{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T13:34:10Z","timestamp":1783776850171,"version":"3.55.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TH862\/1-4"],"award-info":[{"award-number":["TH862\/1-4"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular Biology"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.jmb.2011.03.048","type":"journal-article","created":{"date-parts":[[2011,4,9]],"date-time":"2011-04-09T06:19:15Z","timestamp":1302329955000},"page":"189-201","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["The Crystal Structure of Death Receptor 6 (DR6): A Potential Receptor of the Amyloid Precursor Protein (APP)"],"prefix":"10.1016","volume":"409","author":[{"given":"Miriam","family":"Kuester","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Kemmerzehl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven O.","family":"Dahms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Roeser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel E.","family":"Than","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmb.2011.03.048_bb0005","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S1359-6101(03)00021-2","article-title":"The signaling adaptors and pathways activated by TNF superfamily","volume":"14","author":"Dempsey","year":"2003","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.jmb.2011.03.048_bb0010","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0092-8674(01)00237-9","article-title":"The TNF and TNF receptor superfamilies: integrating mammalian biology","volume":"104","author":"Locksley","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.jmb.2011.03.048_bb0015","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/nri1184","article-title":"Signalling pathways of the TNF superfamily: a double-edged sword","volume":"3","author":"Aggarwal","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jmb.2011.03.048_bb0020","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1023\/A:1025319031417","article-title":"Receptor-mediated choreography of life and death","volume":"23","author":"Bhardwaj","year":"2003","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.jmb.2011.03.048_bb0025","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1146\/annurev.immunol.25.022106.141656","article-title":"The death domain superfamily in intracellular signaling of apoptosis and inflammation","volume":"25","author":"Park","year":"2007","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jmb.2011.03.048_bb0030","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.cellsig.2003.08.007","article-title":"Death receptor-induced cell killing","volume":"16","author":"Thorburn","year":"2004","journal-title":"Cell Signal."},{"key":"10.1016\/j.jmb.2011.03.048_bb0035","first-page":"212","article-title":"Messengers of cell death: apoptotic signaling in health and disease","volume":"88","author":"Rossi","year":"2003","journal-title":"Haematologica"},{"key":"10.1016\/j.jmb.2011.03.048_bb0040","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0092-8674(93)90132-A","article-title":"Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation","volume":"73","author":"Banner","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.jmb.2011.03.048_bb0045","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1038\/14935","article-title":"Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation","volume":"6","author":"Mongkolsapaya","year":"1999","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.jmb.2011.03.048_bb0050","doi-asserted-by":"crossref","first-page":"ra83","DOI":"10.1126\/scisignal.2000954","article-title":"Solution structure of the TNF-TNFR2 complex","volume":"3","author":"Mukai","year":"2010","journal-title":"Sci. Signal."},{"key":"10.1016\/j.jmb.2011.03.048_bb0055","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.jmb.2009.12.030","article-title":"Molecular and structural insight into proNGF engagement of p75NTR and sortilin","volume":"396","author":"Feng","year":"2010","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jmb.2011.03.048_bb0060","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nature07089","article-title":"Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex","volume":"454","author":"Gong","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2011.03.048_bb0065","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cyto.2007.03.005","article-title":"Three is better than one: pre-ligand receptor assembly in the regulation of TNF receptor signaling","volume":"37","author":"Chan","year":"2007","journal-title":"Cytokine"},{"key":"10.1016\/j.jmb.2011.03.048_bb0070","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1126\/science.288.5475.2351","article-title":"A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling","volume":"288","author":"Chan","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.jmb.2011.03.048_bb0075","doi-asserted-by":"crossref","first-page":"13303","DOI":"10.1074\/jbc.270.22.13303","article-title":"Crystallographic evidence for dimerization of unliganded tumor necrosis factor receptor","volume":"270","author":"Naismith","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2011.03.048_bb0080","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0968-0004(01)01995-8","article-title":"The molecular architecture of the TNF superfamily","volume":"27","author":"Bodmer","year":"2002","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.jmb.2011.03.048_bb0085","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0968-0004(97)01164-X","article-title":"Modularity in the TNF-receptor family","volume":"23","author":"Naismith","year":"1998","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.jmb.2011.03.048_bb0090","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/1097-0029(20000801)50:3<184::AID-JEMT2>3.0.CO;2-H","article-title":"TNF alpha and the TNF receptor superfamily: structure-function relationship(s)","volume":"50","author":"Idriss","year":"2000","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.jmb.2011.03.048_bb0095","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/nature07767","article-title":"APP binds DR6 to trigger axon pruning and neuron death via distinct caspases","volume":"457","author":"Nikolaev","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2011.03.048_bb0100","doi-asserted-by":"crossref","first-page":"5381","DOI":"10.1073\/pnas.0911326107","article-title":"Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein","volume":"107","author":"Dahms","year":"2010","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.jmb.2011.03.048_bb0105","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0014-5793(98)00791-1","article-title":"Identification and functional characterization of DR6, a novel death domain-containing TNF receptor","volume":"431","author":"Pan","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jmb.2011.03.048_bb0110","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/j.bbamcr.2009.07.008","article-title":"Functional analysis of the posttranslational modifications of the death receptor 6","volume":"1793","author":"Klima","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jmb.2011.03.048_bb0115","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/S0969-2126(96)00134-7","article-title":"Structures of the extracellular domain of the