{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T13:01:10Z","timestamp":1768827670609,"version":"3.49.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Heart Lung and Blood Institute of the National Institutes of Health","award":["HL109109"],"award-info":[{"award-number":["HL109109"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Molecular Biology"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.jmb.2016.11.014","type":"journal-article","created":{"date-parts":[[2016,11,24]],"date-time":"2016-11-24T07:01:06Z","timestamp":1479970866000},"page":"32-47","source":"Crossref","is-referenced-by-count":13,"title":["The Von Willebrand Factor A1\u2013Collagen III Interaction Is Independent of Conformation and Type 2 Von Willebrand Disease Phenotype"],"prefix":"10.1016","volume":"429","author":[{"given":"Venkata R.","family":"Machha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9909-5262","authenticated-orcid":false,"given":"Alexander","family":"Tischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurie","family":"Moon-Tasson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Auton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.jmb.2016.11.014_bb0005","doi-asserted-by":"crossref","first-page":"3848","DOI":"10.1074\/jbc.M115.703850","article-title":"Mutational constraints on local unfolding inhibit the rheological adaptation of von Willebrand factor","volume":"291","author":"Tischer","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.jmb.2016.11.014_bb0010","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.bpj.2014.07.026","article-title":"Misfolding of VWF to pathologically disordered conformations impacts the severity of von Willebrand disease","volume":"107","author":"Tischer","year":"2014","journal-title":"Biophys. J."},{"key":"10.1016\/j.jmb.2016.11.014_bb0015","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.thromres.2016.02.029","article-title":"Towards a more automatic and rapid laboratory diagnosis of von Willebrand disease","volume":"141","author":"Federici","year":"2016","journal-title":"Thromb. Res."},{"key":"10.1016\/j.jmb.2016.11.014_bb0020","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.thromres.2015.06.019","article-title":"Von Willebrand factor-A1 domain binds platelet glycoprotein Ib\u00ce\u00b1in multiple states with distinctive force-dependent dissociation kinetics","volume":"136","author":"Ju","year":"2015","journal-title":"Thromb. Res."},{"issue":"2","key":"10.1016\/j.jmb.2016.11.014_bb0025","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.bpj.2009.05.009","article-title":"Changes in thermodynamic stability of von Willebrand factor differentially affect the force-dependent binding to platelet GPIb\u03b1","volume":"97","author":"Auton","year":"2009","journal-title":"Biophys. J."},{"issue":"4","key":"10.1016\/j.jmb.2016.11.014_bb0030","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.bpj.2010.06.002","article-title":"The mechanism of VWF-mediated platelet GPIb\u03b1 binding","volume":"99","author":"Auton","year":"2010","journal-title":"Biophys. J."},{"key":"10.1016\/j.jmb.2016.11.014_bb0035","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1538-7836.2006.01742.x","article-title":"The interaction of von Willebrand factor-A1 domain with collagen: mutation G1324S (type 2M von Willebrand disease) impairs the conformational change in A1 domain induced by collagen","volume":"4","author":"Morales","year":"2006","journal-title":"J. Thromb. Res."},{"issue":"1","key":"10.1016\/j.jmb.2016.11.014_bb0040","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1182\/blood.V95.1.164","article-title":"Structure and function of the von Willebrand factor A1 domain: analysis with monoclonal antibodies reveals distinct binding sites involved in recognition of the platelet membrane glycoprotein Ib\u2013IX\u2013V complex and ristocetin-dependent activation","volume":"95","author":"De Luca","year":"2000","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.jmb.2016.11.014_bb0045","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/S0021-9258(18)48430-X","article-title":"Functional analysis of a recombinant glycoprotein Ib\u03b1 polypeptide which inhibits von Willebrand factor binding to the platelet glycoproteinIb-IX complex and to collagen","volume":"267","author":"Cruz","year":"1992","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.jmb.2016.11.014_bb0050","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.bpj.2015.06.008","article-title":"Structural origins of misfolding propensity in the platelet adhesive von Willebrand factor A1 domain","volume":"109","author":"Zimmermann","year":"2015","journal-title":"Biophys. J."