{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:08:17Z","timestamp":1793048897220,"version":"4.5.0"},"reference-count":90,"publisher":"Elsevier BV","issue":"24","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA096865"],"award-info":[{"award-number":["CA096865"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA131231"],"award-info":[{"award-number":["CA131231"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA172115"],"award-info":[{"award-number":["CA172115"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Skaggs Institute for Chemical Biology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Molecular Biology"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.jmb.2014.10.021","type":"journal-article","created":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T08:42:13Z","timestamp":1414831333000},"page":"4030-4048","source":"Crossref","is-referenced-by-count":76,"title":["The High-Risk HPV16 E7 Oncoprotein Mediates Interaction between the Transcriptional Coactivator CBP and the Retinoblastoma Protein pRb"],"prefix":"10.1016","volume":"426","author":[{"given":"Ariane L.","family":"Jansma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Martinez-Yamout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiqing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Jane","family":"Dyson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter E.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmb.2014.10.021_bb0005","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.virol.2004.03.033","article-title":"Classification of papillomaviruses","volume":"324","author":"de Villiers","year":"2004","journal-title":"Virology"},{"key":"10.1016\/j.jmb.2014.10.021_bb0010","first-page":"F55","article-title":"Papillomavirus infections\u2014a major cause of human cancers","volume":"1288","author":"zur Hausen","year":"1996","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jmb.2014.10.021_bb0015","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/nrc798","article-title":"Papillomaviruses and cancer: from basic studies to clinical application","volume":"2","author":"zur Hausen","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.jmb.2014.10.021_bb0020","doi-asserted-by":"crossref","first-page":"7673","DOI":"10.1038\/sj.onc.1209040","article-title":"Recent lessons in gene expression, cell cycle control, and cell biology from adenovirus","volume":"24","author":"Berk","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.jmb.2014.10.021_bb0025","doi-asserted-by":"crossref","first-page":"4417","DOI":"10.1128\/JVI.63.10.4417-4421.1989","article-title":"The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes","volume":"63","author":"Munger","year":"1989","journal-title":"J Virol"},{"key":"10.1016\/j.jmb.2014.10.021_bb0030","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.virol.2008.09.034","article-title":"The common mechanisms of transformation by the small DNA tumor viruses: the inactivation of tumor suppressor gene products: p53","volume":"384","author":"Levine","year":"2009","journal-title":"Virology"},{"key":"10.1016\/j.jmb.2014.10.021_bb0035","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.virol.2008.10.006","article-title":"The human papillomavirus E7 oncoprotein","volume":"384","author":"McLaughlin-Drubin","year":"2009","journal-title":"Virology"},{"key":"10.1016\/j.jmb.2014.10.021_bb0040","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1128\/JVI.65.1.292-298.1991","article-title":"In vitro biological activities of the E6 and E7 genes vary among human papillomaviruses of different oncogenic potential","volume":"65","author":"Barbosa","year":"1991","journal-title":"J Virol"},{"key":"10.1016\/j.jmb.2014.10.021_bb0045","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1128\/JVI.65.1.473-478.1991","article-title":"The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells","volume":"65","author":"Halbert","year":"1991","journal-title":"J Virol"},{"key":"10.1016\/j.jmb.2014.10.021_bb0050","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1126\/science.2157286","article-title":"Association of human papillomavirus types 16 and 18 E6 proteins with p53","volume":"248","author":"Werness","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.jmb.2014.10.021_bb0055","doi-asserted-by":"crossref","first-page":"4442","DOI":"10.1073\/pnas.89.10.4442","article-title":"Efficiency of binding the retinoblastoma protein correlates with the transforming capacity of the E7 oncoproteins of the human papillomaviruses","volume":"89","author":"Heck","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jmb.2014.10.021_bb0060","doi-asserted-by":"crossref","first-page":"10405","DOI":"10.1021\/bi7007917","article-title":"The N-terminal module of HPV16 E7 is an intrinsically disordered domain that confers