":"Anna L.","family":"Ludwig","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John W.B.","family":"Hershey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.","family":"Hagerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmb.2011.01.006_bb0005","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/0092-8674(91)90283-5","article-title":"Variation of the CGG repeat at the fragile X site results in genetic instability: resolution of the Sherman paradox","volume":"67","author":"Fu","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.jmb.2011.01.006_bb0010","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/0092-8674(91)90397-H","article-title":"Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome","volume":"65","author":"Verkerk","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.jmb.2011.01.006_bb0015","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1126\/science.252.5009.1097","article-title":"Instability of a 550-base pair DNA segment and abnormal methylation in fragile X syndrome","volume":"252","author":"Oberle","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.jmb.2011.01.006_bb0020","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/0092-8674(91)90125-I","article-title":"Absence of expression of the FMR-1 gene in fragile X syndrome","volume":"66","author":"Pieretti","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.jmb.2011.01.006_bb0025","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/hmg\/1.6.397","article-title":"DNA methylation represses FMR-1 transcription in fragile X syndrome","volume":"1","author":"Sutcliffe","year":"1992","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jmb.2011.01.006_bb0030","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.gde.2006.04.010","article-title":"Transcription, translation and fragile X syndrome","volume":"16","author":"Garber","year":"2006","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.jmb.2011.01.006_bb0035","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1177\/1073858409333075","article-title":"The state of synapses in fragile X syndrome","volume":"15","author":"Pfeiffer","year":"2009","journal-title":"Neuroscientist"},{"key":"10.1016\/j.jmb.2011.01.006_bb0040","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.neuron.2008.10.004","article-title":"Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function","volume":"60","author":"Bassell","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.jmb.2011.01.006_bb0045","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nrn1667","article-title":"From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome","volume":"6","author":"Bagni","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jmb.2011.01.006_bb0050","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1542\/peds.2008-0317","article-title":"Advances in the treatment of fragile X syndrome","volume":"123","author":"Hagerman","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.jmb.2011.01.006_bb0055","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1002\/ajmg.a.32439","article-title":"Co-occurring conditions associated with FMR1 gene variations: findings from a national parent survey","volume":"146A","author":"Bailey","year":"2008","journal-title":"Am. J. Med. Genet. Part A"},{"key":"10.1016\/j.jmb.2011.01.006_bb0060","doi-asserted-by":"crossref","first-page":"S137","DOI":"10.1097\/00004703-200604002-00012","article-title":"Autism spectrum disorders and attention-deficit\/hyperactivity disorder in boys with the fragile X premutation","volume":"27","author":"Farzin","year":"2006","journal-title":"J. Dev. Behav. Pediatr."},{"key":"10.1016\/j.jmb.2011.01.006_bb0065","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/(SICI)1096-8628(19990528)84:3<300::AID-AJMG27>3.0.CO;2-5","article-title":"Premature ovarian failure (POF) and fragile X premutation females: from POF to fragile X carrier identification, from fragile X carrier diagnosis to POF association data","volume":"84","author":"Uzielli","year":"1999","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.jmb.2011.01.006_bb0070","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/humrep\/15.1.197","article-title":"Association between idiopathic premature ovarian failure and fragile X premutation","volume":"15","author":"Marozzi","year":"2000","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jmb.2011.01.006_bb0075","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1093\/humrep\/deg327","article-title":"Fragile X premutation in women with sporadic premature ovarian failure in Slovenia","volume":"18","author":"Gersak","year":"2003","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jmb.2011.01.006_bb0080","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1093\/humrep\/dei432","article-title":"Influence of intermediate and uninterrupted FMR1 CGG expansions in premature ovarian failure manifestation","volume":"21","author":"Bodega","year":"2006","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jmb.2011.01.006_bb0085","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1212\/WNL.57.1.127","article-title":"Intention tremor, parkinsonism, and generalized brain atrophy in male carriers of fragile