},{"key":"10.1016\/j.jmb.2016.11.014_bb0055","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1002\/prot.24464","article-title":"A molten globule intermediate of the von Willebrand factor A1 domain firmly tethers platelets under shear flow","volume":"82","author":"Tischer","year":"2014","journal-title":"Proteins"},{"key":"10.1016\/j.jmb.2016.11.014_bb0060","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1126\/science.107355","article-title":"Structures of glycoprotein Ib and its complex with von Willebrand factor A1 domain","volume":"297","author":"Huizinga","year":"2002","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.jmb.2016.11.014_bb0070","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1182\/blood.V91.5.1572","article-title":"Type 2M von Willebrand disease: F606I and I662F mutations in the glycoprotein Ib binding domain selectively impair ristocetin- but not botrocetin-mediated binding of von Willebrand factor to platelets","volume":"91","author":"Hillery","year":"1998","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.jmb.2016.11.014_bb0075","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1111\/j.1538-7836.2006.02069.x","article-title":"On Willebrand factor collagen binding assay in von Willebrand disease type 2A, 2B, and 2M","volume":"4","author":"Baronciani","year":"2006","journal-title":"J. Thromb. Haemost."},{"issue":"12","key":"10.1016\/j.jmb.2016.11.014_bb0080","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1111\/j.1538-7836.2005.01638.x","article-title":"Expression studies on a novel type 2B variant of the von Willebrand factor gene (R1308L) characterized by defective collagen binding","volume":"3","author":"Baronciani","year":"2005","journal-title":"J. Thromb. Haemost."},{"issue":"4","key":"10.1016\/j.jmb.2016.11.014_bb0090","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/j.1538-7836.2007.02437.x","article-title":"Von Willebrand factor collagen binding assay with a commercial kit using type III collagen in von Willebrand disease type 2","volume":"5","author":"Veyradier","year":"2007","journal-title":"J. Thromb. Haemost."},{"issue":"2","key":"10.1016\/j.jmb.2016.11.014_bb0095","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1538-7836.2007.02349.x","article-title":"Biochemical characterization of a recombinant von Willebrand factor (VWF) with combined type 2B and type 1 defects in the VWF gene in two patients with a type 2A phenotype of von Willebrand disease","volume":"5","author":"Baronciani","year":"2007","journal-title":"J. Thromb. Haemost."},{"issue":"8","key":"10.1016\/j.jmb.2016.11.014_bb0100","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1182\/blood.V89.8.2766","article-title":"Functional studies on platelet adhesion with recombinant von Willebrand factor type 2B mutants R543Q and R543W under conditions of flow","volume":"89","author":"Lankhof","year":"1997","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.jmb.2016.11.014_bb0105","first-page":"1182","article-title":"A novel von Willebrand factor mutation (I1372S) associated with type 2B-like von Willebrand disease: an elusive phenotype and a difficult diagnosis","volume":"98","author":"Casonato","year":"2007","journal-title":"Thromb. Haemost."},{"issue":"3","key":"10.1016\/j.jmb.2016.11.014_bb0110","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1080\/09537100500441150","article-title":"von Willebrand disease type 2B must be always considered in the differential diagnosis of genetic thrombocytopenias with giant platelets","volume":"17","author":"Loffredo","year":"2006","journal-title":"Platelets"},{"issue":"8","key":"10.1016\/j.jmb.2016.11.014_bb0115","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.3324\/haematol.2009.019927","article-title":"Reduced survival of type 2B von Willebrand factor, irrespective of large multimer representation or thrombocytopenia","volume":"95","author":"Casonato","year":"2010","journal-title":"Haematologica"},{"key":"10.1016\/j.jmb.2016.11.014_bb0120","doi-asserted-by":"crossref","first-page":"S171","DOI":"10.1007\/PL00014348","article-title":"A 2-year-old boy with recurrent severe bleeding: von Willebrand type 2B and ITP- or von Willebrand type 2B alone?","volume":"158","author":"Rauch","year":"1999","journal-title":"Eur. J. Pediatr."