{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T01:18:04Z","timestamp":1773105484698,"version":"3.50.1"},"reference-count":56,"publisher":"Elsevier BV","issue":"21","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular Biology"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.jmb.2019.03.017","type":"journal-article","created":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T18:32:42Z","timestamp":1553711562000},"page":"4354-4367","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Potent Neutralization of Staphylococcal Enterotoxin B In Vivo by Antibodies that Block Binding to the T-Cell Receptor"],"prefix":"10.1016","volume":"431","author":[{"given":"Gang","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatice","family":"Karauzum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Carranza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick W.","family":"Holtsberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie A.","family":"Howell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Abaandou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bojie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"Jarvik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grant C.","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael L.","family":"Gross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisy W.","family":"Leung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaya K.","family":"Amarasinghe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Javad","family":"Aman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachdev S.","family":"Sidhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmb.2019.03.017_bb0005","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nrmicro2200","article-title":"Waves of resistance: Staphylococcus aureus in the antibiotic era","volume":"7","author":"Chambers","year":"2009","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.jmb.2019.03.017_bb0010","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1128\/CMR.13.1.16","article-title":"Exotoxins of Staphylococcus aureus","volume":"13","author":"Dinges","year":"2000","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.jmb.2019.03.017_bb0015","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1038\/nrmicro1289","article-title":"Immune evasion by staphylococci","volume":"3","author":"Foster","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.jmb.2019.03.017_bb0020","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1146\/annurev.micro.55.1.77","article-title":"Toxic shock syndrome and bacterial superantigens: an update","volume":"55","author":"McCormick","year":"2001","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.jmb.2019.03.017_bb0025","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3109\/10408419009105728","article-title":"Staphylococcal and streptococcal pyrogenic toxins involved in toxic shock syndrome and related illnesses","volume":"17","author":"Bohach","year":"1990","journal-title":"Crit. Rev. Microbiol."},{"key":"10.1016\/j.jmb.2019.03.017_bb0030","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1099\/00222615-28-3-163","article-title":"Entero-toxin production by Staphylococcus aureus isolates from cases of septicemia and from healthy carriers","volume":"28","author":"Humphreys","year":"1989","journal-title":"J.\u00a0Med. Microbiol."},{"key":"10.1016\/j.jmb.2019.03.017_bb0035","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00494-13","article-title":"Superantigens are critical for Staphylococcus aureus infective endocarditis, sepsis, and acute kidney injury","volume":"4","author":"Salgado-Pabon","year":"2013","journal-title":"Mbio."},{"key":"10.1016\/j.jmb.2019.03.017_bb0040","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.1016\/j.vaccine.2012.05.067","article-title":"Immunity to Staphylococcus aureus secreted proteins protects rabbits from serious illnesses","volume":"30","author":"Spaulding","year":"2012","journal-title":"Vaccine."},{"key":"10.1016\/j.jmb.2019.03.017_bb0045","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1093\/infdis\/jir389","article-title":"Methicillin-susceptible Staphylococcus aureus endocarditis isolates are associated with clonal complex 30 genotype and a distinct repertoire of enterotoxins and adhesins","volume":"204","author":"Nienaber","year":"2011","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.jmb.2019.03.017_bb0050","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.tim.2017.11.008","article-title":"Staphylococcus aureus and atopic dermatitis: a complex and evolving relationship","volume":"26","author":"Geoghegan","year":"2018","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.jmb.2019.03.017_bb0055","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1097\/QCO.0b013e3280964d8c","article-title":"The role of superantigens of group A Streptococcus and Staphylococcus aureus in Kawasaki disease","volume":"20","author":"Matsubara","year":"2007","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.jmb.2019.03.017_bb0060","series-title":"Textbook of Military Medicine: Medical Aspects of Chemical and Biological Warfare","first-page":"621","article-title":"Staphylococcal enterotoxin B and related pyogenic toxins","author":"Ulrich","year":"1997"},{"key":"10.1016\/j.jmb.2019.03.017_bb0065","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/S0140-6736(86)91859-3","article-title":"Staphylococcal enterotoxin B and toxic shock syndrome toxin-1 are significantly associated with non-menstrual TSS","volume":"1","author":"Schlievert","year":"1986","journal-title":"Lancet."