conformational and recognition plasticity to the oncoprotein","volume":"46","author":"Garcia-Alai","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.jmb.2014.10.021_bb0065","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1002\/cbic.201300172","article-title":"The heterogeneous structural behavior of E7 from HPV16 revealed by NMR spectroscopy","volume":"14","author":"Cal\u00e7ada","year":"2013","journal-title":"Chembiochem"},{"key":"10.1016\/j.jmb.2014.10.021_bb0070","doi-asserted-by":"crossref","first-page":"e72760","DOI":"10.1371\/journal.pone.0072760","article-title":"Conformational dissection of a viral intrinsically disordered domain involved in cellular transformation","volume":"8","author":"Noval","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jmb.2014.10.021_bb0075","doi-asserted-by":"crossref","first-page":"5953","DOI":"10.1038\/sj.onc.1209584","article-title":"Solution structure of the partially folded high-risk human papilloma virus 45 oncoprotein E7","volume":"25","author":"Ohlenschl\u00e4ger","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.jmb.2014.10.021_bb0080","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1074\/jbc.M508455200","article-title":"Structure of the human papillomavirus E7 oncoprotein and its mechanism for inactivation of the retinoblastoma tumor suppressor","volume":"281","author":"Liu","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jmb.2014.10.021_bb0085","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1006\/viro.1995.9926","article-title":"Dimerization of the human papillomavirus E7 oncoprotein in vivo","volume":"214","author":"Clemens","year":"1995","journal-title":"Virology"},{"key":"10.1016\/j.jmb.2014.10.021_bb0090","first-page":"213","article-title":"Identification of domains required for transcriptional activation and protein dimerization in the human papillomavirus type-16 E7 protein","volume":"12","author":"Zwerschke","year":"1996","journal-title":"Oncogene"},{"key":"10.1016\/j.jmb.2014.10.021_bb0095","doi-asserted-by":"crossref","first-page":"10048","DOI":"10.1128\/JVI.00643-11","article-title":"Systematic analysis of the amino acid residues of human papillomavirus type 16 E7 conserved region 3 involved in dimerization and transformation","volume":"85","author":"Todorovic","year":"2011","journal-title":"J Virol"},{"key":"10.1016\/j.jmb.2014.10.021_bb0100","doi-asserted-by":"crossref","first-page":"16033","DOI":"10.1021\/bi002111g","article-title":"Oligomerization properties of the viral oncoproteins adenovirus E1A and human papillomavirus E7 and their complexes with the retinoblastoma protein","volume":"39","author":"Clements","year":"2000","journal-title":"Biochemistry"},{"key":"10.1016\/j.jmb.2014.10.021_bb0105","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1126\/science.2537532","article-title":"The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product","volume":"243","author":"Dyson","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.jmb.2014.10.021_bb0110","doi-asserted-by":"crossref","first-page":"4099","DOI":"10.1002\/j.1460-2075.1989.tb08594.x","article-title":"Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product","volume":"8","author":"M\u00fcnger","year":"1989","journal-title":"EMBO J"},{"key":"10.1016\/j.jmb.2014.10.021_bb0115","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/36038","article-title":"Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7","volume":"391","author":"Lee","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2014.10.021_bb0120","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.1073\/pnas.89.10.4549","article-title":"Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product","volume":"89","author":"Chellappan","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jmb.2014.10.021_bb0125","first-page":"4620","article-title":"E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway","volume":"56","author":"Boyer","year":"1996","journal-title":"Cancer Res"},{"key":"10.1016\/j.jmb.2014.10.021_bb0130","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1006\/viro.1997.8851","article-title":"Destabilization of the RB tumor suppressor protein and stabilization of p53 contribute to HPV type 16 E7-induced apoptosis","volume":"239","author":"Jones","year":"1997","journal-title":"Virology"},{"key":"10.1016\/j.jmb.2014.10.021_bb0135","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1128\/JVI.61.5.1686-1689.1987","article-title":"The major human papillomavirus protein in cervical cancers is a cytoplasmic phosphoprotein","volume":"61","author":"Smotkin","year":"1987","journal-title":"J Virol"},{"key":"10.1016\/j.jmb.2014.10.021_bb0140","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/j.1460-2075.1990.tb08091.x","article-title":"The region of the HPV E7 oncoprotein homologous to adenovirus