X","volume":"57","author":"Hagerman","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.jmb.2011.01.006_bb0090","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1086\/374321","article-title":"Fragile X premutation tremor\/ataxia syndrome: molecular, clinical, and neuroimaging correlates","volume":"72","author":"Jacquemont","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jmb.2011.01.006_bb0095","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/brain\/awh683","article-title":"Neuropathology of fragile X-associated tremor\/ataxia syndrome (FXTAS)","volume":"129","author":"Greco","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.jmb.2011.01.006_bb0100","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1002\/mds.21493","article-title":"Fragile X-associated tremor\/ataxia syndrome: clinical features, genetics, and testing guidelines","volume":"22","author":"Berry-Kravis","year":"2007","journal-title":"Mov. Disord."},{"key":"10.1016\/j.jmb.2011.01.006_bb0105","doi-asserted-by":"crossref","first-page":"830","DOI":"10.2310\/JIM.0b013e3181af59c4","article-title":"Fragile X-associated tremor\/ataxia syndrome: clinical phenotype, diagnosis, and treatment","volume":"57","author":"Leehey","year":"2009","journal-title":"J. Invest. Med."},{"key":"10.1016\/j.jmb.2011.01.006_bb0110","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1093\/hmg\/10.14.1449","article-title":"Reduced FMRP and increased FMR1 transcription is proportionally associated with CGG repeat number in intermediate-length and premutation carriers","volume":"10","author":"Kenneson","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jmb.2011.01.006_bb0115","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00439-004-1086-x","article-title":"A study of the distributional characteristics of FMR1 transcript levels in 238 individuals","volume":"114","author":"Allen","year":"2004","journal-title":"Hum. Genet."},{"key":"10.1016\/j.jmb.2011.01.006_bb0120","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1261\/rna.280807","article-title":"Elevated FMR1 mRNA in premutation carriers is due to increased transcription","volume":"13","author":"Tassone","year":"2007","journal-title":"RNA"},{"key":"10.1016\/j.jmb.2011.01.006_bb0125","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/1096-8628(20000918)94:3<232::AID-AJMG9>3.0.CO;2-H","article-title":"Fragile X males with unmethylated, full mutation trinucleotide repeat expansions have elevated levels of FMR1 messenger RNA","volume":"94","author":"Tassone","year":"2000","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.jmb.2011.01.006_bb0130","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1086\/302720","article-title":"Elevated levels of FMR1 mRNA in carrier males: a new mechanism of involvement in the fragile-X syndrome","volume":"66","author":"Tassone","year":"2000","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jmb.2011.01.006_bb0135","doi-asserted-by":"crossref","first-page":"7419","DOI":"10.1074\/jbc.R800025200","article-title":"Mechanisms of RNA-mediated disease","volume":"284","author":"O'Rourke","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2011.01.006_bb0140","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1001\/archneurol.2007.30","article-title":"Fragile X-associated tremor\/ataxia syndrome: an aging face of the fragile X gene","volume":"65","author":"Amiri","year":"2008","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.jmb.2011.01.006_bb0145","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1086\/386296","article-title":"The fragile-X premutation: a maturing perspective","volume":"74","author":"Hagerman","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jmb.2011.01.006_bb0150","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/bies.080122","article-title":"Microsatellite repeat instability and neurological disease","volume":"31","author":"Brouwer","year":"2009","journal-title":"BioEssays"},{"key":"10.1016\/j.jmb.2011.01.006_bb0155","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1159\/000092501","article-title":"Dominant non-coding repeat expansions in human disease","volume":"1","author":"Dick","year":"2006","journal-title":"Genome Dyn."},{"key":"10.1016\/j.jmb.2011.01.006_bb0160","doi-asserted-by":"crossref","first-page":"5469","DOI":"10.1093\/nar\/gkg766","article-title":"RNA structure of trinucleotide repeats associated with human neurological diseases","volume":"31","author":"Sobczak","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jmb.2011.01.006_bb0165","doi-asserted-by":"crossref","first-page":"93","DOI":"10.4161\/rna.4.2.5039","article-title":"Secondary structure and dynamics of the r(CGG) repeat in the mRNA of the fragile X mental retardation 1 (FMR1) gene","volume":"4","author":"Zumwalt","year":"2007","journal-title":"RNA Biol."