},{"key":"10.1016\/j.jmb.2019.03.017_bb0070","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1093\/infdis\/167.5.997","article-title":"Role of superantigens in human disease","volume":"167","author":"Schlievert","year":"1993","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.jmb.2019.03.017_bb0075","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.3201\/eid1009.040250","article-title":"Laboratory exposures to staphylococcal enterotoxin B","volume":"10","author":"Rusnak","year":"2004","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.jmb.2019.03.017_bb0080","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0272-2712(18)30023-4","article-title":"Toxins as weapons of mass destruction. A comparison and contrast with biological-warfare and chemical-warfare agents","volume":"21","author":"Madsen","year":"2001","journal-title":"Clin. Lab. Med."},{"key":"10.1016\/j.jmb.2019.03.017_bb0085","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1177\/153567600601100303","article-title":"Staphylococcal enterotoxin B as a biological weapon: recognition, management, and surveillance of staphylococcal enterotoxin","volume":"11","author":"Ahanotu","year":"2006","journal-title":"Appl. Biosaf."},{"key":"10.1016\/j.jmb.2019.03.017_bb0090","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/74672","article-title":"Superantigen antagonist protects against lethal shock and defines a new domain for T-cell activation","volume":"6","author":"Arad","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.jmb.2019.03.017_bb0095","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1189\/jlb.69.6.921","article-title":"Superantigen antagonist blocks Th1 cytokine gene induction and lethal shock","volume":"69","author":"Arad","year":"2001","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.jmb.2019.03.017_bb0100","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.imlet.2003.11.003","article-title":"Broad-spectrum immunity against superantigens is elicited in mice protected from lethal shock by a superantigen antagonist peptide","volume":"91","author":"Arad","year":"2004","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.jmb.2019.03.017_bb0105","doi-asserted-by":"crossref","first-page":"4222","DOI":"10.1021\/bi002172e","article-title":"Structure-based design of a bispecific receptor mimic that inhibits T cell responses to a superantigen","volume":"40","author":"Lehnert","year":"2001","journal-title":"Biochemistry."},{"key":"10.1016\/j.jmb.2019.03.017_bb0110","doi-asserted-by":"crossref","first-page":"5676","DOI":"10.1074\/jbc.M309388200","article-title":"Design of chimeric receptor mimics with different TcRV beta isoforms\u2014type-specific inhibition of superantigen pathogenesis","volume":"279","author":"Hong-Geller","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jmb.2019.03.017_bb0115","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/jmr.684","article-title":"Modeling of receptor mimics that inhibit superantigen pathogenesis","volume":"18","author":"Mollhoff","year":"2005","journal-title":"J.\u00a0Mol. Recognit."},{"key":"10.1016\/j.jmb.2019.03.017_bb0120","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nm1584","article-title":"Neutralization of staphylococcal enterotoxin B by soluble, high-affinity receptor antagonists","volume":"13","author":"Buonpane","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.jmb.2019.03.017_bb0125","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1128\/IAI.69.2.875-884.2001","article-title":"Inhibition of bacterial superantigens by peptides and antibodies","volume":"69","author":"Visvanathan","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jmb.2019.03.017_bb0130","doi-asserted-by":"crossref","first-page":"4686","DOI":"10.1128\/iai.64.11.4686-4693.1996","article-title":"Immunogenicity and efficacy against lethal aerosol staphylococcal enterotoxin B challenge in monkeys by intramuscular and respiratory delivery of proteosome-toxoid vaccines","volume":"64","author":"Lowell","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jmb.2019.03.017_bb0135","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1128\/iai.64.5.1706-1713.1996","article-title":"Intranasal and intramuscular proteosome-staphylococcal enterotoxin B (SEB) toxoid vaccines: immunogenicity and efficacy against lethal SEB intoxication in mice","volume":"64","author":"Lowell","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jmb.2019.03.017_bb0140","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1016\/S0264-410X(98)00176-5","article-title":"Development of engineered vaccines effective against structurally related bacterial superantigens","volume":"16","author":"Ulrich","year":"1998","journal-title":"Vaccine."