E1a and SV40 large T antigen contains separate domains for Rb binding and casein kinase II phosphorylation","volume":"9","author":"Barbosa","year":"1990","journal-title":"EMBO J"},{"key":"10.1016\/j.jmb.2014.10.021_bb0145","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1128\/JVI.64.2.723-730.1990","article-title":"The E7 proteins of the nononcogenic human papillomavirus type 6b (HPV-6b) and of the oncogenic HPV-16 differ in retinoblastoma protein binding and other properties","volume":"64","author":"Gage","year":"1990","journal-title":"J Virol"},{"key":"10.1016\/j.jmb.2014.10.021_bb0150","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/j.1742-4658.2009.07540.x","article-title":"Targeting mechanism of the retinoblastoma tumor suppressor by a prototypical viral oncoprotein","volume":"277","author":"Chemes","year":"2010","journal-title":"FEBS J"},{"key":"10.1016\/j.jmb.2014.10.021_bb0155","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/42981","article-title":"Binding and modulation of p53 by p300\/CBP coactivators","volume":"387","author":"Lill","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2014.10.021_bb0160","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/sj.onc.1201002","article-title":"Inhibition of p53-mediated transactivation and cell cycle arrest by E1A through its p300\/CBP-interacting region","volume":"14","author":"Somasundaram","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/j.jmb.2014.10.021_bb0165","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nrm827","article-title":"Adenovirus-5 E1A: paradox and paradigm","volume":"3","author":"Frisch","year":"2002","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jmb.2014.10.021_bb0170","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1101\/gad.14.13.1553","article-title":"CBP\/p300 in cell growth, transformation, and development","volume":"14","author":"Goodman","year":"2000","journal-title":"Genes Dev"},{"key":"10.1016\/j.jmb.2014.10.021_bb0175","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1242\/jcs.114.13.2363","article-title":"p300\/CBP proteins: HATs for transcriptional bridges and scaffolds","volume":"114","author":"Chan","year":"2001","journal-title":"J Cell Sci"},{"key":"10.1016\/j.jmb.2014.10.021_bb0180","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s12038-009-0013-7","article-title":"Human papillomavirus E6 and E7 oncoproteins as risk factors for tumorigenesis","volume":"34","author":"Ganguly","year":"2009","journal-title":"J Biosci"},{"key":"10.1016\/j.jmb.2014.10.021_bb0185","doi-asserted-by":"crossref","first-page":"7871","DOI":"10.1038\/sj.onc.1206896","article-title":"Interaction between the HPV E7 oncoprotein and the transcriptional coactivator p300","volume":"22","author":"Bernat","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.jmb.2014.10.021_bb0190","doi-asserted-by":"crossref","first-page":"9524","DOI":"10.1021\/bi3011863","article-title":"Different regions of the HPV-E7 and Ad-E1A viral oncoproteins bind competitively but through distinct mechanisms to the CH1 transactivation domain of p300","volume":"51","author":"Fera","year":"2012","journal-title":"Biochemistry"},{"key":"10.1016\/j.jmb.2014.10.021_bb0195","doi-asserted-by":"crossref","first-page":"7917","DOI":"10.1128\/JVI.69.12.7917-7924.1995","article-title":"E1A promotes association between p300 and pRB in multimeric complexes required for normal biological activity","volume":"69","author":"Wang","year":"1995","journal-title":"J Virol"},{"key":"10.1016\/j.jmb.2014.10.021_bb0200","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.virol.2008.06.035","article-title":"Human T-cell leukemia virus type 1 Tax modulates interferon-\u03b1 signal transduction through competitive usage of the coactivator CBP\/p300","volume":"379","author":"Zhang","year":"2008","journal-title":"Virology"},{"key":"10.1016\/j.jmb.2014.10.021_bb0205","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1038\/emboj.2009.30","article-title":"Structural basis for recruitment of CBP\/p300 coactivators by STAT1 and STAT2 transactivation domains","volume":"28","author":"Wojciak","year":"2009","journal-title":"EMBO J"},{"key":"10.1016\/j.jmb.2014.10.021_bb0210","doi-asserted-by":"crossref","first-page":"19290","DOI":"10.1073\/pnas.1013078107","article-title":"Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation","volume":"107","author":"Lee","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jmb.2014.10.021_bb0215","doi-asserted-by":"crossref","first-page":"3792","DOI":"10.1021\/ja209936u","article-title":"Quantitative analysis of multisite protein\u2013ligand interactions by NMR: binding of intrinsically disordered p53 transactivation subdomains with the TAZ2 domain of