{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:12:35Z","timestamp":1788307955078,"version":"build-2803163510"},"reference-count":51,"publisher":"Elsevier BV","issue":"18","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T00:00:00Z","timestamp":1565654400000},"content-version":"am","delay-in-days":346,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HG007690"],"award-info":[{"award-number":["HG007690"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL061795"],"award-info":[{"award-number":["HL061795"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM107618"],"award-info":[{"award-number":["GM107618"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular Biology"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.jmb.2018.05.016","type":"journal-article","created":{"date-parts":[[2018,5,20]],"date-time":"2018-05-20T10:11:58Z","timestamp":1526811118000},"page":"2939-2950","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"special_numbering":"PA","title":["Network-Based Disease Module Discovery by a Novel Seed Connector Algorithm with Pathobiological Implications"],"prefix":"10.1016","volume":"430","author":[{"given":"Rui-Sheng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Loscalzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmb.2018.05.016_bb0005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1002822","article-title":"Chapter 11: genome-wide association studies","volume":"8","author":"Bush","year":"2012","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.jmb.2018.05.016_bb0010","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nrg2918","article-title":"Network medicine: a network-based approach to human disease","volume":"12","author":"Barabasi","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.jmb.2018.05.016_bb0015","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s13073-014-0082-6","article-title":"Modules, networks and systems medicine for understanding disease and aiding diagnosis","volume":"6","author":"Gustafsson","year":"2014","journal-title":"Genome Med."},{"key":"10.1016\/j.jmb.2018.05.016_bb0020","doi-asserted-by":"crossref","first-page":"1257601","DOI":"10.1126\/science.1257601","article-title":"Disease networks. Uncovering disease-disease relationships through the incomplete interactome","volume":"347","author":"Menche","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.jmb.2018.05.016_bb0025","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1101\/gr.118992.110","article-title":"Prioritizing candidate disease genes by network-based boosting of genome-wide association data","volume":"21","author":"Lee","year":"2011","journal-title":"Genome Res."},{"key":"10.1016\/j.jmb.2018.05.016_bb0030","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1089\/cmb.2013.0158","article-title":"Computational disease gene prioritization: an appraisal","volume":"21","author":"Gill","year":"2014","journal-title":"J. Comput. Biol."},{"key":"10.1016\/j.jmb.2018.05.016_bb0035","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1111\/j.1742-4658.2012.08471.x","article-title":"Computational approaches to disease-gene prediction: rationale, classification and successes","volume":"279","author":"Piro","year":"2012","journal-title":"FEBS J."},{"key":"10.1016\/j.jmb.2018.05.016_bb0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1004120","article-title":"A DIseAse MOdule Detection (DIAMOnD) algorithm derived from a systematic analysis of connectivity patterns of disease proteins in the human interactome","volume":"11","author":"Ghiassian","year":"2015","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.jmb.2018.05.016_bb0045","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s13073-017-0435-z","article-title":"GLADIATOR: a global approach for elucidating disease modules","volume":"9","author":"Silberberg","year":"2017","journal-title":"Genome Med."},{"key":"10.1016\/j.jmb.2018.05.016_bb0050","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.ajhg.2008.02.013","article-title":"Walking the interactome for prioritization of candidate disease genes","volume":"82","author":"Kohler","year":"2008","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jmb.2018.05.016_bb0055","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1074\/mcp.M400110-MCP200","article-title":"Identifying regulatory subnetworks for a set of genes","volume":"4","author":"Scott","year":"2005","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.jmb.2018.05.016_bb0060","doi-asserted-by":"crossref","first-page":"i223","DOI":"10.1093\/bioinformatics\/btn161","article-title":"Identifying functional modules in protein\u2013protein interaction networks: an integrated exact approach","volume":"24","author":"Dittrich","year":"2008","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jmb.2018.05.016_bb0065","doi-asserted-by":"crossref","first-page":"ra40","DOI":"10.1126\/scisignal.2000350","article-title":"Integrating proteomic, transcriptional, and interactome data reveals hidden components of signaling and regulatory networks","volume":"2","author":"Huang","year":"2009","journal-title":"Sci. Signal."},{"key":"10.1016\/j.jmb.2018.05.016_bb0070","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1089\/cmb.2012.0092","article-title":"Simultaneous reconstruction of multiple signaling pathways via the prize-collecting steiner forest problem","volume":"20","author":"Tuncbag","year":"2013","journal-title":"J. Comput. Biol."