},{"key":"10.1016\/j.jmb.2011.01.006_bb0170","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/nar\/gki186","article-title":"Facile FMR1 mRNA structure regulation by interruptions in CGG repeats","volume":"33","author":"Napierala","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jmb.2011.01.006_bb0175","doi-asserted-by":"crossref","first-page":"6243","DOI":"10.1093\/nar\/gkg818","article-title":"The fragile X syndrome repeats form RNA hairpins that do not activate the interferon-inducible protein kinase, PKR, but are cut by Dicer","volume":"31","author":"Handa","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jmb.2011.01.006_bb0180","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1093\/nar\/28.7.1535","article-title":"Interruption of the fragile X syndrome expanded sequence d(CGG)(n) by interspersed d(AGG) trinucleotides diminishes the formation and stability of d(CGG)(n) tetrahelical structures","volume":"28","author":"Weisman-Shomer","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jmb.2011.01.006_bb0185","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.1093\/nar\/gkh745","article-title":"Destabilization of tetraplex structures of the fragile X repeat sequence (CGG)(n) is mediated by homolog-conserved domains in three members of the hnRNP family","volume":"32","author":"Khateb","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jmb.2011.01.006_bb0190","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/0092-8674(85)90200-4","article-title":"Insertion mutagenesis to increase secondary structure within the 5\u2032 noncoding region of a eukaryotic mRNA reduces translational efficiency","volume":"40","author":"Pelletier","year":"1985","journal-title":"Cell"},{"key":"10.1016\/j.jmb.2011.01.006_bb0195","doi-asserted-by":"crossref","first-page":"5134","DOI":"10.1128\/MCB.9.11.5134","article-title":"Circumstances and mechanisms of inhibition of translation by secondary structure in eucaryotic mRNAs","volume":"9","author":"Kozak","year":"1989","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.jmb.2011.01.006_bb0200","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1073\/pnas.83.9.2850","article-title":"Influences of mRNA secondary structure on initiation by eukaryotic ribosomes","volume":"83","author":"Kozak","year":"1986","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.jmb.2011.01.006_bb0205","doi-asserted-by":"crossref","first-page":"19867","DOI":"10.1016\/S0021-9258(18)54860-2","article-title":"Structural features in eukaryotic mRNAs that modulate the initiation of translation","volume":"266","author":"Kozak","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2011.01.006_bb0210","doi-asserted-by":"crossref","first-page":"3406","DOI":"10.1093\/nar\/gkg595","article-title":"Mfold web server for nucleic acid folding and hybridization prediction","volume":"31","author":"Zuker","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jmb.2011.01.006_bb0215","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1006\/jmbi.1999.2700","article-title":"Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure","volume":"288","author":"Mathews","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jmb.2011.01.006_bb0220","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1017\/S1355838202020642","article-title":"Reduced FMR1 mRNA translation efficiency in fragile X patients with premutations","volume":"8","author":"Primerano","year":"2002","journal-title":"RNA"},{"key":"10.1016\/j.jmb.2011.01.006_bb0225","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/ajmg.b.30241","article-title":"Abnormal elevation of FMR1 mRNA is associated with psychological symptoms in individuals with the fragile X premutation","volume":"139","author":"Hessl","year":"2005","journal-title":"Am. J. Med. Genet. Part B"},{"key":"10.1016\/j.jmb.2011.01.006_bb0230","doi-asserted-by":"crossref","first-page":"5775","DOI":"10.1093\/nar\/gkm636","article-title":"The tetraplex (CGG)n destabilizing proteins hnRNP A2 and CBF-A enhance the in vivo translation of fragile X premutation mRNA","volume":"35","author":"Khateb","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jmb.2011.01.006_bb0235","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1093\/hmg\/ddg331","article-title":"The (CGG)n repeat element within the 5\u2032 untranslated region of the FMR1 message provides both positive and negative cis effects on in vivo translation of a downstream reporter","volume":"12","author":"Chen","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jmb.2011.01.006_bb0240","series-title":"Translational Control in Biology and Medicine","first-page":"87","article-title":"The mechanism of translation initiation in eukaryotes","author":"Pestova","year":"2007"},{"key":"10.1016\/j.jmb.2011.01.006_bb0245","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.sbi.2009.03.005","article-title":"Toward a structural understanding of IRES RNA function","volume":"19","author":"Filbin","year":"2009","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.jmb.2011.01.006_bb0250","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1099\/vir.0.83426-0","article-title":"New insights into internal ribosome entry site elements relevant for viral gene expression","volume":"89","author":"Martinez-Salas","year":"2008","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.jmb.2011.01.006_bb0255","series-title":"Translational Control in Biology and Medicine","first-page":"129","article-title":"Translation initiation by viral internal ribosome entry sites","author":"Doudna","year":"2006"},{"key":"10.1016\/j.jmb.2011.01.006_bb0260","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1039\/b708867a","article-title":"Cap-independent regulation of gene expression in