{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T07:22:41Z","timestamp":1781767361676,"version":"3.54.5"},"reference-count":23,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bavarian Research Network Induced Pluripotent Stem Cells \u201cforIPS\u201d"},{"name":"\u201cStiftung Sibylle Assmus\u201d"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Molecular Biology"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.jmb.2015.10.028","type":"journal-article","created":{"date-parts":[[2015,11,10]],"date-time":"2015-11-10T19:01:43Z","timestamp":1447182103000},"page":"1476-1483","source":"Crossref","is-referenced-by-count":5,"title":["Partial Dedifferentiation of Murine Radial Glia-Type Neural Stem Cells by Brn2 and c-Myc Yields Early Neuroepithelial Progenitors"],"prefix":"10.1016","volume":"428","author":[{"given":"Raffaela","family":"Bung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"W\u00f6rsd\u00f6rfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc Christian","family":"Thier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Lemke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Gebhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Edenhofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmb.2015.10.028_bb0005","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.jmb.2015.10.028_bb0010","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.jmb.2015.10.028_bb0015","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/ncb2164","article-title":"Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy","volume":"13","author":"Efe","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.jmb.2015.10.028_bb0020","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/nature10263","article-title":"Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors","volume":"475","author":"Sekiya","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2015.10.028_bb0025","doi-asserted-by":"crossref","first-page":"7838","DOI":"10.1073\/pnas.1103113108","article-title":"Direct reprogramming of mouse fibroblasts to neural progenitors","volume":"108","author":"Kim","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jmb.2015.10.028_bb0030","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/nature08797","article-title":"Direct conversion of fibroblasts to functional neurons by defined factors","volume":"463","author":"Vierbuchen","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2015.10.028_bb0035","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nature10202","article-title":"Induction of human neuronal cells by defined transcription factors","volume":"476","author":"Pang","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2015.10.028_bb0040","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/nmeth.1972","article-title":"Small molecules enable highly efficient neuronal conversion of human fibroblasts","volume":"9","author":"Ladewig","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jmb.2015.10.028_bb0045","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.stem.2012.03.003","article-title":"Direct conversion of fibroblasts into stably expandable neural stem cells","volume":"10","author":"Thier","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jmb.2015.10.028_bb0050","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.stem.2012.02.021","article-title":"Direct reprogramming of fibroblasts into neural stem cells by defined factors","volume":"10","author":"Han","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jmb.2015.10.028_bb0055","doi-asserted-by":"crossref","first-page":"5250","DOI":"10.1074\/jbc.M113.516112","article-title":"Direct conversion of human fibroblasts into neuronal restricted progenitors","volume":"289","author":"Zou","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2015.10.028_bb0060","first-page":"2857","article-title":"Oct transcription factors in development and stem cells: insights and mechanisms","volume":"140","author":"Tantin","year":"2013"},{"key":"10.1016\/j.jmb.2015.10.028_bb0125","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0166-2236(02)02156-2","article-title":"Radial glia: Multi-purpose cells for vertebrate brain development","volume":"25","author":"Campbell","year":"2002","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.jmb.2015.10.028_bb0075","doi-asserted-by":"crossref","first-page":"e283","DOI":"10.1371\/journal.pbio.0030283","article-title":"Niche-independent symmetrical self-renewal of a mammalian tissue stem cell","volume":"3","author":"Conti","year":"2005","journal-title":"PLoS Biol."},{"key":"10.1016\/j.jmb.2015.10.028_bb0080","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.brainresbull.2005.05.013","article-title":"The midbrain of sauropsides shares a common subdivision pattern defined by embryonic radial glia","volume":"66","author":"Delgado","year":"2005","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.jmb.2015.10.028_bb0085","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/nature08436","article-title":"Direct reprogramming of human neural stem cells by OCT4","volume":"461","author":"Kim","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2015.10.028_bb0090","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1101\/gad.978002","article-title":"Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons","volume":"16","author":"Sugitani","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.jmb.2015.10.028_bb0095","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/cr.2010.142","article-title":"Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules","volume":"21","author":"Li","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.jmb.2015.10.028_bb0100","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.scr.2013.08.009","article-title":"Adhesion, but not a specific cadherin code, is indispensable for ES cell and induced pluripotency","volume":"11","author":"Bedzhov","year":"2013","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.jmb.2015.10.028_bb0105","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/cr.2012.11","article-title":"Neural crest stem cells: Discovery, properties and potential for therapy","volume":"22","author":"Achilleos","year":"2012","journal-title":"Cell Res."},{"key":"10.1016\/j.jmb.2015.10.028_bb0110","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nature729","article-title":"Changing potency by spontaneous fusion","volume":"416","author":"Ying","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2015.10.028_bb0115","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1387\/ijdb.103193mt","article-title":"Exploring refined conditions for reprogramming cells by recombinant Oct4 protein","volume":"54","author":"Thier","year":"2010","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.jmb.2015.10.028_bb0120","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1101\/gad.1616208","article-title":"Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage","volume":"22","author":"Elkabetz","year":"2008","journal-title":"Genes Dev."}],"container-title":["Journal of Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283615006221?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283615006221?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,4,4]],"date-time":"2021-04-04T17:37:44Z","timestamp":1617557864000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022283615006221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["S0022283615006221"],"URL":"https:\/\/doi.org\/10.1016\/j.jmb.2015.10.028","relation":{},"ISSN":["0022-2836"],"issn-type":[{"value":"0022-2836","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]}}}