},{"issue":"5","key":"10.1016\/j.jmb.2016.11.014_bb0125","doi-asserted-by":"crossref","first-page":"10822","DOI":"10.1074\/jbc.270.18.10822","article-title":"Interaction of the von Willebrand factor (VWF) with collagen","volume":"18","author":"Cruz","year":"1995","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.jmb.2016.11.014_bb0130","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1055\/s-0038-1650400","article-title":"A3 domain is essential for interaction of von Willebrand factor with collagen type III","volume":"75","author":"Lankhof","year":"1996","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.jmb.2016.11.014_bb0135","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1111\/j.1538-7836.2006.02111.x","article-title":"Von Willebrand factor A1 domain can adequately substitute for A3 domain in recruitment of flowing platelets to collagen","volume":"4","author":"Bonnefoy","year":"2006","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.jmb.2016.11.014_bb0140","series-title":"Destabilization of the A1 Domain in Von Willebrand Factor Dissociates the A1A2A3 Tridomain and Provokes Spontaneous Binding to Glycoprotein Ib and Platelet Activation under Shear Stress","author":"Auton","year":"2010"},{"key":"10.1016\/j.jmb.2016.11.014_bb0145","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1002\/pro.2294","article-title":"The linker between the D3 and A1 domains of VWF suppresses A1\u2013GPIb\u03b1 catch bonds by site-specific binding to the A1 domain","volume":"22","author":"Tischer","year":"2013","journal-title":"Protein Sci."},{"issue":"8","key":"10.1016\/j.jmb.2016.11.014_bb0150","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1021\/ac60214a047","article-title":"Smoothing and differentiation of data by simplified least squares procedures","volume":"36","author":"Savitsky","year":"1964","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jmb.2016.11.014_bb0155","first-page":"750","article-title":"Effect of shear rate on platelet interaction with subendothelium in citrated and native blood. I. Shear ratedependent decrease of adhesion in von Willebrand disease and the Bernard\u2013Soulier syndrome","volume":"92","author":"Weiss","year":"1978","journal-title":"J. Lab. Clin. Med."},{"issue":"21","key":"10.1016\/j.jmb.2016.11.014_bb0160","doi-asserted-by":"crossref","first-page":"8326","DOI":"10.1021\/bi00447a010","article-title":"Cross-linking of a monomeric 39\/34-kD dispase fragment of von Willebrand factor (Leu-480\/Val-481\u2013Gly-718) to the N-terminal region of the \u03b1-chain of membrane glycoprotein Ib on intact platelets with bis (sulfosuccinimidyl) suberate","volume":"28","author":"Andrews","year":"1989","journal-title":"Biochemistry"},{"issue":"1","key":"10.1016\/j.jmb.2016.11.014_bb0165","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1182\/blood.V97.1.162","article-title":"Ristocetin-dependent, but not botrocetin-dependent, binding of von Willebrand factor to the platelet glycoprotein Ib\u2013IX\u2013V complex correlates with shear-dependent interactions","volume":"97","author":"Dong","year":"2001","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.jmb.2016.11.014_bb0170","first-page":"029803,1","article-title":"Differential surface activation of the A1 domain of von Willebrand factor","volume":"11","author":"Tronic","year":"2016","journal-title":"Biointerfaces"},{"key":"10.1016\/j.jmb.2016.11.014_bb0175","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1182\/blood-2008-06-077891","article-title":"The GPIIb\/IIIa (integrin \u03b1IIb\u03b23) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend","volume":"112","author":"Coller","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.jmb.2016.11.014_bb0180","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1055\/s-0037-1616217","article-title":"Platelet collagen receptors","volume":"86","author":"Clemetson","year":"2001","journal-title":"Thromb. Haemost."},{"issue":"5","key":"10.1016\/j.jmb.2016.11.014_bb0185","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1182\/blood-2004-04-1365","article-title":"The platelet glycoprotein Ibvon Willebrand factor interaction activates the collagen receptor \u03b12\u03b21 to bind collagen: activation-dependent conformational change of the \u03b12-I domain","volume":"105","author":"Cruz","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jmb.2016.11.014_bb0190","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1172\/JCI112736","article-title":"Involvement of large plasma von Willebrand factor (VWF) multimers and unusually large VWF forms derived from endothelial cells in shear stress-induced platelet aggregation","volume":"78","author":"Moake","year":"1986","journal-title":"J. Clin. Invest."