apoptosis","volume":"3","author":"Graber","year":"2007","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.jmb.2011.01.006_bb0265","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1042\/BC20070098","article-title":"Re-programming of translation following cell stress allows IRES-mediated translation to predominate","volume":"100","author":"Spriggs","year":"2008","journal-title":"Biol. Cell"},{"key":"10.1016\/j.jmb.2011.01.006_bb0270","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0076-6879(07)29015-9","article-title":"Analysis of ribosomal shunting during translation initiation in eukaryotic mRNAs","volume":"429","author":"Mauro","year":"2007","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jmb.2011.01.006_bb0275","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.virusres.2005.10.017","article-title":"Translation reinitiation and leaky scanning in plant viruses","volume":"119","author":"Ryabova","year":"2006","journal-title":"Virus Res."},{"key":"10.1016\/j.jmb.2011.01.006_bb0280","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1126\/science.7732383","article-title":"Translational suppression by trinucleotide repeat expansion at FMR1","volume":"268","author":"Feng","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.jmb.2011.01.006_bb0285","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1093\/hmg\/ddh053","article-title":"Redistribution of transcription start sites within the FMR1 promoter region with expansion of the downstream CGG-repeat element","volume":"13","author":"Beilina","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jmb.2011.01.006_bb0290","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1261\/rna.2309906","article-title":"Control of mammalian translation by mRNA structure near caps","volume":"12","author":"Babendure","year":"2006","journal-title":"RNA"},{"key":"10.1016\/j.jmb.2011.01.006_bb0295","doi-asserted-by":"crossref","first-page":"7266","DOI":"10.1016\/S0021-9258(18)68637-5","article-title":"Discriminatory interaction of purified eukaryotic initiation factors 4F plus 4A with the 5\u2032 ends of reovirus messenger RNAs","volume":"263","author":"Lawson","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2011.01.006_bb0300","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/1471-2199-9-89","article-title":"Identifying intrinsic and extrinsic determinants that regulate internal initiation of translation mediated by the FMR1 5\u2032 leader","volume":"9","author":"Dobson","year":"2008","journal-title":"BMC Mol. Biol."},{"key":"10.1016\/j.jmb.2011.01.006_bb0305","doi-asserted-by":"crossref","first-page":"37916","DOI":"10.1074\/jbc.M105584200","article-title":"The 5\u2032-untranslated region of the FMR1 message facilitates translation by internal ribosome entry","volume":"276","author":"Chiang","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2011.01.006_bb0310","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1093\/nar\/18.9.2828","article-title":"Evaluation of the fidelity of initiation of translation in reticulocyte lysates from commercial sources","volume":"18","author":"Kozak","year":"1990","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jmb.2011.01.006_bb0315","doi-asserted-by":"crossref","first-page":"5031","DOI":"10.1016\/S0021-9258(18)83694-8","article-title":"Translation initiation at non-AUG triplets in mammalian cells","volume":"264","author":"Peabody","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2011.01.006_bb0320","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.cbpa.2006.08.010","article-title":"Where to begin? The mechanism of translation initiation codon selection in eukaryotes","volume":"10","author":"Algire","year":"2006","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.jmb.2011.01.006_bb0325","doi-asserted-by":"crossref","first-page":"24325","DOI":"10.1074\/jbc.271.40.24325","article-title":"Nucleosome assembly on methylated CGG triplet repeats in the fragile X mental retardation gene 1 promoter","volume":"271","author":"Godde","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2011.01.006_bb0330","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1006\/jmbi.1996.0593","article-title":"Long CCG triplet repeat blocks exclude nucleosomes: a possible mechanism for the nature of fragile sites in chromosomes","volume":"263","author":"Wang","year":"1996","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jmb.2011.01.006_bb0335","doi-asserted-by":"crossref","first-page":"8301","DOI":"10.1073\/pnas.87.21.8301","article-title":"Downstream secondary structure facilitates recognition of initiator codons by eukaryotic ribosomes","volume":"87","author":"Kozak","year":"1990","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.jmb.2011.01.006_bb0340","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1186\/1471-2105-8-318","article-title":"AUG_hairpin: prediction of a downstream secondary structure influencing the recognition of a translation start site","volume":"8","author":"Kochetov","year":"2007","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.jmb.2011.01.006_bb0345","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.1091\/mbc.E07-12-1264","article-title":"The DEAD-box RNA helicase DDX3 associates with export messenger ribonucleoproteins as well as tip-associated protein and participates