{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:15:46Z","timestamp":1784873746315,"version":"3.55.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"16","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"CIHR","doi-asserted-by":"crossref","award":["HPR85525"],"award-info":[{"award-number":["HPR85525"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008220","name":"Canadian Foundation for AIDS Research","doi-asserted-by":"crossref","award":["023-013"],"award-info":[{"award-number":["023-013"]}],"id":[{"id":"10.13039\/100008220","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Molecular Biology"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.jmb.2013.05.015","type":"journal-article","created":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T23:18:02Z","timestamp":1369351082000},"page":"2840-2852","source":"Crossref","is-referenced-by-count":11,"title":["A Naturally Occurring Vif Mutant (I107T) Attenuates Anti-APOBEC3G Activity and HIV-1 Replication"],"prefix":"10.1016","volume":"425","author":[{"given":"Jinyu","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhujun","family":"Ao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Matthews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Ramdahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blake","family":"Ball","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Fowke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Plummer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Embree","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojian","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmb.2013.05.015_bb0005","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0092-8674(03)00515-4","article-title":"Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif","volume":"114","author":"Mariani","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.jmb.2013.05.015_bb0010","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1038\/nm946","article-title":"HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation","volume":"9","author":"Marin","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.jmb.2013.05.015_bb0015","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S1097-2765(03)00353-8","article-title":"HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability","volume":"12","author":"Stopak","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jmb.2013.05.015_bb0020","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/nature00939","article-title":"Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein","volume":"418","author":"Sheehy","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2013.05.015_bb0025","doi-asserted-by":"crossref","first-page":"33177","DOI":"10.1074\/jbc.M402062200","article-title":"The interaction between HIV-1 Gag and APOBEC3G","volume":"279","author":"Cen","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2013.05.015_bb0030","doi-asserted-by":"crossref","first-page":"34083","DOI":"10.1074\/jbc.C400235200","article-title":"APOBEC3G is incorporated into virus-like particles by a direct interaction with HIV-1 Gag nucleocapsid protein","volume":"279","author":"Alce","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2013.05.015_bb0035","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.virol.2004.08.006","article-title":"Specific packaging of APOBEC3G into HIV-1 virions is mediated by the nucleocapsid domain of the gag polyprotein precursor","volume":"328","author":"Schafer","year":"2004","journal-title":"Virology"},{"key":"10.1016\/j.jmb.2013.05.015_bb0040","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1126\/science.1083338","article-title":"Hypermutation of HIV-1 DNA in the absence of the Vif protein","volume":"300","author":"Lecossier","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.jmb.2013.05.015_bb0045","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature01709","article-title":"Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts","volume":"424","author":"Mangeat","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2013.05.015_bb0050","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/nature01707","article-title":"The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA","volume":"424","author":"Zhang","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2013.05.015_bb0055","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.1128\/JVI.06594-11","article-title":"The cellular antiviral protein APOBEC3G interacts with HIV-1 reverse transcriptase and inhibits its function during viral replication","volume":"86","author":"Wang","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.jmb.2013.05.015_bb0060","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1038\/nm945","article-title":"The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif","volume":"9","author":"Sheehy","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.jmb.2013.05.015_bb0065","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1126\/science.1089591","article-title":"Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif\u2013Cul5\u2013SCF complex","volume":"302","author":"Yu","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.jmb.2013.05.015_bb0070","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1742-4690-1-27","article-title":"Production of infectious human immunodeficiency virus type 1 does not require depletion of APOBEC3G from virus-producing cells","volume":"1","author":"Kao","year":"2004","journal-title":"Retrovirology"},{"key":"10.1016\/j.jmb.2013.05.015_bb0075","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1101\/gad.1249904","article-title":"Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation","volume":"18","author":"Mehle","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.jmb.2013.05.015_bb0080","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1101\/gad.1250204","article-title":"Selective assembly of HIV-1 Vif\u2013Cul5\u2013ElonginB\u2013ElonginC E3 ubiquitin ligase complex through a novel SOCS box and upstream cysteines","volume":"18","author":"Yu","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.jmb.2013.05.015_bb0085","doi-asserted-by":"crossref","first-page":"8656","DOI":"10.1128\/JVI.00767-08","article-title":"Structural insight into the human immunodeficiency virus Vif SOCS box and its role in human E3 ubiquitin ligase assembly","volume":"82","author":"Stanley","year":"2008","journal-title":"J. Virol."