},{"key":"10.1016\/j.jmb.2019.03.017_bb0145","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1128\/IAI.69.4.2031-2036.2001","article-title":"Mucosal vaccination with recombinantly attenuated staphylococcal enterotoxin B and protection in a murine model","volume":"69","author":"Stiles","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jmb.2019.03.017_bb0150","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S1521-6616(03)00066-4","article-title":"Generation of protective immunity by inactivated recombinant staphylococcal enterotoxin B vaccine in nonhuman primates and identification of correlates of immunity","volume":"108","author":"Boles","year":"2003","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.jmb.2019.03.017_bb0155","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1128\/CVI.00399-16","article-title":"Safety and immunogenicity of a parenterally administered, structure-based rationally modified recombinant staphylococcal enterotoxin B protein vaccine, STEBVax","volume":"23","author":"Chen","year":"2016","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.jmb.2019.03.017_bb0160","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1086\/376630","article-title":"Intravenous immunoglobulin G therapy in streptococcal toxic shock syndrome: a European randomized, double-blind, placebo-controlled trial","volume":"37","author":"Darenberg","year":"2003","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.jmb.2019.03.017_bb0165","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1086\/381979","article-title":"Differences in potency of intravenous polyspecific immunoglobulin G against streptococcal and staphylococcal superantigens: implications for therapy of toxic shock syndrome","volume":"38","author":"Darenberg","year":"2004","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.jmb.2019.03.017_bb0170","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1084\/jem.180.2.615","article-title":"Monoclonal antibodies defining functional sites on the toxin superantigen staphylococcal enterotoxin B","volume":"180","author":"Hamad","year":"1994","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.jmb.2019.03.017_bb0175","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1128\/IAI.68.6.3261-3268.2000","article-title":"Inhibition of staphylococcal enterotoxin B-induced lymphocyte proliferation and tumor necrosis factor alpha secretion by MAb5, an anti-toxic shock syndrome toxin 1 monoclonal antibody","volume":"68","author":"Pang","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jmb.2019.03.017_bb0180","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1128\/IAI.01121-09","article-title":"Potent neutralization of staphylococcal enterotoxin B by synergistic action of chimeric antibodies","volume":"78","author":"Tilahun","year":"2010","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jmb.2019.03.017_bb0185","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1476-8518-8-9","article-title":"Generation and characterization of high affinity human monoclonal antibodies that neutralize staphylococcal enterotoxin B","volume":"8","author":"Drozdowski","year":"2010","journal-title":"J.\u00a0Immune Based Ther. Vaccines"},{"key":"10.1016\/j.jmb.2019.03.017_bb0190","doi-asserted-by":"crossref","first-page":"9737","DOI":"10.1074\/jbc.M110.212407","article-title":"Generation, characterization, and epitope mapping of neutralizing and protective monoclonal antibodies against staphylococcal enterotoxin B-induced lethal shock","volume":"286","author":"Varshney","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jmb.2019.03.017_bb0195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013253","article-title":"Inhibition of toxic shock by human monoclonal antibodies against staphylococcal enterotoxin B","volume":"5","author":"Larkin","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jmb.2019.03.017_bb0200","doi-asserted-by":"crossref","first-page":"25203","DOI":"10.1074\/jbc.M112.364075","article-title":"Synthetic human monoclonal antibodies toward staphylococcal enterotoxin B (SEB) protective against toxic shock syndrome","volume":"287","author":"Karauzum","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jmb.2019.03.017_bb0205","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/368711a0","article-title":"3-Dimensional structure of a human class-II histocompatibility molecule complexed with superantigen","volume":"368","author":"Jardetzky","year":"1994","journal-title":"Nature."},{"key":"10.1016\/j.jmb.2019.03.017_bb0210","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S1074-7613(00)80646-9","article-title":"Three-dimensional structure of the complex between a T cell receptor beta chain and the superantigen staphylococcal enterotoxin B","volume":"9","author":"Li","year":"1998","journal-title":"Immunity."