},{"issue":"11","key":"10.1016\/j.jmb.2016.11.014_bb0195","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.1182\/blood-2001-11-0060","article-title":"Ultralarge multimers of von Willebrand factor form spontaneous high-strength bonds with the platelet glycoprotein Ib\u2013IX complex: studies using optical tweezers","volume":"99","author":"Arya","year":"2002","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.jmb.2016.11.014_bb0200","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.1182\/blood-2002-05-1401","article-title":"ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions","volume":"100","author":"Dong","year":"2002","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.jmb.2016.11.014_bb0205","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1160\/TH10-06-0360","article-title":"Evaluation of commercial von Willebrand factor collagen binding assays to assist the discrimination of types 1 and 2 von Willebrand disease","volume":"104","author":"Favaloro","year":"2010","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.jmb.2016.11.014_bb0210","series-title":"Crucial Role for the VWF A1 Domain in Binding to Type IV Collagen","author":"Flood","year":"2015"},{"key":"10.1016\/j.jmb.2016.11.014_bb0215","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1111\/j.1538-7836.2012.04746.x","article-title":"Critical von Willebrand factor A1 domain residues influence type VI collagen binding","volume":"10","author":"Flood","year":"2012","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.jmb.2016.11.014_bb0220","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1111\/j.1538-7836.2012.04747.x","article-title":"Comparison of type I, type III and type VI collagen binding assays in diagnosis of von Willebrand disease","volume":"10","author":"Flood","year":"2012","journal-title":"J. Thromb. Haemost."},{"issue":"7","key":"10.1016\/j.jmb.2016.11.014_bb0225","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1182\/blood.V97.7.1915","article-title":"How I treat patients with von Willebrand disease","volume":"97","author":"Mannucci","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.jmb.2016.11.014_bb0230","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1055\/s-0037-1614447","article-title":"Post-DDAVP thrombocytopenia in type 2B von Willebrand disease is not associated with platelet consumption: failure to demonstrate glycocalicin increase or platelet activation","volume":"81","author":"Casonato","year":"1999","journal-title":"Thromb. Haemost."},{"issue":"9","key":"10.1016\/j.jmb.2016.11.014_bb0235","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1002\/pro.2301","article-title":"Urea-temperature phase diagrams capture the thermodynamics of denatured state expansion that accompany protein unfolding","volume":"22","author":"Tischer","year":"2013","journal-title":"Protein Sci."},{"key":"10.1016\/j.jmb.2016.11.014_bb0240","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/j.dib.2016.05.004","article-title":"Data on the purification and crystallization of the loss-of-function von Willebrand disease variant (p.Gly1324Ser) of the von Willebrand factor A1 domain","volume":"7","author":"Campbell","year":"2016","journal-title":"Data Brief"},{"issue":"3","key":"10.1016\/j.jmb.2016.11.014_bb0245","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.jmb.2006.10.067","article-title":"Conformational stability and domain unfolding of the von Willebrand factor A domains","volume":"366","author":"Auton","year":"2007","journal-title":"J. Mol. Biol."},{"issue":"18","key":"10.1016\/j.jmb.2016.11.014_bb0250","doi-asserted-by":"crossref","first-page":"6578","DOI":"10.1016\/S0021-9258(19)46970-6","article-title":"Collagen fibril formation. Optimal in vitro conditions and preliminary kinetic results","volume":"253","author":"Williams","year":"1978","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2016.11.014_bb0255","doi-asserted-by":"crossref","first-page":"e29","DOI":"10.1016\/j.thromres.2011.09.030","article-title":"Coating conditions matter to collagen matrix formation regarding von Willebrand factor and platelet binding","volume":"129","author":"Raviv","year":"2012","journal-title":"Thromb. Res."}],"container-title":["Journal of Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002228361630506X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002228361630506X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T18:48:23Z","timestamp":1657824503000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002228361630506X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S002228361630506X"],"URL":"https:\/\/doi.org\/10.1016\/j.jmb.2016.11.014","relation":{},"ISSN":["0022-2836"],"issn-type":[{"value":"0022-2836","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]}}}