},{"key":"10.1016\/j.jmb.2013.05.015_bb0090","doi-asserted-by":"crossref","first-page":"8201","DOI":"10.1128\/JVI.00395-07","article-title":"Identification of two distinct human immunodeficiency virus type 1 Vif determinants critical for interactions with human APOBEC3G and APOBEC3F","volume":"81","author":"Russell","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.jmb.2013.05.015_bb0095","doi-asserted-by":"crossref","first-page":"8544","DOI":"10.1128\/JVI.00651-09","article-title":"Identification of a novel WxSLVK motif in the N terminus of human immunodeficiency virus and simian immunodeficiency virus Vif that is critical for APOBEC3G and APOBEC3F neutralization","volume":"83","author":"Dang","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.jmb.2013.05.015_bb0100","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.jmb.2008.06.061","article-title":"Characterization of conserved motifs in HIV-1 Vif required for APOBEC3G and APOBEC3F interaction","volume":"381","author":"He","year":"2008","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jmb.2013.05.015_bb0105","doi-asserted-by":"crossref","first-page":"8674","DOI":"10.1128\/JVI.00653-09","article-title":"A patch of positively charged amino acids surrounding the human immunodeficiency virus type 1 Vif SLVx4Yx9Y motif influences its interaction with APOBEC3G","volume":"83","author":"Chen","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.jmb.2013.05.015_bb0110","doi-asserted-by":"crossref","first-page":"5741","DOI":"10.1128\/JVI.00079-10","article-title":"Identification of 81LGxGxxIxW89 and 171EDRW174 domains from human immunodeficiency virus type 1 Vif that regulate APOBEC3G and APOBEC3F neutralizing activity","volume":"84","author":"Dang","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.jmb.2013.05.015_bb0115","doi-asserted-by":"crossref","first-page":"8561","DOI":"10.1128\/JVI.00960-10","article-title":"Identification of a critical T(Q\/D\/E)x5ADx2(I\/L) motif from primate lentivirus Vif proteins that regulate APOBEC3G and APOBEC3F neutralizing activity","volume":"84","author":"Dang","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.jmb.2013.05.015_bb0120","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1128\/JVI.01898-08","article-title":"Regulation of APOBEC3 proteins by a novel YXXL motif in human immunodeficiency virus type 1 Vif and simian immunodeficiency virus SIVagm Vif","volume":"83","author":"Pery","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.jmb.2013.05.015_bb0125","first-page":"230","article-title":"Mechanisms involved in non-progressive HIV disease","volume":"5","author":"Mikhail","year":"2003","journal-title":"AIDS Rev."},{"key":"10.1016\/j.jmb.2013.05.015_bb0130","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1371\/journal.ppat.0010006","article-title":"Natural variation in Vif: differential impact on APOBEC3G\/3F and a potential role in HIV-1 diversification","volume":"1","author":"Simon","year":"2005","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jmb.2013.05.015_bb0135","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1006\/viro.1994.1453","article-title":"In vivo genetic variability of the HIV-1 vif gene","volume":"203","author":"Wieland","year":"1994","journal-title":"Virology"},{"key":"10.1016\/j.jmb.2013.05.015_bb0140","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1099\/0022-1317-78-2-393","article-title":"Diversity of the vif gene of human immunodeficiency virus type 1 in Uganda","volume":"78","author":"Wieland","year":"1997","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.jmb.2013.05.015_bb0145","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1089\/aid.2008.0077","article-title":"Molecular analysis of HIV type 1 vif sequences from Cape Town, South Africa","volume":"24","author":"Jacobs","year":"2008","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1016\/j.jmb.2013.05.015_bb0150","doi-asserted-by":"crossref","first-page":"9259","DOI":"10.1128\/JVI.00888-06","article-title":"Population level analysis of human immunodeficiency virus type 1 hypermutation and its relationship with APOBEC3G and vif genetic variation","volume":"80","author":"Pace","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.jmb.2013.05.015_bb0155","doi-asserted-by":"crossref","first-page":"531","DOI":"10.3855\/jidc.471","article-title":"Deletion, insertion and stop codon mutations in vif genes of HIV-1 infecting slow progressor patients","volume":"3","author":"Rangel","year":"2009","journal-title":"J. Infect. Dev. Ctries."