},{"key":"10.1016\/j.jmb.2019.03.017_bb0215","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.4049\/jimmunol.1401268","article-title":"Structure of the superantigen staphylococcal enterotoxin B in complex with TCR and peptide-MHC demonstrates absence of TCR\u2013peptide contacts","volume":"193","author":"Rodstrom","year":"2014","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jmb.2019.03.017_bb0220","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.jmb.2012.11.037","article-title":"CDR-H3 diversity is not required for antigen recognition by synthetic antibodies","volume":"425","author":"Persson","year":"2013","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.jmb.2019.03.017_bb0225","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0145-305X(02)00039-3","article-title":"IMGT unique numbering for immunoglobulin and T cell receptor variable domains and Ig superfamily V-like domains","volume":"27","author":"Lefranc","year":"2003","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.jmb.2019.03.017_bb0230","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0022-2836(02)00264-4","article-title":"Comprehensive functional maps of the antigen-binding site of an anti-ErbB2 antibody obtained with shotgun scanning mutagenesis","volume":"320","author":"Vajdos","year":"2002","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.jmb.2019.03.017_bb0235","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1016\/j.celrep.2018.04.096","article-title":"Allosteric coupling of CARMIL and V-1 binding to capping protein revealed by hydrogen\u2013deuterium exchange","volume":"23","author":"Johnson","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.jmb.2019.03.017_bb0240","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0027203","article-title":"Chimeric anti-staphylococcal enterotoxin B antibodies and lovastatin act synergistically to provide in vivo protection against lethal doses of SEB","volume":"6","author":"Tilahun","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jmb.2019.03.017_bb0245","doi-asserted-by":"crossref","first-page":"5333","DOI":"10.1128\/iai.61.12.5333-5338.1993","article-title":"Toxicity of staphylococcal enterotoxins potentiated by lipopolysaccharide\u2014major histocompatibility complex class-II molecule dependency and cytokine release","volume":"61","author":"Stiles","year":"1993","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jmb.2019.03.017_bb0250","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1093\/infdis\/jiu198","article-title":"Humanized staphylococcal enterotoxin B (SEB)-specific monoclonal antibodies protect from SEB intoxication and Staphylococcus aureus infections alone or as adjunctive therapy with vancomycin","volume":"210","author":"Varshney","year":"2014","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.jmb.2019.03.017_bb0255","series-title":"Making and Using Antibodies: A Practical Handbook","first-page":"157","article-title":"Making antibodies in bacteria","author":"Fellouse","year":"2006"},{"key":"10.1016\/j.jmb.2019.03.017_bb0260","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/protein\/gzv043","article-title":"A\u00a0switchable yeast display\/secretion system","volume":"28","author":"Van Deventer","year":"2015","journal-title":"Protein Eng. Des. Sel."},{"key":"10.1016\/j.jmb.2019.03.017_bb0265","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120481","article-title":"Development and characterization of recombinant antibody fragments that recognize and neutralize in vitro Stx2 toxin from Shiga toxin-producing Escherichia coli","volume":"10","author":"Luz","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jmb.2019.03.017_bb0270","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jim.2007.01.008","article-title":"Antibody internalization studied using a novel IgG binding toxin fusion","volume":"321","author":"Mazor","year":"2007","journal-title":"J.\u00a0Immunol. Methods"},{"key":"10.1016\/j.jmb.2019.03.017_bb0275","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1007\/s13361-016-1398-9","article-title":"Native MS and ECD characterization of a fab-antigen complex may facilitate crystallization for x-ray diffraction","volume":"27","author":"Zhang","year":"2016","journal-title":"J.\u00a0Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.jmb.2019.03.017_bb0280","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00320315","article-title":"Isolation of human-monocytes by ficoll density gradient centrifugation","volume":"43","author":"Berthold","year":"1981","journal-title":"Blut."}],"container-title":["Journal of Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283619301482?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283619301482?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T21:30:19Z","timestamp":1758317419000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022283619301482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":56,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["S0022283619301482"],"URL":"https:\/\/doi.org\/10.1016\/j.jmb.2019.03.017","relation":{},"ISSN":["0022-2836"],"issn-type":[{"value":"0022-2836","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potent Neutralization of Staphylococcal Enterotoxin B In Vivo by Antibodies that Block Binding to the T-Cell Receptor","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmb.2019.03.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}