},{"key":"10.1016\/j.jmb.2018.05.016_bb0075","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/ng.3396","article-title":"A comprehensive 1,000 genomes-based genome-wide association meta-analysis of coronary artery disease","volume":"47","author":"Nikpay","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jmb.2018.05.016_bb0080","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nrg.2016.160","article-title":"Genetics of coronary artery disease: discovery, biology and clinical translation","volume":"18","author":"Khera","year":"2017","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.jmb.2018.05.016_bb0085","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGEN.117.001813","article-title":"Improving interpretation of cardiac phenotypes and enhancing discovery with expanded knowledge in the Gene Ontology","volume":"11","author":"Lovering","year":"2018","journal-title":"Circ. Genom. Precis. Med."},{"key":"10.1016\/j.jmb.2018.05.016_bb0090","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aad3812","article-title":"Neuropilin-1 mediates vascular permeability independently of vascular endothelial growth factor receptor-2 activation","volume":"9","author":"Roth","year":"2016","journal-title":"Sci. Signal."},{"key":"10.1016\/j.jmb.2018.05.016_bb0095","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/ncomms1705","article-title":"Network physiology reveals relations between network topology and physiological function","volume":"3","author":"Bashan","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jmb.2018.05.016_bb0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142143","article-title":"Network physiology: how organ systems dynamically interact","volume":"10","author":"Bartsch","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jmb.2018.05.016_bb0105","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.cell.2005.08.029","article-title":"A human protein\u2013protein interaction network: a resource for annotating the proteome","volume":"122","author":"Stelzl","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.jmb.2018.05.016_bb0110","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/nature04209","article-title":"Towards a proteome-scale map of the human protein\u2013protein interaction network","volume":"437","author":"Rual","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2018.05.016_bb0115","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nmeth.1280","article-title":"An empirical framework for binary interactome mapping","volume":"6","author":"Venkatesan","year":"2009","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jmb.2018.05.016_bb0120","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.cell.2014.10.050","article-title":"A proteome-scale map of the human interactome network","volume":"159","author":"Rolland","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.jmb.2018.05.016_bb0125","doi-asserted-by":"crossref","first-page":"D841","DOI":"10.1093\/nar\/gkr1088","article-title":"The IntAct molecular interaction database in 2012","volume":"40","author":"Kerrien","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jmb.2018.05.016_bb0130","doi-asserted-by":"crossref","first-page":"D857","DOI":"10.1093\/nar\/gkr930","article-title":"MINT, the molecular interaction database: 2012 update","volume":"40","author":"Licata","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jmb.2018.05.016_bb0135","doi-asserted-by":"crossref","first-page":"D470","DOI":"10.1093\/nar\/gku1204","article-title":"The BioGRID interaction database: 2015 update","volume":"43","author":"Chatr-Aryamontri","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jmb.2018.05.016_bb0140","doi-asserted-by":"crossref","first-page":"D767","DOI":"10.1093\/nar\/gkn892","article-title":"Human protein reference database\u20142009 update","volume":"37","author":"Keshava Prasad","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jmb.2018.05.016_bb0145","doi-asserted-by":"crossref","first-page":"D497","DOI":"10.1093\/nar\/gkp914","article-title":"CORUM: the comprehensive resource of mammalian protein complexes\u20142009","volume":"38","author":"Ruepp","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jmb.2018.05.016_bb0150","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.cell.2012.08.011","article-title":"A census of human soluble protein complexes","volume":"150","author":"Havugimana","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jmb.2018.05.016_bb0155","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1093\/nar\/gkg108","article-title":"TRANSFAC: transcriptional regulation, from patterns to profiles","volume":"31","author":"Matys","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jmb.2018.05.016_bb0160","doi-asserted-by":"crossref","first-page":"D261","DOI":"10.1093\/nar\/gkr1122","article-title":"PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse","volume":"40","author":"Hornbeck","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jmb.2018.05.016_bb0165","doi-asserted-by":"crossref","first-page":"9880","DOI":"10.1073\/pnas.0802208105","article-title":"The implications of human metabolic network topology for disease comorbidity","volume":"105","author":"Lee","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jmb.2018.05.016_bb0170","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nature11503","article-title":"Structure-based prediction of protein\u2013protein interactions on a genome-wide scale","volume":"490","author":"Zhang","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2018.05.016_bb0175","doi-asserted-by":"crossref","first-page":"rs8","DOI":"10.1126\/scisignal.2001699","article-title":"A directed protein interaction network for investigating intracellular signal transduction","volume":"4","author":"Vinayagam","year":"2011","journal-title":"Sci. Signal."