},{"key":"10.1016\/j.jmb.2013.05.015_bb0160","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1089\/088922203771881211","article-title":"Hypermutation of HIV type 1 genomes isolated from infants soon after vertical infection","volume":"19","author":"Koulinska","year":"2003","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1016\/j.jmb.2013.05.015_bb0165","doi-asserted-by":"crossref","first-page":"e24118","DOI":"10.1371\/journal.pone.0024118","article-title":"Expression of APOBEC3G\/3F and G-to-A hypermutation levels in HIV-1-infected children with different profiles of disease progression","volume":"6","author":"Amoedo","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jmb.2013.05.015_bb0170","doi-asserted-by":"crossref","first-page":"35350","DOI":"10.1074\/jbc.M110.173286","article-title":"Differential anti-APOBEC3G activity of HIV-1 Vif proteins derived from different subtypes","volume":"285","author":"Iwabu","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2013.05.015_bb0180","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1086\/421504","article-title":"Long-term survivors in Nairobi: complete HIV-1 RNA sequences and immunogenetic associations","volume":"190","author":"Fang","year":"2004","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jmb.2013.05.015_bb0175","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1089\/aid.2004.20.1015","article-title":"Construction of an infectious HIV type 1 molecular clone from an African patient with a subtype D\/C recombinant virus","volume":"20","author":"Shi","year":"2004","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1016\/j.jmb.2013.05.015_bb0185","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1093\/nar\/gkg500","article-title":"Multiple sequence alignment with the Clustal series of programs","volume":"31","author":"Chenna","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jmb.2013.05.015_bb0190","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.virol.2003.11.021","article-title":"Codon optimization of the HIV-1 vpu and vif genes stabilizes their mRNA and allows for highly efficient Rev-independent expression","volume":"319","author":"Nguyen","year":"2004","journal-title":"Virology"},{"key":"10.1016\/j.jmb.2013.05.015_bb0195","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1089\/aid.2007.0200","article-title":"Full-length HIV type 1 proviral sequencing of 10 highly exposed women from Nairobi, Kenya reveals a high proportion of intersubtype recombinants","volume":"24","author":"Land","year":"2008","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1016\/j.jmb.2013.05.015_bb0200","doi-asserted-by":"crossref","first-page":"11444","DOI":"10.1073\/pnas.0502440102","article-title":"Primate lentiviral virion infectivity factors are substrate receptors that assemble with cullin 5-E3 ligase through a HCCH motif to suppress APOBEC3G","volume":"102","author":"Luo","year":"2005","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"10.1016\/j.jmb.2013.05.015_bb0205","doi-asserted-by":"crossref","first-page":"17259","DOI":"10.1074\/jbc.M602413200","article-title":"A zinc-binding region in Vif binds Cul5 and determines cullin selection","volume":"281","author":"Mehle","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2013.05.015_bb0210","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1089\/hum.2010.012","article-title":"Characterization of anti-HIV activity mediated by R88-APOBEC3G mutant fusion proteins in CD4+ T cells, peripheral blood mononuclear cells, and macrophages","volume":"22","author":"Ao","year":"2011","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.jmb.2013.05.015_bb0215","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1089\/aid.1996.12.1543","article-title":"A high frequency of defective vif genes in peripheral blood mononuclear cells from HIV type 1-infected individuals","volume":"12","author":"Tominaga","year":"1996","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1016\/j.jmb.2013.05.015_bb0220","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1007\/s007050050692","article-title":"Comparison of proviral accessory genes between long-term nonprogressors and progressors of human immunodeficiency virus type 1 infection","volume":"145","author":"Yamada","year":"2000","journal-title":"Arch. Virol."},{"key":"10.1016\/j.jmb.2013.05.015_bb0225","series-title":"HIV Sequence Compendium 2001","first-page":"608","author":"Kuiken","year":"2001"},{"key":"10.1016\/j.jmb.2013.05.015_bb0230","doi-asserted-by":"crossref","first-page":"8650","DOI":"10.1128\/JVI.00508-10","article-title":"Importin alpha3 interacts with HIV-1 integrase and contributes to HIV-1 nuclear import and replication","volume":"84","author":"Ao","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.jmb.2013.05.015_bb0235","doi-asserted-by":"crossref","first-page":"7032","DOI":"10.1128\/JVI.69.11.7032-7044.1995","article-title":"Mutagenic analysis of human immunodeficiency virus type 1 Vpr: role of a predicted N-terminal alpha-helical structure in Vpr nuclear localization and virion incorporation","volume":"69","author":"Yao","year":"1995","journal-title":"J. Virol."},{"key":"10.1016\/j.jmb.2013.05.015_bb0240","doi-asserted-by":"crossref","first-page":"e1995","DOI":"10.1371\/journal.pone.0001995","article-title":"Vpr14-88-Apobec3G fusion protein is efficiently incorporated into Vif-positive HIV-1 particles and inhibits viral infection","volume":"3","author":"Ao","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.jmb.2013.05.015_bb0245","doi-asserted-by":"crossref","first-page":"10544","DOI":"10.1074\/jbc.M111.317057","article-title":"Contribution of host nucleoporin 62 in HIV-1 integrase chromatin association and viral DNA integration","volume":"287","author":"Ao","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2013.05.015_bb0250","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1743-422X-7-68","article-title":"Characterization of the HIV-1 integrase chromatin- and LEDGF\/p75-binding abilities by mutagenic analysis within the catalytic core domain of integrase","volume":"7","author":"Zheng","year":"2010","journal-title":"Virol. J."}],"container-title":["Journal of Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002228361300329X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002228361300329X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T02:51:04Z","timestamp":1595818264000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002228361300329X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":50,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S002228361300329X"],"URL":"https:\/\/doi.org\/10.1016\/j.jmb.2013.05.015","relation":{},"ISSN":["0022-2836"],"issn-type":[{"value":"0022-2836","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]}}}