type I tumor necrosis factor receptor","volume":"4","author":"Naismith","year":"1996","journal-title":"Structure"},{"key":"10.1016\/j.jmb.2011.03.048_bb0120","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.jmb.2007.05.022","article-title":"Inference of macromolecular assemblies from crystalline state","volume":"372","author":"Krissinel","year":"2007","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jmb.2011.03.048_bb0125","doi-asserted-by":"crossref","first-page":"6910","DOI":"10.4049\/jimmunol.0904033","article-title":"Structural and functional insights of RANKL-RANK interaction and signaling","volume":"184","author":"Liu","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.jmb.2011.03.048_bb0130","doi-asserted-by":"crossref","first-page":"31171","DOI":"10.1074\/jbc.M004414200","article-title":"Crystal structure of TRAIL-DR5 complex identifies a critical role of the unique frame insertion in conferring recognition specificity","volume":"275","author":"Cha","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2011.03.048_bb0135","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/j.str.2006.06.015","article-title":"The crystal structure of the costimulatory OX40-OX40L complex","volume":"14","author":"Compaan","year":"2006","journal-title":"Structure"},{"key":"10.1016\/j.jmb.2011.03.048_bb0140","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.str.2010.12.004","article-title":"Decoy strategies: the structure of TL1A:DcR3 complex","volume":"19","author":"Zhan","year":"2011","journal-title":"Structure"},{"key":"10.1016\/j.jmb.2011.03.048_bb0145","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1126\/science.288.5475.2354","article-title":"Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations","volume":"288","author":"Siegel","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.jmb.2011.03.048_bb0150","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S1097-2765(00)80207-5","article-title":"Triggering cell death: the crystal structure of Apo2L\/TRAIL in a complex with death receptor 5","volume":"4","author":"Hymowitz","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jmb.2011.03.048_bb0155","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.jmb.2005.12.053","article-title":"Solution conformation and heparin-induced dimerization of the full-length extracellular domain of the human amyloid precursor protein","volume":"357","author":"Gralle","year":"2006","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jmb.2011.03.048_bb0160","doi-asserted-by":"crossref","first-page":"33923","DOI":"10.1074\/jbc.M105410200","article-title":"Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease","volume":"276","author":"Scheuermann","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2011.03.048_bb0165","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1093\/bioinformatics\/btn334","article-title":"Accelerating and focusing protein-protein docking correlations using multi-dimensional rotational FFT generating functions","volume":"24","author":"Ritchie","year":"2008","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jmb.2011.03.048_bb0170","doi-asserted-by":"crossref","first-page":"26571","DOI":"10.1016\/S0021-9258(19)74350-6","article-title":"Amyloid-like properties of peptides flanking the epitope of amyloid precursor protein-specific monoclonal antibody 22C11","volume":"268","author":"Hilbich","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2011.03.048_bb0175","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1002\/prot.22962","article-title":"Computational prediction and analysis of the DR6-NAPP interaction","volume":"79","author":"Ponomarev","year":"2011","journal-title":"Proteins"},{"key":"10.1016\/j.jmb.2011.03.048_bb0180","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/protein\/5.3.191","article-title":"Quantitative analysis of protein far UV circular dichroism spectra by neural networks","volume":"5","author":"Bohm","year":"1992","journal-title":"Protein Eng."},{"key":"10.1016\/j.jmb.2011.03.048_bb0185","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1107\/S0907444994003112","article-title":"The CCP4 suite: programs for protein crystallography","volume":"50","year":"1994","journal-title":"Acta Crystallogr. D"},{"key":"10.1016\/j.jmb.2011.03.048_bb0190","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1107\/S0108767307043930","article-title":"A short history of SHELX","volume":"64","author":"Sheldrick","year":"2008","journal-title":"Acta Crystallogr. A"},{"key":"10.1016\/j.jmb.2011.03.048_bb0195","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/S0076-6879(97)76073-7","article-title":"Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods","volume":"276","author":"de La Fortelle","year":"1997","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jmb.2011.03.048_bb0200","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1107\/S0907444995008754","article-title":"Methods used in the structure determination of bovine mitochondrial F1 ATPase","volume":"52","author":"Abrahams","year":"1996","journal-title":"Acta Crystallogr. D"},{"key":"10.1016\/j.jmb.2011.03.048_bb0205","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1107\/S0907444906022116","article-title":"The Buccaneer software for automated model building. 1. Tracing protein chains","volume":"62","author":"Cowtan","year":"2006","journal-title":"Acta Crystallogr. D"},{"key":"10.1016\/j.jmb.2011.03.048_bb0210","series-title":"Weiterentwicklung eines Programms f\u00fcr Molek\u00fclgraphik und Elektronendichte-Manipulation und seine Anwendung auf verschiedene Protein Strukturaufkl\u00e4rungen. PhD thesis","author":"Turk","year":"1992"},{"key":"10.1016\/j.jmb.2011.03.048_bb0215","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1107\/S0907444998003254","article-title":"Crystallography & NMR system: A new software suite for macromolecular structure determination","volume":"54","author":"Brunger","year":"1998","journal-title":"Acta Crystallogr. D"},{"key":"10.1016\/j.jmb.2011.03.048_bb0220","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0065-3233(08)60402-7","article-title":"Conformation of polypeptides and proteins","volume":"23","author":"Ramachandran","year":"1968","journal-title":"Adv. Protein Chem."},{"key":"10.1016\/j.jmb.2011.03.048_bb0225","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/bioinformatics\/btn584","article-title":"ProtorP: a protein\u2013protein interaction analysis server","volume":"25","author":"Reynolds","year":"2009","journal-title":"Bioinformatics"}],"container-title":["Journal of Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283611003378?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283611003378?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T21:14:26Z","timestamp":1758316466000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022283611003378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S0022283611003378"],"URL":"https:\/\/doi.org\/10.1016\/j.jmb.2011.03.048","relation":{},"ISSN":["0022-2836"],"issn-type":[{"value":"0022-2836","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Crystal Structure of Death Receptor 6 (DR6): A Potential Receptor of the Amyloid Precursor Protein (APP)","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmb.2011.03.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}