in translational control","volume":"19","author":"Lai","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.jmb.2011.01.006_bb0350","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.cell.2008.10.037","article-title":"Translation initiation on mammalian mRNAs with structured 5\u2032UTRs requires DExH-box protein DHX29","volume":"135","author":"Pisareva","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.jmb.2011.01.006_bb0355","doi-asserted-by":"crossref","first-page":"6212","DOI":"10.1128\/MCB.20.17.6212-6223.2000","article-title":"Termination and peptide release at the upstream open reading frame are required for downstream translation on synthetic shunt-competent mRNA leaders","volume":"20","author":"Hemmings-Mieszczak","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.jmb.2011.01.006_bb0360","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1016\/j.biocel.2009.04.021","article-title":"Identification of proteins whose synthesis is preferentially enhanced by polyamines at the level of translation in mammalian cells","volume":"41","author":"Nishimura","year":"2009","journal-title":"Int. J. Biochem. Cell. Biol."},{"key":"10.1016\/j.jmb.2011.01.006_bb0365","doi-asserted-by":"crossref","first-page":"54","DOI":"10.4161\/rna.6.1.7567","article-title":"Reconciling contradictory reports regarding translation of BACE1 mRNA: initiation mechanism is altered by different expression systems","volume":"6","author":"Koh","year":"2009","journal-title":"RNA Biol."},{"key":"10.1016\/j.jmb.2011.01.006_bb0370","doi-asserted-by":"crossref","first-page":"pe32","DOI":"10.1126\/scisignal.125pe32","article-title":"A cunning stunt: an alternative mechanism of eukaryotic translation initiation","volume":"1","author":"Morley","year":"2008","journal-title":"Sci. Signal."},{"key":"10.1016\/j.jmb.2011.01.006_bb0375","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1128\/MCB.01446-07","article-title":"Translation of cIAP2 mRNA is mediated exclusively by a stress-modulated ribosome shunt","volume":"28","author":"Sherrill","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.jmb.2011.01.006_bb0380","doi-asserted-by":"crossref","first-page":"11533","DOI":"10.1073\/pnas.90.24.11533","article-title":"Translation of the human LINE-1 element, L1Hs","volume":"90","author":"McMillan","year":"1993","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.jmb.2011.01.006_bb0385","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1365-2958.1993.tb01713.x","article-title":"Inhibition of translational initiation in Saccharomyces cerevisiae by secondary structure: the roles of the stability and position of stem\u2013loops in the mRNA leader","volume":"9","author":"Oliveira","year":"1993","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jmb.2011.01.006_bb0390","doi-asserted-by":"crossref","first-page":"6453","DOI":"10.1016\/S0021-9258(18)53273-7","article-title":"Inhibition of translational initiation in the yeast Saccharomyces cerevisiae as a function of the stability and position of hairpin structures in the mRNA leader","volume":"268","author":"Vega Laso","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2011.01.006_bb0395","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1093\/nar\/24.12.2441","article-title":"Sequence and structure determinants of Drosophila Hsp70 mRNA translation: 5\u2032UTR secondary structure specifically inhibits heat shock protein mRNA translation","volume":"24","author":"Hess","year":"1996","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jmb.2011.01.006_bb0400","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1128\/MCB.11.6.3115","article-title":"Degradation of a developmentally regulated mRNA in Xenopus embryos is controlled by the 3\u2032 region and requires the translation of another maternal mRNA","volume":"11","author":"Bouvet","year":"1991","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.jmb.2011.01.006_bb0405","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1111\/j.1471-4159.2008.05747.x","article-title":"CGG-repeat length and neuropathological and molecular correlates in a mouse model for fragile X-associated tremor\/ataxia syndrome","volume":"107","author":"Brouwer","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.jmb.2011.01.006_bb0410","doi-asserted-by":"crossref","first-page":"7151","DOI":"10.1523\/JNEUROSCI.1790-06.2006","article-title":"Local protein synthesis and spine morphogenesis: fragile X syndrome and beyond","volume":"26","author":"Grossman","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jmb.2011.01.006_bb0415","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"}],"container-title":["Journal of Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283611000234?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283611000234?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:49:58Z","timestamp":1712105398000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022283611000234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":83,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["S0022283611000234"],"URL":"https:\/\/doi.org\/10.1016\/j.jmb.2011.01.006","relation":{},"ISSN":["0022-2836"],"issn-type":[{"value":"0022-2836","type":"print"}],"subject":[],"published":{"date-parts":[[2011,3]]}}}