CBP","volume":"134","author":"Arai","year":"2012","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.jmb.2014.10.021_bb0220","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1006\/jmbi.2000.4141","article-title":"Solution structure of the TAZ2 (CH3) domain of the transcriptional adaptor protein CBP","volume":"303","author":"De Guzman","year":"2000","journal-title":"J Mol Biol"},{"key":"10.1016\/j.jmb.2014.10.021_bb0225","doi-asserted-by":"crossref","first-page":"13260","DOI":"10.1073\/pnas.0906770106","article-title":"Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein","volume":"106","author":"Ferreon","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jmb.2014.10.021_bb0230","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0014-5793(97)01474-9","article-title":"Chemical shift dispersion and secondary structure prediction in unfolded and partly folded proteins","volume":"419","author":"Yao","year":"1997","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jmb.2014.10.021_bb0235","doi-asserted-by":"crossref","first-page":"37868","DOI":"10.1074\/jbc.M504877200","article-title":"Molecular determinants for the complex formation between the retinoblastoma protein and LXCXE sequences","volume":"280","author":"Singh","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jmb.2014.10.021_bb0240","doi-asserted-by":"crossref","first-page":"8298","DOI":"10.1158\/0008-5472.CAN-05-0054","article-title":"The ability of E1A to rescue ras-induced premature senescence and confer transformation relies on inactivation of both p300\/CBP and Rb family proteins","volume":"65","author":"Deng","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.jmb.2014.10.021_bb0245","doi-asserted-by":"crossref","first-page":"6737","DOI":"10.1128\/JVI.75.15.6737-6747.2001","article-title":"Destabilization of the retinoblastoma tumor suppressor by human papillomavirus type 16 E7 is not sufficient to overcome cell cycle arrest in human keratinocytes","volume":"75","author":"Helt","year":"2001","journal-title":"J Virol"},{"key":"10.1016\/j.jmb.2014.10.021_bb0250","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/35083062","article-title":"Acetylation control of the retinoblastoma tumour-suppressor protein","volume":"3","author":"Chan","year":"2001","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jmb.2014.10.021_bb0255","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1038\/sj.emboj.7600176","article-title":"Acetylation regulates the differentiation-specific functions of the retinoblastoma protein","volume":"23","author":"Nguyen","year":"2004","journal-title":"EMBO J"},{"key":"10.1016\/j.jmb.2014.10.021_bb0260","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.1038\/emboj.2010.235","article-title":"CBP\/p300 double null cells reveal effect of coactivator level and diversity on CREB transactivation","volume":"29","author":"Kasper","year":"2010","journal-title":"EMBO J"},{"key":"10.1016\/j.jmb.2014.10.021_bb0265","doi-asserted-by":"crossref","first-page":"212","DOI":"10.4161\/cc.10.2.14542","article-title":"Double null cells reveal that CBP and p300 are dispensable for p53 targets p21 and Mdm2 but variably required for target genes of other signaling pathways","volume":"10","author":"Kasper","year":"2011","journal-title":"Cell Cycle"},{"key":"10.1016\/j.jmb.2014.10.021_bb0270","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/S0966-842X(00)01874-6","article-title":"Viral replication and the coactivators p300 and CBP","volume":"8","author":"Hottiger","year":"2000","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.jmb.2014.10.021_bb0275","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/374081a0","article-title":"A family of transcriptional adaptor proteins targeted by the E1A oncoprotein","volume":"374","author":"Arany","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2014.10.021_bb0280","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1101\/gad.8.8.869","article-title":"Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor","volume":"8","author":"Eckner","year":"1994","journal-title":"Genes Dev"},{"key":"10.1016\/j.jmb.2014.10.021_bb0285","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1021\/bi048161t","article-title":"CBP\/p300 TAZ1 domain forms a structured scaffold for ligand binding","volume":"44","author":"De Guzman","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.jmb.2014.10.021_bb0290","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1042\/BJ20040564","article-title":"The CBP\/p300 TAZ1 domain in its native state is not a binding partner of MDM2","volume":"381","author":"Matt","year":"2004","journal-title":"Biochem J"},{"key":"10.1016\/j.jmb.2014.10.021_bb0295","first-page":"425","article-title":"Casein kinase II phosphorylation of the human papillomavirus-18 E7 protein is critical for promoting S-phase entry","volume":"11","author":"Chien","year":"2000","journal-title":"Cell