{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:14:36Z","timestamp":1791332076698,"version":"4.3.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"20","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T00:00:00Z","timestamp":1395705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"name":"European Union's Seventh Framework Programme","award":["241865"],"award-info":[{"award-number":["241865"]}]},{"name":"European Union's Seventh Framework Programme","award":["602080"],"award-info":[{"award-number":["602080"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Molecular Biology"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.jmb.2014.03.007","type":"journal-article","created":{"date-parts":[[2014,3,22]],"date-time":"2014-03-22T04:37:10Z","timestamp":1395463030000},"page":"3442-3453","source":"Crossref","is-referenced-by-count":69,"title":["Molecular Basis for the Antiparasitic Activity of a Mercaptoacetamide Derivative That Inhibits Histone Deacetylase 8 (HDAC8) from the Human Pathogen Schistosoma mansoni"],"prefix":"10.1016","volume":"426","author":[{"given":"Diana A.","family":"Stolfa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Marek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Lancelot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander-Thomas","family":"Hauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Walter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emeline","family":"Leproult","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Melesina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Rumpf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marie","family":"Wurtz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Cavarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Sippl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond J.","family":"Pierce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Romier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmb.2014.03.007_bb0010","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/sj.icb.7100014","article-title":"Immunopathology of schistosomiasis","volume":"85","author":"Wilson","year":"2007","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.jmb.2014.03.007_bb0015","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0035-9203(02)90405-0","article-title":"Resistance of Schistosoma mansoni to praziquantel: is there a problem?","volume":"96","author":"Doenhoff","year":"2002","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.jmb.2014.03.007_bb0020","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1586\/14787210.4.2.199","article-title":"Praziquantel for the treatment of schistosomiasis: its use for control in areas with endemic disease and prospects for drug resistance","volume":"4","author":"Doenhoff","year":"2006","journal-title":"Expert Rev Anti Infect Ther"},{"key":"10.1016\/j.jmb.2014.03.007_bb0025","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.molbiopara.2009.04.007","article-title":"Schistosoma mansoni P-glycoprotein levels increase in response to praziquantel exposure and correlate with reduced praziquantel susceptibility","volume":"167","author":"Messerli","year":"2009","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.jmb.2014.03.007_bb0030","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1007\/s00436-009-1575-x","article-title":"Cloning, molecular characterization of a 13-kDa antigen from Schistosoma japonicum, Sj13, a putative salivary diagnosis candidate for Schistosomiasis japonica","volume":"105","author":"Zhou","year":"2009","journal-title":"Parasitol Res"},{"key":"10.1016\/j.jmb.2014.03.007_bb0035","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nature08160","article-title":"The genome of the blood fluke Schistosoma mansoni","volume":"460","author":"Berriman","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2014.03.007_bb0040","doi-asserted-by":"crossref","first-page":"e1455","DOI":"10.1371\/journal.pntd.0001455","article-title":"A systematically improved high quality genome and transcriptome of the human blood fluke Schistosoma mansoni","volume":"6","author":"Protasio","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.jmb.2014.03.007_bb0045","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/ng.1065","article-title":"Whole-genome sequence of Schistosoma haematobium","volume":"44","author":"Young","year":"2012","journal-title":"Nat Genet"},{"key":"10.1016\/j.jmb.2014.03.007_bb0050","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1126\/science.1063127","article-title":"Translating the histone code","volume":"293","author":"Jenuwein","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.jmb.2014.03.007_bb0055","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jmb.2011.01.040","article-title":"Operating on chromatin, a colorful language where context matters","volume":"409","author":"Gardner","year":"2011","journal-title":"J Mol Biol"},{"key":"10.1016\/j.jmb.2014.03.007_bb0060","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nrg2752","article-title":"Chromatin structure and the inheritance of epigenetic information","volume":"11","author":"Margueron","year":"2010","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.jmb.2014.03.007_bb0065","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1749-6632.2003.tb05964.x","article-title":"Histone deacetylases: unique players in shaping the epigenetic histone code","volume":"983","author":"Thiagalingam","year":"2003","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jmb.2014.03.007_bb0070","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2007.02.005","article-title":"Chromatin modifications and their