},{"key":"10.1016\/j.jmb.2018.05.016_bb0180","doi-asserted-by":"crossref","first-page":"D514","DOI":"10.1093\/nar\/gki033","article-title":"Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders","volume":"33","author":"Hamosh","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jmb.2018.05.016_bb0185","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/978-1-4939-3167-5_2","article-title":"UniProtKB\/Swiss-Prot, the manually annotated section of the UniProt KnowledgeBase: how to use the entry view","volume":"1374","author":"Boutet","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jmb.2018.05.016_bb0190","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/ejhg.2013.96","article-title":"Phenotype\u2013Genotype Integrator (PheGenI): synthesizing genome-wide association study (GWAS) data with existing genomic resources","volume":"22","author":"Ramos","year":"2014","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.jmb.2018.05.016_bb0195","doi-asserted-by":"crossref","first-page":"D901","DOI":"10.1093\/nar\/gkm958","article-title":"DrugBank: a knowledgebase for drugs, drug actions and drug targets","volume":"36","author":"Wishart","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jmb.2018.05.016_bb0200","doi-asserted-by":"crossref","first-page":"D787","DOI":"10.1093\/nar\/gkp1014","article-title":"Update of TTD: Therapeutic Target Database","volume":"38","author":"Zhu","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jmb.2018.05.016_bb0205","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/978-1-62703-435-7_20","article-title":"PharmGKB: The Pharmacogenomics Knowledge Base","volume":"1015","author":"Thorn","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jmb.2018.05.016_bb0210","doi-asserted-by":"crossref","first-page":"D1100","DOI":"10.1093\/nar\/gkr777","article-title":"ChEMBL: a large-scale bioactivity database for drug discovery","volume":"40","author":"Gaulton","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jmb.2018.05.016_bb0215","doi-asserted-by":"crossref","first-page":"D198","DOI":"10.1093\/nar\/gkl999","article-title":"BindingDB: a web-accessible database of experimentally determined protein\u2013ligand binding affinities","volume":"35","author":"Liu","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jmb.2018.05.016_bb0220","doi-asserted-by":"crossref","first-page":"D1098","DOI":"10.1093\/nar\/gkt1143","article-title":"The IUPHAR\/BPS guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands","volume":"42","author":"Pawson","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jmb.2018.05.016_bb0225","doi-asserted-by":"crossref","first-page":"D115","DOI":"10.1093\/nar\/gkh131","article-title":"UniProt: the universal protein knowledgebase","volume":"32","author":"Apweiler","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jmb.2018.05.016_bb0230","doi-asserted-by":"crossref","first-page":"D52","DOI":"10.1093\/nar\/gkq1237","article-title":"Entrez gene: gene-centered information at NCBI","volume":"39","author":"Maglott","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jmb.2018.05.016_bb0235","doi-asserted-by":"crossref","DOI":"10.1093\/database\/baq020","article-title":"GeneCards Version 3: the human gene integrator","volume":"2010","author":"Safran","year":"2010","journal-title":"Database (Oxford)"},{"key":"10.1016\/j.jmb.2018.05.016_bb0240","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.tcs.2008.06.046","article-title":"The Steiner tree problem on graphs: inapproximability results","volume":"406","author":"Chlebik","year":"2008","journal-title":"Theor. Comput. Sci."},{"key":"10.1016\/j.jmb.2018.05.016_bb0245","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.93911","article-title":"Network analysis of the genomic basis of the placebo effect","volume":"2","author":"Wang","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.jmb.2018.05.016_bb0250","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.jmb.2018.05.016_bb0255","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1093\/bioinformatics\/btp128","article-title":"GS2: an efficiently computable measure of GO-based similarity of gene sets","volume":"25","author":"Ruths","year":"2009","journal-title":"Bioinformatics"}],"container-title":["Journal of Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283618304273?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283618304273?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T21:23:12Z","timestamp":1758316992000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022283618304273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":51,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["S0022283618304273"],"URL":"https:\/\/doi.org\/10.1016\/j.jmb.2018.05.016","relation":{},"ISSN":["0022-2836"],"issn-type":[{"value":"0022-2836","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Network-Based Disease Module Discovery by a Novel Seed Connector Algorithm with Pathobiological Implications","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmb.2018.05.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}