Growth Differ"},{"key":"10.1016\/j.jmb.2014.10.021_bb0300","doi-asserted-by":"crossref","first-page":"5187","DOI":"10.1073\/pnas.88.12.5187","article-title":"Negative charge at the casein kinase II phosphorylation site is important for transformation but not for Rb protein binding by the E7 protein of human papillomavirus type 16","volume":"88","author":"Firzlaff","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jmb.2014.10.021_bb0305","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.str.2008.12.009","article-title":"Structural basis for p300 Taz2-p53 TAD1 binding and modulation by phosphorylation","volume":"17","author":"Feng","year":"2009","journal-title":"Structure"},{"key":"10.1016\/j.jmb.2014.10.021_bb0310","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1107\/S1399004714009262","article-title":"Structural insights into interactions of C\/EBP transcriptional activators with the Taz2 domain of p300","volume":"70","author":"Bhaumik","year":"2014","journal-title":"Acta Crystallogr Sect D Biol Crystallogr"},{"key":"10.1016\/j.jmb.2014.10.021_bb0315","doi-asserted-by":"crossref","first-page":"5883","DOI":"10.1073\/pnas.87.15.5883","article-title":"Retinoblastoma growth suppressor and a 300-kDa protein appear to regulate cellular DNA synthesis","volume":"87","author":"Howe","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jmb.2014.10.021_bb0320","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.1128\/MCB.16.7.3454","article-title":"Association of p300 and CBP with simian virus 40 large T antigen","volume":"16","author":"Eckner","year":"1996","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jmb.2014.10.021_bb0325","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/S0092-8674(00)80304-9","article-title":"Recruitment of p300\/CBP in p53-dependent signal pathways","volume":"89","author":"Avantaggiati","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.jmb.2014.10.021_bb0330","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/42972","article-title":"Synergistic activation of transcription by CBP and p53","volume":"387","author":"Gu","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2014.10.021_bb0335","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/nature12294","article-title":"Modulation of allostery by protein intrinsic disorder","volume":"498","author":"Ferreon","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2014.10.021_bb0340","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1006\/viro.1996.8315","article-title":"Repression of p53 transcriptional activity by the HPV E7 proteins","volume":"227","author":"Massimi","year":"1997","journal-title":"Virology"},{"key":"10.1016\/j.jmb.2014.10.021_bb0345","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1006\/viro.2002.1375","article-title":"Stabilization and functional impairment of the tumor suppressor p53 by the human papillomavirus type 16 E7 oncoprotein","volume":"295","author":"Eichten","year":"2002","journal-title":"Virology"},{"key":"10.1016\/j.jmb.2014.10.021_bb0350","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1128\/JVI.66.4.2418-2427.1992","article-title":"Structure\u2013function analysis of the human papillomavirus type 16 E7 oncoprotein","volume":"66","author":"Phelps","year":"1992","journal-title":"J Virol"},{"key":"10.1016\/j.jmb.2014.10.021_bb0355","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1128\/JVI.67.4.2402-2407.1993","article-title":"The human papillomavirus E7 oncoprotein and the cellular transcription factor E2F bind to separate sites on the retinoblastoma tumor suppressor protein","volume":"67","author":"Wu","year":"1993","journal-title":"J Virol"},{"key":"10.1016\/j.jmb.2014.10.021_bb0360","doi-asserted-by":"crossref","first-page":"7267","DOI":"10.1128\/MCB.13.12.7267","article-title":"Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes","volume":"13","author":"Fattaey","year":"1993","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jmb.2014.10.021_bb0365","doi-asserted-by":"crossref","first-page":"5755","DOI":"10.1038\/onc.2010.311","article-title":"Cell cycle-dependent acetylation of Rb2\/p130 in NIH3T3 cells","volume":"29","author":"Schwarze","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.jmb.2014.10.021_bb0375","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1006\/viro.2000.0514","article-title":"Differential phosphorylation of the HPV-16 E7 oncoprotein during the cell cycle","volume":"276","author":"Massimi","year":"2000","journal-title":"Virology"},{"key":"10.1016\/j.jmb.2014.10.021_bb0380","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1073\/pnas.0510012103","article-title":"The E7 proteins of low- and high-risk human papillomaviruses share the ability to target the pRB family member p130 for