function","volume":"128","author":"Kouzarides","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.jmb.2014.03.007_bb0075","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.molbiopara.2009.06.001","article-title":"Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni","volume":"168","author":"Dubois","year":"2009","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.jmb.2014.03.007_bb0080","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.bbrc.2008.10.090","article-title":"The class I histone deacetylases of the platyhelminth parasite Schistosoma mansoni","volume":"377","author":"Oger","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jmb.2014.03.007_bb0085","doi-asserted-by":"crossref","first-page":"e1003645","DOI":"10.1371\/journal.ppat.1003645","article-title":"Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoni","volume":"9","author":"Marek","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jmb.2014.03.007_bb0090","doi-asserted-by":"crossref","first-page":"4669","DOI":"10.1021\/jm991091h","article-title":"Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation","volume":"42","author":"Jung","year":"1999","journal-title":"J Med Chem"},{"key":"10.1016\/j.jmb.2014.03.007_bb0095","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1158\/1541-7786.MCR-07-2110","article-title":"Destabilization of ERBB2 transcripts by targeting 3\u2032 untranslated region messenger RNA associated HuR and histone deacetylase-6","volume":"6","author":"Scott","year":"2008","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.jmb.2014.03.007_bb0100","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.neuropharm.2012.06.043","article-title":"Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity","volume":"64","author":"Fass","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jmb.2014.03.007_bb0105","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1021\/jm00008a020","article-title":"The synthesis of N-hydroxy-N\u2032-phenyloctanediamide and its inhibitory effect on proliferation of AXC rat prostate cancer cells","volume":"38","author":"Stowell","year":"1995","journal-title":"J Med Chem"},{"key":"10.1016\/j.jmb.2014.03.007_bb0110","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.bmcl.2004.10.074","article-title":"Identification of a potent non-hydroxamate histone deacetylase inhibitor by mechanism-based drug design","volume":"15","author":"Suzuki","year":"2005","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.jmb.2014.03.007_bb0115","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1021\/jm049207j","article-title":"Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates","volume":"48","author":"Suzuki","year":"2005","journal-title":"J Med Chem"},{"key":"10.1016\/j.jmb.2014.03.007_bb0120","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.bmcl.2005.01.006","article-title":"Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors","volume":"15","author":"Chen","year":"2005","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.jmb.2014.03.007_bb0125","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1016\/j.bmc.2005.12.047","article-title":"Carbonyl- and sulfur-containing analogs of suberoylanilide hydroxamic acid: potent inhibition of histone deacetylases","volume":"14","author":"Gu","year":"2006","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.jmb.2014.03.007_bb0130","doi-asserted-by":"crossref","first-page":"301","DOI":"10.7164\/antibiotics.47.301","article-title":"FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity","volume":"47","author":"Ueda","year":"1994","journal-title":"J Antibiot (Tokyo)"},{"key":"10.1016\/j.jmb.2014.03.007_bb0135","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/ja.2011.35","article-title":"Romidepsin (Istodax, NSC 630176, FR901228, FK228, depsipeptide): a natural product recently approved for cutaneous T-cell lymphoma","volume":"64","author":"VanderMolen","year":"2011","journal-title":"J Antibiot (Tokyo)"},{"key":"10.1016\/j.jmb.2014.03.007_bb0140","doi-asserted-by":"crossref","first-page":"22429","DOI":"10.1016\/S0021-9258(18)41547-5","article-title":"Trapoxin, an antitumor cyclic tetrapeptide, is an irreversible inhibitor of mammalian histone deacetylase","volume":"268","author":"Kijima","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jmb.2014.03.007_bb0145","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/S0960-894X(02)00175-0","article-title":"Novel histone deacetylase inhibitors: N-hydroxycarboxamides possessing a terminal bicyclic aryl group","volume":"12","author":"Uesato","year":"2002","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.jmb.2014.03.007_bb0150","doi-asserted-by":"crossref","first-page":"e2428","DOI":"10.1371\/journal.pntd.0002428","article-title":"Schistosoma mansoni sirtuins: characterization and potential as chemotherapeutic targets","volume":"7","author":"Lancelot","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.jmb.2014.03.007_bb0155","doi-asserted-by":"crossref","first-page":"7307","DOI":"10.1021\/jm060118b","article-title":"Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition","volume":"49","author":"Trapp","year":"2006","journal-title":"J Med Chem"},{"key":"10.1016\/j.jmb.2014.03.007_bb0160","doi-asserted-by":"crossref","first-page":"4626","DOI":"10.1016\/j.bmc.2011.06.030","article-title":"Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors","volume":"19","author":"Whitehead","year":"2011","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.jmb.2014.03.007_bb0165","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/leu.2008.9","article-title":"A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas","volume":"22","author":"Balasubramanian","year":"2008","journal-title":"Leukemia"},{"key":"10.1016\/j.jmb.2014.03.007_bb0170","doi-asserted-by":"crossref","first-page":"12474","DOI":"10.1021\/ja205972n","article-title":"Structural basis of the antiproliferative activity of largazole, a depsipeptide