degradation","volume":"103","author":"Zhang","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jmb.2014.10.021_bb0385","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.molcel.2005.10.017","article-title":"MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein","volume":"20","author":"Sdek","year":"2005","journal-title":"Mol Cell"},{"key":"10.1016\/j.jmb.2014.10.021_bb0390","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/sj.emboj.7600486","article-title":"Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation","volume":"24","author":"Uchida","year":"2005","journal-title":"EMBO J"},{"key":"10.1016\/j.jmb.2014.10.021_bb0395","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.tibs.2012.10.007","article-title":"Deciphering the retinoblastoma protein phosphorylation code","volume":"38","author":"Rubin","year":"2013","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.jmb.2014.10.021_bb0400","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1101\/gad.189837.112","article-title":"Structures of inactive retinoblastoma protein reveal multiple mechanisms for cell cycle control","volume":"26","author":"Burke","year":"2012","journal-title":"Genes Dev"},{"key":"10.1016\/j.jmb.2014.10.021_bb0405","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.cell.2005.09.044","article-title":"Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release","volume":"123","author":"Rubin","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.jmb.2014.10.021_bb0410","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.pep.2007.10.018","article-title":"Overexpression of post-translationally modified peptides in Escherichia coli by co-expression with modifying enzymes","volume":"57","author":"Sugase","year":"2008","journal-title":"Protein Expression Purif"},{"key":"10.1016\/j.jmb.2014.10.021_bb0415","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.jmb.2004.08.087","article-title":"ZZ domain of CBP: an unusual zinc finger fold in a protein interaction module","volume":"343","author":"Legge","year":"2004","journal-title":"J Mol Biol"},{"key":"10.1016\/j.jmb.2014.10.021_bb0420","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/BF00197809","article-title":"NMRPipe: a multidimensional spectral processing system based on UNIX pipes","volume":"6","author":"Delaglio","year":"1995","journal-title":"J Biomol NMR"},{"key":"10.1016\/j.jmb.2014.10.021_bb0425","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/BF00404272","article-title":"NMRView: a computer program for the visualization and analysis of NMR data","volume":"4","author":"Johnson","year":"1994","journal-title":"J Biomol NMR"},{"key":"10.1016\/j.jmb.2014.10.021_bb0430","series-title":"SPARKY 3","author":"Goddard","year":"2006"},{"key":"10.1016\/j.jmb.2014.10.021_bb0435","doi-asserted-by":"crossref","first-page":"6291","DOI":"10.1021\/ja00042a003","article-title":"Correlating backbone amide and side chain resonances in larger proteins by multiple relayed triple resonance NMR","volume":"114","author":"Grzesiek","year":"1992","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.jmb.2014.10.021_bb0440","first-page":"432","article-title":"Improved 3D triple-resonance NMR techniques applied to a 31 kDa protein","volume":"96","author":"Grzesiek","year":"1992","journal-title":"J Magn Reson"},{"key":"10.1016\/j.jmb.2014.10.021_bb0445","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1006\/jmrb.1993.1033","article-title":"HNCACB, a high-sensitivity 3D NMR experiment to correlate amide-proton and nitrogen resonances with the alpha- and beta-carbon resonances in proteins","volume":"101","author":"Wittekind","year":"1993","journal-title":"J Magn Reson"},{"key":"10.1016\/j.jmb.2014.10.021_bb0450","first-page":"425","article-title":"1H-1H correlation via isotropic mixing of 13C magnetization, a new three-dimensional approach for assigning 1H and 13C spectra of 13C-enriched proteins","volume":"88","author":"Bax","year":"1990","journal-title":"J Magn Reson"},{"key":"10.1016\/j.jmb.2014.10.021_bb0455","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1126\/science.282.5397.2270","article-title":"p53-independent role of MDM2 in TGF-beta1 resistance","volume":"282","author":"Sun","year":"1998","journal-title":"Science"}],"container-title":["Journal of Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283614005725?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283614005725?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T22:09:53Z","timestamp":1650492593000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022283614005725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":90,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S0022283614005725"],"URL":"https:\/\/doi.org\/10.1016\/j.jmb.2014.10.021","relation":{},"ISSN":["0022-2836"],"issn-type":[{"value":"0022-2836","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]}}}