inhibitor of the histone deacetylases","volume":"133","author":"Cole","year":"2011","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.jmb.2014.03.007_bb0175","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.expneurol.2012.10.005","article-title":"Mercaptoacetamide-based class II HDAC inhibitor lowers Abeta levels and improves learning and memory in a mouse model of Alzheimer's disease","volume":"239","author":"Sung","year":"2013","journal-title":"Exp Neurol"},{"key":"10.1016\/j.jmb.2014.03.007_bb0180","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/cmdc.201100522","article-title":"Chiral mercaptoacetamides display enantioselective inhibition of histone deacetylase 6 and exhibit neuroprotection in cortical neuron models of oxidative stress","volume":"7","author":"Kalin","year":"2012","journal-title":"ChemMedChem"},{"key":"10.1016\/j.jmb.2014.03.007_bb0185","doi-asserted-by":"crossref","first-page":"3054","DOI":"10.1021\/jm070178x","article-title":"Functional differences in epigenetic modulators-superiority of mercaptoacetamide-based histone deacetylase inhibitors relative to hydroxamates in cortical neuron neuroprotection studies","volume":"50","author":"Kozikowski","year":"2007","journal-title":"J Med Chem"},{"key":"10.1016\/j.jmb.2014.03.007_bb0190","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jsb.2011.02.001","article-title":"Deciphering correct strategies for multiprotein complex assembly by co-expression: application to complexes as large as the histone octamer","volume":"175","author":"Diebold","year":"2011","journal-title":"J Struct Biol"},{"key":"10.1016\/j.jmb.2014.03.007_bb0195","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1021\/ml3002709","article-title":"Inhibitors of the NAD(+)-dependent protein desuccinylase and demalonylase Sirt5","volume":"3","author":"Maurer","year":"2012","journal-title":"ACS Med Chem Lett"},{"key":"10.1016\/j.jmb.2014.03.007_bb0200","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.ymeth.2005.03.003","article-title":"In vitro assays for the determination of histone deacetylase activity","volume":"36","author":"Heltweg","year":"2005","journal-title":"Methods"},{"key":"10.1016\/j.jmb.2014.03.007_bb0205","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","article-title":"Processing of X-ray diffraction data collected in oscillation mode","volume":"276","author":"Otwinowski","year":"1997","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.jmb.2014.03.007_bb0210","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","article-title":"PHENIX: a comprehensive Python-based system for macromolecular structure solution","volume":"66","author":"Adams","year":"2010","journal-title":"Acta Crystallogr Sect D Biol Crystallogr"},{"key":"10.1016\/j.jmb.2014.03.007_bb0215","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","article-title":"Coot: model-building tools for molecular graphics","volume":"60","author":"Emsley","year":"2004","journal-title":"Acta Crystallogr Sect D Biol Crystallogr"},{"key":"10.1016\/j.jmb.2014.03.007_bb0220","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1107\/S0907444904016427","article-title":"Refinement of severely incomplete structures with maximum likelihood in BUSTER-TNT","volume":"60","author":"Blanc","year":"2004","journal-title":"Acta Crystallogr Sect D Biol Crystallogr"},{"key":"10.1016\/j.jmb.2014.03.007_bb0225","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1107\/S0907444909042073","article-title":"MolProbity: all-atom structure validation for macromolecular crystallography","volume":"66","author":"Chen","year":"2010","journal-title":"Acta Crystallogr Sect D Biol Crystallogr"},{"key":"10.1016\/j.jmb.2014.03.007_bb0235","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/sj.embor.7401047","article-title":"Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex","volume":"8","author":"Vannini","year":"2007","journal-title":"EMBO Rep"},{"key":"10.1016\/j.jmb.2014.03.007_bb0240","series-title":"Suite 2012: Maestro version 9.3, Protein Preparation Wizard, Epik version 2.3, Glide version 5.8","year":"2012"},{"key":"10.1016\/j.jmb.2014.03.007_bb0245","series-title":"Molecular Operating Environment (MOE), 2012.10","year":"2012"},{"key":"10.1016\/j.jmb.2014.03.007_bb0250","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1006\/jmbi.1996.0897","article-title":"Development and validation of a genetic algorithm for flexible docking","volume":"267","author":"Jones","year":"1997","journal-title":"J Mol Biol"},{"key":"10.1016\/j.jmb.2014.03.007_bb0255","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.molbiopara.2005.12.006","article-title":"Schistosoma mansoni CBP\/p300 has a conserved domain structure and interacts functionally with the nuclear receptor SmFtz-F1","volume":"146","author":"Bertin","year":"2006","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.jmb.2014.03.007_bb0260","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/0014-4894(74)90076-9","article-title":"Schistosoma mansoni: defined system for stepwise transformation of cercaria to schistosomule in vitro","volume":"36","author":"Ramalho-Pinto","year":"1974","journal-title":"Exp Parasitol"}],"container-title":["Journal of Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283614001314?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283614001314?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T20:09:02Z","timestamp":1648670942000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022283614001314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":50,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0022283614001314"],"URL":"https:\/\/doi.org\/10.1016\/j.jmb.2014.03.007","relation":{},"ISSN":["0022-2836"],"issn-type":[{"value":"0022-2836","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]}}}